22 results about "Phenethylamine" patented technology

The invention discloses preparation and application of a reductive amination catalyst. The preparation method of the catalyst comprises the following steps: step 1, preparing an SrTiO3 carrier; step 2, loading a nickel source into the prepared SrTiO3 carrier to form a nickel-loaded SrTiO3 catalyst precursor; and step 3, roasting the SrTiO3 catalyst precursor to obtain the SrTiO3 loaded nickel catalyst. Large-scale production of the non-noble metal catalyst is realized by adopting a co-precipitation method and an impregnation method which are simple in process and environment-friendly under the condition of room temperature, the obtained material can be used for reductive amination reaction of acetophenone under the condition of taking water as a solvent and shows excellent catalytic performance, and after 50 times of application, the acetophenone conversion rate is gt; the selectivity of alpha-phenylethylamine is gt; the selectivity of the alpha-phenethyl alcohol is 1t; and 2%.

The utility model relates to the technical field of phenylethylamine preparation, in particular to a heat-preservation stirring device for dextro-phenylethylamine preparation, which comprises a box body, the box body is of a cavity structure, two through holes are formed in the box body, a liquid inlet pipe and a liquid outlet pipe are respectively and fixedly arranged in the two through holes, a drying box and a filter box are fixedly arranged on the outer wall of the box body, and the filter box is arranged in the box body. A cover plate is arranged at the upper part of the box body, a detachable driving motor is mounted at the upper part of the cover plate, a fixed rod is fixedly connected with a stirring blade, and a cooling pipe and a heating wire are arranged between the outer wall of the reaction tank and the inner wall of the box body. The first rotating rod rotates to drive the vertical bevel gear on the lower portion to rotate, then the second rotating rod and the third rotating rod can rotate, the connecting rods on the two sides can do circular motion with the second rotating rod and the third rotating rod as the circle center, and therefore stirring rods at the two ends of the connecting rods can stir stirring liquid up and down; the upper and lower temperatures of the reaction liquid are more balanced.

The invention discloses a multi-copper oxidase mutant sourced from Psychrobacter sp. And capable of efficiently degrading biogenic amine and application of the multi-copper oxidase mutant. According to the multi-copper oxidase mutant, the 183rd site of an amino acid sequence shown in SEQ ID NO.1 is mutated into histidine from phenylalanine, the 221st site of the amino acid sequence shown in SEQ ID NO.1 is mutated into aspartic acid from asparagine, the 261st site of the amino acid sequence shown in SEQ ID NO.1 is mutated into glutamic acid from glutamine, and the 292nd site of the amino acid sequence shown in SEQ ID NO.2 is mutated into arginine from lysine. Compared with wild type multi-copper oxidase, the multi-copper oxidase mutant disclosed by the invention has a good degradation effect on tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine, and the degradation rate on the spermidine and the spermine is increased to 100%, so that the multi-copper oxidase mutant has a good application prospect in food fermentation safety production.

The invention discloses a huperzia serrata HsCAO1b gene and application thereof, and belongs to the technical field of molecular biology and genetic engineering. Aiming at the problems that huperzia serrata wild resources are scarce, and CAO family genes of the huperzia serrata have unknown functions and are difficult to clone, the invention provides a complete coding sequence SEQ ID NO: 1 of the gene, constructs an expression vector containing the gene, and introduces the expression vector into host cells and plants. The gene can be used for regulating the metabolism of amine substances in plants, reducing the content of 2-phenylethylamine, piperidine or putrescine and increasing the content of spermidine or spermine; alkaloid synthesis is regulated and controlled, and total alkaloid is reduced or nicotine content is increased; the quantity of rosette leaves in the bolting period is increased to regulate and control plant growth and development, and gene resources are provided for production of active ingredients such as huperzine A and the like.

The invention concerns a compound of formula (I) (I) R1═H, —CH3 or acyl group, preferably R1═—CH3R2═H or halogen atom selected in the group consisting of: F, Cl, Br, I, preferably R2═H or a pharmaceutically acceptable isomer, salt and / or solvate thereof, for use in preventing and / or treating neurodegenerative diseases when central muscarinic neurotransmission is compromised, wherein said neurodegenerative disease is selected in the group consisting of Alzheimer's Disease (AD), vascular dementia, Dementia with Lewy bodies (DLB), mixed dementia, frontotemporal lobar degeneration (FTLD), and Parkinson's disease (PD).

