287 results about "Tissue healing" patented technology

Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.

Devices and methods for utilizing electromagnetic radiation and other forms of energy to treat a volume of tissue at depth are described. In one aspect, a device modulates the flux incident on surface tissue to control and vary the depth in the tissue at which an effective dose of radiant energy is delivered and, thereby, treat a specific volume of tissue. The methods and devices disclosed are used to perform various treatments, including treatments to prevent and relieve pain and promote healing of tissue.

A system, method, and apparatus are disclosed for dressing a wound and for minimizing scarring. The apparatus promotes scar-minimizing healing of a wound where negative pressure wound therapy is applied, and comprises a wound contact layer containing silicone, polysiloxanes, or other related compounds.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

The invention relates to a modified starch material for biocompatible hemostasis, biocompatible anti-adhesion, tissue healing promotion, absorbable surgery sealing and tissue adhesion. The invention applies biocompatible modified starch to animal tissues, wherein the modified starch material has the molecular weight of more than 15,000 daltons, and the particle diameter of between 1 and 1,000 mu m. The modified starch hemostatic material has stypticity, reduces hemorrhage, blood oozing and tissue fluid oozing of wounds, maintains relative moistening or drying of wound surfaces or the wounds, inhibits bacterium growth and inflammation reaction, and contributes to locally diminish inflammation of the wounds and relieve pain of patients. Moreover, the modified starch material can wash local parts after operation is over and remove redundant modified starch which does not participate in hemostasis, and can easily remove haemostatic under the condition of debridement treatment after self-help and first-aid treatment of war wounds; and hemostatic materials with a small amount of modified starch can be absorbed by the body, so that the pain of tearing of gauzes and bandages on people is avoided.

Embodiments include coatings or surface treatments for medical instruments, devices, and/or implants that promote soft tissue healing. More particularly, embodiments relate to treating portions of instruments, devices, and implants where tissue healing is desired with tissue healing promoting treatments.

An iontophoresis device includes an active electrode assembly including an active electrode element and at least one active agent reservoir. Active agents include one or more angiogenic growth factors suitable to promote or enhance healing or repair of injured or damaged tissue.

The invention relates to a bone implanting and internal fixation appliance with bioactivity and absorbability, which belongs to the field of bio-medical appliances, particularly to the field of medical appliances used for bone wound surgery, reparative and reconstructive surgery and plastic and cosmetic surgery. The appliance includes bone nails and a bone plate made of magnesium and the alloy thereof with bioactivity and absorbability. The bone implanting and internal fixation appliance is a bone internal fixation device, which comprises a blade plate and matched screws, intramedullary nails, a fracture and dislocation fixing device of vertebral column, bone nails or screws having individual fixation effect, wherein the bone internal fixation device is made of magnesium and the alloy thereof with bioactivity and absorbability. The bone internal fixation device can solve the problem in bioactivity of prior bone internal fixation device and promote healing the tissue where the device in implanted. The device also includes a protection layer prepared on the surface of the internal fixation device for controlling the degradation rate of magnesium alloy and the dissolution rate of magnesium ions, thus controlling the bioactivity and the absorption speed of the magnesium alloy device in an organism.

Synthetic Stem Cell-like Tissue Healing and Regeneration Medication with Anti-inflammatory, Protein Synthesis, Enzyme Deficiency Activation and Genetic Therapy, and Anti-cancer Agent derived from a series of inventions that include these products of Biomolecular Engineering, Drug Discovery from a Biologic Periodic Table of Applied Biochemistry and Biophysics. Tissue has a self healing effect promoting tissue healing and tissue regeneration. Not only does it maintain good health but also it has been observed that the patient's blood is withdrawn from the patient and applied to the ulcer has healing qualities. Cartilage placed in a wound promotes and accelerates wound healing. The anabolic biochemical and biophysical equivalent of tissue has been found in these embodiments to have the same pharmacologic qualities, when devoid of genetic DNA mismatch and other catabolic factors including the catabolic effects of microorganism overgrowth that lacks pro-biotic qualities. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.

The invention discloses an acellular tissue matrix composite and a preparation method thereof. The composite is formed by smashing an acellular tissue matrix, adding water or digestive juice for digestion, evenly mixing the product with polyelectrolyte and conducting freezing and drying, wherein the acellular tissue matrix is obtained by conducting acellular implantation on animal tissue. The product is in a porous sponge shape, in-situ implantation induction host vascularization and cell proliferation and growth are achieved with the composite as the support, and therefore tissue healing is promoted, and the composite can be used for tissue repairing such as wound surface repairing, subcutaneous filling and tissue-engineered muscle establishing. By means of the composite, active growth factors are kept, the support with complicated shape and adjustable size can also be established, and the micro-porous size, porosity and degradation time can be adjustable.

