115 results about "Tissue healing" patented technology

The invention discloses a plastic effect simulation display method and system based on a 3D simulation technology, and relates to the technical field of medical information, and the method comprises the steps: collecting the facial data of a patient, and constructing a multi-level facial structure initial model; constructing a hybrid deformation model; individual characteristic parameters of a patient are extracted, and an individual biomechanical parameter set is generated through the biomechanical parameter prediction network; applying the personalized biomechanical parameter set to the mixed deformation model; operation input parameters of plastic surgery are received, and the deformation result of each layer of structure is calculated and displayed in real time based on a GPU parallel computing framework; constructing a tissue healing and recovery kinetic model, and generating appearance prediction data at different postoperative time points in combination with the deformation result; and performing three-dimensional visualization processing on the appearance prediction data. According to the method, CT / MRI, 3D structured light scanning and expression dynamic video sequences are creatively integrated, the limitation of traditional single-mode data modeling is broken through, and the soft tissue boundary recognition precision is remarkably improved.

The invention relates to the field of biomedical textile materials, and discloses a partially absorbable sports medicine orthopedic suture line and a preparation method thereof.The suture line is prepared from, by mass, 50%-90% of polylactic acid and 10%-20% of polyglycolic acid. The mass content of polyglycolic acid is 10%-50%, the composite material further comprises a bioactive component, the mass content of the bioactive component is 0.1%-10%, the bioactive component comprises bone morphogenetic protein, silver nanoparticles and hydroxyapatite, the tensile strength of the suture line is 30-120 MPa, and under different physiological conditions, the suture line is not prone to fracture, and the suture line is not prone to fracture. And the degradation product can be compatible with surrounding tissues. The shape of the suture line can be automatically adjusted at the physiological temperature by embedding the shape memory alloy, and the suture line can adapt to dynamic changes of the tissue and provide uniform tension and support when interacting with the biological tissue due to the intelligent response capability, so that the tissue healing is effectively promoted.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The invention discloses a visual multifunctional injectable hydrogel with endogenous and endogenous stimulation responsiveness as well as a preparation method and application of the visual multifunctional injectable hydrogel. The hydrogel is mainly prepared from oxygen vacancy molybdenum oxide nanoparticles Ce6-coated PEG-MoOx, transglutaminase and gelatin, wherein the oxygen vacancy molybdenum oxide nanoparticles Ce6-coated PEG-MoOx are loaded with a photosensitizer chlorin e6 and are modified by polyethylene glycol. The hydrogel disclosed by the invention can be applied to preparation of anti-inflammatory, anti-infection or wound repair promoting medicines, especially medicines for treating periodontitis or oral infection. The visible multifunctional injectable hydrogel with endogenous and endogenous stimulus responsiveness, which is constructed by the invention, can be developed through photoacoustic imaging, can play a role of a contrast agent, presents a morphological structure of an area in which the hydrogel is located, can eliminate negative oxidative stress of tissues, can efficiently and quickly kill bacteria, and can be used for preparing a medical dressing for treating endogenous and endogenous stimulus responsiveness. The inorganic signal molecules are controlled in a long-acting and controlled-release manner to play anti-inflammatory and angiogenesis promoting roles, so that tissue healing is promoted.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The utility model discloses a poly (p-dioxanone) medical suture with an anti-inflammation capsule, and relates to the technical field of medical sutures. The protein anti-inflammatory suture line comprises a suture line inner core, a protein adhesive layer, a protein microcapsule and anti-inflammatory drug particles, wherein the suture line inner core is made of a PPDO material. According to the utility model, the anti-inflammatory drug of the wound can be fully and comprehensively absorbed; the inner core of the suture line has good compatibility, and rejection and tissue inflammation are reduced; the suture line can be gradually degraded in the body and finally converted into carbon dioxide, water and the like, and the carbon dioxide, the water and the like are naturally discharged by the human body and do not need to be removed through a secondary operation, so that the infection risk possibly caused by the secondary operation is reduced, and the infection risk is reduced; the suture line has long strength maintenance time and can provide continuous support for the wound until the tissue is healed; the protein microcapsules and the anti-inflammatory drug particles are beneficial to reducing inflammatory reaction.