The invention discloses a preparation method of a tovorafenib intermediate, and belongs to the field of organic synthesis. The tovorafenib intermediate is (R)-2-(1-aminoethyl)-N-(5-chloro-4-(trifluoromethyl) pyridine-2-yl) thiazole-5-carboxamide, and the method mainly comprises the following steps: dissolving 2-acetyl-N-(5-chloro-4-(trifluoromethyl) pyridine-2-yl) thiazole-5-carboxamide in a solvent, adding p-toluenesulfonic acid, dropwise adding S (-)-alpha-phenylethylamine for reaction, and carrying out column chromatography separation to obtain the tovorafenib intermediate. Recovering the solvent from the product to obtain an oily intermediate; then dropwise adding S (-)-alpha-phenylethylamine, and adding DBU for reaction; and after the reaction is finished, carrying out reduced pressure distillation to recover the S (-)-alpha-phenylethylamine, so as to obtain an oily substance, adding water into the oily substance, and crystallizing, so as to obtain the tovorafenib intermediate. According to the method, S (-)-alpha-phenylethylamine is used as a reactant and a chiral inducer at the same time, p-toluenesulfonic acid is used as a condensation catalyst, and DBU is used for catalyzing epimerization; the theoretical 100% yield is achieved through high-temperature racemization.

The present invention discloses a preparation method of (S)-5-allyl-2-oxabicyclo[3.3.0]oct-8-ene, which comprises the following steps: (1) 2-oxocyclopentanedicarbonyl methyl ester (M8) and 2-iodo-1-ethyl acetate (M2) are alkylated in anhydrous acetone, and then cyclized with p-TsOH to obtain M9; (2) The obtained M9 is hydrolyzed with a base and resolved with α-phenylethylamine in a solvent to obtain M10a; (3) The obtained M10a is condensed with Meldrum's acid to obtain M11a; (4) The obtained M11a is reduced to obtain M12a; (5) The obtained M12a is dehydrated under the action of acetyl chloride and triethylamine to obtain (S)-5-allyl-2-oxabicyclo[3.3.0]oct-8-ene. The reaction route of the present invention is short, the raw materials are easily available, the by-products are less, the reaction conditions are stable, the operation is simple, and it is suitable for large-scale production.

The invention discloses phenylethylamine and serotonin in preparation of a kit for evaluating a microplastic nerve disturbance effect and application of the kit. The invention further provides a method for detecting the content of phenylethylamine and / or serotonin in excrement by using an ultra-high performance liquid chromatography-high resolution mass spectrometry technology so as to identify whether the micro-plastic disturbs the nerve effect or not. The detection method is high in sensitivity and strong in specificity, has the characteristics of no invasiveness, simplicity in operation, mild conditions, rapidness, high repeatability, high stability and the like, and can provide effective technical support for research and intervention of nervous disorder mechanisms, diagnosis and evaluation of nervous disorder, research and intervention of mental diseases and the like.

This invention relates to a recombinant bacterial cell for de novo synthesis of xanthocyanin WGX-50 using glucose as a carbon source, its construction method, and its applications. The recombinant bacterial cell uses *Escherichia coli* as the host strain and integrates the following three heterologous biosynthetic modules: a 3,4-dimethoxyphenylethylamine de novo synthesis module, which contains an enzyme system catalyzing the generation of dopamine from L-tyrosine and further stepwise methylation of dopamine to 3,4-dimethoxyphenylethylamine; a cinnamoyl-CoA synthesis module, which contains an enzyme system catalyzing the generation of cinnamoyl-CoA from phenylalanine or glucose metabolic intermediates; and an amidation module, which contains an acyltransferase capable of catalyzing the condensation of 3,4-dimethoxyphenylethylamine and cinnamoyl-CoA to generate xanthocyanin WGX-50. This invention achieves, for the first time, the de novo biosynthesis of xanthocyanin in microorganisms, completely eliminating dependence on the expensive exogenous precursor 3,4-dimethoxyphenylethylamine and significantly reducing raw material costs.