A process for the manufacture of a prosthetic sheet with improved tissue healing characteristics useful in reinforcing tissue defects is disclosed. Generally the prosthetic may be comprised of any material that does not promote fibrosis and inflammation. In particular, the prosthetic may be comprised of non-absorbable hydrogel reinforced with fiber, so that the fiber reinforcement is encapsulated and shielded from interaction with tissue. The prosthetic may contain pores that pass through it to encourage tissue through-growth. These pores may be made by removing material from a sheet of reinforced hydrogel or the reinforcement means may contain a porosity around which the hydrogel is formed and the porosity is maintained.

The invention discloses a bioadhesive, which contains a polymer and a solvent, wherein the polymer is a graft of dopamine or mussel adhesive protein and oxidized graft A; the graft A is a graft of a macromolecular substance andan acrylate compound; a six-membered ring in a macromolecular substance in the oxidized graft A is bonded with an aldehyde group; the macromolecular substance is selected from at least one of hyaluronic acid, chondroitin sulfate, gelatin, polypeptide, alginic acid and chitosan; and the acrylate compound is selected from one of methyl methacrylate, methacrylate, glycidyl methacrylate and acrylic ester. The invention further provides a preparation method of the bioadhesive. The bioadhesive has the advantages of being good in biological activity, relatively good in mechanical property and biodegradable, and is capable of promoting tissue healing in a moist environment.

A method of treating an intervertebral disc without piercing the disc involves navigating a treatment element to the intervertebral disc and contacting the treatment element with an exterior of the intervertebral disc. The method further involves applying an energy-based treatment to the exterior of the intervertebral disc to modify a property of a target tissue of the intervertebral disc. The target tissue may be, for example, annulus fibrosus and/or nucleus pulposus tissue. The treatment element is then removed, and the property remains modified after the treatment element is removed and the target tissue heals, thereby treating the intervertebral disc.

The invention relates to a preparation method of a biological mimetic and structural bionic tissue adhesive in order to overcome disadvantages of present technological technologies for preparing mussel mucoprotein bionic biological tissue adhesives and improve the viscosity, the biocompatibility and the structural bionic property of a material. The preparation method comprises the following steps: grafting a natural polymer material with dopamine or other catechol group-containing derivatives through an amidation reaction by adopting DMTMM as a carboxyl group activator; and further modifying the grafted natural polymer material with lysine or polylysine by adopting the same technology to obtain the novel biological mimetic and structural bionic tissue adhesive containing dopamine analog and polylysine analog. The tissue adhesive plays a full role in tissue adhesion in wet and physiologic environment, has good tissue adherence and high biological safety, and can be slowly degraded in the tissue healing process until complete degradation. The preparation method of the biological adhesive has the advantages of simplicity, mild reaction conditions, increase of the reaction efficiency, improvement of the operability of the enterprise production process, and facilitation of amplified production of enterprises.

The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.

The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated with differing concentrations of PSGAG.

The present invention relates to a patch, which can be used to secure catheters, wound drainage devices, and/or drug delivery devices, when said catheter and related devices are inserted into the body. The invention also can deliver antimicrobial substances to the site of insertion of a catheter and related devices into a body as well as other medicinal factors, such as wound and tissue healing factors that may be desired to be delivered to the site of insertion.

The invention discloses an absorbable and degradable multipurpose biocompatible material. The raw materials of the absorbable and degradable multipurpose biocompatible material comprise chitosan, collagen and hyaluronic acid or sodium alginate in a weight ratio of (2 to 8): (0.5 to 3): (1 to 5); adding a dehydrating agent; generating hydrogel by a cross-linking reaction; and finally performing freeze-drying to prepare sponge or film. The absorbable and degradable multipurpose biocompatible material disclosed by the invention can be used as a bleeding-stopping anti-adhesion material, good in tissue adhesion, remarkable in anti-adhesion effect, capable of rapidly stopping bleeding, preventing adhesion, promoting tissue healing, preventing rebleeding, eliminating the inevitable virus hidden troubles of gelatine and animal collagen, and greatly improving safety, complete in degradation, capable of being absorbed and utilized by the body, and free of side effects on the body. The absorbable and degradable multipurpose biocompatible material can also be used as a scaffold for tissue engineering, artificial skin and the like, and good in biocompatibility, absorbability and degradability.