39 results about "Tissue healing" patented technology

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The application relates to the field of biomaterials, in particular to a preparation method of injectable acellular matrix powder and application thereof. The preparation method of the injectable acellular matrix powder is obtained through two discontinuous crosslinking steps of once crosslinking and twice crosslinking after crushing of acellular basement membrane. The obtained injectable acellular matrix powder with a unique crosslinking network structure is adapted to the natural skin pH value, greatly enhances the biocompatibility, simultaneously inhibits excessive inflammatory reaction and accelerates tissue healing through the induction of M2 polarized macrophage activation, effectively relieves the local tissue compression risk possibly caused by high cohesive force due to amino acid modification and introduction of a double crosslinking agent, realizes dynamic balance of mechanical stability and physiological friendliness, continuously stimulates the generation of skin collagen by using controllable moderate inflammatory reaction, and promotes gradual reconstruction and improvement of tissues.

A device for safely and effectively disinfecting a catheter while it remains implanted in a patient's body is provided. [Solution] Methods and devices for providing therapeutic electromagnetic radiation (EMR) to inactivate infectious agents and / or enhance healthy cell growth in, on, or around a catheter (10) placed in a patient's body cavity. Non-ultraviolet therapeutic EMR is transmitted axially along the lumen of the catheter body and / or along an optical element (14) within the catheter body. Delivery of the therapeutic EMR to specific infected areas and / or areas requiring tissue healing results in inactivation of primary sources of infection in, on, and around the catheter and / or enhancement of healthy cell growth around the catheter through the use of controlled relative intensity and treatment-site-specific dose projection of the therapeutic EMR radially emitted from the optical element. Specific embodiments for urinary catheters and peritoneal dialysis catheters are also disclosed.

Provided herein are compositions and methods that include hydrogen gas or a mixture of hydrogen gas and oxygen gas or a solution of hydrogen and oxygen for ocular therapies and tissue healing. The compositions can be incorporated into a container with a quick-release seal allowing for efficient topical administration of the medicaments of the composition to tissues desired for treatment, such as the human eye.

The invention belongs to the technical field of medical experimental animal models, and discloses a small animal model for skull base high-flow cerebrospinal fluid leakage and skull base reconstruction as well as a construction method and application of the small animal model. The technical obstacle that due to the fact that the nasal cavity of a small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the skull base through the nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for tissue healing after the endoscopic transnasal skull base surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow cerebrospinal fluid leakage of small animals, the standardized bone defect constructed in the middle skull base butterfly saddle area can cause continuous and high-flow cerebrospinal fluid leakage; autologous bone flap and free mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde intracranial infection research after an operation.

The utility model belongs to the technical field of uterine curettage devices, and particularly relates to a uterine curettage device which comprises a grab handle, a length adjusting mechanism is arranged on the left side of the grab handle, a curettage head mounting mechanism is arranged on the left side of the length adjusting mechanism, a curettage head is arranged on the left side of the curettage head mounting mechanism, and the curettage head is used for curettage operation in the uterus. The curettage head mounting mechanism is used for mounting and dismounting the curettage head, the length adjusting mechanism is used for adjusting the length of the uterine curettage device, the curettage head comprises a fixing ring, and the top of the fixing ring is fixedly connected with an elastic ring. According to the novel uterine curettage device, the curettage head is placed in a medicament with the effect of promoting tissue healing, the medicament is absorbed by the medicament placing sponge, the curettage head is controlled by the grab handle to extend into the uterus of a patient to perform curettage operation, and during curettage, the medicament placing sponge is extruded by the elastic ring, so that medicament factors in the medicament placing sponge are released, and the healing of the tissue at the curettage part is promoted; therefore, operative treatment and postoperative repair of the uterine curettage device can be carried out synchronously.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The present invention relates to a nanoformulation comprising L-leucyl-L-leucine methyl ester (LLOMe) and a polymer for wound healing, which promotes multiple molecular signaling pathways essential for faster wound healing. The nanoformulation offers faster and improved wound and tissue healing, axon regeneration, antiviral immunity, stem cell proliferation, embryonic development, and anti-aging effects.

