70 results about "Tissue healing" patented technology

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The utility model discloses a poly (p-dioxanone) medical suture with an anti-inflammation capsule, and relates to the technical field of medical sutures. The protein anti-inflammatory suture line comprises a suture line inner core, a protein adhesive layer, a protein microcapsule and anti-inflammatory drug particles, wherein the suture line inner core is made of a PPDO material. According to the utility model, the anti-inflammatory drug of the wound can be fully and comprehensively absorbed; the inner core of the suture line has good compatibility, and rejection and tissue inflammation are reduced; the suture line can be gradually degraded in the body and finally converted into carbon dioxide, water and the like, and the carbon dioxide, the water and the like are naturally discharged by the human body and do not need to be removed through a secondary operation, so that the infection risk possibly caused by the secondary operation is reduced, and the infection risk is reduced; the suture line has long strength maintenance time and can provide continuous support for the wound until the tissue is healed; the protein microcapsules and the anti-inflammatory drug particles are beneficial to reducing inflammatory reaction.

The application relates to the field of biomaterials, in particular to a preparation method of injectable acellular matrix powder and application thereof. The preparation method of the injectable acellular matrix powder is obtained through two discontinuous crosslinking steps of once crosslinking and twice crosslinking after crushing of acellular basement membrane. The obtained injectable acellular matrix powder with a unique crosslinking network structure is adapted to the natural skin pH value, greatly enhances the biocompatibility, simultaneously inhibits excessive inflammatory reaction and accelerates tissue healing through the induction of M2 polarized macrophage activation, effectively relieves the local tissue compression risk possibly caused by high cohesive force due to amino acid modification and introduction of a double crosslinking agent, realizes dynamic balance of mechanical stability and physiological friendliness, continuously stimulates the generation of skin collagen by using controllable moderate inflammatory reaction, and promotes gradual reconstruction and improvement of tissues.

A device for safely and effectively disinfecting a catheter while it remains implanted in a patient's body is provided. [Solution] Methods and devices for providing therapeutic electromagnetic radiation (EMR) to inactivate infectious agents and / or enhance healthy cell growth in, on, or around a catheter (10) placed in a patient's body cavity. Non-ultraviolet therapeutic EMR is transmitted axially along the lumen of the catheter body and / or along an optical element (14) within the catheter body. Delivery of the therapeutic EMR to specific infected areas and / or areas requiring tissue healing results in inactivation of primary sources of infection in, on, and around the catheter and / or enhancement of healthy cell growth around the catheter through the use of controlled relative intensity and treatment-site-specific dose projection of the therapeutic EMR radially emitted from the optical element. Specific embodiments for urinary catheters and peritoneal dialysis catheters are also disclosed.

The utility model discloses a skin flap taking device applied to an oral cavity, relates to the technical field of medical auxiliary tools, and aims to solve the problems that when palate skin flaps are cut, sharp blades are usually adopted for cutting, the sizes are not consistent, the widths are not uniform, the palate skin flaps are easily broken or cut off, appropriate soft tissue flaps cannot be obtained, suturing is not facilitated, and the palate skin flaps cannot be taken out easily. And later tissue healing and keratinized gingival formation are not facilitated. According to the flap taking device applied to the oral cavity, the flap cutting size can be adjusted according to needs, and observation is facilitated. Comprising a first connecting rod and a second connecting rod which are arranged in a crossed mode and rotationally connected, one ends of the first connecting rod and the second connecting rod are provided with a cutting part and a fixing part respectively, the other ends of the first connecting rod and the second connecting rod are provided with adjusting structures, the adjusting structures control the opening degree of the first connecting rod and the second connecting rod, and the cutting part is provided with a blade used for cutting.

