4 results about "Collagen membrane" patented technology

A glaucoma drainage tube and its manufacturing process are disclosed, relating to the field of ophthalmic medical device technology. The tube is manufactured using a drainage tube manufacturing device, which includes a negative electrode, a positive electrode, and a power source. The negative electrode comprises a middle section and a terminal section, with the outer surface of the terminal section being trumpet-shaped. The negative electrode consists of two interlocking parts. The distance between the central axis of the middle section and the positive electrode is 0.3–2 cm. The positive and negative terminals of the power source are connected to the negative and positive electrodes, respectively. The manufacturing process includes the following steps: providing an acidic electrolyte; placing the working electrode and the positive electrode in the electrolyte for an electrochemical reaction to form a collagen film on the circumferential surface of the working electrode, obtaining a preliminary product; cross-linking the preliminary product; and then extracting the two parts of the negative electrode from within the collagen film towards the terminal section, respectively, to obtain the glaucoma drainage tube. This method can produce a glaucoma drainage tube with trumpet-shaped ends, improving the problem of easy displacement of existing glaucoma drainage tubes after implantation into the eye.

The present application relates to the technical field of biological materials, in particular to a double-layer guided tissue regeneration membrane and a preparation method thereof, so as to improve the comprehensive performance of the double-layer guided tissue regeneration membrane. In the preparation, collagen type I is dissolved in acid to prepare a collagen type I solution; then, an alkali is added to adjust the pH value, so as to prepare collagen type I fibers; then, the collagen type I fibers are processed and molded, and gradient freeze-drying is performed, so as to prepare a collagen type I membrane; then, the collagen type I membrane is crosslinked with a crosslinking agent, so as to prepare the double-layer guided tissue regeneration membrane; wherein, the concentration of the collagen type I solution is 0.5-1.5%, and the pH value is 7-9. The double-layer guided tissue regeneration membrane prepared by the above preparation method is composed of a dense layer and a loose layer formed on the surface of the dense layer, the thickness of the dense layer is 0.2-0.8 mm, and the thickness of the loose layer is 0.4-0.8 mm. The tensile strength is greater than or equal to 28 N, the suture strength is greater than or equal to 4.7 N, and the porosity is greater than or equal to 65.8%, which effectively solves the problems of insufficient mechanical performance and low biological safety of the existing double-layer guided tissue regeneration membrane. The preparation process is simple, green and large-scale.

The present application relates to the technical field of medical and cosmetic raw materials, and particularly relates to a triple helix structure collagen membrane and a preparation method and application thereof. The triple helix structure collagen membrane is prepared by vacuum freeze-drying treatment without involving a chemical cross-linking agent, and has excellent mechanical properties and high production efficiency. The triple helix structure collagen membrane has excellent biocompatibility, so that when the triple helix structure collagen membrane is applied to the preparation of medicines or cosmetics, the triple helix structure collagen membrane cannot cause skin inflammation and other immune responses.

The present application relates to a kind of preparation methods of transparent collagen membrane, the method includes the following steps: (a) obtaining animal-derived acellular collagen membrane;(b) at least three times transparentization is carried out to collagen membrane.The present application uses animal-derived material to obtain collagen membrane by decellularization, makes its triple helix structure more close to tissue itself, has good mechanical property and degradation performance.At the same time, the collagen membrane prepared by the method according to the present application is treated by three times transparentization, collagen network structure is uniform, and stable is uniformly transparent color, and the light transmittance of material cannot be influenced by the change of pH, can maintain the beauty of healed tissue while accelerating the process of wound repair healing.