116 results about "Cyclohexanecarboxylic acid" patented technology

C7-C12 secondary alcohol esters of cyclohexanecarboxylic acids are especially useful as plasticizers for PVC and other plasticizable polymers. In embodiments, these plasticizers are useful in plastisol formulations to help improved processability of flexible

PVC material. In other embodiments these same plasticizers can be used in blends with other plasticizers to improve processability. In preferred embodiments these same plasticizers can be used to prepare flexible PVC compounds with enhanced low temperature flexibility, low toxicity, and improved resistance to outdoor aging.

The invention relates to a method for preparing praziquantel, which is a one-pot method and comprises the following steps: performing an ammonolysis reaction of chloroacetaldehyde dimethyl acetal and an ammonia aqueous solution to generate aminoacetaldehyde dimethyl acetal; performing a condensation reaction of beta-phenylethylamine and chloroacetyl chloride in an organic solvent in alkaline environment to generate an intermediate 1; performing a condensation reaction of the intermediate 1 and the aminoacetaldehyde dimethyl acetal in an organic solvent to generate an intermediate 2; performing cyclization of the intermediate 2 in the presence of an acidic catalyst to generate an intermediate 3; performing a reaction of the intermediate 3 and cyclohexanecarboxylic acid chloride in an organic solvent in alkaline environment, and performing solvent crystallization to obtain the target product of praziquantel.

The present invention pertains generally to the field of ocular treatment, and more specifically to the use of a liquid cooling agent composition comprising a cooling agent for the treatment of (e.g., the alleviation of symptoms of; the amelioration of) eye discomfort. The preferred cooling agent is (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarboxylic acid 2,3-dihydroxy-propyl ester (referred to herein as CPS-030). The liquid cooling agent composition is topically administered to at least a portion of the external surface of the eyelid (preferably the closed eyelid) of the eye to be treated. Preferably, the liquid cooling agent composition is carried on or in a wipe, pad, or towelette, for example, an eye wipe.

This invention relates to hydrogenation processes for making cyclohexane compounds. More specifically, this invention relates to hydrogenation processes in the presence of tertiary amide solvent compounds, as well as compositions that can result from such processes. The invention thus provides processes for making cyclohexanecarboxylic acid compounds and processes for making hydroxymethylcyclohexane compounds.

The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3′-bipyridin-6′-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

The invention provides a catalyst for synthesizing cyclohexane carboxylic acid through benzoic acid hydrogenation. The catalyst contains a carrier, an assistant and an active ingredient, wherein the carrier is nickel foam, the assistant is activated carbon, and the active ingredient is a metallic element Pd. The invention further provides a preparation method of the catalyst and application of the catalyst as a monolithic catalyst in a fixed bed. According to the catalyst provided by the invention, the preparation method is simple, the raw materials are wide in source and are easily obtained, and the usage amount of precious metal is small; during application, the catalyst has strong carbon oxide poisoning resistance, high catalytic activity and good selectivity; compared with the traditional powder catalysts, the catalyst provided by the invention has the advantages that the problems of catalyst ingredient loss and catalyst wear are solved thoroughly, the separation of a reaction solution from the catalyst is not required, and the loading and replacing of the catalyst are very convenient and fast.

The present invention provides a caprolactam production method, which comprises the following processes that: toluene is oxidized under an effect of a cobalt salt catalyst to generate benzoic acid, benzoic acid is subjected to hydrogenation under an effect of a palladium carbon catalyst to generate cyclohexanecarboxylic acid, the cyclohexanecarboxylic acid and nitrosylsulfuric acid are subjected to an amidation reaction in an amidation reactor to generate an amide liquid, cyclohexanone is subjected to an oximation reaction to generate cyclohexanone oxime, the amide liquid and the cyclohexanone oxime are subjected to a rearrangement reaction in a rearrangement reactor, and the reaction product is subjected to processes such as neutralization, crystallization, extraction and refinement to prepare the ??caprolactam, wherein a rearrangement reaction temperature is 70-130 DEG C, pressure is 0-1.0 MPa, and a molar ratio of the acid in the amide liquid to the cyclohexanone oxime is 1-2:1. With the present invention, combination of the two processes such as a toluene method and a cyclohexanone-hydroxylamine method is achieved, a caprolactam yield is increased without increase of ammonium sulfate by-production, nicotinic acid consumption and ammonium sulfate by-production are reduced, the production process is simplified, and construction investment and production cost are saved.