The utility model provides an antibacterial composite dressing plaster which is easy to use, and relates to the technical field of medical dressings. Comprising an adhesive layer, a drug delivery layer and a protective layer which are laminated, the protective layer comprises two sheet bodies, and the two sheet bodies are respectively covered on the drug delivery layer; wherein one ends and two sides of the two tablet bodies are all adhered to the edge of the adhesive layer, and the other ends of the two tablet bodies extend to the administration layer and cover the administration layer in a staggered manner. According to the utility model, the second sponge layer is arranged as a high-absorptivity dressing; the first sponge layer absorbs liquid, resists bacteria and promotes tissue healing; the sponge barrel is antibacterial, becomes gel after meeting water, and is easy to adhere to the skin around the wound to form a stable physical barrier, so that the wound surface is protected, the diffusion of outer layer imbibition is limited, and the surrounding environment is prevented from being polluted; the microporous film layer is low in viscosity and high in air permeability, and adhesion with tissues is prevented.

The application discloses an adhesion-treatment synergic integrated tissue adhesive and a preparation method and application thereof, and belongs to the technical field of medical adhesives. The adhesion-treatment synergic integrated tissue adhesive comprises: (1) 100 parts by mass of an adhesion precursor, wherein the adhesion precursor is a mixture of a silk fibroin-polyphenol composite hydrogel and urea; and (2) 0.1-100 parts by mass of a medically acceptable metal oxide particle, wherein the metal oxide particle has a hollow mesoporous shell structure and is loaded with a tissue repair promoting component. The adhesion-treatment synergic integrated tissue adhesive not only has excellent adhesion strength, mechanical bearing capacity and a suitable curing window time, can be adapted to the repair of complex tissue damage sites, but also has biological activity and good compatibility for promoting tissue healing, so that the adhesion fixation, the repair and regeneration of the tissue are effectively realized.

The present invention relates to a non-invasive magneto-acoustic apparatus for healthy tissue healing and cancer regression comprising at least one pulsed ultrasound unit (LIPUS), at least one permanent magnet, at least one module housing, at least one permanent magnets, at least one control system for controlling pulsed ultrasound unit to energize the unit with desired pulse duration, intensity and active / ON time. The invention is to synchronously use the low intensity pulsed ultrasound (LIPUS) and static magnetic field (SMF) to selectively activate cellular activities specific to cartilage, bone, skin leading to accelerated tissue healing, regeneration. The invention apparatus is to inhibit cancer cellular activities specific to cancers of breast, skin, bone leading to enhanced cancer regression, while leaving the healthy cells unaffected using magneto-acoustic apparatus appropriately. The apparatus exhibit no toxicity to healthy cells and can reduce overall treatment time and costs due to accelerated tissue repair and tumor regression.

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.

HUMANOIDSYNC discloses an end-to-end humanoid robotics architecture that delivers full-scale, biomechanically accurate, self-repairing robots capable of performing industrial, domestic, medical, defense, and extraterrestrial tasks. The system integrates a skeletal meta-alloy chassis, modular electro-hydraulic muscles, and bio-synthetic soft-tissue overlays coordinated by a symbolic AI kernel that enforces consent, ethics, and mission-bound constraints in real time. Swappable powerpacks (solid-state batteries, hydrogen fuel, or micro-reactor pods) enable >24-hour untethered operation, while an on-board nanofactory performs autonomous spare part printing and tissue healing. Multi-sensor fusion (LiDAR, event-camera, tactile mesh, chem sniffer) feeds a closed-loop whole-body control stack achieving <5 ms reflex latency. All firmware and hardware modules register on a treaty-aware ledger using zero-knowledge proofs to validate safety, export compliance, and battlefield Rules-of-Engagement. HUMANOIDSYNC solves design, production, deployment, and lifecycle hurdles—providing a universal, regulation ready platform for humanoid robots across terrestrial and off-world environments.

