The application provides a
tissue engineering gel
scaffold and a preparation method, a composite gel
scaffold and an application thereof, wherein the
tissue engineering gel
scaffold comprises a
decellularized matrix of a
cephalopod, and a tissue source of the
decellularized matrix of the
cephalopod comprises at least one of a mantle of the
cephalopod and a brachialia of the cephalopod. The
tissue engineering gel scaffold of the application is based on the
decellularized matrix of the cephalopod, has good
biocompatibility, and has a regular arrangement structure, strong water absorption performance and strong mechanical properties. The structure,
water content, mechanical properties and degradation rate of the tissue
engineering gel scaffold are similar to those of
soft tissue, the content of high proportion of unsaturated fatty acids, in which the content of
omega-3 is much greater than that of
omega-6, is beneficial to the inhibition of
inflammation and the repair of tissue, and the tissue
engineering gel scaffold can be compounded or used in combination with various active molecules, cells and the like, is used for defect filling and
tissue repair in
soft tissue regeneration, and is beneficial to promoting the
soft tissue regeneration process.