41results about How to "Reduce rejection" patented technology

The degradable breast prosthesis shaping net bag with the heterogeneous hierarchical porous structure is composed of the large-aperture structure layer and the micro-aperture structure layer, the large-aperture structure layer and the micro-aperture structure layer are formed by combining degradable fibers in a staggered mode, the degradable breast prosthesis shaping net bag and the breast prosthesis are perfectly conformal, and the mechanical property and the tissue adhesion property needed by the net bag are provided; the two cooperate to realize the integration function of the prosthesis and the tissue, and an additional suture fixing device is not needed; the overall shape of the net bag is designed to be the hemispherical upper cover and the lower end cover edge, the process of adding the net bag and a prosthesis is simplified, the operation efficiency is improved, the net bag has excellent mechanical performance and shaping capacity, the micropore structure is beneficial to adhesion and immigration of cells, rejection reaction of a body is reduced, the incidence rate of capsular contracture is remarkably reduced, and the net bag is suitable for popularization and application. The invention has the characteristics of hierarchical porous structure design, mechanical shaping capability customization and capsule contracture prevention, and provides an innovative breast prosthesis shaping and biological performance improvement scheme for breast cancer patients.

The preparation method comprises the following steps: grinding an iodine block to obtain iodine powder, adding the iodine powder into double distilled water, and carrying out ultrasonic stripping to obtain an iodine nanosheet suspension; under the conditions of stirring and water bath heating, dissolving polyvinyl alcohol with double distilled water to obtain a polyvinyl alcohol solution, adding sodium alginate in batches, and continuously stirring in a water bath to obtain a moldable composite hydrogel precursor solution; dissolving tannic acid by adopting an iodine nanosheet suspension, then adding into the moldable composite hydrogel precursor solution, uniformly stirring at room temperature, adjusting the pH value of the solution to be neutral, finally dropwise adding a borax solution, and stirring into gel to obtain the I2 / PBST moldable antibacterial composite hydrogel. The prepared composite hydrogel not only can play an antibacterial role and reduce the bacterial infection probability of infection sites, but also has excellent properties such as plasticity, stretchability, self-healing property, adhesion and degradability, is convenient to fill defect parts with different shapes, and is firm in adhesion.

The invention discloses a cartilage repair hydrogel material and a preparation method thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: adding a vitamin E water-soluble derivative D-alpha-tocopherol polyethylene glycol 1000 succinate, T-ZIF-8 modified by 2, 4-toluene diisocyanate and Mg-MOF modified by SIKVAV peptide into a mixed solution obtained by compounding silk fibroin peptide, oxidized chondroitin sulfate and 3-aminophenylboronic acid, and carrying out crosslinking under ultraviolet light, so as to obtain the cartilage repair hydrogel material. The hydrogel material prepared by the method has a three-dimensional complex cross-linked structure and is high in mechanical property and stability; through the synergistic effect of the components, an adhesion group and a hydrophilic group are created for the surface of the hydrogel material, the binding opportunity of bone cells and the surface of the hydrogel material is increased, adhesion and proliferation of the bone cells are promoted, rejection reaction of tissues to metal materials is reduced, inflammatory reaction is reduced, and collagen secretion and cartilage regeneration are promoted.

The invention discloses a database construction method and device and a database-based data processing method and device, and relates to the technical field of data processing. The database construction method comprises the following steps: obtaining a dynamic extensible database template; traversing the dynamic extensible database template based on a programming language and a database language to establish an instance database structure; and constructing the instance database according to the instance database structure. According to the embodiment of the invention, the method can improve the flexibility of the database, can update and modify the instance database by updating and modifying the dynamic extensible database template when the demand change is subsequently coped with or when the business field is changed, does not need to carry out database reconstruction design and system redevelopment, and is high in practicability. Manpower, material resources and financial resources are saved, and the later upgrading cost of the system is reduced.

The present invention relates to the field of ceramic materials, specifically a high bending resistance ceramic material for 5G communication base stations and a preparation method thereof. The steps include: calcination preparation of bending resistance sintering aids; preparation of HA-coated ceramic sintering powder; composite and column sintering of ceramic particles. The present invention uses polyacrylamide / L-dopamine membrane as an organic template to induce HA mineralization, which ensures that the HA crystal forms an ordered structure, so that the crystal obtains good mechanical properties, effectively reduces the problem of porosity in ceramics caused by grain growth, and improves the density of ceramics. In addition, some pores and cracks are inevitably generated in the ceramic green body during the sintering process. When the finished ceramic is subjected to an external load, the cracks will continue to expand. At this time, the HA crystals and cracks meet to consume the energy of the external load, thereby enhancing the strength of the ceramic and greatly improving the bending resistance of the ceramic material.

