163 results about "Pediatric patient" patented technology

Methods of administering sotalol hydrochloride in an amount effective for treating one or more cardiovascular disease or disorder in pediatric patients are described and include IV and / or oral doses based on age-specific creatinine clearance ranges.

The invention relates to the technical field of intelligent medical treatment, in particular to a pediatric patient nursing guidance method and system based on data analysis. According to the method and the device, the short-time fluctuation and the long-term trend of the physiological characteristics of the patient can be dynamically captured by acquiring the physiological sign data in the specified time period, calculating the fluctuation condition and forming the health state fluctuation information instead of only depending on single-point measurement data, so that the change characteristics of the health state are reflected more accurately. According to the method, the physiological signs conforming to the mean value or standard deviation range are screened, the individual health baseline is established, and the deviation between the individual health baseline and the physiological signs is compared, so that health assessment can be adaptively adjusted according to the reference states of different individuals instead of unified standard assessment, and misjudgment caused by individual differences is reduced. The nursing intervention level is set based on the change trend of the physiological signs, and the nursing intensity can be flexibly adjusted through factors such as duration and frequency of the fluctuation trend, so that the nursing suggestions have higher pertinence.

The invention relates to the technical field of medical apparatus and instruments, in particular to a multi-dimensional adjustable traction device for pediatric orthopedic nursing, which comprises a bottom plate and further comprises a shaking assembly connected to the bottom plate; the bed frame is connected to the output end of the rocking assembly, an upper lying plate and a lower lying plate which can rotate are connected to the bed frame, and the same mattress is placed on the upper lying plate and the lower lying plate; and the traction mechanism comprises a fixing assembly and a traction assembly. The traction mechanism and the fixing assembly are arranged to limit the legs of a pediatric patient, injury and pain caused by leg movement of the patient are relieved when the patient is nursed, the direction of traction force is the same as the direction of a fracture line, and a good treatment effect is guaranteed; the bed frame is driven by the shaking assembly to slightly shake front and back, the mood of a child patient is pacified, the metal block which is magnetically locked is kept stable relative to the bed frame, and traction stability is kept.

The present disclosure relates to solid-state forms and corresponding pharmaceutical compositions of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, and methods of treatment, including treatment of rheumatoid arthritis and juvenile idiopathic arthritis using the same. The treatment methods generally comprise administering to a patient (e.g., a pediatric patient) a therapeutically effective amount of upadacitinib as a stable liquid pharmaceutical composition or a solid dosage form, at a dose based on patient body weight.

A system for aiding in a medical clinical trial involving one or more pediatric patients includes a patient passport, individual achievement stickers that are awarded to pediatric patients and that are placed within the patient passport, and an interactive companion toy having distinctive patterns thereon. A camera of a mobile device scans the individual achievement stickers in the patient passport and / or the distinctive patterns on the interactive companion toy, and an interactive incentivization application logic section of the mobile device unlocks and display reward content to the pediatric patient. The interactive companion toy, the mobile application, and the physical passport can be customized to match particular protocols of the clinical trial. The pediatric patient is thus incentivized to participate and continue the clinical trial. Virtual medical play associated with the clinical trial can be practiced on the interactive companion toy in an augmented reality environment. Parents are assisted through automatic text message reminders, and electronic patient-reported outcomes are collected, transmitted, processed, and summarized for visualization and insights via a cloud-based clinical trial portal.

Described herein are pediatric garments for infants and children with medical needs. The pediatric garment is designed to provide quick and easy access to the body, specifically for pediatric patients, and any medical equipment, devices, and / or attachments related to the pediatric care of the patient. The pediatric garment features may include a unique combination of openings with locations that are placed according to the medical needs of a pediatric patient.

Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.

Provided are methods for clinical treatment of Atypical Hemolytic Uremic Syndrome (aHUS) using an anti-C5 antibody, or antigen binding fragment thereof, in pediatric patients.

Provided herein are methods of preparing an engineered heart valve for implantation into a subject in need (e.g., a pediatric patient). For example, a porcine pulmonary valve can be decellularized and then recellularized with cells from the subject. Hydrogels can be used to facilitate cell delivery and growth within the sub-endothelial layer (e.g., spongiosa) of a heart valve, which is essential for long-term success of the implantation.

