Composite material as well as preparation method and application thereof

A technology of composite materials and doped materials, which is applied in the field of composite materials and their preparation, can solve problems such as inability to carry out quality control, decrease in physical properties of materials, and large gaps, etc., to achieve good drug sustained release effects, strong mechanical properties of materials, and high loading capacity. drug distribution effect

Inactive Publication Date: 2015-04-08
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing technology cannot realize biomedical composite materials with uniform structure and good repeatability in the regulation of physical and chemical properties at the micron or nanoscale
The most significant disadvantage is that due to the non-uniform distribution of composite nano-doped materials, the repair effect of the material is uncertain. It is possible that a certain part of a single product or some of a batch of products have good results, while others The effect may vary greatly, quality control cannot be carried out, and it is impossible to form a commercial product
And due to the uneven accumulation of doped particles to form micro-defects inside the material, the internal stress tends to concentrate on the defect part during the stress process, resulting in a decrease in the physical properties of the material

Method used

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  • Composite material as well as preparation method and application thereof
  • Composite material as well as preparation method and application thereof
  • Composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1. Preparation of Aminocellulose / Carboxyl Surface Polystyrene Micron-scale Microsphere Membrane Material

[0053] The sieved polystyrene balls (Ps, 10 micron particle size, product of Aladdin Company, P107783) were placed in a sand core funnel, swollen with dichloromethane, washed twice with tetrahydrofuran, and washed with tetrahydrofuran for two times. Then, the volume ratios of tetrahydrofuran and distilled water are 3:1, 1:1, 1:3, respectively, for 1 time filtration, and then 10 times with cold distilled water and boiled distilled water to remove the monomers and low molecular weights in Ps. Finally, wash and filter twice with absolute ethanol and methanol, and vacuum dry to constant weight for use. Add phthalic anhydride powder and a certain amount of anhydrous methanol to the three-necked flask, ultrasonically vibrate for 10 min, and then add the treated Ps (the mass ratio of Ps to phthalic anhydride is 3:1), add to the reaction flask After passing the pu...

Embodiment 2

[0058] Example 2. Preparation of pyrazinamide-loaded urethane starch / carboxyl surface-modified polystyrene nanoscale microsphere porous material

[0059] The sieved polystyrene balls (Ps, 200 nanometer particle size, product of Aladdin Company, P107773) were placed in a sand core funnel, swollen with dichloromethane, washed and filtered twice, and then washed with tetrahydrofuran twice. Then, the volume ratios of tetrahydrofuran and distilled water are 3:1, 1:1, 1:3, respectively, for 1 time filtration, and then 10 times with cold distilled water and boiled distilled water to remove the monomers and low molecular weights in Ps. Finally, wash and filter twice with absolute ethanol and methanol, and vacuum dry to constant weight for use. Add phthalic anhydride powder and a certain amount of anhydrous methanol to the three-necked flask, ultrasonically vibrate for 20 min, and then add the treated Ps (the mass ratio of Ps to phthalic anhydride is 3:1), and add it to the reaction fl...

Embodiment 3

[0064] Example 3. Preparation of amino-terminated polycaprolactone / carboxyl surface-modified ferric oxide particle dense material

[0065] Ferric chloride hexahydrate and ferrous chloride hexahydrate were respectively dissolved in 40ml of deionized water and mixed in a 250ml there-necked flask (the mol ratio of ferric chloride and ferrous chloride was 2:1), placed in the flask. Stir well in a 40°C water bath, add 18ml of concentrated ammonia water dropwise, add 4.26g of oleic acid dropwise after 1min, continue to stir rapidly for 1h in a 70°C water bath, wash twice with alcohol after the reaction to remove excess oleic acid, Then wash with deionized water until neutral. Take 20ml of the magnetic microsphere suspension 40mg / ml prepared above, add 150ml of 20mg / ml KMnO 4 solution, under ice bath conditions, crushed in an ultrasonic cell pulverizer for 20min, placed the oxidized and crushed magnetic microspheres in a three-necked flask, stirred at high speed for 5h and washed 3 ...

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Abstract

The invention provides a composite material as well as a preparation method and an application thereof. The preparation method of the composite material comprises the following steps: carrying out self-assembly reaction on a polymer with charges and micron or nano-scale doped material particles with surface charges in a solvent to generate a colloid, and removing the solvent from the colloid to obtain the composite material. The invention further provides a medicine carrying system which takes the composite material as a carrier. The composite material prepared from micron or nano-scale doped material particles which can be dispersed uniformly by coating the solvent with the colloid has a micron or nano-scale uniform and repetitive structure. Because the micron or nano-scale doped material particles for preparing the composite material are doped uniformly, and the polymer highly coats the micron or nano-scale doped material particles, the composite material has strong mechanical performance. The medicine carrying system with a micron or nano-scale structure can ensure that the medicines carried by the composite material are distributed uniformly. Because the polymer highly coats the micron or nano-scale doped material particles, the medicine carrying system has a better medicine slow-release effect than the traditional medicine carrying systems and can release the medicines more uniformly in a three-dimensional space than the traditional medicine carrying systems.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a composite material and its preparation method and application. Background technique [0002] Biomedical composite materials are biomedical materials composed of two or more different materials. Various materials learn from each other in terms of performance and produce synergistic effects, so that the comprehensive performance of the composite material is better than that of the original constituent materials to meet various requirements. Tissue engineering is a science that combines the principles of engineering with the principles of cytology and tissue biology to replace defective (aged, damaged or diseased) tissues and organs. [0003] Study the mechanical behavior of biomedical materials under various stress states of the human body system, guide the structural design and processing of materials from the perspective of biomechanics, adjust their structure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08L3/04C08L67/04C08L5/08C08L33/02C08L25/06C08K9/04C08K9/06C08K3/36C08K3/22C08K3/26C08K3/32C08J9/28C08J7/14C08G63/91C08G63/664A61K47/38A61K47/36A61K47/34A61K47/32A61K47/04A61K47/02
Inventor 吴德成张健杨飞
Owner INST OF CHEM CHINESE ACAD OF SCI
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