The invention provides a face recognition model training method and device, computer equipment, a storage medium and a computer program product. The method comprises the following steps: acquiring a plurality of face image samples, and inputting each face image sample into a pre-trained teacher model and a to-be-trained student model to obtain teacher features, student features and prediction categories of each face image sample; determining feature distribution loss information based on the teacher features and the student features of each face image sample, and determining feature classification loss information based on the student features and the prediction categories of each face image sample; total loss information is determined based on the feature distribution loss information and the feature classification loss information; and based on the total loss information, training a to-be-trained student model until a preset training condition is met, and obtaining a final student model as a face recognition model. By adopting the method, the recognition accuracy of the face recognition model can be effectively improved on the premise of considering efficiency and computing resources.

According to the technical scheme, the enema device is characterized in that the enema device comprises a shell, an instrument groove is formed in one side of the shell, a drug delivery block is arranged in the instrument groove, and an insertion tube is movably installed at one end of the drug delivery block; the lubricating assembly is arranged on one side of the interior of the instrument groove and used for lubricating the insertion pipe, lubricating liquid in a lubricating block is pumped out through a first water pump, the lubricating liquid is sprayed out through an atomization spray head, the lubricating liquid is sprayed out and sprayed to the insertion pipe in a mist shape, the insertion pipe lubricating effect is achieved, and the lubricating liquid can be heated through a heater; the sprayed lubricating liquid is in a proper temperature range, the temperature of the surface of the insertion tube is increased, the situation that a patient is stimulated when the insertion tube is inserted into the anus is avoided, the insertion moderation feeling is improved, a lubricating block is pushed to be close to the insertion tube through a telescopic shaft of a first electric push rod, the lubricating liquid is smeared more sufficiently, and non-uniform manual smearing is avoided; the pain risk of enema treatment of a patient is increased, and the workload of medical staff is reduced.

This invention provides a formulation and preparation method for an exosome-based skin medication. Taking the preparation of a 100g finished formulation as an example, it consists of active ingredients, a nanogel carrier, a composite stabilizer, a moisturizer, a pH adjuster, a preservative, and deionized water. By constructing a nanogel sustained-release system adapted to exosomes and a composite protection mechanism, the exosomes are stably and slowly released and efficiently absorbed on the skin surface within 7 days. This solves the problems of rapid release, low utilization rate, poor stability, and frequent reapplication required for exosome-based skin medications, thereby improving the skin care and treatment effects of exosomes.

The invention discloses an implant support nail with adjustable support wire tension force, which relates to the technical field of medical device technology. The technical problem to be solved is to provide an implant support nail with adjustable support wire tension force, and the scheme adopted is: the top of the screw part is fused to the connecting part, the threaded connecting rod is threadedly connected in the connecting part, the top of the threaded connecting rod is connected to the rotating sleeve through a sliding groove, one side end of the rotating sleeve is engaged with a connecting block, the top of the rotating sleeve is threadedly connected to the neck of the nail body, the nail head is fused to the top of the nail body neck, and one side end of the rotating sleeve is threadedly connected to a sealing block. The implant support nail with adjustable support wire tension force can adjust the tension force of the support wire through the first through hole and the second through hole of the rotating sleeve, and can also adjust the height of the support wire through the connecting part and the threaded connecting rod, and can adjust the angle of the support wire connected to the rotating sleeve, and can also use this rotation to reel in the support wire to adjust the tension force of the support wire.

The invention discloses a method for preparing recombinant collagen microspheres by microfluidics, which comprises the following steps: dissolving recombinant collagen in deionized water as a dispersion phase, taking petroleum ether containing a surfactant as a continuous phase, and respectively injecting the dispersion phase and the continuous phase into a microdroplet generation chip by using a micro-injection pump of a microfluidic reaction device, emulsion microspheres are prepared under the shearing action; and putting the emulsion microspheres into a stationary liquid containing a cross-linking agent, curing, washing, and freeze-drying to obtain the recombinant collagen microspheres with uniform size. The recombinant collagen microspheres are prepared by using a microfluidic technology, the preparation process is simple, convenient and rapid, the operation is easy, and the prepared microspheres have good biocompatibility, can effectively promote the expression of local collagen genes after subcutaneous implantation, and are expected to be used as a facial filler in the medical beauty industry.