The present invention provides methods of treating or preventing atrial fibrillation, atrial flutter, or a combination thereof comprising intravenously administering sotalol hydrochloride to a subject in need thereof. Embodiments of the present invention further provide novel methods of intravenously administering sotalol hydrochloride for example in pediatric patients. The present invention provides a novel intravenous, prophylactic, antiarrhythmic method of sotalol administration.

The invention belongs to the field of intelligent medical treatment, and particularly relates to a method, equipment, medium and program product for predicting RMPP based on lung microvascular changes. The method comprises the following steps: S101, acquiring a CT image of a pediatric MPP patient; s102, the CT image is extracted to obtain a quantitative PBV parameter, the quantitative PBV parameter comprises BV10%, and BV10% refers to the percentage of the blood volume in a blood vessel with the blood vessel cross section area larger than 10 mm < 2 > in the total lung blood volume; and S103, if BV10% is higher than a first threshold value, judging that the pediatric MPP patient develops into a prediction result with high RMPP risk, and otherwise, outputting a prediction result with low RMPP risk. According to the application, the prediction effect on the occurrence and development of the RMPP is found by quantitatively measuring the microvascular change in the CT, and the clinical value of early diagnosis of the RMPP is realized, so that the clinical early treatment is driven.

A method of treating cancer in a pediatric patient in need thereof comprises administering to the patient 9-ING-41 in combination with an additional therapeutic agent.

The present invention provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units and processes for their preparation. The present invention provides an extended-release capsule dosage form of metoprolol succinate in the form of discrete units, wherein said capsule dosage form is bioequivalent to the marketed Toprol-CL® tablet. Moreover, the extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration for patients who have difficulty swallowing tablets or capsules, e.g., paediatric patients or geriatrics.

To provide methods of providing sedation or analgesia to a pediatric patient.SOLUTION: The presently disclosed subject matter relates to methods of administering an effective amount of dexmedetomidine to a pediatric patient in order to reduce the incidence of neurological damage. More specifically, the presently disclosed subject matter relates to methods of providing sedation or analgesia to a pediatric patient by administering a dexmedetomidine infusion and optionally a loading dose. The dexmedetomidine can be administered before, during or after surgery.SELECTED DRAWING: Figure 1

The present disclosure is related to a device for gripping catheters that are used in interventional cardiac procedures without causing internal catheter damage. The present disclosure will allow the operator to maintain improved stability and maneuverability compared with current approaches, including, primarily, digital manipulation, which can lead to fatigue, instability and inappropriate catheter movement. Specifically in the pediatric population where small movements can lead to severe and permanent complications, the present disclosure has the potential to increase the safety profile of already high-risk interventional catheterization and electrophysiology procedures.

Compositions and methods for treating hair loss and / or nail brittleness, fragility, and pitting, particularly in pediatric patients, using topically administered JAK / STAT inhibitors and one or more penetration enhancer are described herein.

The invention relates to the technical field of virtual reality, in particular to a traditional Chinese medicine pediatric acupuncture training system combined with virtual reality guidance, which comprises a virtual behavior generation module, a feedback module, an evaluation module and a guidance module. By simulating the physiological behavior of a pediatric child patient, providing sensory feedback, quantitatively evaluating the operation technique in real time and guiding the dialectical diagnosis and treatment process, high-simulation pediatric acupuncture skill training is achieved, and the clinical pertinence of training is effectively improved.

The present invention provides a liquid composition comprising effective amount of Hydroxyurea for oral administration. The invention further discloses liquid formulation in form of ready to use oral suspension which remains stable at room temperature at the time of dispensing, storage and even after reopening of the container comprising the suspension. Also provided is a method of preparing the formulation and treating sickle cell anemia in pediatric patients.

An oral formulation of granules of an active ingredient such as gepotidacin or a pharmaceutically acceptable salt thereof that rapidly disperses in water, or an oral formulation comprising such granules. Such granules provide an oral suspension with good mouthfeel and palatability. This oral suspension is particularly useful for pediatric patient populations or patient populations with difficulty swallowing.

