The application provides a method and device for generating a reference brain image,
electronic equipment and a storage medium, wherein the method comprises: in response to a received evaluation instruction, obtaining an individual brain image to be evaluated indicated by the evaluation instruction; and inputting the individual brain image into a trained variational
autoencoder model to obtain a reference brain image corresponding to the individual brain image output by the variational
autoencoder model, the reference brain image being used to indicate brain features in a healthy state of the individual to be evaluated. The AI model is used to reconstruct the brain image of the individual to be evaluated based on brain features of a
normal population, so that a more targeted reference brain image is obtained, a personalized normal reference brain image is formed, and the
individual health evaluation is better assisted.