The present application relates to the technical field of functional materials, in particular to an injectable silk fibroin / zinc oxide / magnetic mica sheet nano-enzyme hydrogel, a preparation method and application thereof, after the prepared silk fibroin aqueous solution, nano-zinc oxide and magnetic mica sheet are uniformly mixed, the pH value is adjusted, and physical gelation is carried out through simple ultrasonic crushing, so that the injectable nano-enzyme hydrogel can be obtained. The preparation method is simple, controllable, the prepared nano-enzyme hydrogel has good injection performance and biocompatibility, and based on the nano-enzyme strategy, the in-situ self-produced hydrogen peroxide can be catalyzed into active oxygen without relying on stimuli such as light, so that the synergistic antibacterial ability and the ability to promote wound tissue healing are significantly improved.

Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical / therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector / substrate / support / scaffold for direct application.

Provided herein are compositions and methods that include hydrogen gas or a mixture of hydrogen gas and oxygen gas or a solution of hydrogen and oxygen for ocular therapies and tissue healing. The compositions can be incorporated into a container with a quick-release seal allowing for efficient topical administration of the medicaments of the composition to tissues desired for treatment, such as the human eye.

The invention belongs to the technical field of medical experimental animal models, and discloses a small animal model for skull base high-flow cerebrospinal fluid leakage and skull base reconstruction as well as a construction method and application of the small animal model. The technical obstacle that due to the fact that the nasal cavity of a small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the skull base through the nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for tissue healing after the endoscopic transnasal skull base surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow cerebrospinal fluid leakage of small animals, the standardized bone defect constructed in the middle skull base butterfly saddle area can cause continuous and high-flow cerebrospinal fluid leakage; autologous bone flap and free mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde intracranial infection research after an operation.

The utility model belongs to the technical field of uterine curettage devices, and particularly relates to a uterine curettage device which comprises a grab handle, a length adjusting mechanism is arranged on the left side of the grab handle, a curettage head mounting mechanism is arranged on the left side of the length adjusting mechanism, a curettage head is arranged on the left side of the curettage head mounting mechanism, and the curettage head is used for curettage operation in the uterus. The curettage head mounting mechanism is used for mounting and dismounting the curettage head, the length adjusting mechanism is used for adjusting the length of the uterine curettage device, the curettage head comprises a fixing ring, and the top of the fixing ring is fixedly connected with an elastic ring. According to the novel uterine curettage device, the curettage head is placed in a medicament with the effect of promoting tissue healing, the medicament is absorbed by the medicament placing sponge, the curettage head is controlled by the grab handle to extend into the uterus of a patient to perform curettage operation, and during curettage, the medicament placing sponge is extruded by the elastic ring, so that medicament factors in the medicament placing sponge are released, and the healing of the tissue at the curettage part is promoted; therefore, operative treatment and postoperative repair of the uterine curettage device can be carried out synchronously.

The application discloses a PAM-AA-NHS-based multifunctional biomimetic polymer adhesive for wound repair and a preparation method thereof, and belongs to the field of biomaterial preparation and biomedical application. N-hydroxysuccinimide acrylate copolymerized polyacrylamide hydrogel is used as a substrate and as a main chain network, and functionalized materials tannic acid and phenolic hydroxyl chitosan containing o-diphenol groups are introduced, so that effective adhesion can be formed at a biological tissue interface, and cross-linking can be generated with the main chain network through hydrogen bond action to form a secondary network. In addition, aldehyde group-rich oxidized dextran side chains are introduced, which can form Schiff base cross-linking with the main chain network and amino groups in the biological tissue interface to form long-acting adhesion performance. The adhesive has good tissue adhesion, biocompatibility, antibacterial activity and wound healing promotion capacity, can replace sutures, has a positive effect on the formation of new tissues and tissue healing, and is expected to be applied in clinical treatment of wound surfaces.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The present invention relates to a nanoformulation comprising L-leucyl-L-leucine methyl ester (LLOMe) and a polymer for wound healing, which promotes multiple molecular signaling pathways essential for faster wound healing. The nanoformulation offers faster and improved wound and tissue healing, axon regeneration, antiviral immunity, stem cell proliferation, embryonic development, and anti-aging effects.

