109 results about "Digestants" patented technology

The invention discloses a personalized in-vitro total digestion glycolysis simulation system, and belongs to the technical field of in-vitro digestion simulation. According to the invention, by dynamically regulating and controlling the emptying amount and the flow velocity of digestive juice, the process of'digesting and absorbing at the same time 'in the small intestine is simulated, and the interaction of colon flora and colon organs is enhanced in combination with a micro-fluidic chip technology, so that the accurate detection of the digestion process and digestion products is realized. The digestion product simulated by the method disclosed by the invention and the flora structure are very close to the real in-vivo structure, so that the method has relatively high authenticity and credibility.

The invention relates to the technical field of data management, in particular to a self-service enema method and system based on intelligent proportioning, and the method comprises the following steps: collecting intestinal tract and physiological data, monitoring intestinal tract movement frequency, intestinal wall tension, instantaneous pressure, digestive juice secretion rate, heart rate and blood pressure in real time, removing abnormal data, and adjusting the data range. And forming a physiological parameter data set. According to the method, a refined data set is constructed by monitoring multiple physiological data in real time, so that the liquid medicine proportion better conforms to the individual characteristics, flow rate correction and pressure adjustment are introduced in the liquid medicine mixing process, it is ensured that the proportion is accurate and liquid medicine conveying is stable, and real-time pressure monitoring and excrement flow state analysis help to optimize the conveying rate and improve the liquid medicine absorption efficiency; the influence of individual difference is reduced, so that the accuracy and the effect of treatment are enhanced.

The invention relates to the technical field of tissue isolation, and particularly discloses a high-activity intestinal crypt and an isolation method and application thereof. The separation method comprises the following steps: S1, taking fresh intestinal tracts, cleaning contents, and scraping mucous membrane layer tissues to obtain intestinal mucous membrane tissues; s2, shearing intestinal mucosa layer tissues, mixing the intestinal mucosa layer tissues with the separation liquid after cleaning, and digesting and dissociating to obtain intestinal mucosa tissue digestive juice; s3, centrifuging the intestinal mucosa tissue digestive juice, removing supernate, mixing the supernate with the protective liquid to obtain intestinal crypt mixed liquid, filtering, centrifuging, and taking precipitate to obtain high-activity intestinal crypts; wherein the separation liquid comprises collagenase I, collagenase II, collagenase IV, elastase, DNA enzyme I and a ROCK inhibitor; the protection liquid comprises an RPMI1640 culture medium, antibiotics, fetal calf serum, bovine serum albumin and a ROCK inhibitor. The technical scheme provided by the invention aims to shorten the intestinal tract crypt separation time and improve the cell viability.

The invention discloses double-layer cross-linked artificial matrigel and an application method of the double-layer cross-linked artificial matrigel in a small intestine micro-physiological system. Low-concentration calcium ions are adopted for primary crosslinking to form a soft inner layer structure, and then high-concentration calcium ions are used for secondary crosslinking to improve the overall rigidity. The matrigel is used for dynamic culture of small intestine organoid and is combined with a micro-fluidic chip to form a small intestine micro-physiological system. In the system, the digestive absorption process of the small intestine is dynamically simulated by controlling the flow ratio and rate of digestive fluid and culture fluid. Compared with the traditional natural matrigel, the matrigel disclosed by the invention has more appropriate mechanical strength and structural stability, supports long-term growth of the organoids, and improves the multiplication capacity, tight connection and structural integrity of the organoids in an in-vitro environment. The method can be used for researching intestinal diseases, food digestion and drug absorption, and is an in-vitro digestion simulation platform with high biocompatibility and stability.

The invention discloses a fibroin / zein-based dual-protein nanocapsule and a preparation method and application thereof.The dual-protein nanocapsule is prepared through a microfluidic-assisted nano-coprecipitation technology and comprises the following steps that silk fibroin is dissolved in a citric acid aqueous solution, and a mixed solution is obtained; the preparation method comprises the following steps: dissolving zein, curcumin and linseed oil in ethanol, rapidly mixing through a microchannel, and carrying out nano coprecipitation to obtain the dual protein nanocapsule. Through electrostatic interaction and amphiphilic regulation, a stable double protein shell structure is formed, curcumin is effectively protected from being damaged by gastric acid and digestive juice, targeted release of intestinal tracts is achieved, and the bioavailability of curcumin is remarkably improved. The obtained nanocapsule is uniform in particle size and good in dispersity, is suitable for a functional beverage system, and has a wide application prospect.