An ion wind-assisted electrostatic printing nozzle structure and method for micro / nano structures on insulating substrate surfaces includes an electrostatic printing nozzle, with an ion wind generating module coaxially connected to the outer side of the nozzle. The inlet at the top of the nozzle is connected to a driving air pressure source, and the nozzle at the bottom is connected to a high-voltage power supply. The ion wind generating module has a built-in ionization electrode that generates positive and negative ions upon applying a high voltage. These ions are then driven by airflow to form an ion wind, which is focused on the printing area below the nozzle, keeping the insulating substrate surface in a near-zero potential state, thus forming a virtual grounding electrode. This invention utilizes ion wind to construct a virtual grounding electrode on the insulating surface, solving the problem of unstable electric field during printing caused by variations in printing height and charge accumulation on the insulating surface, thereby improving the applicability of electrostatic printing to insulating substrates.

The invention discloses a novel breast tissue marker, and relates to the technical field of medical instruments, the novel breast tissue marker comprises a metal core and a marker shell wrapping the outer surface of the metal core, the metal core is a non-magnetic metal core, and the marker shell has a compressed state when not absorbing water and an expanded state when being expanded after absorbing water. The marker shell is of a hard structure in a compressed state, and the marker shell is made of a flexible material in an expanded state. According to the arrangement, the metal characteristic of the metal core ensures that the marker is easy to find under X-ray; due to the non-magnetic characteristic of the metal core, noise generated during magnetic resonance is reduced, the developing property of magnetic resonance is improved, and the marker can be easily found during magnetic resonance; the marker shell has an expansion state of expanding after absorbing water, and can absorb body fluid after the whole marker is implanted into a human body, so that the marker shell absorbs water to expand, the volume of the marker shell is expanded, the developing performance of an ultrasonic image is improved, and the marker shell can be found more easily during ultrasonic examination.

The present invention relates to the technical field of spinal correction, and in particular to a plastic brace device for spinal deformity, comprising an analysis module, a first preparation model and a second preparation model. When the force difference between two feet of a patient is less than a first preset value, the first preparation model is used to prepare a first correction brace that completely fits the patient's feet. When the patient is wearing the first correction brace and the inclination angle of the patient's upper body midline is less than a second preset value, the second preparation model is used to prepare a second correction brace for the patient's upper body. The second correction brace can correct the patient's spine. The correction degree of the second correction brace on the patient's spine can be adjusted, that is, the correction process of the patient's spine is slow. In order to improve the patient's comfort, the intensity of the second correction brace on the patient's spine gradually changes, thereby improving the adaptability of the second correction brace and reducing the patient's treatment cost.

The invention discloses a nerve suture line and a preparation method thereof. The preparation method comprises the following steps: step 1, mixing type I collagen powder, glycerol and glutaraldehyde according to a weight ratio of 95: (4-10): (1-5); 2, preheating and melting the mixture, then carrying out melt spinning, and carrying out cooling, stretching and surface treatment on spun tows to obtain a primary suture line product; step 3, mixing the PLGA solution and the dexamethasone solution according to a volume ratio of 9: (1-6), and carrying out high-speed shearing emulsification on the mixed solution; 4, coating, drying and curing, surface treatment and sterilization treatment are conducted on the primary suture line product through an impregnation method, and the nerve suture line is obtained. The suture line prepared by adopting the preparation method of the nerve suture line can realize sustained release of dexamethasone, and is beneficial to reducing inflammatory response at the early stage of nerve injury and promoting nerve repair; in addition, dexamethasone also has the effect of reducing foreign body reaction, rejection reaction of an organism after the suture line is implanted can be reduced, and the biocompatibility of the suture line is improved.

The utility model discloses an oropharynx dredging type gastrointestinal endoscope mouthpiece which comprises an oropharynx ventilation assembly. The oropharynx breather comprises an oropharynx breather assembly, a breather tube device, an oropharynx breather and a dense tooth limiter, the oropharynx breather is sleeved with the breather tube device, the dense tooth limiter is fixedly connected to the outer side wall of the inner end of the breather tube device, and the oropharynx breather is a semicircular rubber tube; the anti-corrosion assembly comprises a colloid basin body, a tongue hole, gastric acid holes and a first oropharynx through tube hole, the tongue hole is formed in the lower end of the colloid basin body in a penetrating mode, a plurality of gastric acid holes are formed in the surface of the colloid basin body in a penetrating mode, and a deacidification medicine is fixedly placed on the surface of the end, with an outward opening, of each gastric acid hole in the colloid basin body. A first oropharynx dredging tube hole is formed in the upper end of the colloid basin body in a penetrating manner, and the first oropharynx dredging tube hole is connected to the dense tooth limiter in a clamping manner; the utility model can reduce the discomfort of a patient and the rejection reaction, is beneficial to the work of a doctor, and weakens the corrosion capability of gastric acid, thereby protecting teeth from being corroded by the gastric acid.