The utility model provides an antibacterial composite dressing plaster which is easy to use, and relates to the technical field of medical dressings. Comprising an adhesive layer, a drug delivery layer and a protective layer which are laminated, the protective layer comprises two sheet bodies, and the two sheet bodies are respectively covered on the drug delivery layer; wherein one ends and two sides of the two tablet bodies are all adhered to the edge of the adhesive layer, and the other ends of the two tablet bodies extend to the administration layer and cover the administration layer in a staggered manner. According to the utility model, the second sponge layer is arranged as a high-absorptivity dressing; the first sponge layer absorbs liquid, resists bacteria and promotes tissue healing; the sponge barrel is antibacterial, becomes gel after meeting water, and is easy to adhere to the skin around the wound to form a stable physical barrier, so that the wound surface is protected, the diffusion of outer layer imbibition is limited, and the surrounding environment is prevented from being polluted; the microporous film layer is low in viscosity and high in air permeability, and adhesion with tissues is prevented.

According to the antibacterial coating and the preparation method provided by the invention, the degradation rate of the magnesium alloy can be remarkably reduced by the composite coating formed by combining the micro-arc oxidation film layer and the copper-doped ZIF-8 coating, copper is doped when the ZIF-8 coating is prepared, and the ZIF-8 coating can be endowed with relatively strong antibacterial performance aiming at gram-positive bacteria and gram-negative bacteria; the coating material is mainly applied to the surface of a magnesium alloy implantation instrument, and a stable surface structure with excellent biocompatibility is formed by controlling the degradation rate of magnesium alloy, so that subcutaneous gas accumulation generated by rapid degradation and hemolysis and bone dissolution caused by a local strong alkaline environment are avoided; severely, the problems that an implantation instrument loses fixing and supporting functions before tissue healing, and implantation fails are caused are solved; meanwhile, the early adhesion of bacteria and the formation of bacterial biofilms are effectively inhibited by utilizing the antibacterial function of the coating, so that the infection risk generated in the implanting and using processes of the implanting instrument is reduced.

The application discloses an adhesion-treatment synergic integrated tissue adhesive and a preparation method and application thereof, and belongs to the technical field of medical adhesives. The adhesion-treatment synergic integrated tissue adhesive comprises: (1) 100 parts by mass of an adhesion precursor, wherein the adhesion precursor is a mixture of a silk fibroin-polyphenol composite hydrogel and urea; and (2) 0.1-100 parts by mass of a medically acceptable metal oxide particle, wherein the metal oxide particle has a hollow mesoporous shell structure and is loaded with a tissue repair promoting component. The adhesion-treatment synergic integrated tissue adhesive not only has excellent adhesion strength, mechanical bearing capacity and a suitable curing window time, can be adapted to the repair of complex tissue damage sites, but also has biological activity and good compatibility for promoting tissue healing, so that the adhesion fixation, the repair and regeneration of the tissue are effectively realized.

The utility model relates to the technical field of medical equipment, and discloses a device for prosthesis breast augmentation shaping and tissue healing promotion, which comprises a cold therapy machine body, a control switch is arranged on the cold therapy machine body, a connecting pipe is inserted on the cold therapy machine body, a cold therapy head is arranged at the end part of the connecting pipe, and a fixing frame is arranged outside the cold therapy head. The fixing frame is arranged outside the cold therapy head, the protective sleeve is installed in the fixing frame, the cold therapy head can be effectively covered and prevented from making direct contact with the skin, so that frostbite is avoided, the protective sleeve can be stably clamped in the fixing frame through the design of the clamping assembly, the protective sleeve is prevented from sliding or falling off in the treatment process, and the protective effect is ensured; when a traditional cold therapy machine is used, a towel needs to be placed at the chest, the device does not need to additionally place the towel through the design of the protective sleeve and the clamping assembly, a patient can keep a certain movement freedom degree when subjected to cold therapy, the patient is not limited by placing the towel, and the comfort degree in the treatment process is improved.