Compositions for intranasal delivery of benzodiazepines, such as diazepam, midazolam, and lorazepam and methods for their use to treat and prevent seizures in pediatric subjects aged 2-5, inclusive. Compositions for rapid therapeutic onset with a decreased incidence and / or severity of adverse effects after administration and methods of improving patient compliance with a prescribed treatment regimen.

Examples of the disclosure are directed to adjustable back plates or backboards for a mechanical compression device to accommodate different patient sizes and / or for ease of storage. Examples of the disclosure includes back plates that can be folded, pieced together, or otherwise have a variable distance between connectors that attach to legs of a chest compression device. Examples also include back plates which may have two sides, such as an adult patient side and a pediatric patient side, to accommodate different patient sizes.

Disclosed is a pediatric emergency kit for esophageal tamponade procedures in pediatric patients and methods of use thereof. The pediatric emergency kit includes at least one esophageal balloon catheter for the tamponade of blood flow, and an inflation hand pump equipped with a pressure gauge for inflating a balloon on the balloon catheter. The pediatric emergency kit can be configured to include multiple compartments, optionally, with a first container / compartment containing at least the esophageal balloon catheter and a second container / compartment containing at least the inflation handpump, and optionally a second esophageal balloon catheter. Optionally, both the first and second containers / compartments contain a syringe, a 3-way luer lock stopcock, and / or a guidewire. Also provided are instructions and / or methods of using the kit for correct placement and inflation of the esophageal balloon to effectively manage arterio-esophageal fistulas.

The invention discloses a pediatric surgical operation fixing device which comprises an operating bed and an L-shaped pressing plate located above the operating bed, four supporting legs symmetrically distributed in pairs are fixedly connected to the lower surface of the operating bed, an air bag is installed on the L-shaped pressing plate, a first positioning mechanism used for driving the L-shaped pressing plate to move in the vertical direction is arranged below the operating bed, and a second positioning mechanism used for driving the L-shaped pressing plate to move in the vertical direction is arranged below the operating bed. And the second positioning mechanism is used for driving the L-shaped pressing plate to move in the horizontal direction. According to the device, the first positioning mechanism drives the L-shaped pressing plate to move downwards to the lowest point, so that the L-shaped pressing plate is close to a child patient, then the second positioning mechanism drives the L-shaped pressing plate to move to the preset position in the horizontal direction, so that the L-shaped pressing plate avoids the position where an operation is about to be conducted, and finally the air bag is inflated through an external air pump; according to the device, the air bag is arranged to limit the pediatric patient and prevent the pediatric patient from moving randomly, and vertical movement and horizontal movement of the L-shaped pressing plate can be controlled through the driving shaft, so that the overall convenience of the device is effectively improved.

A supplement, and a method of treatment utilizing the supplement to elicit positive responses in a patient with neurological conditions is disclosed. The supplement comprises four components: N-acetylcysteine, glycine, choline, and biotin. In the preferred embodiment for treating adult patients, the effective supplement daily dosage comprises at least 1500 mg of glycine, 1500 mg of N-acetylcysteine, 1000 mg of choline, and 1000 μg of biotin. In another embodiment for treating pediatric patients, the supplement may comprise an effective supplement daily dosage of at least 500 mg of glycine, 500 mg of N-acetylcysteine, 250 mg of choline, and 250 μg of biotin. In a method embodiment, regular daily dosages of a supplement comprising over 1 g total of the four components are administered, resulting in improved outcomes among patients with cognitive impediments.

The invention belongs to the technical field of medication safety, and discloses a children medication evaluation method, and the children medication evaluation comprises the following specific operation steps: S1, checking the safety of a medicine: checking the toxicity and adverse events of the medicine according to the medication condition of a child, and particularly paying attention to the special reaction of the child; according to the invention, the body data of the child patient is imported into the evaluation system, so that the body data is compared with the internal information of the data management module, and then similar cases are found and compared with the medication conditions, so that the situation that the cases are far away from the medication conditions is avoided; meanwhile, the medicine use condition of medical staff is checked through the medicine information module and the clinical test management module, the situation that whether medicine conflicts exist or not and potential safety hazards are caused is avoided, the treatment condition is connected through feedback after medicine use of a patient, and data in the data management module are compared; therefore, the medication condition of children can be evaluated conveniently.

