The invention discloses a wild-imitation breeding method for river eel. The method comprises the following steps: A, preparing for pond conditions and other work; B, stocking seeds, wherein the seeds include river eel, penaeus monodon, chub and bighead; C, feedstuff feeding; D, daily management: (1) aerating by adopting an aerator; (2) disinfecting a water body; (3) applying a microbial preparation; (4) changing water; (5) controlling diseases: preventing, controlling and treating diseases by using Chinese Herbal medicines; E, modifying an artificial wild-imitation environment. According to the method, river eel, penaeus monodon, chub and bighead are bred in a breeding pond in a mixed way, so that the stability of a breeding system can be improved; meanwhile, the water quality environment of the pond can be improved, and the breeding benefit of unit area is increased; a marine drug prepared by compounding natural Chinese herbal medicines has the advantages of natural property, multi-functionality, small toxic and side effects and no drug resistance, the quality of marine products is improved remarkably, and the immunologic functions of aquatic animals are improved.