The invention discloses a tilapia skin DPP-IV inhibitory peptide as well as a preparation method and application thereof, and belongs to the technical field of food-borne active peptide development. The preparation method comprises the following steps: taking tilapia skin as a raw material, extracting gelatin from the tilapia skin through an acid-alkali treatment method, and then performing simulated gastrointestinal digestion on the gelatin by utilizing simulated digestive juice prepared from pepsin, trypsin and chymotrypsin to obtain a digestion product with DPP-IV inhibitory activity; the tilapia skin active peptide with relatively high DPP-IV inhibitory activity is obtained through further ultrafiltration and identification, amino acid sequences of the tilapia skin active peptide are AKVELLK, VPGPMGPMGPR and DGIR respectively, and the three inhibitory peptides have good DPP-IV inhibitory activity and can be used for developing food, health care products or medicines for assisting in regulating blood sugar.

The invention discloses a digestible quality analysis system for chicken feed, relates to the technical field of chicken feed analysis, and aims to solve the problem of poor simulation effect of digestion of the chicken feed. According to the method, low-temperature and high-temperature staged drying treatment is adopted, the characteristics of components such as moisture and fat in the residues are fully considered, the secretion rules of different alimentary canal parts of animals are simulated, sufficient and reasonable contact of digestive juice and feed is ensured, the simulation process is closer to the real physiological condition, and the situation that the digestion analysis result is affected by liquid amount errors is avoided; animal digestive tracts are scientifically segmented into stomach, small intestine and large intestine stages, corresponding external buffer solution and internal digestive juice are injected respectively, and a real digestion scene is comprehensively simulated from a physical structure to a chemical environment.

According to the probiotic gel microspheres disclosed by the invention, probiotics are wrapped by the gel microspheres, so that the probiotics are protected from being absorbed or the influence of gastric acid and intestinal digestive juice is reduced, and the release of the probiotics in intestinal tracts is promoted. When the probiotics adopt functional coatings, after the probiotics gel microspheres reach the intestinal tract and release the probiotics, the coating layers on the surfaces of the probiotics can promote the probiotics to adhere to the intestinal mucosa, and the problem that traditional probiotics are difficult to colonize in the intestinal tract is solved. The probiotic gel microspheres disclosed by the invention have an obvious radiation injury protection effect after being orally taken, and can be used for relieving whole-body radiation injury or local radiation injury (such as radioactive intestinal injury) caused by whole-body radiation or local radiation (such as abdominal radiotherapy).

The invention belongs to the field of food nutrition and functional factors, and particularly relates to a method for preparing ovotransferrin hydrolysate with high immunocompetence based on an adult gastrointestinal simulated digestion system. According to the method, ovotransferrin is treated through the stomach and intestine of a simulated adult, OVT hydrolysate is prepared, and the OVT hydrolysate contains HTEGSTT, TTSY and / or RTAGWVIPMG. The invention finds that the immunomodulatory activity of OVT is enhanced after gastrointestinal digestion and hydrolysis, the OVT is more easily hydrolyzed in simulated adult digestive juice than in infant digestive juice, and a contrast experiment shows that the nutrition intervention of OVT adult and infant simulated digestion products can promote the generation of short-chain fatty acids such as acetic acid, propionic acid and butyric acid; the swelling injury caused by inflammation to small intestine mucous membrane tissues is effectively relieved, so that the intestinal barrier immune function is obviously improved, and the OIA shows higher intestinal immune activity than the OIB.

The utility model discloses an instrument for preventing gas, digestive juice and tumor from entering the abdominal cavity during endoscopic full-thickness surgery, which comprises a pipe sleeve, a ring enclosed by inner-layer metal wires and a ring enclosed by outer-layer metal wires are arranged at the front end of the pipe sleeve, the diameter of the ring enclosed by the inner-layer metal wires is smaller than that of the ring enclosed by the outer-layer metal wires, and the diameter of the ring enclosed by the inner-layer metal wires is smaller than that of the ring enclosed by the outer-layer metal wires. A ring defined by the inner-layer metal wires and a ring defined by the outer-layer metal wires are connected through a transparent film layer, the rear end of the pipe sleeve is connected with a handle, and the ring defined by the outer-layer metal wires is covered with an outer-layer film. The utility model not only can be embedded into the perforated part, but also can prevent gas, liquid and tumor in the tube cavity from entering the abdominal cavity.

