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Selegiline-containing adhesive preparation

A preparation, pressure-sensitive adhesive technology, applied in the field of adhesive preparations, can solve the problem of unknown inhibition of drug transfer to the skin, and achieve the effect of less possibility and less side effects

Inactive Publication Date: 2011-09-21
FUJIMOTO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In this connection, although medium-chain fatty acid triglyceride and diisopropyl adipate are known as skin penetration enhancers (see JP-A-2000-281570, International Publication WO 2006 / 082888 and JP-A-10-218793) , but they are not known to have the effect of inhibiting drug transfer into the skin

Method used

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  • Selegiline-containing adhesive preparation
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Examples

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Embodiment

[0063] The present invention will be described in detail below with reference to Examples, but the present invention is not limited to these Examples. In this connection, "parts" and "%" used in the following description refer to "parts by weight" and "% by weight", respectively.

[0064] (Preparation of acrylic pressure-sensitive adhesive)

[0065] In an inert gas atmosphere, 72 parts 2-ethylhexyl acrylate (2-EHA), 25 parts N-vinyl-2-pyrrolidone (VP), 3 parts acrylic acid (AA) and 0.2 parts The azobisisobutyronitrile was subjected to solution polymerization in ethyl acetate, thereby preparing a solution of an acrylic pressure-sensitive adhesive. The weight average molecular weight of the acrylic pressure-sensitive adhesive is about 1,800,000.

[0066] (Preparation of selegiline-containing adhesive preparations of Examples 1 to 3 and Comparative Examples 1 to 3)

[0067] Various pressure-sensitive adhesive solutions were prepared according to the blending ratio shown in Table 1 belo...

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Abstract

The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (-)-(R)-N,[alpha]-dimethyl-N-2-propynylphenethylamine and / or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and a component which is liquid at 25 DEG C. and has two or more ester bonds in one molecule thereof.

Description

Technical field [0001] The present invention relates to an adhesive preparation comprising (-)-(R)-N,α-dimethyl-N-2-propynyl phenethylamine (hereinafter referred to as "selegiline (selegiline) The free form of selegiline) and / or its pharmaceutically acceptable salt (hereinafter referred to as the "selegiline salt", the salt and the aforementioned "free form of selegiline" are collectively referred to as "selegiline "). Specifically, the present invention relates to an adhesive preparation that is attached to the skin surface to continuously administer selegiline from the skin surface to a living body. Background technique [0002] The essential drug selegiline is effective as an anti-Parkinson's disease drug and is known as an inhibitor of monoamine oxidase (MAO). There are different subtypes of MAO, namely, type A (MAO-A) and type B (MAO-B). Selegiline as an oral preparation is a selective inhibitor of type B. However, it has been reported so far that oral administration of s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/14A61K47/32A61P25/16
CPCA61K47/14A61K31/137A61K47/12A61K9/7061A61P1/08A61P25/00A61P25/08A61P25/16A61P25/18A61P25/24A61P25/28A61P27/06A61P31/18A61P43/00A61K9/7038A61K31/135
Inventor 雨山智西浦英里中村光史上山真史丸尾浩树保坂京子堀光彦
Owner FUJIMOTO CO LTD
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