The utility model discloses a medical suture belongs to medical supplies technical field. The medical suture includes suture body and the tail end setting of its stop flab, and stop flab width is greater than suture body, and is equipped with at least two orifices that can pass through suture body along suture body extension direction. When the above -mentioned medical suture is used to carry out tissue suture, by the abutment of stop flab and the tissue to be sutured, suture body is connected with tissue again after setting aperture, can make suture force evenly dispersed on stop flab, thereby dispersing force to greater area, significantly reduce the stress of tissue at the suture, reduce tissue deformation and breakage risk, especially suitable for the suture of fragile tissue, provide good environment for tissue healing. Meanwhile, stop flab increases the contact area with tissue, provides more stable support and fixed.

The invention belongs to the technical field of high polymer materials, and particularly relates to a double-electric-field composite material, a preparation method and application in cartilage repair. The invention firstly provides a double-electric-field composite material. The double-electric-field composite material comprises a hydrogel compound for generating an endogenous electric field and a primary battery for generating an external electric field, the hydrogel compound comprises a piezoelectric material, a hydrogel material and a conductive material. The double-electric-field composite material provided by the invention can be effectively used for cartilage repair, human body tissue fluid is used as electrolyte, an internal primary battery structure can be activated to generate an endogenous electric field due to the existence of the tissue fluid, in addition, a piezoelectric electric field is generated by a piezoelectric material, and the two electric fields are coupled to generate an endogenous electric field. The cell activity and the tissue healing are more efficiently promoted.

The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and / or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

The invention provides a preparation method and application of a conductive hydrogel composite film, and belongs to the technical field of composite materials. The conductive hydrogel composite membrane is obtained by repeatedly freezing and thawing polyvinyl alcohol (PVA), pectin (Pectin) and MXene and crosslinking with CaCl2 to form a three-dimensional network, the MXene is introduced into a PVA and Pectin hydrogel system, the hydrogel composite membrane is endowed with good mechanical performance, biocompatibility and osteogenesis performance, the hydrogel composite membrane has excellent swelling degradability and conductivity, and the hydrogel composite membrane can be applied to the field of biomedical materials. And the hydrogel composite membrane provided by the invention is non-toxic and has good chemical stability. The hydrogel composite membrane disclosed by the invention can promote bone tissue healing, remarkably enhance the expression of osteogenic factors, promote formation of new blood vessels, promote formation of the blood vessels into bones and strengthen nutrient substance delivery, can further accelerate bone tissue healing in combination with electrical stimulation, and shows a wide application prospect in the field of bone tissue engineering.

The invention provides a polypeptide-modified bacterial outer membrane vesicle and application thereof in preparation of a drug for promoting cell growth, and relates to the technical field of biological medicines. According to the invention, a growth promoting polypeptide VTPYGGGGVLLY with a brand new structure is designed on the basis of two micromolecular polypeptides VTPY and VLLY from sea cucumbers, and the engineering bacterial outer membrane vesicle W-VTPVLY OMV with a relatively strong growth promoting effect is prepared by combining the growth promoting polypeptide VTPYGGGGVLLY with bacterial outer membrane protein ClyA by utilizing a genetic engineering technology. The W-VTPVLY OMV provided by the invention has a remarkable promoting effect on HUVEC cell proliferation, migration and revascularization, can play a role in promoting cell proliferation within a short time, and can maintain the proliferation promoting effect for a relatively long time. The W-VTPVLY OMV provided by the invention is expected to become a new medicine for promoting wound regeneration and tissue healing, and provides a new thought and application reference for the fields of tissue engineering and medical materials.

The invention discloses a medical titanium metal surface slow-release antibacterial peptide coating and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the following steps that after medical titanium is activated, silane polyethylene glycol active ester, an azide-active oxygen response connecting arm N3-TK-PEG-NH2 and DBCO modified antibacterial peptide DBCO-GL13K are sequentially grafted; an active oxygen responsive slow-release antibacterial coating is constructed on the surface through freeze drying; according to the medical titanium metal surface slow-release antibacterial peptide coating and the preparation method and application thereof, the active oxygen response bond TK and the antibacterial peptide GL13K are connected to the medical titanium metal surface, the TK bond is oxidized and broken by active oxygen, the antibacterial peptide GL13K can be released, medicine controlled release and accurate release are achieved, meanwhile, excessive active oxygen is consumed, the local microenvironment steady state is maintained, and the medical titanium metal surface slow-release antibacterial peptide coating has the advantages of being safe and reliable. And tissue healing and regeneration in an inflammatory state are promoted.