The present invention provides a sampling capsule, which includes a housing, a partition member that is circumferentially and sealingly connected to the inner wall of the housing and divides the inner cavity of the housing into a sampling cavity and a device cavity, and an extraction assembly provided on the housing corresponding to the sampling cavity. The partition member has a through hole communicating the sampling cavity and the device cavity, and a waterproof and breathable membrane covering the through hole. In the sampling capsule of the present invention, by providing a waterproof and breathable membrane on the through hole communicating the sampling cavity and the device cavity, the gases in the sampling cavity and the device cavity are connected. After using a syringe to evacuate the sampling cavity through the extraction assembly, the sampling cavity and the device cavity simultaneously form a vacuum state. Therefore, before sampling, the sampling capsule can maintain a vacuum state for a long time. Thus, during sampling, there is a sufficient pressure difference inside and outside the sampling capsule, and an expected amount of digestive juice can be obtained.

The invention relates to a preparation method of a placenta trophoblast-derived transporter and application of the placenta trophoblast-derived transporter in a medicine for treating spontaneous abortion, which comprises the following steps of: taking out a placenta of a suckling mouse, cutting the placenta into fine tissue blocks, resuspending by using digestive juice, digesting in a water bath kettle at 37 DEG C for 20 minutes, and then stopping digestion by using 1640 culture containing high-temperature heat-inactivated fetal calf serum; diluting and neutralizing collagenase digestive juice according to 5 times of volume; and centrifuging the collagenase digestive juice for multiple times to obtain a precipitate, namely the exosome. And carrying out density gradient centrifugation on the coarse migration body by using Optiprep as a density medium, washing, precipitating and centrifuging by using PBS on an ultra-high-speed centrifuge by using a horizontal rotor to obtain the placental trophoblast source migration body. The invention finds that the generation of the placental trophoblast cell source migration body is related to the physiological process of pregnancy for the first time, and the placental trophoblast cell source migration body can enter the circulatory system and reach the placenta through in-vitro supplementation.

The invention relates to the technical field of tissue repair materials, and particularly discloses a porcine-derived decellularized patch as well as a preparation method and application thereof. The preparation method of the porcine-derived decellularized patch specifically comprises the following steps: sequentially carrying out washing and repeated freezing and thawing treatment, trypsin digestive juice treatment, SDS-containing isopropanol solution treatment, TritonX-100-containing isopropanol solution treatment, 100wt% isopropanol solution treatment and freeze drying on a porcine-derived patch sample, so as to obtain the porcine-derived decellularized patch. The trypsin digestive juice is a solution containing 0.1 wt%-0.5 wt% of trypsin and 0.1 wt%-0.5 wt% of EDTA (Ethylene Diamine Tetraacetic Acid). Through the preparation method, the pig-derived decellularized patch prepared by the application has relatively low content of DNA and has excellent mechanical properties.

The invention relates to the technical field of microorganisms, in particular to Witzia ciliaris, a penicillium and application of the Witzia ciliaris and the penicillium. According to the present invention, the Weizmania coagulans is Weizmania coagulans Naqu.VC-1201, the Weizmania coagulans is preserved in the China Center for Type Culture Collection, and the preservation number of the Weizmania coagulans is CCTCC (China Center for Type Culture Collection): M 20231577; according to the present invention, the bacillus coagulans Naqu.VC-1201 has characteristics of strong antioxidant activity, strong antibacterial ability and artificial digestive juice tolerance; according to the present invention, with the addition of the Witzia ciliaris metagen in the walnut sauce product, the oxidation rancidity of the oil can be effectively inhibited, the shelf life of the walnut sauce can be prolonged, the nutritional value of the walnut sauce can be improved, the probiotic effect can be enhanced, and the human health can be easily achieved. And the problem of poor smearing property caused by addition of an emulsion stabilizer in the prior art can be solved, and the use is convenient.