Bioactive ceramic particles (such as bioglass) that are customized with ions to enhance tissue healing. The ions may include one or more of Magnesium, Copper, Cobalt, Silver, Aluminum, Iron, Manganese, Zinc, Calcium, Lithium, Gallium, Strontium and / or other Group 5 based ions. Medical applications for use of the customized bioglass particles include wound (dermis) repair, orthopedics (bone), spine, tendon, ligaments, cartilage, neurologic and dental. Embodiments of the customized bioglass particles contain multiple layers, each layer having a different composition. In some embodiments, the ions in each layer work in conjunction with a biologic process. Also disclosed are methods for forming the customized bioglass particles.

The application relates to the field of biomaterials, in particular to a preparation method of injectable acellular matrix powder and application thereof. The preparation method of the injectable acellular matrix powder is obtained through two discontinuous crosslinking steps of once crosslinking and twice crosslinking after crushing of acellular basement membrane. The obtained injectable acellular matrix powder with a unique crosslinking network structure is adapted to the natural skin pH value, greatly enhances the biocompatibility, simultaneously inhibits excessive inflammatory reaction and accelerates tissue healing through the induction of M2 polarized macrophage activation, effectively relieves the local tissue compression risk possibly caused by high cohesive force due to amino acid modification and introduction of a double crosslinking agent, realizes dynamic balance of mechanical stability and physiological friendliness, continuously stimulates the generation of skin collagen by using controllable moderate inflammatory reaction, and promotes gradual reconstruction and improvement of tissues.

A device for safely and effectively disinfecting a catheter while it remains implanted in a patient's body is provided. [Solution] Methods and devices for providing therapeutic electromagnetic radiation (EMR) to inactivate infectious agents and / or enhance healthy cell growth in, on, or around a catheter (10) placed in a patient's body cavity. Non-ultraviolet therapeutic EMR is transmitted axially along the lumen of the catheter body and / or along an optical element (14) within the catheter body. Delivery of the therapeutic EMR to specific infected areas and / or areas requiring tissue healing results in inactivation of primary sources of infection in, on, and around the catheter and / or enhancement of healthy cell growth around the catheter through the use of controlled relative intensity and treatment-site-specific dose projection of the therapeutic EMR radially emitted from the optical element. Specific embodiments for urinary catheters and peritoneal dialysis catheters are also disclosed.

The utility model discloses a skin flap taking device applied to an oral cavity, relates to the technical field of medical auxiliary tools, and aims to solve the problems that when palate skin flaps are cut, sharp blades are usually adopted for cutting, the sizes are not consistent, the widths are not uniform, the palate skin flaps are easily broken or cut off, appropriate soft tissue flaps cannot be obtained, suturing is not facilitated, and the palate skin flaps cannot be taken out easily. And later tissue healing and keratinized gingival formation are not facilitated. According to the flap taking device applied to the oral cavity, the flap cutting size can be adjusted according to needs, and observation is facilitated. Comprising a first connecting rod and a second connecting rod which are arranged in a crossed mode and rotationally connected, one ends of the first connecting rod and the second connecting rod are provided with a cutting part and a fixing part respectively, the other ends of the first connecting rod and the second connecting rod are provided with adjusting structures, the adjusting structures control the opening degree of the first connecting rod and the second connecting rod, and the cutting part is provided with a blade used for cutting.

The present invention discloses a method and system for simulating and displaying plastic surgery effects based on 3D simulation technology, which relates to the field of medical information technology. The method includes collecting facial data of a patient and constructing an initial model of a multi-level facial structure; constructing a hybrid deformation model; extracting individualized characteristic parameters of the patient and generating a personalized set of biomechanical parameters through a biomechanical parameter prediction network; applying the personalized set of biomechanical parameters to the hybrid deformation model; receiving operation input parameters of a plastic surgery, and calculating and displaying the deformation results of each layer structure in real time based on a GPU parallel computing framework; constructing a tissue healing and recovery dynamics model, combining the deformation results, and generating appearance prediction data at different time points after the surgery; and performing three-dimensional visualization processing on the appearance prediction data. The present invention creatively integrates CT / MRI, 3D structured light scanning and expression dynamic video sequences, breaks through the limitations of traditional single-modal data modeling, and significantly improves the accuracy of soft tissue boundary recognition.

The present invention belongs to the field of biomedicine technology and discloses an anti-glycation amino acid derivative having a structure of general formula I or an isomer of general formula I: #imgabs0# wherein R 1 is selected from the group consisting of alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, and the residue after condensation of L-glutamic acid-1-tert-butyl ester, R 2 Select one of the following structures: -C 15 H 29 ,‑C 15 H 31 ,‑C 15 H 27 , ‑CHOHC 14 H 27 , ‑CHOHC 14 H 29 The present invention also discloses a synthesis method and application of anti-glycation amino acid derivatives. Such compounds improve the fat solubility of amino acid compounds, which is conducive to penetration into the skin, and show excellent effects in anti-oxidation, anti-glycation, skin barrier repair, tissue healing and the like.

