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Composition capable of bidirectional adjusting gastrointestinal smooth muscle contraction

A two-way regulation, gastrointestinal technology, applied in the direction of drug combination, hydrocarbon compound active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of easy standardization and reduce the possibility of side effects

Inactive Publication Date: 2008-04-30
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the research on the two herbs of citrus aurantium and peony as a compound.

Method used

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  • Composition capable of bidirectional adjusting gastrointestinal smooth muscle contraction
  • Composition capable of bidirectional adjusting gastrointestinal smooth muscle contraction
  • Composition capable of bidirectional adjusting gastrointestinal smooth muscle contraction

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1～3

[0046] Conditions taken in Experimental Examples 1-3:

[0047] Drug groups (compounds):

[0048] Paeoniflorin (purity of 98wt%) was purchased from Kunming Changchunhua Technology Co., Ltd.; naringin (purity of 98wt%) and synephrine (purity of 98wt%) were purchased from Shaanxi Xuhuang Plant Technology Development Co., Ltd.; hesperidin (purity 98wt%) was purchased from Chengdu Huakang Chengdu Huakang Biological Engineering Co., Ltd.; neohesperidin (purity 95wt%) was purchased from Guilin Laiyin Biological Products Co., Ltd.; limonene (purity 98wt%) was purchased from Shanghai Meishuang trade co., LTD.

[0049] Using the principle of statistics, the 6 compound components were combined according to the orthogonal experiment grouping. For the sake of accuracy, each group of monomers is divided into three levels: full amount, half amount, and no amount. Design according to L18(36) orthogonal table.

[0050] Table 1 Orthogonal design table for the experiment of Fructus Fructus P...

experiment example 1

[0056] Effects of the combination of different drug monomers on the propulsion rate of carbon powder in healthy mice

[0057] The experimental results are shown in Figure 1 below. Results Statistical analysis found that synephrine significantly inhibited the propulsion rate of carbon powder in healthy mice.

experiment example 2

[0059] Effects of the combination of different drug monomers on the propulsion rate of carbon powder in atropine-induced mice

[0060] The experimental results are shown in Figure 2 below. Results Statistical analysis found that synephrine significantly inhibited the propulsion rate of carbon powder in healthy mice. Paeoniflorin and hesperidin can significantly promote the propulsion rate of charcoal powder in healthy mice.

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Abstract

The invention relates to a Chinese medicament composition with the function of bidirectionally regulating the smooth muscular contraction in gastrointestinal tract, which is measured by weight (briefly marked by share) and contains synephrine 5-24 parts, hesperidin 2-10 parts, and paeoniflorin 5-24 parts, or synephrine 5-24 parts, hesperidin 2-8 parts, paeoniflorin 5-24 parts, new hesperidin 1-5 parts, maringin 8-40 parts, and limonene 2-10 parts. In comparison with the prior Chinese medicament compositions which take original medicamnet as raw materials, the invention has the function of bidirectionally regulating the smooth muscular contraction in gastrointestinal tract, and has the advantages of reducing the possibility of side effect caused by unknown component of traditional Chinese medicine compositions, easily standardizing and the like.

Description

technical field [0001] The invention relates to a composition, in particular to a traditional Chinese medicine composition with the function of bidirectionally regulating the contraction of smooth muscle in the gastrointestinal tract. Background technique [0002] In recent years, human beings have made great progress in the understanding of gastrointestinal motility disease and its dysfunction, as well as the abnormal contraction of gastrointestinal smooth muscle behind it. The contraction of gastrointestinal smooth muscle is one of the important physiological functions of the human gastrointestinal tract. First, it has received more and more attention and research in the medical field. The low contraction of gastrointestinal smooth muscle often leads to indigestion, constipation and other diseases, and the hypercontraction of gastrointestinal smooth muscle often leads to diarrhea and other diseases. Many drugs have been used to treat abnormal contraction of gastrointestina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/00A61P1/12A61K31/01
Inventor 刘建文房一时山冬梅徐文黄永平胡爱鹏李长龙吴宏忠邓皖利孙丽娟于有军王芳王劲顾星波沈小东
Owner EAST CHINA UNIV OF SCI & TECH
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