The invention belongs to the field of veterinary drugs, and provides a compound preparation for promoting rumination of ruminants, which is prepared from the following medicaments by weight: 4-7 g of veratrum nigrum, 0.1-0.2 g of yucca extract, 0.05-0.1 g of concentrated sodium chloride, 0.1-0.3 g of bighead atractylodes rhizome, 0.2-0.5 g of pericarpium citri reticulatae, 0.2-0.5 g of medicated leaven and 0.6-1.2 g of yeast culture. The preparation method comprises the following steps: selecting veratrum nigrum roots or whole herbs with roots, cleaning and drying bighead atractylodes rhizome and dried orange peel, carrying out wall breaking treatment, removing large or small particles through a screen to ensure uniform particle size, mixing all the medicaments, granulating, drying and finishing the granules, mixing with superfine silica powder and sodium stearate, and uniformly mixing, thereby obtaining the drug for treating the hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia and hyperlipidemia. Finally, tabletting and coating are conducted through a tabletting machine and a coating machine, the overall preparation process is completed after packaging, the number and vitality of microorganisms in the rumen are improved through metabolites of the yeast culture, the digestion and utilization efficiency of the feed is improved, rumen peristalsis is increased through all the Chinese herbal medicine components, and digestive juice secretion is promoted.

The utility model discloses a kind of gastric cavity plugging catheters of gastrostomy in the medical instrument technical field, the device increases plugging balloon and sealing clamping piece, can be held by inside and outside, hold stomach wall and skin to position the device, while plugging balloon seals and isolates the puncture of stomach wall inside gastric cavity, effectively avoid gastric juice to flow out, avoid gastric juice to overflow along the puncture and cause skin burning;Positioning baffle is also increased, can be unfolded inside duodenum, positioning baffle can position nutrition tube, avoid nutrition tube to slide and separate, can also effectively block pylorus, effectively avoid enteric digestive juice to enter stomach, and do not hinder gastric juice to flow into intestine normally, and by pressure relief port and pressure relief pipe, stomach is conveniently decompressed, effectively avoid that pressure is too high and nutrition liquid is refluxed to esophagus.

This utility model discloses a protective anal tube for rectal anastomosis after surgery, relating to the field of medical device technology. It solves the initial problem of the need to develop a protective anal tube for rectal anastomosis after surgery that has three-dimensional isolation, facilitates negative pressure drainage, and has a biological barrier function. The utility model includes a tube body with two support members on it for supporting the intestine. Both support members are capable of mechanical deformation, and the contact surfaces between the two support members and the intestine are annular, which can support both sides of the intestinal anastomosis. Thus, a cavity is formed between the two support members and the anastomotic segment of the intestine. The purpose is that the two support members form a physical barrier through the annular contact surfaces, completely preventing the leakage of intestinal contents into the anastomotic area, avoiding contamination of the wound by feces and digestive juices, maintaining a moist environment, and promoting the migration of epithelial cells and the growth of granulation tissue.

The Endoscopic Adjustable Gastric Barrier represents a groundbreaking innovation in the management of obesity, offering a unique, minimal invasive approach without the complications and limitation of other currently available interventional managements., this revolutionary technique works by dividing the stomach into a smaller, tube-like space for food, without altering the stomach's natural anatomy or functions. This preserves the stomach's function to produce hormones and digestive juices, while effectively reducing food intake hence significant weight loss. What makes this innovation (EAGB) unique is its adjustability and reversibility, and when ideal weight is achieved it can be removed endoscopically. It is secured to the stomach by clips with minimal injury and without risk of necrosis and leak. Additionally, all endoscopic and laparoscopic interventions are possible as normal population.

To provide a method for quantitatively evaluating the progress degree of digestion of food.SOLUTION: A stomach body constituting the stomach model device is filled with artificial digestive juice, food is put therein, the stomach model is made to perform a movement similar to the peristaltic movement of the stomach, and a color moving image of the digestive state of the food with time in a specific range is photographed. Then, texture analysis (average value of luminance, variance of luminance, contrast of luminance, skewness of luminance, kurtosis of luminance, energy of luminance, entropy of luminance) is performed on the captured image to quantify the digestion state.SELECTED DRAWING: Figure 1