The application discloses a medical titanium metal surface slow-release antibacterial peptide coating and a preparation method and application thereof, relates to the technical field of biomedical materials, and comprises the following steps: after medical titanium is activated, silane polyethylene glycol active ester, azide-active oxygen response connecting arm N3-TK-PEG-NH2 and DBCO modified antibacterial peptide DBCO-GL13K are sequentially grafted; and an active oxygen response slow-release antibacterial coating is constructed on the surface of the medical titanium through freeze drying; the medical titanium metal surface slow-release antibacterial peptide coating and the preparation method and application thereof connect the active oxygen response bond TK and the antibacterial peptide GL13K on the surface of the medical titanium metal; the TK bond is oxidized and broken by active oxygen to release the antibacterial peptide GL13K, drug controlled release and precise release are achieved, excessive active oxygen is consumed, the local microenvironment homeostasis is maintained, and tissue healing and regeneration in an inflammatory state are promoted.

The utility model relates to the technical field of medical rivets, and provides an antibacterial absorbable gentamicin-loaded silk fibroin medical rivet and a mold. The rivet rod of the rivet is provided with an inner hexagonal notch and a wire passing through hole, and the screw pitches of threads at the near end and the far end of the rivet are different, so that the fixing strength of the rivet in sclerotin can be enhanced; the material overcomes the defects that metal cannot be absorbed and polylactic acid is used as a material, and can be degraded in time, resist bacteria, reduce foreign body reaction and inflammation and promote tissue healing; and the internal structural design of the rivet can meet the use requirement of the rivet under an arthroscopic surgery. The personalized mold is suitable for the special preparation process of fibroin, a mold body is composed of an upper mold body and a lower mold body which are detachable, and a pouring cavity formed by butt joint of pouring grooves of the upper mold body and the lower mold body can precisely mold the appearance of a rivet; the inner core assembly comprises an inner hexagonal column, a circular column and a positioning seat, and the inner structure of the rivet can be accurately formed. And the rivet is integrally formed to avoid later processing, so that high standard and consistency of products are ensured. The mold is ingenious in overall matching, convenient to assemble, maintain and operate, and time-saving and labor-saving.

This invention discloses the application of fucoidan in the preparation of products for promoting physiological recovery after coral cutting. The invention utilizes 100 mg / L fucoidan to treat cut corals by immersing them in a solution for 30 min / day for 7 consecutive days. Results show that the treated corals exhibit increased net weight gain, and the levels of redox-related enzymes, symbiotic zooxanthellae density, and chlorophyll a content rapidly recovered to or approached pre-operative normal levels. The increase in zooxanthellae density and chlorophyll a content indicates that fucoidan treatment can increase the photosynthetic activity of corals, providing sufficient energy for coral repair. The decrease in redox-related enzyme levels indicates that fucoidan treatment can directly remove some reactive oxygen species from corals, reducing oxidative damage and creating a favorable internal environment for tissue healing. In short, this invention discloses that fucoidan treatment can promote the survival rate of transplanted corals after cutting and optimize coral reef ecological restoration, which is of great significance for coral transplantation.

The present disclosure belongs to the technical field of biological medicines. Disclosed is a novel ceramide which has a structure represented as formula IFurther disclosed in the present disclosure are a preparation method for and the use of the ceramide. The present disclosure uses naturally-sourced and readily-available 10-hydroxycarboxylic acid as a starting raw material to construct the ceramide having a novel structure. The preparation method has a simple and convenient synthetic route and is suitable for large-scale production. Meanwhile, the obtained ceramide shows more excellent effects in the aspects of tissue repair, anti-inflammatory repair, tissue healing, moisturizing and anti-aging, and thus can be used in the fields of health care products, cosmetics and drugs.