The utility model discloses a foam removal device for phenylethylamine production, and relates to the technical field of phenylethylamine production equipment, the foam removal device comprises a reaction kettle, a motor, a rotating shaft, stirring blades, a rotating plate and a fixed plate, the bottom of the reaction kettle is provided with supporting legs, the top of the reaction kettle is provided with a feed port, and the bottom of the reaction kettle is provided with a discharge port; the motor is fixedly arranged in the center of the top of the reaction kettle, the rotating shaft is vertically arranged in the reaction kettle, the upper end of the rotating shaft rotationally penetrates through the top of the reaction kettle and is connected with the output end of the motor, the lower end of the rotating shaft is rotationally connected with the center of the bottom of the reaction kettle, and the stirring blades are arranged on the rotating shaft and are lower than the liquid level; the rotating shaft is adopted to drive the rotating plate and the first crushing rod at the bottom of the rotating plate to rotate, and the second crushing rod on the fixed plate between the rotating shaft and the side wall of the reaction kettle is matched to impact and crush foams on the liquid surface, so that the foams are eliminated, the situation that the foams adhere to the wall is reduced, the safety problem caused by the foams is avoided, and the product yield is improved.

The application discloses a quasi-two-dimensional red light perovskite LED device and a preparation method thereof, and belongs to the technical field of light emitting diodes, wherein the preparation method comprises the following steps: depositing a PEDOT:PSS aqueous solution on a substrate surface by a spin coating method, and performing a first annealing treatment; mixing TFB and PVK in a chlorobenzene solution, and depositing the mixture on the substrate surface after the first annealing treatment by a spin coating method, and performing a second annealing treatment; depositing a calcium lignosulfonate solution on the substrate surface after the second annealing treatment by a spin coating method; dissolving lead iodide, cesium iodide, zinc iodide, 3,3-diphenylpropylamine iodine, 1-naphthalene methylamine iodine and phenylethylamine iodine in an N,N-dimethylformamide solution to obtain a perovskite precursor solution; dropping the perovskite precursor solution on the substrate surface after the above treatment to prepare a thin film, and performing a third annealing treatment on the thin film; and evaporating an electron transport layer and a cathode electrode on the thin film to obtain the quasi-two-dimensional red light perovskite LED device. The quasi-two-dimensional red light perovskite LED device has a small turn-on voltage, high brightness and high external quantum efficiency.

The present disclosure provides monoamine neurotransmitter releasers and / or monoamine uptake inhibitor compounds that have biogenic amine transporter activity but lack substantial activity at the 5-HT2 receptor subtype. The phenethylamine compounds or vinylogous phenethylamine compounds of the present disclosure are useful in treating diseases, conditions, and / or disorders mediated by the activity of one or more monoamine neurotransmitters.

The application discloses a biosynthesis method based on multi-enzyme cascade reaction and belongs to the field of bioengineering. The biosynthesis method based on multi-enzyme cascade reaction has the following steps: S1, adding omega-transaminase to racemic-alpha-phenethylamine until the racemic-alpha-phenethylamine is converted into phenylacetone by (S)-alpha-phenethylamine under the action of the omega-transaminase, and (R)-alpha-phenethylamine is left; S2, adding aldehyde-ketone reductase to the phenylacetone so that the phenylacetone is reduced into (R)-alpha-phenethyl alcohol under the action of the aldehyde-ketone reductase, and glutamate dehydrogenase is added in S1 and S2 to maintain the cycle of coenzyme NADPH / NADP + and the auxiliary substrate alpha-ketoglutarate / glutamate, (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol are generated by the three-enzyme one-pot method catalysis of the racemic-alpha-phenethylamine; (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol are generated by the three-enzyme co-expression of the catalysis of the engineering bacteria; (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol can be synthesized simultaneously, the method can be suitable for various industrial production scenes, and has important industrial application value.

Use of an aromatic L-amino acid decarboxylase as a marker in a detection product for hepatic encephalopathy. It has been confirmed that the abundance of aromatic L-amino acid decarboxylase genes encoded by gut microbiota, as well as the product of aromatic L-amino acid decarboxylase, phenylethylamine, are increased in patients with hepatic encephalopathy; and compared with blood ammonia, hepatic encephalopathy can be more accurately diagnosed by means of phenylethylamine. This suggests that the occurrence of hepatic encephalopathy and the degree of progression of the disease can be quickly confirmed by detecting the patients' feces and serum, which increases the demand for clinical detection of hepatic encephalopathy. It has been confirmed that the baseline serum phenylethylamine level can effectively predict the incidence of hepatic encephalopathy at 3 months after TIPS surgery, which provides a detection means for early warning of hepatic encephalopathy.