A device for applying a tissue healing agent includes an insertion member extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, a delivery element including a first surface and a second surface opposing one another, the delivery element movable between a closed configuration, in which the delivery element is compressed to be received within the channel, and an open configuration, in which the delivery element is substantially planar, and a first tissue healing agent formed in a sheet configuration and disposed on the first surface of the delivery element.

The present application relates to the technical field of functional materials, in particular to an injectable silk fibroin / zinc oxide / magnetic mica sheet nano-enzyme hydrogel, a preparation method and application thereof, after the prepared silk fibroin aqueous solution, nano-zinc oxide and magnetic mica sheet are uniformly mixed, the pH value is adjusted, and physical gelation is carried out through simple ultrasonic crushing, so that the injectable nano-enzyme hydrogel can be obtained. The preparation method is simple, controllable, the prepared nano-enzyme hydrogel has good injection performance and biocompatibility, and based on the nano-enzyme strategy, the in-situ self-produced hydrogen peroxide can be catalyzed into active oxygen without relying on stimuli such as light, so that the synergistic antibacterial ability and the ability to promote wound tissue healing are significantly improved.

The invention relates to the technical field of hydrogel, in particular to bionic hydrogel dressing and a preparation method thereof.The bionic hydrogel dressing is prepared from a hydrogel matrix, polylysine, phenylalanine-based gel, propylene glycol and deionized water, the invention discloses an antibacterial hydrogel dressing, which is prepared from the following components in parts by weight: 1 to 5 parts of hydrogel matrix, 0.1 to 1 part of polylysine, 0.01 to 0.1 part of phenylalanine-based gel, 1 to 5 parts of propylene glycol and 89 to 98 parts of deionized water. The antibacterial hydrogel dressing can effectively solve the problems that the existing hydrogel dressing still lacks structural bionics in the use process, is difficult to promote cell regeneration and wound surface tissue healing, has no antibacterial property, is difficult to promote wound surface tissue healing, and cannot be used for treating the wound surface tissue healing. And once bacterial infection occurs, a stable environment for cell regeneration cannot be maintained, and enough mechanical stability and self-repairing capability are lacked.

An electronic patch, for stimulating tissue healing at a target site, is flexible enough to generally conform to a body surface adjacent to the target site, and includes a battery or an arrangement of multiple batteries less than 5 mm thick; a capacitor connected durectly with a coil in series; and pulse generating circuitry, powered by the battery or batteries. The circuitry repeatedly changes the voltage across the capacitor and coil, to produce pulses of current in the coil. The current produces a pulsed electromagnetic field at the target site for stimulating tissue healing, most of the electromagnetic field energy of each pulse being converted into electrostatic energy of the capacitor at the end of the pulse and back into electromagnetic field energy of the next pulse.

A process for preparing one of a patient's upper and lower jaw for a full arch teeth replacement may include extracting every tooth in a patient's arch to define a corresponding number of post-extraction root sockets, wherein each tooth is extracted atraumatically to substantially maintain the patient's original alveolar bone and original keratinized gingiva, waiting a period of time to allow for tissue healing and substantial osteoblast / osteoclasts interaction and remodeling such that newly ossifying bone fills space in each of the post-extraction root sockets, installing a plurality of socket-sized implants less than the number of post-extraction root sockets into corresponding post-extraction root sockets, and allowing for osseointegration of each of the socket-sized implants into the newly ossifying bone of the corresponding post-extraction root sockets.

Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical / therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector / substrate / support / scaffold for direct application.

A method for evaluating an intestinal anastomosis stent is provided. By establishing an animal model of mechanical intestinal obstruction, an intestinal anastomosis stent implantation environment is simulated after intestinal tumor surgery in patients. It was observed that in the digestive tract anastomosis after intestinal severance under this intestinal obstruction animal model, the implantation of the anastomosis stent can promote wound healing at the intestinal anastomosis site, and the degree of abdominal adhesion is reduced during the healing process, and the intestinal bursting pressure strength is well restored; at the same time, according to the tissue section analysis of this site, it can be seen that its tissue healing process conforms to the physiological healing law and is better than the healing of the group without stent implantation. Moreover, from the expression of the degree of inflammation, the expression of new blood vessels, and the degree of fibrosis, it can be judged by comparing the stent implantation group and the group without stent implantation whether the stent to be tested has a significant advantage in promoting healing after intestinal anastomosis in this mechanical intestinal obstruction animal model. This provides an intuitive detection method for evaluating new materials for preparing intestinal anastomosis stents.

