436 results about "Diagnosis early" patented technology

A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after transplantation to identify and allow treatment of possible transplanted organ rejection and other disease conditions related and unrelated to the transplantation, compares the gene expression patterns from a patient's peripheral blood monocytes-lymphocyte's gene system with either the similar gene expression patterns of a normal person, or with the similar gene expression patterns of a person known to have the condition being screened for. Differences between the patient's gene expression patterns for particular genes and the normal patterns indicates the presence of the condition with the number of differences indicating the probability of the condition. Similarities between the patient's gene expression patterns for those particular genes and the patterns of a person known to have the condition indicates the presence of the condition with the number of similarities indicating the probability of the condition. For example, particular genes for use in identifying pancreatic cancer are disclosed.

A device and method to diagnose an internal abnormality in a living subject by sensing a passively occurring electromagnetic radiation signal associated with the abnormality and inside an orifice of the subject. Diagnosis includes detection, imaging or identification of the abnormality. An instrument is used either to bring a sensor into the orifice or to transmit the signal to a sensor located outside of the orifice. An example of the instrument includes a prior art endoscope.

The invention discloses a computerized auxiliary diagnosing method for malignant tumor in early stage based on deep learning algorithm. According to the invention, a deep convolution neural network is used to extract the high-level characteristics of an image layer by layer so that the obtained characteristic dimensions become smaller and smaller. To realize the dimension matching between an outputted probability predicting image and a pre-segmented image, the method uses the reverse convolution network to expand the dimensions of the characteristic image so as to obtain a dimension-consistent probability predicting image. The network generated probability predicting image extracts the binarization of the predicting image through the training of a softmax classifier to finally obtain the segmentation result of the prostate tissue. To some extent, the method effectively increases the accuracy and efficiency for doctors to diagnose prostate diseases.

The present invention uses peripheral blood monocyte-lymphocyte for the early diagnosis of pancreatic cancer, as well as other conditions of the pancreas and other organs. The peripheral blood lymphocytes recognize the new neoplasm in the pancreas, as well as disease processes in other organ systems. The evaluation of this specific recognition of the disease process by the peripheral blood monocyte-lymphocyte through gene microarray expression patterns constitute a successful method for the early detection of pancreatic cancer and other organ disease processes. This document describes the process used in this method of early diagnosis.

A device and method to non-invasively identify pathological skin lesions. The method and device detect and identify of different kinds of skin nevi, tumors, lesions and cancers (namely, melanoma) by combined analyses of visible and infra-red optical signals based on integral and spectral regimes for detection and imaging leading earlier warning and treatment of potentially dangerous conditions.

The invention provides a pancreatic cancer marker, and a detection method, a kit and a biochip thereof. The pancreatic cancer marker provided by the invention contains 36 kinds of micro ribonucleic acids which stably exist in the serum / plasma of a person receiving the test and can be detected. The invention also provides a kit and a biochip of tools or elements for detecting the pancreatic cancer marker. The combination, the method, the kit and the biochip provided by the invention can be used for auxiliary diagnosis and differential diagnosis of pancreatic cancers, predication of occurrence and recrudescence of disease complications, evaluation of the curative effect, screening of active ingredients of medicaments, evaluation of pesticide effectiveness and the like, and has the advantages of wide detection range, high sensitivity, low detection cost, readily available raw materials, easy storage of samples and the like; and the method is widely applied to work related to the general survey of pancreatic cancers, improves the specificity and sensitivity which are low in the single marker due to individual difference, obviously increases clinical detection rate of pancreatic cancers and becomes an effective method for early diagnosis of pancreatic cancers.

A hemodynamic method and instrument for early diagnosis of cerebrovascular diseases features that the Doppler probe and ultrasonography B are used to detect the blood flowing speed, the ultrasonography B is used to detect the physical characteristics of blood vassel, the diameter and wall thickness of blood vessel are measured to obtain the flow of blood in the vessel, and a pressure probe is used to detect blood pressure.

The invention discloses a cloud storage based remote equipment health management method and a system using the same, and belongs to the technical field of remote management. The cloud storage based remote equipment health management method comprises the steps of acquiring equipment information of at least a terminal device in an LAN (Local Area Netwrk) in real time; uploading the equipment information to a cloud-end server in a public network; providing a data receiving service and a data storing service by the cloud-end server; storing the equipment information intensively, wherein the coding for the equipment information has uniqueness; providing a calculation engine service for received data; and showing a result to a user terminal. Through the cloud storage based remote equipment health management method and the system using the same, remote storage of multipoint big data can be realized, diagnosis early warning can be carried out for faults which have happened or will happen, statistical summary can be carried out for health data of the terminal equipment, the purpose of remote real-time monitoring can be realized, a user can know and maintain the health condition of the terminal equipment in time and conveniently, and safe operation of the terminal equipment can be guaranteed.