The invention provides an oligonucleotide separation and recovery method and application thereof, and the method comprises the following steps: mixing an oligonucleotide-containing test solution with an acetone solution of a lithium salt, then centrifuging the mixed solution, and reserving the precipitate, wherein the lithium salt is selected from any one or two of lithium chloride and lithium sulfate. The method has the advantages of simple operation, high separation efficiency, high recovery rate of oligonucleotide, high product purity, and good industrial application prospect.

The utility model relates to medical supplies technical field discloses a big mesh hole hernia repair patch, including a plurality of medical textile monofilament, a plurality of antibacterial fiber and a plurality of flow fiber, a plurality of medical textile monofilament and a plurality of flow fiber are respectively perpendicular to each other interlaced weaving arrangement, a plurality of antibacterial fiber is respectively arranged in the clearance of a plurality of parallelly arranged flow fiber, the side wall of a plurality of flow fiber is respectively surrounded and is opened a plurality of drainage holes. The utility model provides a plurality of medical textile monofilament, a plurality of antibacterial fiber and a plurality of flow fiber are arranged mutually, and the interval is set to 3mm, can improve the mesh size of patch, does not influence the fibrous tissue production of affected part simultaneously can reduce the rejection phenomenon, and antibacterial fiber has excellent biocompatibility, can be absorbed and metabolized by human body part, contains amino in its molecular structure, makes it have antibacterial activity, can improve the antibacterial effect of patch, prevents the situation of infection.

The invention relates to an efficient polypeptide photosensitizer and a preparation method and application thereof, and relates to the technical field of medicine, the structure of the efficient polypeptide photosensitizer is A-B-A, A is a polypeptide sequence with positive charges, and B is a photodynamic therapy photosensitizer. According to the high-efficiency polypeptide photosensitizer prepared by the invention, the formed nanoparticles enhance the permeation of tumor tissues, selectively transmit the photosensitizer to a tumor site, enhance the targeting of tumors, realize the retention of the photosensitizer at the tumor site, and relieve the aggregation of photosensitizer monomers, so that a better photodynamic therapy effect is achieved. The method is expected to provide a better treatment method for photodynamic tumor treatment, and a new thought is provided for realizing intelligent delivery and improving the treatment effect.

The utility model relates to the technical field of electrocardio electrodes of medical instruments, and particularly discloses an embedded epidermal electrocardio collecting electrode, which comprises an electrode mounting component, an electrode buckle consisting of an upper electrode buckle and a lower electrode buckle, and an adhesive layer. The electrode mounting assembly is provided with a snakelike electrode network, an assembly fitting part and an assembly hole, the assembly hole is formed along the center of the assembly fitting part, and the snakelike electrode network is arranged along the peripheral area of the assembly fitting part; the upper electrode buckle and the lower electrode buckle are both provided with a protruding part and a flat part, the protruding part of the lower electrode buckle penetrates through the assembly hole of the electrode installation assembly, and the flat part of the lower electrode buckle is attached to the side, close to the human body end, of the assembly attachment part; the upheaval part of the upper electrode buckle sleeves the upheaval part of the lower electrode buckle for interference fit, and the flat part of the upper electrode buckle is attached to the other side of the assembly attaching part; the whole snake-shaped electrode network deforms and deviates towards the human body end along the connecting position of the snake-shaped electrode network and the assembly attaching part, so that the side, close to the human body end, of the snake-shaped electrode network and the bottom end of the lower electrode buckle flat part are located on the same plane.

The present invention discloses a bionic nerve graft and a preparation method thereof. The bionic nerve graft includes a helical stent, a nanofiber membrane, guide fibers and hBMSC-ECM. A surface of the helical stent is coated with the nanofiber membrane, the guide fibers and the hBMSC-ECM are placed in a tube cavity of the helical stent, and the raw materials of the helical stent, the nanofiber membrane and the guide fibers are all chitosan. The preparation method includes the following steps: preparing the helical stent by a mold pouring method, coating the surface of the helical stent with the nanofiber membrane by an electrostatic spinning method, preparing the guide fibers by a template method, and filling the guide fibers and the hBMSC-ECM in the helical stent with the surface coated with the nanofiber membrane. The method provided by the method is simple and low in cost. The prepared bionic nerve graft ensures sufficient mechanical support, good compliance and guidance, provides a sufficient space for the transmission of nerve regeneration nutrients, provides microenvironment elements for nerve regeneration, and has high biocompatibility and low immunogenicity.