Provided herein are compositions and methods that include hydrogen gas or a mixture of hydrogen gas and oxygen gas or a solution of hydrogen and oxygen for ocular therapies and tissue healing. The compositions can be incorporated into a container with a quick-release seal allowing for efficient topical administration of the medicaments of the composition to tissues desired for treatment, such as the human eye.

The invention belongs to the technical field of medical experimental animal models, and discloses a small animal model for skull base high-flow cerebrospinal fluid leakage and skull base reconstruction as well as a construction method and application of the small animal model. The technical obstacle that due to the fact that the nasal cavity of a small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the skull base through the nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for tissue healing after the endoscopic transnasal skull base surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow cerebrospinal fluid leakage of small animals, the standardized bone defect constructed in the middle skull base butterfly saddle area can cause continuous and high-flow cerebrospinal fluid leakage; autologous bone flap and free mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde intracranial infection research after an operation.

The utility model provides an absorbable fixing nail and a repairing fixer, which relate to the field of medical instruments, and comprise a spiral body, a connecting rod and a tail part, one end of the connecting rod is connected with the spiral body, the other end of the connecting rod is connected with the tail part, the spiral body spirally surrounds the outer wall of the connecting rod, and the spiral body is not contacted with the tail part; the tail part comprises a base table and driving wings, the driving wings are distributed on the two sides of the base table, and the connecting rod and the base table are each provided with a hollow structure. The hollow structure of the absorbable nail is optimized, the quantity of implants is reduced, stimulation to a body is relieved, two mixed loading methods are adopted, the puncture effect is good, the absorbable nail can be used in a complex fixing environment such as the periphery of a bony structure, and degradation does not affect tissue healing of a repaired part; the absorbable nails made of different materials are loaded through the same repairing fixator, the advantages of the materials are integrated, the application range and flexibility of the repairing fixator are improved, and extra fixing instruments are prevented from being detached.

The utility model belongs to the technical field of uterine curettage devices, and particularly relates to a uterine curettage device which comprises a grab handle, a length adjusting mechanism is arranged on the left side of the grab handle, a curettage head mounting mechanism is arranged on the left side of the length adjusting mechanism, a curettage head is arranged on the left side of the curettage head mounting mechanism, and the curettage head is used for curettage operation in the uterus. The curettage head mounting mechanism is used for mounting and dismounting the curettage head, the length adjusting mechanism is used for adjusting the length of the uterine curettage device, the curettage head comprises a fixing ring, and the top of the fixing ring is fixedly connected with an elastic ring. According to the novel uterine curettage device, the curettage head is placed in a medicament with the effect of promoting tissue healing, the medicament is absorbed by the medicament placing sponge, the curettage head is controlled by the grab handle to extend into the uterus of a patient to perform curettage operation, and during curettage, the medicament placing sponge is extruded by the elastic ring, so that medicament factors in the medicament placing sponge are released, and the healing of the tissue at the curettage part is promoted; therefore, operative treatment and postoperative repair of the uterine curettage device can be carried out synchronously.

The application discloses a PAM-AA-NHS-based multifunctional biomimetic polymer adhesive for wound repair and a preparation method thereof, and belongs to the field of biomaterial preparation and biomedical application. N-hydroxysuccinimide acrylate copolymerized polyacrylamide hydrogel is used as a substrate and as a main chain network, and functionalized materials tannic acid and phenolic hydroxyl chitosan containing o-diphenol groups are introduced, so that effective adhesion can be formed at a biological tissue interface, and cross-linking can be generated with the main chain network through hydrogen bond action to form a secondary network. In addition, aldehyde group-rich oxidized dextran side chains are introduced, which can form Schiff base cross-linking with the main chain network and amino groups in the biological tissue interface to form long-acting adhesion performance. The adhesive has good tissue adhesion, biocompatibility, antibacterial activity and wound healing promotion capacity, can replace sutures, has a positive effect on the formation of new tissues and tissue healing, and is expected to be applied in clinical treatment of wound surfaces.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The present invention relates to a nanoformulation comprising L-leucyl-L-leucine methyl ester (LLOMe) and a polymer for wound healing, which promotes multiple molecular signaling pathways essential for faster wound healing. The nanoformulation offers faster and improved wound and tissue healing, axon regeneration, antiviral immunity, stem cell proliferation, embryonic development, and anti-aging effects.