The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatment, including validation of biomarkers for clinical trials.

The invention provides a cTn I (cardiac troponin I) hypersensitive detection kit and a preparation method thereof. The kit comprises at least one strain of a first anti-cTn I antibody marked with a tracing marker and at least one strain of a second anti-cTn I antibody coated with magnetic micro-spheres, wherein a binding site between the first anti-cTn I antibody and cTn I is different from a binding site between the second anti-cTn I antibody and cTn I; and the kit can preferably further comprise a diluent, and by adopting the diluent, the non-specific binding in a detection process can be significantly reduced, and the detection accuracy and sensitivity can be further improved. The invention also provides a method for detecting cTn I by using the kit, and the method provided by the invention has very high sensitivity, can be used for sensitively and accurately detecting the cTn I content in a sample, and can provide more timely and reliable information for early diagnosis and treatment of AMI.

The present invention is related to methods of early diagnosis of ovarian cancer in a patient by determining serum levels of blood markers using a novel LabMAP™ technology (Luminex Corp., Austin, Tex.), which allows for simultaneous measurement of the blood markers in serum. The panel of blood markers offers extremely high predictive power for discrimination of ovarian cancer from both healthy control patients and from patients with benign pelvic / ovarian tumors. The methods of the present invention allow for rapid, early diagnosis of ovarian cancer with extremely high sensitivity and specificity to be clinically useful in disease diagnosis.

The invention belongs to the field of the tumor molecule biology, in particular to a diagnosis reagent, a reagent knit and prevention and cure drugs of endometrial carcinoma, which provides a new diagnosis reagent and medicine for the early diagnosis and the prevention of endometrial carcinoma, and also provides a new method for filtering the medicine used for preventing endometrial carcinoma. The diagnosis reagent for endometrial carcinoma of the invention contains a reagent which can test the expressing level of a human cyclophilin A protein or the content of the mRNA of genes of the human cyclophilin A protein. The medicine which can prevent endometrial carcinoma of the invention includes: the expressing carrier of a shPNA molecule which can express the human cyclophilin A, etc. can change the expressing level of the human cyclophilin A protein or the mRNA content of the genes of the human cyclophilin A protein. The diagnosis reagent of the invention can be used for the early diagnosis of endometrial carcinoma, which has a wide application prospect.

The invention relates to a medical diagnostic reagent, in particular to a quick detection reagent for the early diagnosis of acute myocardial infarction and a test strip. The invention provides a double-index united detection reagent containing a specific antibody resisting a human heart-type fatty acid binding protein H-FABP and a human cardiac troponin cTnI. The invention also provides a colloidal gold labeling immunological chromatographic test strip containing the specific antibody resisting the H-FABP and the cTnI, which is used for quickly detecting the acute myocardial infarction. The double-index united detection reagent can carry out early diagnosis on a patient having the acute myocardial infarction, can also prevent the missed diagnosis of a patient having long-time chronic myocardial infarction with mild symptoms and better solves the influence caused by a difference existing in the detection time. The colloidal gold labeling immunological chromatographic test strip provides a quick, convenient, cheap and practical detection tool for the early diagnosis of the acute myocardial infarction, is hopefully used for hospitals at all levels and can also be used for the self monitoring of the patient.

A method, system and apparatus for early diagnosis and real time remote intervention of crop condition by correlating collected crop characteristics with known plant parameters, economic variables and algorithms to computer generate an irrigation decision, remotely execute the same and notify the end user.

The invention relates to a breast cancer detecting marker by utilizing 16 specific tiny ribonucleic acids steadily existing in blood serum and blood plasma of a human body as well as a detecting method, a kit and a biological chip thereof, and the detecting marker can be used in the aspects of diagnosis and differential diagnosis of breast cancer, occurrence and recurrence forecast as well as efficacy assessment of disease complications, screening and therapeutic evaluation of medicinal active ingredients and the like, and has the advantages of wide detection pedigree, high sensitivity and low detection cost, the materials are conveniently taken, the samples are easy to store and the like. The method can be widely used in related work such as breast cancer census, the defects of low specificity and low sensitivity caused by insuperable individual difference of a single marker can be improved and the clinical detectable rate of the breast cancer is notably improved, and is an effective mean of early breast cancer diagnosis.