The invention discloses a preparation method and application of a pepper placenta protoplast single-cell suspension. The preparation method disclosed by the invention comprises the following steps: acquiring a pepper fetal base tissue, transferring the pepper fetal base tissue into enzymatic hydrolysate for digestion, adding a DB buffer solution to terminate digestion, and collecting digestive juice; enabling the digestive juice to pass through a cell sieve, collecting filtrate to obtain a crude extracting solution of the pepper placenta protoplast single cell, then performing centrifugal treatment on the crude extracting solution of the pepper placenta protoplast single cell, collecting precipitates, resuspending the precipitates by using the DB buffer solution, and repeating the steps of centrifuging and resuspending to obtain the pepper placenta protoplast single cell suspension. The method disclosed by the invention is suitable for preparing the placenta protoplast single-cell suspensions of a plurality of pepper varieties, and the prepared placenta protoplast single-cell suspensions are complete in cell morphology and high in density, can meet the on-machine requirements of the quality of the cell suspensions of various high-throughput single-cell sequencing platforms and subsequent related experiments of the protoplast, and can be used for preparing the placenta protoplast single-cell suspensions. And the method has extremely high application value.

The invention discloses an intraluminal negative pressure flushing drainage device which comprises a drainage outer sleeve, a built-in flushing tube and a negative pressure suction tube. A drainage channel is arranged in the drainage outer sleeve, a tube head is arranged at one end of the drainage outer sleeve, a sponge piece is sleeved on the drainage outer sleeve, a flushing channel is arranged on the drainage outer sleeve, the built-in flushing tube is embedded in the flushing channel, the built-in flushing tube is provided with a flushing hole, and a water outlet is arranged on the outer wall of the drainage outer sleeve. The negative pressure suction tube is inserted into the drainage channel, a suction hole is formed in one end of the negative pressure suction tube, and a drainage hole is formed in the drainage outer sleeve. The device can be placed at a ventage through a natural orifice, and lumen liquid is prevented from overflowing out of a lumen through low-flow normal saline flushing and continuous low-negative-pressure suction. By using the device, the chance of lacuna infection caused by the ventage can be greatly reduced, the ventage can be healed as soon as possible due to the fact that digestive juice is prevented from overflowing through the ventage, the treatment course of a patient can be shortened, the medical cost is reduced, and dangerous complications are reduced.

The invention provides oral superabsorbent hydrogel capable of occupying volume in stomach as well as a preparation method and application of the oral superabsorbent hydrogel, and relates to the technical field of biomedical materials and food science. According to the hydrogel, ion exchange is carried out on a high polymer material capable of carrying out ion exchange and polyvalent metal cations, the hydrogel of a cross-linked network structure is formed, and drug molecules are carried; the hydrogel can improve the stability of drug molecules in the digestive juice and digestive enzyme environment of the human digestive tract, and can absorb water to expand to occupy the space in the stomach, so that the functions of increasing satiety, improving the bioavailability of the drug, performing targeted release on the intestinal tract and the like are realized.

The present invention provides a self-assembling peptide gel for use in preventing a leak of digestive fluid and a self-assembling peptide gel for use in protecting an organ against digestion by a digestive fluid. The self-assembling peptide gel comprises a self-assembling peptide and water, whereby the self-assembling peptide gel has an adhesion persistence ratio with respect to a collagen sheet of at least 40% and a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days, and the self-assembling peptide gel is positively charged as a whole.

The invention discloses a dynamic bionic stomach digestion model and application thereof in micro-plastic detection.The dynamic bionic stomach digestion model comprises a box body, a fixing plate, an artificial stomach model, rolling wheels, a pylorus squeezing plate, a pH meter, a heating mechanism, a gastric acid solution cavity, a gastric juice solution cavity, a peristaltic pump and a micro-dialysis probe, and the rolling wheels are rotationally arranged on the fixing plate and located on the periphery of the outer surface of the artificial stomach model; the pylorus extrusion plate is movably arranged on the fixing plate and located on the outer side of the lower end of the artificial stomach model so as to extrude the lower end of the artificial stomach model, and the gastric acid solution cavity and the gastric juice solution cavity are communicated with the upper end of the artificial stomach model through the peristaltic pump. The method comprises the following steps: adding an aged biofilm-loaded micro-plastic sample or a micro-plastic sample loaded with heavy metal and the like and agar balls into an artificial stomach model, digesting in the artificial stomach model, detecting discharged liquid, solids and the like after digestion is completed, detecting the concentration change of digestive juice, micro-plastic particles and micro-plastic precipitates on agar ball particles, and determining the concentration change of the micro-plastic precipitates on the micro-plastic particles and the agar balls. Product identification and the like.