The invention discloses an S100A9 inhibitor gel and a preparation method thereof, and the preparation method comprises the following steps: step 1, mixing and uniformly stirring 0.1-5% by weight of a thickening agent, 0.1-5% by weight of a humectant, 0.05-0.5% by weight of a preservative, 0.1-1% by weight of a stabilizer, 0.01-0.2% by weight of a pH regulator and 88.3-99.64% by weight of water to prepare a water-soluble gel matrix; 2, under the conditions that the pressure is 0.08-0.3 MPa and the temperature is 100-126 DEG C, the water-soluble gel matrix prepared in the step 1 is subjected to high-pressure sterilization for 15-30 minutes, and the water-soluble gel matrix is naturally cooled to the room temperature; step 3, adding an inhibitor into the gel matrix cooled in the step 2 according to a preset proportion, and slowly stirring and uniformly mixing to prepare gel; and step 4, subpackaging the gel prepared in the step 3 into aluminum tubes, and filling and sealing to prepare a medicinal gel finished product containing the S100A9 inhibitor for later use. The gel can be directly smeared on injured wounds caused by surgical wounds, burns, scalds, ulcers and the like, wound tissue healing is promoted, healing time is shortened, and the curative effect is good.

The utility model provides an antibacterial composite dressing plaster which is easy to use, and relates to the technical field of medical dressings. Comprising an adhesive layer, a drug delivery layer and a protective layer which are laminated, the protective layer comprises two sheet bodies, and the two sheet bodies are respectively covered on the drug delivery layer; wherein one ends and two sides of the two tablet bodies are all adhered to the edge of the adhesive layer, and the other ends of the two tablet bodies extend to the administration layer and cover the administration layer in a staggered manner. According to the utility model, the second sponge layer is arranged as a high-absorptivity dressing; the first sponge layer absorbs liquid, resists bacteria and promotes tissue healing; the sponge barrel is antibacterial, becomes gel after meeting water, and is easy to adhere to the skin around the wound to form a stable physical barrier, so that the wound surface is protected, the diffusion of outer layer imbibition is limited, and the surrounding environment is prevented from being polluted; the microporous film layer is low in viscosity and high in air permeability, and adhesion with tissues is prevented.

According to the antibacterial coating and the preparation method provided by the invention, the degradation rate of the magnesium alloy can be remarkably reduced by the composite coating formed by combining the micro-arc oxidation film layer and the copper-doped ZIF-8 coating, copper is doped when the ZIF-8 coating is prepared, and the ZIF-8 coating can be endowed with relatively strong antibacterial performance aiming at gram-positive bacteria and gram-negative bacteria; the coating material is mainly applied to the surface of a magnesium alloy implantation instrument, and a stable surface structure with excellent biocompatibility is formed by controlling the degradation rate of magnesium alloy, so that subcutaneous gas accumulation generated by rapid degradation and hemolysis and bone dissolution caused by a local strong alkaline environment are avoided; severely, the problems that an implantation instrument loses fixing and supporting functions before tissue healing, and implantation fails are caused are solved; meanwhile, the early adhesion of bacteria and the formation of bacterial biofilms are effectively inhibited by utilizing the antibacterial function of the coating, so that the infection risk generated in the implanting and using processes of the implanting instrument is reduced.

The application discloses an adhesion-treatment synergic integrated tissue adhesive and a preparation method and application thereof, and belongs to the technical field of medical adhesives. The adhesion-treatment synergic integrated tissue adhesive comprises: (1) 100 parts by mass of an adhesion precursor, wherein the adhesion precursor is a mixture of a silk fibroin-polyphenol composite hydrogel and urea; and (2) 0.1-100 parts by mass of a medically acceptable metal oxide particle, wherein the metal oxide particle has a hollow mesoporous shell structure and is loaded with a tissue repair promoting component. The adhesion-treatment synergic integrated tissue adhesive not only has excellent adhesion strength, mechanical bearing capacity and a suitable curing window time, can be adapted to the repair of complex tissue damage sites, but also has biological activity and good compatibility for promoting tissue healing, so that the adhesion fixation, the repair and regeneration of the tissue are effectively realized.