6 results about "Cyclohexanecarboxylic acid" patented technology

The application discloses a trienomycin photoaffinity probe, a preparation method and application, and comprises the following steps: taking Trienomycinol as a substrate, carrying out a substitution reaction with an iodine-substituted bisaziridine, then removing propylidene protection to obtain a corresponding photoaffinity negative probe; using Fmoc-D-alanine to selectively esterify a hydroxyl group at position 11 of the negative probe, then removing an Fmoc protection group on nitrogen and carrying out condensation with cyclohexanecarboxylic acid to obtain a corresponding photoaffinity positive probe; trienomycin protein target identification comprises the following steps: (1) enrichment of an intermediate Trienomycinol and synthesis of a trienomycin photoaffinity positive probe; (2) target identification of trienomycin by using the photoaffinity probe and molecular biology research on the target. The separated trienomycin intermediate, the synthesized trienomycin probe derivative and the identified trienomycin protein target have the advantages of high originality and high yield.

This invention relates to the field of pharmaceutical synthesis technology, specifically to a method for synthesizing key intermediates of telexamine, aiming to solve the problems of expensive raw materials, high pollution, high safety risks, and unsuitability for industrial production in existing telexamine intermediate synthesis processes. The key intermediates of this invention are 2-(2-thienyl)cyclohexanone and 2-bromo-2-(2-thienyl)cyclohexanone. The synthesis method uses thiophene and cyclohexanecarboxylic acid as starting materials, and obtains 2-(2-thienyl)cyclohexanone through a solvent-free condensation reaction mediated by polyphosphoric acid, followed by bromination with a brominating reagent and purification in an alcohol phase to obtain 2-bromo-2-(2-thienyl)cyclohexanone. This invention uses inexpensive and readily available raw materials, operates under mild conditions, is simple to operate, is environmentally friendly and safe, and achieves a target product yield of up to 73% and an HPLC purity of up to 98.22%, significantly reducing the synthesis cost of telexamine and making it suitable for large-scale industrial production.

The application provides a synthesis method of piperquilon and belongs to the technical field of drug synthesis. The synthesis method uses cheap and easily available glycine and cyclohexyl chloride as starting materials to synthesize cyclohexanecarboxylic acid glycine, and then through a photocatalytic radical deacidification Minisci reaction strategy, the cyclohexanecarboxylic acid glycine is reacted with isoquinoline to efficiently prepare a key intermediate N-(1-isoquinolin-1-ylmethyl)-cyclohexanecarboxamide, and finally piperquilon is synthesized. Compared with the prior art, the synthesis method has the advantages of cheap and easily available raw materials, simple and safe reaction operation, mild reaction conditions, low catalyst dosage (as low as 0.01 mol %) for photo-reaction, simple post-reaction treatment, high yield and the like, and provides a new possible scheme for the industrialized scale preparation of piperquilon.

A bicyclic peptide composition and its application are disclosed, relating to the field of peptide technology. The cyclic peptide composition comprises component X and component Y, wherein component X is cyclic tetrapeptide-24-aminocyclohexanecarboxylate, and component Y is selected from one or more of the following cyclic peptides: cyclic hexapeptide-8, cyclic octapeptide-69, Cyclo-(Gly-His-Lys-Lys), Cyclo-(Arg-Arg-Gln-D-Met-Glu-Glu), Cyclo-(Pro-Lys-Glu-Lys), and Cyclo-(Val-Leu-Gln-Trp-Val-Lys). Specifically, the cyclic peptide composition and its use in the preparation of cosmetics are discussed.

The application discloses a kind of wide band gap perovskite solar cell based on bottom interface modification and preparation method thereof, its device structure sequentially includes conductive substrate, hole transport layer, interface modification layer, perovskite functional layer, electron transport layer and metal electrode layer from bottom to top, wherein the interface modification layer contains trans-4-guanidyl cyclohexane carboxylic acid (t-GCHA) and its derivative additive.The wide band gap perovskite solar cell containing trans-4-guanidyl cyclohexane carboxylic acid and its derivative interface modification is obtained by spin-coating solution containing such additive on the hole transport layer to form interface modification layer, using the bifunctional group characteristics of guanidyl and carboxyl in molecule, the effective passivation to buried bottom interface defect and the optimization of energy level arrangement are realized, the film forming quality of perovskite film is improved, so that perovskite solar cell with excellent photoelectric performance is further prepared.The preparation process of the application is simple, low in cost, and helps the commercialization of perovskite solar cell.

Disclosed are a bicyclic peptide composition and application thereof in skin care, and relate to the technical field of polypeptides, the composition comprising s-mu-conotoxin CnIIIC and a cyclic tetrapeptide-24 aminocyclohexane formate ester.The composition can be used for oil control, acne removal, repair, tightening, wrinkle reduction or anti-aging.