The utility model discloses a device suitable for fat stromal cell extraction, which comprises a bag body, the bag body internally comprises at least a first accommodating cavity and a second accommodating cavity, the first accommodating cavity is used for filling cleaning fluid, and the second accommodating cavity is used for filling digestive juice; the liquid inlet pipe is connected with one side of the accommodating cavity I; the waste liquid pipe is connected with one side of the accommodating cavity I; the liquid outlet pipe is connected with one side of the first containing cavity. According to the device, the fat matrix can be directly cleaned and digested in the same device suitable for extracting the fat matrix cells, an operator does not need to add cleaning liquid and digestion liquid, operation steps are reduced, and cross contamination can be effectively avoided.

The present invention provides a material or method that can serve as an alternative to a related-art digestive fluid leak preventative material and method of preventing a leak of a digestive fluid. The digestive fluid leak preventative material of the present invention includes a self-assembling peptide gel, has an adhesion persistence ratio with respect to a collagen sheet of at least 40%, and has a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days.

The invention belongs to the technical field of health food processing, and particularly relates to dictyophora rubrovolvata health vinegar and a preparation method thereof. Through the scientific formula and process, the effect of the dictyophora rubrovolvata health-care vinegar is effectively guaranteed, and the dictyophora rubrovolvata health-care vinegar contains various trace elements. The beverage contains a large amount of acetic acid, organic acid, vitamin b, vitamin c and vitamin e. Compared with the prior art, the health-care food has the advantages that human body benefiting substances such as carbohydrates and vitamins B1, B12, C and D can effectively promote secretion of digestive juice in intestinal tracts so as to promote intestinal tract movement, and the health-care food can play roles in tonifying middle-Jiao and Qi, promoting production of body fluid to quench thirst, clearing away heat and toxic materials and calming liver and suppressing Yang. The effect of improving deficiency of qi and blood is achieved. The health-care tea has health-care effects, can resist free radicals in the body, has the effect of whitening the skin, and can eliminate fatigue and balance the pH value in the body. Operation is simple, the process is easy to control, raw materials are easy to obtain, and manufacturing cost is low.

This invention belongs to the field of food nutrition and functional factors, specifically relating to a method for preparing highly immunomodulatory ovotransferrin (OVT) hydrolysates based on an adult gastrointestinal simulated digestive system. The method involves processing OVT using a simulated adult gastrointestinal tract to prepare OVT hydrolysates containing HTEGSTT, TTSY, and / or RTAGWVIPMG. This invention reveals that OVT exhibits enhanced immunomodulatory activity after gastrointestinal digestion and hydrolysis, and is more readily hydrolyzed in simulated adult digestive fluids than in infant digestive fluids. Comparative experiments show that nutritional intervention with OVT simulated digestive products from adults and infants can promote the production of short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, effectively alleviate swelling and damage to the small intestinal mucosa caused by inflammation, significantly improve intestinal barrier immune function, and OVT IA exhibits higher intestinal immune activity than OVT IB.

The utility model discloses a retraction-free small intestine stoma tube, which relates to the technical field of medical instruments and is characterized by comprising an outer sleeve, main catheter supporting blocks are fixedly mounted at four corners of the inner wall of the outer sleeve, the main catheter supporting blocks are trapezoidal, and the length direction of the main catheter supporting blocks is consistent with the axial direction of the outer sleeve. A main catheter is fixedly installed on the side, away from the inner wall of the outer sleeve, of the main catheter supporting block, and the main catheter extends in the axial direction of the outer sleeve. The disposable stoma tube is simple in structure and convenient to use, effectively prevents the problem of unsmooth excrement flow turning caused by displacement, reduces the leakage risk of an anastomotic stoma, achieves smooth flow turning of digestive juice and excrement, avoids the trouble that a traditional stoma tube needs a secondary operation, remarkably improves the postoperative living quality of a patient, and reduces economic and mental burdens.

The invention discloses an application of a nutritional composition in preparation of an immunoregulation product. The nutritional composition comprises a lactoferrin gastrointestinal digest and a selenium gastrointestinal digest, wherein in the nutritional composition, the content of the lactoferrin gastrointestinal digests is 80 to 180 [mu] g / mL; in terms of selenium element, the content of selenium gastrointestinal digests is 12-28 ng / mL. The nutritional composition provided by the invention contains digestive juice compounded by lactoferrin and selenium, and compared with single lactoferrin and selenium, the nutritional composition has a better synergistic anti-inflammatory effect.