The invention discloses a heart disease risk prediction system, comprising a computer vision pipeline for processing cardiac ultrasound, wherein the computer vision pipeline for processing cardiac ultrasound comprises a view identification classification, a U-Net convolution neural network for cardiac structure identification, cardiac muscle shape tracking, cardiac muscle shape feature vector extraction, electrocardiogram feature data extraction, clinical feature data extraction, depth learning network architecture and data acquisition and training to predict the probability; Through artificial intelligence to assist automatic ultrasound image recognition and diagnosis, Multidimensional myocardial speckle tracking and prediction of ischemic heart failure were calculated, The combination of medical history, clinical data and biomarkers realizes disease prediction on the machine learning platform, and establishes the first artificial intelligence-assisted accurate, sensitive, efficient,automated and scalable cardiovascular screening system, which realizes low-cost, high-accuracy heart disease prediction and early diagnosis system.

The invention discloses a knowledge graph-based cross-department early-diagnosis and decision support system for chronic kidney diseases. The system comprises a patient information model establishmentmodule, a patient information model library storage module, a knowledge graph association module, a knowledge graph reasoning module and a decision support feedback module. According to the invention, a patient information model is constructed, and an OMOP CDM standard term system is utilized to construct electronic medical record data of patients into the patient information model with unified concept codes and unified semantic structures; the advantages of a semantic technology in data interaction and expansion are given to play, so the system has better adaptability and expandability to heterogeneous data of different hospitals; and meanwhile, clinical suggestions obtained through knowledge reasoning based on the knowledge graph are originated from clinical guidelines and doctor experience conforming to evidence-based medicine, and reasoning process and suggestion reasons can be traced and acquired by constructing reasoning instances, so the reasoning process and the suggestion reason can be given while clinical suggestions are given, and the credibility of doctors to decision support suggestions is improved.

A system (100) and method for clinical evaluation of neurodegenerative disease present in a subject is described. The system (100) comprises an image acquisition module (122) operable to acquire image data representative of a brain of a subject, and an image analyser (124). The image analyser (124) is operable to determine a quantitative value from the image data that is indicative of the level of neurodegenerative disease present in the brain of the subject. Various embodiments of the invention provide a tool that aids in improved early diagnosis and monitoring of neurodegenerative diseases, such as, for example, Alzheimer's disease (AD).

The present invention relates to the health and medical community monitoring field, the new generation high speed mobile communication field and the intelligent embedded system field. The device name is tracking body diagnosis pre-warning nursing device based on a rear 3G high speed wireless net. A set of medical sensor used for obtaining human body physiology data is also required to be matched with the device when in use. The technical problems to be solved includes obtaining the parameter of a multiple-parameter nondestructive examination medical sensor, analog-to-digital conversion of sensor signal, building a short distance miniature movable sensor network, accessing the rear 3G net in the air, a method of accessing the rear 3G net in the movable sensor network, a remote exact tracing method, etc. The key points are that the latest wireless mobile technology is adopted to nurse and diagnose the latent sudden disease carrier, the mental sickness patient, the parturient women, the organ transplanters, etc., in real time and process the sudden danger in time. The device of the present invention can be widely applied to every large medical treatment and nursing mechanism and is also fit for small scale monitoring in family.

Embodiments of the invention provides methods, devices and kits for determining the likelihood of an individual having an active fibrotic condition and / or early diagnosis, and subsequently prognosis evaluation of an individual having an active fibrotic condition such as systemic sclerosis (SSc) and / or nephrogenic systemic fibrosis (NSF) by measuring the levels of several biomarkers: α-enolase (ENO1), reticulocalbin 3 (RCN-3), alpha smooth muscle actin (α-SMA), reticulocalbin 1 (RCN-1) and pigment epithelium-derived factor (PEDF) in the individual.

The invention provides a health state diagnosis early-warning circuit and method of an electric automobile high-voltage system. The circuit comprises an insulation resistance detection module, a connecting resistance detection module, a battery management module, a motor control module, a pre-charging monitoring module, a relay monitoring module and a control computing module. The modules are used for detecting an insulation resistance value between a serial-connection battery pack of an electric automobile and an automobile body, a connecting resistance value of a high-voltage circuit, the health state, voltage and current of the serial-connection battery pack, a fault grade of a driving motor system, voltage and current of the direct-current input end of the driving motor system, a fault grade of a pre-charging circuit and a fault grade of a relay on line. Quantified comprehensive representation and on-line recognition are achieved for the health state of the high-voltage system, and therefore high-voltage safe management is performed on the safety state of the electric automobile high-voltage system more scientifically and reasonably.