This invention discloses a two-dimensional and three-dimensional perovskite heterojunction optical thin film, belonging to the field of perovskite optical thin film technology. The thin film comprises a ternary cationic three-dimensional perovskite substrate, a composite two-dimensional perovskite passivation layer, and functional additives. The three-dimensional substrate has a chemical composition of FA. 0.7‑0.9 Cs 0.1‑0.2 Rb 0.05‑0.1 Pb(I 1‑x Br x The two-dimensional passivation layer (x = 0~0.5) is a mixture of phenylethylamine lead iodine and its monofluorinated derivatives, and the functional additive is a composite of CsPbBr₃ quantum dots and thiourea. The thin film is prepared by solution spin coating. This invention significantly improves the structural order, carrier mobility, and stability of heterojunctions through multi-element synergy, composite passivation, and additive assistance, and can be widely used in optoelectronic devices such as solar cells, lasers, photoelectric sensors, and light-emitting diodes.

The invention discloses a method for preparing high-quality Ag2Se colloidal quantum dot (CQDs) ink and film, comprising the following steps: S1, mixing an Ag2Se CQDs solution with a ligand solution, shaking, and then centrifuging to obtain an Ag2Se CQDs substrate at the bottom of a centrifuge tube, wherein the ligand solution is a mixed solution of silver iodide, potassium iodide, and N,N-dimethylformamide; S2, adding n-octane to the Ag2Se CQDs substrate, shaking for 30 seconds, and then washing the substrate; S3, adding n-butylamine, n-hexylamine solution, and ligand solution to the Ag2Se CQDs substrate after washing several times, standing for 2 minutes, and then shaking for 1 minute, adding ethyl acetate, and centrifuging to obtain the Ag2Se CQDs substrate at the bottom of the centrifuge tube; S4, adding a mixed solution of N,N-dimethylformamide, dimethyl sulfoxide, n-butylamine, β-phenylethylamine, and n-hexylamine to the Ag2Se CQDs substrate, shaking, and then centrifuging to obtain the final Ag2Se The present invention realizes the preparation of liquid phase Ag2Se CQDs ink for the first time through the steps of preparing CQDs substrate, the preparation method is simple and effective, and the prepared Ag2Se CQDs film is smooth and uniform with low roughness.

The invention discloses a method for recovering an edoxaban intermediate resolving agent R-phenylethylamine, which comprises the following steps: S1, adding an organic solvent A into a mother solution containing free R-phenylethylamine salt, cooling to 5-15 DEG C, adding inorganic acid to adjust the pH value to acidity, heating to 25-30 DEG C, and collecting a water phase; s2, cooling the water phase to 5-15 DEG C, adding inorganic alkali to adjust the pH to be alkaline, heating to 25-30 DEG C, adding an organic solvent B, and collecting an organic phase; and carrying out reduced pressure desolventizing distillation under the vacuum of-0.09 to-0.1 MPa at the temperature of less than or equal to 50 DEG C until no fraction exists, heating to 50-110 DEG C, carrying out reduced pressure distillation, and collecting the fraction with the top temperature of 80-100 DEG C, thereby obtaining the (R)-(+)-phenylethylamine. According to the method, the mother liquor is subjected to acid adjustment, solvent extraction, water phase alkali adjustment, solvent extraction and reduced pressure distillation and concentration, so that the yield and the recovery purity of the product can be improved, and the method is stable in process, easy to operate, short in time consumption and low in cost.

This invention discloses a strain of *Lactobacillus sarcodactylis* with stable biogenic amine degradation ability and its applications, belonging to the field of microbial fermentation technology. This invention screened a strain of *Lactobacillus sarcodactylis* L18 from fermented soybean paste, capable of degrading biogenic amines. This strain can simultaneously degrade eight common biogenic amines: tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine, and spermine. The *Lactobacillus sarcodactylis* L18 screened in this invention exhibits rapid growth, strong environmental adaptability, and stable amine-reducing performance. It can continuously exert its biogenic amine degradation effect under low to medium-high salt, acidic to weakly alkaline conditions, and common fermentation temperature conditions, making it particularly suitable for the effective control of biogenic amines such as tyramine in fermented foods.