The invention relates to a partially absorbable intelligent hernia repair net and a preparation method thereof, and belongs to the technical field of textile materials. The partially absorbable intelligent hernia repair net comprises monofilament units, an antibacterial unit and a monitoring unit, the monofilament units can be partially absorbed by a human body, the multiple monofilament units are connected to form a hernia repair net body, at least part of the antibacterial unit is formed on the surfaces of the monofilament units, and the monitoring unit is connected with the hernia repair net body. The monitoring unit monitors the strain and position of the hernia repair net. According to the hernia repair net, the pain of a patient after hernia repair can be greatly relieved, the hospitalization time and the rehabilitation cycle of the patient can be shortened, the position of the hernia repair net can be monitored in real time, the recurrence risk of hernia repair is reduced, and the life quality of the patient after hernia repair is improved.

The invention discloses an automatic dissimilar blocky bone cutting and finishing mechanical device, and relates to the technical field of blocky bone finishing equipment, the automatic dissimilar blocky bone cutting and finishing mechanical device comprises a finishing table, two connecting belts are mounted at the rear end of the finishing table, and a first mounting groove and a second mounting groove are symmetrically formed in the upper end of the finishing table; blocky bone fixing bases are mounted in the first mounting groove and the second mounting groove, and a scanning instrument is mounted in the second mounting groove. According to the external control platform, clinical CT data of a patient is imported, a virtual three-dimensional model of the required bone mass is designed, and a bone block trimming path is set. And by precisely controlling the operation of the device, the personalized xenogeneic blocky bone material is obtained through finishing. By using the device, the time for trimming bone blocks beside a clinical chair can be shortened, operative wounds are reduced, the occurrence rate of infection and the like is reduced, the device can be better attached to the bone surface, and osteogenesis of the bone blocks is promoted.

The application relates to the technical field of biomaterials, in particular to a silk fibroin-based biomaterial containing growth factors for injection and a preparation method. The silk fibroin and sodium hyaluronate are cross-linked, the gel is freeze-dried to ensure the stability of the product, the SF-HA freeze-dried powder is compounded with cross-linked sodium hyaluronate as a dispersion medium to form a composite gel particle system, the composite gel is sterilized, and then is blended with growth factors to obtain the silk fibroin-based biomaterial, in which the silk fibroin particles are wrapped by the hyaluronic acid cross-linked lattices. The silk fibroin-based biomaterial is prepared, the degradation period of the product is prolonged, and meanwhile, the uniformity, biocompatibility and active ingredient reservation of the material are considered.

There was no method for producing a cell preparation which contains an amount of xenogenic component as small as possible and is highly safe in order to reduce the xenogenic rejection and the risk of transmission of a prion or a viral pathogen after trypsin was used for releasing and dispersing cells. Provided is a method for producing a cell preparation, comprising: a step of culturing a cell which adheres to a base material, a step of releasing the cell from the base material using trypsin, and a step of contacting a human platelet lysate (hPL) with both the trypsin and the cell after said releasing.

The invention discloses an automatic telescopic child stomach tube device capable of preventing abdominal distension and regurgitation under noninvasive ventilation. The device is used for preventing abdominal distension of a child patient under noninvasive ventilation. A nasal gastrointestinal tube head, a controller, an automatic breathing machine airflow blocker, a stomach tube body and a supporting strip form a whole, the automatic breathing machine airflow blocker is fixed to the upper middle portion of the stomach tube, in the process of using the stomach tube, medical workers place the stomach tube with the automatic breathing machine airflow blocker into the stomach through the esophagus of a child patient, and the stomach tube with the automatic breathing machine airflow blocker is fixed to the upper middle portion of the stomach tube. After the controller is pressed down, the airflow blocker of the automatic breathing machine fills the gap between the stomach tube and the esophagus, the situation that airflow enters the stomach through the esophagus to cause abdominal distension of a child patient in the application process of the non-invasive breathing machine is avoided, meanwhile, the influence of gastric regurgitation on the child patient is prevented, and therefore the situation that feeding of the child patient is affected by non-invasive ventilation is prevented.

