The invention belongs to a pump, in particular to a guide screw piston pump. The guide screw piston pump consists of an electromotor, a main shaft commutator, a guide screw, a nut leader, a connecting supported lever, a nut, a piston rod, a discharging valve, a piston, a cylinder, an outlet flange, an inlet flange, a sucking valve, an upper support seat, a lower support seat, a lower limit switch, and an upper limit switch. The piston, the piston rod, and the nut are connected together, and the nut and the guide screw are meshed. The invention adopts the structure that the piston, the piston rod and the nut are connected into a whole, the meshed motion of the nut and the guide screw is used as the power of the pump body, the discharging pressure is strong, the structural action parts are less, the cost is low, and the power is high. The invention is in particular applicable for the viscous medium and long-distance transmission, and is energy-saving and efficient.