The invention discloses a pediatric clinical cooling device, and relates to the technical field of pediatrics, the pediatric clinical cooling device comprises a bed board platform, four corners of the lower end of the bed board platform are provided with support legs, the upper surface of the front end of the bed board platform is provided with a headrest, and the upper surface of the headrest is provided with a rubber cushion pad. The head cooling mechanism is arranged on the front side of the bed board platform, and a body position cooling mechanism is arranged on the rear side of the bed board platform; the head cooling mechanism comprises a first adjusting rod, and a top box is arranged on the outer side of the first adjusting rod; the body position cooling mechanism comprises a cooling box. The problems that a cooling device and a pillow are combined and matched for use, only the neck of a patient can be cooled, the forehead of the patient often needs to be cooled under the conventional high-temperature condition, meanwhile, in a pediatric patient, high temperature is gradually transmitted, the whole body is infected, and the body part of the patient needs to be cooled at the moment are solved.

This invention discloses an artificial intelligence-assisted method and system for predicting the timing of extubation in pediatric patients, belonging to the field of clinical medical technology. It includes sample information collection: collecting large-sample clinical data of respiratory waveform signals, facial expression video streams, and vital sign data of the child to obtain sample information; and sample information processing: preprocessing the sample information and establishing a repository to store the preprocessed sample information to obtain a database. This invention uses a set state setting method combined with a model generation method, and integrates high-precision ventilator data, child facial expression video data, and vital sign data to predict the timing of extubation, thereby replacing the current subjective judgment method. This provides specific computer-aided decision support for sequential mechanical ventilation treatment during the resuscitation and extubation phase. Simultaneously, different timing prediction models are trained according to different child characteristics to improve the accuracy of computer-aided decision support.

Orodispersible film (ODF) is an innovative drug formulation that allows for adjustable dosing and improved patient compliance. It is administered into the mouth where it dissolves, making it suitable for children. The present invention provides an optimized ODF gel formulation and an optimal ODF containing therapeutic doses of hydrocortisone-type corticosteroids (HTC). This ODF is thin, flexible and transparent, and suitable for production in hospital pharmacy using standard equipment. The ODF of the invention allows accurate hydrocortisone levels to be released systemically in patients in need thereof, and its good physico-chemical stability is herein demonstrated for several months. This opens up new opportunities for use in pediatric patients, notably for children suffering from congenital adrenal hyperplasia.

This invention belongs to the field of medical device technology and discloses an endoscope. The endoscope includes a serpentine joint, an instrument channel, and a camera core wire. A traction wire threading structure is provided on the serpentine joint for the traction wire to pass through. The wall thickness of the traction wire threading structure on the side facing the center of the serpentine joint is less than the wall thickness on the side away from the center of the serpentine joint. The instrument channel is disposed within the serpentine joint, forming a cavity. The axis of the instrument channel is parallel to the axis of the serpentine joint. This embodiment of the endoscope can increase the internal space of the serpentine joint while effectively reducing the outer diameter of the serpentine joint, allowing the endoscope to enter extremely narrow cavities at lesion sites, such as the digestive tract of pediatric patients or severely narrowed lesion areas. This provides opportunities for observation and treatment of these patients, increasing the product's market coverage and application scenarios.

A traditional Chinese medicine composition for treating pediatric exogenous wind-heat and a preparation method thereof are provided and relate to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for treating the pediatric exogenous wind-heat includes the following raw materials: Menthae Haplocalycis Herba, Bombyx Batryticatus, Gypsum Fibrosum, Anemarrhenae Rhizoma, Scutellariae Radix, Artemisiae Annuae Herba, Scrophulariae Radix, and Lycii Cortex. This traditional Chinese medicine composition can treat pediatric exogenous wind-heat invading the exterior pattern can significantly improve the clinical symptoms and signs of the pediatric patient and enhance the body's immunity, with remarkable effectiveness and high safety, thus being worthy of clinical promotion and application.