It is intended to provide an evaluation method and a
screening method capable of eliminating a substance that disturbs
in vivo kinetics in an individual and capable of simply and easily searching a substance having an action of activating / suppressing an innate immune mechanism without being affected by LPS derived from
bacteria, which can be contaminated during the search, as well as a
drug and a food for activating / suppressing the innate immune mechanism, and methods of producing the same. The present invention provides a method of evaluating or screening the substance having the action of activating / suppressing the innate immune mechanism using a muscular contraction of an
organism having the innate immune mechanism as an indicator, and methods of producing the
drug and the food for activating / suppressing the innate immune mechanism. Also, an innate
immunity activator and the food having the action of activating the innate immune mechanism containing the substance having the action of contracting the
muscle of the
organism having the innate immune mechanism, and an innate
immunity suppressor and the food having the action of suppressing the innate
immunity containing the substance having the action of suppressing the contraction of the
muscle of the
organism having the innate immune mechanism are provided.