The invention discloses a liquid chromatography-tandem mass spectrometry determination method for six biogenic amines in food. The six biogenic amines are cadaverine, putrescine, tyramine, histamine, 2-phenylethylamine, 2-phenylethylamine and tryptamine; the food is frozen marine fish, marine shrimps, fresh oysters, mollusks, marine products, fermented meat products, pickled vegetables, fermented vegetable products, fermented bean products, infant supplementary food, fermented milk products and fermented wine. The infant supplementary food is one or more of infant canned supplementary food containing fish or shrimp, dried fish floss and fish sausage. The method provided by the invention adopts the high performance liquid chromatography-tandem mass spectrometry, and compared with the existing high performance liquid chromatography, the method reduces the use of organic reagents, simplifies the pretreatment process, improves the sensitivity, and has the advantages of wide detection range, high analysis speed, high sensitivity and the like when being used for detecting the content of biogenic amines in various food components.

Described herein are neurotrophic and nootropic compositions and methods for treating subjects with such compositions. In one aspect the composition comprises one or more tryptamines in pure form or extracts from psilocybin containing mushrooms, or combinations thereof optionally combined with one or more phenethylamines or amphetamines in pure form or extracts from a plant or mushroom, or combinations thereof, optionally one or more erinacines or hericenones in pure form, extracts from Hericium mushroom species (e.g., H. erinaceus, H. coralloides, H. ramosum) or combinations thereof, optionally one or more cannabinoids in pure form or extracts from Cannabis sativa, Cannabis sativa, Cannabis indica, or Cannabis ruderalis, optionally, one or more adversive compounds, and optionally one or more pharmaceutically acceptable excipients. In another aspect, tryptamine compositions described herein enhance neuroplasticity by promoting neuronal branching through the formation of neurites (i.e., neurite outgrowth) and neurite elongation (i.e., increasing neurite length).

The invention discloses low-temperature conductive silver paste and a preparation method thereof, and relates to the technical field of conductive silver paste. According to the preparation method, the two-dimensional silver nanosheets are taken as a main body, the one-dimensional carbon nanotubes are overlapped and interspersed on the surfaces and in gaps of the two-dimensional silver nanosheets through an evaporation self-assembly technology to form a silver nanosheet reinforcement body, and the carbon nanotubes have higher conductivity and can fill the gaps of the silver nanosheets, so that the effect of improving the conductivity of the silver paste is achieved; then, the silver nanosheet reinforcement and silver nanoparticles are compounded to form a composite conductive filler, 3, 4-dimethoxyphenylethylamine is used for surface modification of the composite conductive filler, amino groups on 3, 4-dimethoxyphenylethylamine molecules can be adsorbed on the surface of the composite conductive filler through coordination, and the surface of the composite conductive filler is modified; due to the existence of benzene rings and methoxyl, the steric hindrance among the fillers is increased, the dispersion stability is effectively improved, and meanwhile, the conductivity of the conductive silver paste is further enhanced due to the enhancement of the uniformity of a conductive network. The conductive silver paste prepared by the invention has the effects of high conductivity and stability.

The application discloses a low-temperature conductive silver paste and a preparation method thereof, and relates to the technical field of conductive silver paste.The application takes two-dimensional silver nanosheets as a main body, and makes one-dimensional carbon nanotubes overlap and interpenetrate in the surface and gaps of the two-dimensional silver nanosheets through an evaporation self-assembly technology to form a silver nanosheet reinforcer.The carbon nanotubes have higher conductivity, can fill the gaps of the silver nanosheets, and can improve the conductivity of the silver paste; subsequently, the silver nanosheet reinforcer is compounded with silver nanoparticles to form a composite conductive filler, and the composite conductive filler is surface-modified by using 3,4-dimethoxyphenethylamine.The amino group on the 3,4-dimethoxyphenethylamine molecule can be adsorbed on the surface of the composite conductive filler through coordination, and the existence of benzene rings and methoxy groups increases the steric hindrance between the fillers, effectively improves the dispersion stability, and simultaneously, the strengthening of the uniformity of the conductive network further enhances the conductive performance of the conductive silver paste.The conductive silver paste prepared by the application has the effects of high conductivity and stability.