The present invention relates to a non-invasive magneto-acoustic apparatus for healthy tissue healing and cancer regression comprising at least one pulsed ultrasound unit (LIPUS), at least one permanent magnet, at least one module housing, at least one permanent magnets, at least one control system for controlling pulsed ultrasound unit to energize the unit with desired pulse duration, intensity and active / ON time. The invention is to synchronously use the low intensity pulsed ultrasound (LIPUS) and static magnetic field (SMF) to selectively activate cellular activities specific to cartilage, bone, skin leading to accelerated tissue healing, regeneration. The invention apparatus is to inhibit cancer cellular activities specific to cancers of breast, skin, bone leading to enhanced cancer regression, while leaving the healthy cells unaffected using magneto-acoustic apparatus appropriately. The apparatus exhibit no toxicity to healthy cells and can reduce overall treatment time and costs due to accelerated tissue repair and tumor regression.

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.

The application discloses a locking ring locking unit and a locking cutting device. In the locking ring locking unit, an eccentric part is arranged on the side of the extrusion part away from the extrusion cavity, and the extrusion part is driven to move so that the cavity of the extrusion cavity gradually becomes smaller to extrude the locking ring, until the locking ring clamps and fixes the suture. In the process that the locking ring enters the extrusion cavity and is extruded into place, the locking ring does not move relative to the locking ring locking unit, so that the distance between the locking ring and the sutured tissue position is increased, the implant is increased, the healing time of the sutured tissue is increased, the locking ring moves away from the sutured tissue during the process of gradually clamping the suture, the sutured tissue is at risk of being pulled, the implanted suture is too long, after the suture is cut, the implanted suture retreats into the sutured tissue, the sutured tissue cannot be closely attached, and the healing time of the sutured tissue is further increased.

This invention provides a multifunctional injectable tissue adhesive, characterized by comprising component A: an active protein with chemically modified reduced polyphenol groups and a surface rich in RGD sequences, lysine, aspartic acid, and / or glutamic acid; component B: a natural polysaccharide with chemically modified active ester groups; and gelation buffers: an alkaline buffer solution and an acidic solution. The tissue adhesive provided by this invention combines good biocompatibility and adhesion, exhibits antibacterial activity, and can promote tissue healing, showing great promise for clinical application.

HUMANOIDSYNC discloses an end-to-end humanoid robotics architecture that delivers full-scale, biomechanically accurate, self-repairing robots capable of performing industrial, domestic, medical, defense, and extraterrestrial tasks. The system integrates a skeletal meta-alloy chassis, modular electro-hydraulic muscles, and bio-synthetic soft-tissue overlays coordinated by a symbolic AI kernel that enforces consent, ethics, and mission-bound constraints in real time. Swappable powerpacks (solid-state batteries, hydrogen fuel, or micro-reactor pods) enable >24-hour untethered operation, while an on-board nanofactory performs autonomous spare part printing and tissue healing. Multi-sensor fusion (LiDAR, event-camera, tactile mesh, chem sniffer) feeds a closed-loop whole-body control stack achieving <5 ms reflex latency. All firmware and hardware modules register on a treaty-aware ledger using zero-knowledge proofs to validate safety, export compliance, and battlefield Rules-of-Engagement. HUMANOIDSYNC solves design, production, deployment, and lifecycle hurdles—providing a universal, regulation ready platform for humanoid robots across terrestrial and off-world environments.

The utility model discloses a medical suture belongs to medical supplies technical field. The medical suture includes suture body and the tail end setting of its stop flab, and stop flab width is greater than suture body, and is equipped with at least two orifices that can pass through suture body along suture body extension direction. When the above -mentioned medical suture is used to carry out tissue suture, by the abutment of stop flab and the tissue to be sutured, suture body is connected with tissue again after setting aperture, can make suture force evenly dispersed on stop flab, thereby dispersing force to greater area, significantly reduce the stress of tissue at the suture, reduce tissue deformation and breakage risk, especially suitable for the suture of fragile tissue, provide good environment for tissue healing. Meanwhile, stop flab increases the contact area with tissue, provides more stable support and fixed.