The application discloses an implant assembly and a preparation method thereof, relates to the technical field of stomatology, and discloses the implant assembly, which comprises a wear-resistant base and an anti-infection coating. The raw material components of the wear-resistant base comprise a matrix powder, an antibacterial powder and a wear-resistant additive. The anti-infection coating is arranged on at least part of the surface of the wear-resistant base, and the raw material components of the anti-infection coating comprise an organic matrix, a metallized porphyrin and an extracellular vesicle. The implant assembly provided by the application can effectively improve the success rate of implant surgery of a tooth patient, meets the long-term use requirement of the implant in an oral environment, and the raw materials used in the application are low in price, the preparation method is simple, and the application is easy to popularize.

The utility model discloses a toothbrush for children, which comprises a brush head, a brush neck and a brush handle which are sequentially connected, the brush head is provided with bristles, the brush handle comprises a holding part, the holding part is of a wide structure, the bristles at least comprise first bristles and prompt bristles, and the use amount of toothpaste is prompted through the prompt bristles. The first brush bristles and the prompt brush bristles have different colors, children or parents can distinguish the first brush bristles and the prompt brush bristles easily according to the different colors, the function of prompting the use amount of toothpaste is achieved through the prompt brush bristles, the problem of excessive toothpaste is avoided, the thickness range of the brush head is set to be 3mm-3.2 mm, the ultrathin brush head can go deep into the oral cavity of an infant for cleaning, foreign body sensation of tooth brushing is reduced, and the toothbrush is convenient to use. The brush neck and the brush head are arranged in an inclined mode, and the structure is attached to the radian of the oral cavity of the teeth of the infant, so that parents can assist the infant in tooth brushing more easily.

There is provided a clay-like thermal conductive member having low adhesion and low hardness. A soft thermal conductive member comprising grease and thermal conductive particles, wherein the thermal conductive particles are contained in an amount of 550 to 800 parts by mass with respect to 100 parts by mass of the grease, the thermal conductive particles are composed of first thermal conductive particles having an average particle diameter of 30 to 55µm and second thermal conductive particles having an average particle diameter of 3 to 15µm, and a blending ratio of the first thermal conductive particles and the second thermal conductive particles is 7:3 to 5:5 on a mass basis, the type OO hardness is 70 or less, an adhesive strength at a temperature of 25°C in which a circular area with a diameter of 13mm is defined as a unit area is 10N or less, and a thermal conductivity is 0.4W / m K or more.

The invention discloses a biodegradable large-diameter intravascular stent and a preparation method thereof.The stent comprises a soft stent body and a hard stent body, the hard stent body comprises a woven fixing ring and a hard net pipe, and the soft stent body is connected with the hard stent body through the woven fixing ring; the other end of the woven fixing ring is fixedly connected with the hard net pipe; the large-diameter biodegradable stent has supporting force, prevents blood flow from being affected by vascular adhesion, has flexibility, adapts to the environment of blood vessel bending, and improves the treatment effect of the stent; the invention discloses a preparation method of a stent. The preparation method comprises the following steps: blow molding a hard stent pipe; performing laser cutting on the hard stent tube; weaving a soft bracket net body; the soft bracket is welded with a sealing end; spraying medicine on the surface of the stent; pressing, holding and forming the bracket; according to the stent packaging and the preparation method of the stent, the problem that the biodegradable large-diameter intravascular stent is difficult to prepare is solved, the stent can be used for large-scale production, and guidance is provided for manufacturing of other related products.

The present invention provides a silk protein composite hydroxyapatite microsphere filler for injection and a preparation method thereof, wherein the preparation method comprises S1: preparation of silk protein solution; S2: preparation of silk protein-hydroxycellulose gel; S3: preparation of hydroxyapatite microspheres modified by layer-by-layer self-assembly; S4: preparation of silk protein composite hydroxyapatite microsphere filler for injection; no chemical cross-linking agent and photoinitiator need to be added during the whole preparation method, and no photocross-linking or irradiation cross-linking is required. The use of the above-mentioned silk protein composite hydroxyapatite microsphere filler for injection is used as a medical filler or a medical filler, such as for the face, trunk, limbs, etc. or for one or more of tear grooves, crow's feet, temples, nose, chin, nasolabial grooves, corners of the mouth, forehead and temporal region, and genitals. The various ingredients added above all have good biocompatibility, can reduce the rejection of the filler in the body, and avoid allergic and red and swollen skin problems after filling.