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Improved-performance tablet and preparation method thereof

A tablet, performance technology, applied in the direction of pill delivery, etc.

Inactive Publication Date: 2013-12-11
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above technologies have not been fully applied to (hydrophilic porous) tablets (or rapidly disintegrating and / or dissolving tablets in the oral cavity) to improve the performance of the above tablets, such as improving the mechanical properties of the above tablets

Method used

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  • Improved-performance tablet and preparation method thereof
  • Improved-performance tablet and preparation method thereof
  • Improved-performance tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0417] Embodiment 1 and its comparative example

[0418]

[0419] [Preparation method] Take components 3-4, heat and melt, mix well, cool, and pulverize to 100-120 mesh to obtain solid dispersion ( / body) powder (the average particle size of the dispersoid is not greater than 10nm); the above-mentioned powder Mix with components 1-2, 5-9 that have passed through a 100-mesh sieve (ground if necessary), press the tablet with a pressure of about 0.18t / pestle (tablet hardness 1.5kp, n=5), and reheat the tablet Heat to 80°C and keep warm for 5 minutes, then cool to room temperature.

Embodiment 2

[0421] Embodiment 2 and its comparative example

[0422]

Embodiment 2-1

[0423] [Example 2-1 Preparation method] Take components 1-3 and dissolve or disperse them in an appropriate amount of water, spray or freeze-dry the solution to obtain solid dispersion ( / body) powder 1; take components 4-5, heat and melt, Mix evenly, cool down, and pulverize to 100-120 mesh to obtain solid dispersion ( / body) powder 2 (the average particle size of the dispersoid is about 70-100nm); mix the above-mentioned powder 1 and 2, mix well and put into suitable bubbles Put it in the eye or tablet mold, then heat to 85°C and keep it warm for 15 minutes, then cool to room temperature.

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Abstract

The invention discloses an improved-performance tablet which comprises an active component A1, a hydrophilic diluent B1 and a meltable solid dispersion and / or a solid coating C1, wherein the diluent B1 and / or the active component A1 are / is bonded and bridged by the solidified melt of the meltable solid dispersion and / or solid coating C1; and / or the tablet comprises a hydrophilic diluent B2 and a meltable solid dispersion containing an active component A2 and / or a solid coating C2, wherein the diluent B2 is bonded and bridged by the solidified melt of the meltable solid dispersion and / or solid coating C2. The invention also discloses a preparation method of the tablet. The tablet has stronger mechanical performance and / or better weather resistance and / or better hydrophilcity or better disintegration property or better medicine dissolubility and higher porosity.

Description

technical field [0001] The present invention relates to a tablet with improved properties. More specifically, a hydrophilic tablet whose mechanical properties and / or weather resistance and / or hydrophilicity and / or drug dissolution and / or / safety are further strengthened. The invention also relates to a preparation method of the tablet. Background of the invention [0002] The porosity and mechanical strength of the tablet play a very important role in the tablet. High porosity is beneficial to the dissolution and release of drugs in tablets, especially poorly soluble drugs, especially the rapid disintegration / or dissolution of tablets in the oral cavity. High mechanical strength is conducive to maintaining the shape of the tablet during production and transportation, ensuring the accuracy of a single dose, thereby ensuring the safety of medication. [0003] However, porosity and mechanical strength are often not organically unified in the same tablet, but contradictory: hi...

Claims

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Application Information

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IPC IPC(8): A61K9/20
Inventor 钟术光
Owner 钟术光
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