13 results about "Tissue transplant" patented technology

A tissue graft delivery system and associated devices are described. The tissue graft delivery devices utilized a conveyor belt moved by an actuator mechanism to shuttle a tissue graft, such as bone graft material, from a chute containing the graft into a surgical site, such as an intervertebral disc space. The interactive system and devices eliminate graft packing, inefficient tissue delivery, and other difficulties arising from friction between the bone graft material and graft contact surfaces of existing prior art systems, such as bone funnels.

The application provides a construction method of a humanized keloid mouse model, comprising the following steps: BAC plasmid construction and preparation; superovulation of experimental mice and collection of zygotes; pronuclear microinjection of zygotes; post-injection embryo transplantation; genotype identification; breeding and genetic analysis; and verification of construction results of the humanized immune system by immunohistochemistry and immunofluorescence. In the application, peripheral blood mononuclear cells treated by sCD27 and skin around keloids (homologous cells and tissues) are transplanted into NSG-MHC-DKO immune-deficient mice with overexpression of CD70 genes, so that HLA rejection of different homologous immune cells and tissues can be avoided, the internal microenvironment of keloids and the interaction between the internal microenvironment and the immune system can be restored to the maximum extent, and the influence of immune factors on the occurrence and development of keloids can be realized in vitro. The application first discovers and verifies that the activation of the CD27-CD70 axis can promote the occurrence and development of keloids, and provides a suitable animal model for the research and development of anti-keloid drugs, especially immunotherapy.

The disclosure provides compositions and methods for directing the growth of blood vessels in a tissue graft. The compositions and methods provide the advantage of directing the growth, size and pattern of blood vessels from the periphery of the graft, which recapitulates or improves the native blood vessel orientation in the host tissue. The compositions comprise a tissue graft that comprises a matrix attached to a barrier. The barrier comprises a porous membrane that permits passage of water and nutrients but blocks blood vessel growth. The methods comprise implanting the tissue graft on a host tissue in a subject and incubating the graft on the host tissue such that blood vessels grow around the edges (periphery) of the barrier or through intentional internal openings in the barrier and into the matrix. The methods can further comprise transplanting the vascularized tissue graft to a second location in the subject. Thus, the methods can be used in a staged implant procedure to create autologous, vascularized bioengineered tissue grafts.

A subchondral implant is disclosed, which is designed as a bone void filler for damaged bone tissue. The subchondral implant comprises a body component configured in a cylindrical shape with a hollow interior cavity and an exterior curved sidewall. The curved sidewall includes a plurality of helical ribs in a spaced apart manner for optimal fixation. The top surface comprises a plurality of through-holes for sutures, when securing tissue graft. An adjacent subchondral implant can be utilized with the subchondral implant and is nested against it for use. The nested implants allow users to repair large, elongated areas that may not be repaired by a single subchondral implant.

The present disclosure provides a method for producing regulatory T (Treg) cells, the method comprising a step of inhibiting RBPJ activity in conventional T (Tconv) cells, and a Treg cell produced by the method. The disclosure also provides agents for inducing Treg cells that can be used in the methods of the disclosure. The present disclosure also provides an agent for immunosuppression comprising the Treg cells manufactured by the method of the present disclosure or an agent for inducing Treg cells. The agents for immunosuppression of the present disclosure are useful in the treatment of autoimmune diseases or tissue transplantation patients.

The invention discloses an oral threaded retention nail and a method for fixing a gingival flap in a free gingival transplantation operation. The retention nail comprises a head part, the head part is connected with a polished rod, one end of the polished rod is provided with a threaded part, and the threaded part is connected with a tail part; a drug delivery mechanism is arranged in the polish rod, a plurality of slow-release micropores are formed in the threaded part and the tail part, and the slow-release micropores are connected with the drug delivery mechanism; the medicine feeding mechanism is connected with a pressing assembly, and the pressing assembly is located at the head. The method comprises the following steps: anesthetizing a recipient area and a donor area, preparing the recipient area, obtaining transplanted tissues, transplanting the transplanted tissues to the wound surface of the recipient area, and treating the wound surface of the donor area. According to the method, the gingival flap can be continuously and tightly attached to the planted bed, the tissue flap rejection risk is remarkably reduced, and the transplanting survival rate is increased; meanwhile, through the arrangement of the pressing assembly and the dosing mechanism, regular and long-term dosing is facilitated.

Provided herein are improved anti-CD2 antibodies and methods for their use in the treatment and / or prevention of chronic or acute disorders of the immune system. Also provided herein are methods for treating or preventing an immune related disorder or disease in a subject by administering an anti-CD2 antibody or an antigen-binding fragment thereof and a CTLA-4 co-stimulation blockade. Compositions for use with these methods and kits are also disclosed.

The current disclosure provides novel methods and compositions to suppress immunity and are useful for treating autoimmune and inflammatory conditions, and in some circumstances, cancers. Accordingly, aspects of the disclosure relate to a method for treating an inflammatory, autoimmune, autoinflammatory or cancer disease or condition in a subject comprising administering a DUX4 polypeptide or nucleic acid encoding a DUX4 polypeptide to the subject. Further aspects relate to a method for treating a tissue transplant subject, the method comprising administering a DUX4 polypeptide or nucleic acid encoding a DUX4 polypeptide to the subject. The present inventions also relate to universal donor stem cells that overcome immune rejection in cell-based transplantation therapies.

A subchondral implant is disclosed, which is designed as a bone void filler for damaged bone tissue. The subchondral implant comprises a body component configured in a cylindrical shape with a hollow interior cavity and an exterior curved sidewall. The curved sidewall includes a plurality of helical ribs in a spaced apart manner for optimal fixation. The top surface comprises a plurality of through-holes for sutures, when securing tissue graft. An adjacent subchondral implant can be utilized with the subchondral implant and is nested against it for use. The nested implants allow users to repair large, elongated areas that may not be repaired by a single subchondral implant.

The present disclosure relates to compounds which are capable of selectively binding to and inhibiting the activity of the potassium channel Kv1.3. The invention also relates to a method of preparing said compounds, intermediates of said compounds, pharmaceutical compositions comprising such compounds and to the use of said compounds and said pharmaceutical compositions in medicine, including the treatment or prevention of autoimmune diseases, diabetes, obesity, parodontitis and / or tissue transplant rejection.

Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and / or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.

The application discloses a kind of oral cavity thread retaining pin and the method for fixing gum flap in free gingival transplantation, the retaining pin includes head;The head is connected with light pole, and the light pole is provided with threaded portion at one end, and the threaded portion is connected with tail portion;Drug delivery mechanism is arranged in the light pole, and a plurality of sustained-release micropores are arranged on the threaded portion and tail portion, and the sustained-release micropore is connected with drug delivery mechanism;The drug delivery mechanism is connected with pressing assembly, and the pressing assembly is located at the head.The method comprises the following steps: anesthesia is carried out to recipient area and donor area, recipient area is prepared, grafting tissue is obtained, and the grafting tissue is transplanted to recipient area wound surface and donor area wound surface is handled.The application can keep the close contact between gum flap and recipient bed, significantly reduce the risk of tissue flap rejection, and improve the survival rate of transplantation;Meanwhile, through the setting of pressing assembly and drug delivery mechanism, it is convenient to give medicine regularly and for a long time.