The present invention belongs to the technical field of biopharmaceuticals and discloses a ceramide derived from an amino acid, a compound having the structure of general formula I, or an isomer thereof. is JPEG2026513487000069.jpg58170, and the said R 27 , 14 , 29 , 14 , 27 is a residue to which a polypeptide is condensed, and the said R 3 is selected from alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, L-glutamic acid-1-tert-butyl ester, and a residue to which a polypeptide is condensed. The said polypeptide is one formed by condensation of 2 to 10 amino acids. R 2 is -C 15 H 29 、-C 15 H 31 、-C 15 H 27 、-CHOHC 14 H 27 、-CHOHC 14 H 29 is selected from. The present invention further discloses a synthesis method of such a compound. Such a compound has excellent effects in moisturizing, antioxidation, anti-glycation, skin barrier repair, tissue healing, etc.

The invention relates to the technical field of medical instruments, in particular to a gradient degradation composite absorbable suture line and a preparation process. The invention discloses a gradient degradation composite absorbable suture line which sequentially comprises a supporting layer, a middle layer and an outer layer from inside to outside in the radial direction, and the outer layer is prepared from, by weight, 50%-70% of polyglycolic acid, 20%-35% of polyethylene glycol-polylactic acid segmented copolymer and 5%-10% of basic salt buffering particles. According to the composite absorbable suture line and the preparation process, through material compounding and structural design, staged regulation and control of the degradation rate and the mechanical strength are achieved, and it is ensured that the strength of the suture line is synchronous with the tissue healing process.

The utility model discloses a grafting knife device for magnolia grafting belongs to grafting knife technical field, the device includes handle and blade, is equipped with the medicine storage jar, spray pump and battery and button on handle, and spray pump is connected with spray head through spray pipe, and the blade is connected with the limiting block, and the spray head is connected with the limiting block. The utility model integrates the cutting function of cutter and the spraying function of protective liquid, and the operator can spray the protective liquid immediately after completing the cutting action, forms the protective layer at the cutting surface, thereby effectively slows down the oxidation process, improves the tissue healing rate between the scion and the stock, and significantly improves the grafting survival rate. The structure is compact, the operation is simple, and it is suitable for field operation or nursery use. Compared with the traditional spraying treatment mode, spraying is more timely. The spray head can switch work on both sides of the blade. The left and right switching not only meets the spraying needs of the inner and outer sides of the grafting knife, but also can adapt to both hands when holding the grafting knife, greatly facilitating the operator to use.

A buttress material for a surgical stapling instrument, the buttress material attachable to one or both of a cartridge jaw or an anvil jaw of the surgical stapling instrument and configured to reinforce the staple line and containing a bioactive glass material to enhance tissue healing. The buttress material can be impregnated with the bioactive glass or the bioactive glass can be weaved into the buttress material. The bioactive glass can be in a powder form applied to the buttress material or in a fiber form applied to the buttress material.

This invention discloses a method and system for self-assessment of orthopedic patient rehabilitation. The method includes: collecting multimodal biomechanical data of patients performing standardized rehabilitation movements to generate a spatiotemporally synchronized motion-mechanical coupling dataset; inputting the motion-mechanical coupling dataset into a variational autoencoder to form a three-dimensional biomechanical feature matrix; inputting the three-dimensional biomechanical feature matrix into a dynamic graph neural network to output dual-channel prediction results of joint stability risk probability and tissue healing abnormality probability; spatiotemporally aligning the dual-channel prediction results with a personalized knowledge graph constructed from the patient's historical rehabilitation data to generate a quantitative risk level; generating a dynamic heatmap of anatomical structure based on the quantitative risk level, and outputting an interactive three-dimensional report containing the location of key rehabilitation bottlenecks. Using this invention, a three-dimensional visual interactive self-assessment of orthopedic patient rehabilitation can be achieved, improving the objectivity, accuracy, and clinical applicability of rehabilitation assessment.

The present invention relates to a nanoformulation comprising L-leucyl-L-leucine methyl ester (LLOMe) and a polymer for wound healing, which promotes multiple molecular signaling pathways essential for faster wound healing. The nanoformulation offers faster and improved wound and tissue healing, axon regeneration, antiviral immunity, stem cell proliferation, embryonic development, and anti-aging effects.