The invention belongs to the technical field of high polymer materials, and particularly relates to a double-electric-field composite material, a preparation method and application in cartilage repair. The invention firstly provides a double-electric-field composite material. The double-electric-field composite material comprises a hydrogel compound for generating an endogenous electric field and a primary battery for generating an external electric field, the hydrogel compound comprises a piezoelectric material, a hydrogel material and a conductive material. The double-electric-field composite material provided by the invention can be effectively used for cartilage repair, human body tissue fluid is used as electrolyte, an internal primary battery structure can be activated to generate an endogenous electric field due to the existence of the tissue fluid, in addition, a piezoelectric electric field is generated by a piezoelectric material, and the two electric fields are coupled to generate an endogenous electric field. The cell activity and the tissue healing are more efficiently promoted.

The invention belongs to the technical field of biological medicine, and particularly relates to a knotting-free surgical suture modified by maleoyl YIGSR peptide, and a preparation method and application thereof. The method comprises the following steps: (1) obtaining a suture line base material, and carrying out cleaning and hydrophilicity improving treatment on the suture line base material; 2) oxidizing alcoholic hydroxyl groups on the surface of the suture line base material to generate carboxyl groups on the surface, then activating the carboxyl groups, and reacting with a sulfhydrylation reagent to obtain a sulfhydrylation suture line; (3) coupling the SMCC with the YIGSR peptide; the invention discloses a surgical suture which comprises the following steps: (1) preparing a Y IGSR peptide-cross-linking agent conjugate, (2) dissolving the Y IGSR peptide-cross-linking agent conjugate in a maleimide solution, (3) immersing a sulfhydrylation suture into the maleimide-Y IGSR peptide-cross-linking agent conjugate for reacting, and (4) cross-linking and curation.The surgical suture has the advantages that the tissue adhesion capacity is higher, postoperative tissue healing can be effectively promoted, and the risk of complications is reduced.

The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and / or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

The application relates to a mesenchymal stem cell exosome overexpressing Anxal and a preparation method and application thereof, and belongs to the technical field of inflammatory disease medicine preparation. The umbilical cord mesenchymal stem cell exosome overexpressing Anxal provided by the application is obtained by the following steps: cell electrotransfection of a modified Anxal mRNA sequence which is not easy to degrade into umbilical cord mesenchymal stem cells, culture, collection of cell supernatant, and then super-high-speed centrifugation or tangential flow. The umbilical cord mesenchymal stem cell exosome overexpressing Anxal protein can efficiently improve nerve tissue inflammation caused by trauma, improve nerve function, reduce chronic inflammation of local tissues of limbs caused by diabetes, burns and the like, and accelerate tissue healing.

This invention relates to the field of biological agents, and more particularly to the application of adenosine diphosphate; it provides the application of adenosine diphosphate in the preparation of drugs for treating bone defects; it provides a preparation for treating bone defects, comprising: adenosine diphosphate; the preparation of this invention does not require the collection of the patient's own bone marrow and peripheral blood, and will not cause additional damage or pain to the patient; the preparation containing adenosine diphosphate can accelerate bone tissue healing more conveniently and safely, providing conditions for early weight-bearing and functional exercises after surgery, and improving the patient's quality of life; the preparation method of the preparation of this invention is simple and easy to operate.

The invention provides a preparation method and application of a conductive hydrogel composite film, and belongs to the technical field of composite materials. The conductive hydrogel composite membrane is obtained by repeatedly freezing and thawing polyvinyl alcohol (PVA), pectin (Pectin) and MXene and crosslinking with CaCl2 to form a three-dimensional network, the MXene is introduced into a PVA and Pectin hydrogel system, the hydrogel composite membrane is endowed with good mechanical performance, biocompatibility and osteogenesis performance, the hydrogel composite membrane has excellent swelling degradability and conductivity, and the hydrogel composite membrane can be applied to the field of biomedical materials. And the hydrogel composite membrane provided by the invention is non-toxic and has good chemical stability. The hydrogel composite membrane disclosed by the invention can promote bone tissue healing, remarkably enhance the expression of osteogenic factors, promote formation of new blood vessels, promote formation of the blood vessels into bones and strengthen nutrient substance delivery, can further accelerate bone tissue healing in combination with electrical stimulation, and shows a wide application prospect in the field of bone tissue engineering.