In one aspect of the invention, there is provided a method for early detection of subacute, potentially catastrophic illness in an infant. The method comprises: (a) monitoring heart rate variability in the infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be used to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect of the present invention, there is provided a method for early detection of subacute, potentially catastrophic illness in an infant, which comprises: (a) monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.

The invention provides a four-autoantibody combined detection kit for diagnosing an early esophageal squamous cancer and application thereof. The four-autoantibody combined detection kit for diagnosing the early esophageal squamous cancer comprises a solid substrate and antigen protein which coats the solid substrate; and the antigen protein comprises TP53, HRAS, CTAG1A and NSG1. The four-autoantibody combined detection kit for diagnosing the early esophageal squamous cancer, provided by the invention, has the advantages that the TP53, the HRAS, the CTAG1A and the NSG1 are firstly adopted as acombination to be used for early diagnosis of ESCC, higher sensibility and higher specificity are realized, the detection kit is conducive to further improvement of serologic screening quality of ESCC early diagnosis, and therefore, the cure rate and survival rate of patients are further promoted.

The invention relates to an early diagnosis kit and an early warning kit, in particular to an early diagnosis and early warning kit for transplanted kidney rejection reaction and a use method of the kit, and further to some proteins applied in the early warning of transplanted kidney acute rejection reaction or transplanted kidney rejection reaction. By applying a liquid protein chip (luminex) detection technique, the expression level of 96 cytokines / chemokines and receptors thereof in 266 serum samples from 142 patients having acute transplanted kidney rejection reaction and transplant recipients with stable function of transplanted kidneys are monitored and comprehensively analyzed. An early warning system for the transplanted kidney rejection reaction comprising at least one combined marker and an early diagnosis system for the transplanted kidney rejection reaction comprising at least one factor combined marker are established. The prediction and accuracy rate of the acute rejection achieve 98.6%, and the internal cross validation rates are 97.1% and 97.2%, respectively.

The invention provides a kit for detecting 7 genetic markers of peripheral blood in early diagnosis of nasopharyngeal darcinoma. The kit comprises a peripheral blood total RNA extracting reagent, RT-PCR reaction liquid, time fluorescence quantitative RT-PCR reaction liquid and an SVM nasopharyngeal darcinoma diagnosis model, wherein the time fluorescence quantitative RT-PCR reaction liquid comprises primers of which the sequences are shown as SEQ IDNO:1-16; the primer sequences are SYBR Green fluorescence quantitative RT-PCR detection primers of the 7 genetic markers and reference gene GAPD; and the 7 genetic markers are HERC5, DLG7, PPARG, PLK1, KIF15, KLHL25 and MYST4. The invention also provides a using method for the kit. The kit has the advantages of high sensitivity, specificity and convenience, and can be used as aided diagnosis and early diagnosis technology for the nasopharyngeal darcinoma.

The invention relates to a kit for performing gene detection on middle east respiratory syndrome coronaviruses, in particular to a kit for detecting middle east respiratory syndrome viruses UPE and N genes through multiple real-time fluorescent polymerase chain reaction technologies. The kit mainly comprises an RT-PCR solution, a primer probe mixed solution, an RT-PCR enzyme system, DEPC H2O and a packaging box for packaging reagent bottles or tubes in a separated and concentrated mode. Due to the fact that the mode that various fluorescent channels are used for detection respectively is adopted for the kit, a one-step method real-time fluorescent PCR mode is applied, the middle east respiratory syndrome coronaviruses UPE and the N genes can be accurately and fast detected, and the kit can be widely applied to various fields of cloinical early-stage diagnosis, epidemic situation prevention and control, scientific research and the like of a middle east respiratory syndrome.

Described are methods for detection of neuronal pathologies using quantitative analysis in bodily fluids of synapse and / or neurite small RNAs and application of these methods to early diagnosis and monitoring of neurodegenerative diseases and other neurological disorders.

A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.

Health is a complex state that represents the continuously changing outcome of nearly all human activities and interactions. The invention provides efficient methods and arrays for health monitoring, diagnosis, treatment, and preventive care. The invention monitors a broad range of identifying molecules from a subject, such as circulating antibodies, and the invention evaluates a pattern of binding of those molecules to a peptide array. The characterization of the pattern of binding of such molecules to a peptide array with the methods of the invention provide a robust measure of a state of health of a subject.