The invention discloses a preparation method of edoxaban intermediate (1S, 3R, 4R)-3-tert-butoxycarbonylamino-4-hydroxy-cyclohexanecarboxylic acid. According to the preparation method, 3-amino-4-hydroxy-cyclohexane carboxylate represented by formula IV is taken as a raw material, protective reaction with amino protection groups is carried out so as to obtain 3-tert-butoxycarbonylamino-4-hydroxy-cyclohexane carboxylate represented by formula V, enzyme catalyzed esterification resolution reaction is carried out so as to obtain optically pure (1S, 3R, 4R)-3-tert-butoxycarbonylamino-4-hydroxy-cyclohexane carboxylate represented by formula VII, and at last lithium hydroxide hydrolysis is adopted so as to obtain the (1S, 3R, 4R)-3-tert-butoxycarbonylamino-4-hydroxy-cyclohexanecarboxylic acid represented by formula VI. The preparation method possesses following advantages: operation is simple, the preparation method is green, is friendly to the environment, and is high in selectivity and lowin cost, large scale industrialized production can be realized, and it is convenient for industrial popularization.

The invention discloses a ruthenium palladium/carbon catalyst of cyclohexanecarboxylic acid synthesized through benzoic acid hydrogenation. The catalyst comprises a carbon material carrier, an active component of metal element Ru nanoparticles and an auxiliary of metal element Pd nanoparticles. The loading capacity of the Ru nanoparticles is 0.5-0.8%, and the loading capacity of the Pd nanoparticles is 0.05-2.0%. The invention further discloses a preparation method of the ruthenium palladium/carbon catalyst. Firstly, the carbon material carrier is prepared, then the active component ruthenium and the auxiliary palladium are loaded, a catalyst precursor is obtained, and finally the catalyst precursor is dried and reduced. The catalyst avoids use of a large amount of palladium, has high reaction activity, selectivity and stability, can be used circularly and remarkably reduces production cost. The catalyst is used for synthesizing cyclohexanecarboxylic acid through benzoic acid catalytic hydrogenation. The raw material conversion rate is 100%, the purity of a target product can be higher than 99.5%, process conditions are moderate, equipment is simple, three wastes are not emitted, and industrialization is easily achieved.

A preparation method of a 2-(2-alkylphenoxy)pyridine derivative adopts a reaction of a 2-phenoxypyridine derivative and a primary bromoalkane compound. The method concretely comprises the following steps: directly adding the 2-phenoxypyridine derivative, the primary bromoalkane compound, a catalyst, an additive, an alkali and a solvent into a reaction device, stirring and heating the above added substances until the temperature is 90-130 DEG C, carrying out a reaction for 18-36 h, and separating the obtained product to obtain the 2-(2-alkylphenoxy)pyridine derivative, wherein the catalyst is dichloro(p-cymene)ruthenium dimer; the alkali is potassium carbonate or lithium carbonate; the additive is 1-adamantanecarboxylic acid or naphthenic acid; and the solvent is benzene or DMF or ethylene glycol dimethyl ether. The method has the advantages of easiness in obtaining of synthesis raw materials, simple process, and very good specificity of the reaction.

This invention relates to hydrogenation processes for making cyclohexane compounds. More specifically, this invention relates to hydrogenation processes in the presence of tertiary amide solvent compounds, as well as compositions that can result from such processes. The invention thus provides processes for making cyclohexanecarboxylic acid compounds and processes for making hydroxymethylcyclohexane compounds.

The invention provides a high-yield fermentation production method of doramectin. The high-yield fermentation production method comprises the following steps: dissolving a doramectin precursor into water, methanol or ethanol or dispersing the doramectin precursor into a glycerol emulsifying system so as to be convenient for disinfection and material supplementation, wherein the doramectin precursor is cyclohexanecarboxylic acid or sodium cyclohexanecarboxylate; inoculating a strain seed solution into a fermentation culture medium and fermenting; adding the precursor which accounts for 0.02 to0.08 percent of the total weight of the fermentation culture medium at the early period of fermentation for induction; adding the precursor which accounts for 0.18 to 0.22 percent of the total weightof the fermentation culture medium at the middle period of the fermentation; adding the precursor which accounts for 0.02 to 0.08 percent of the total weight of the fermentation culture medium at thelater period of the fermentation. The method is simple and effective, and can be used for rapidly improving a fermentation level of the doramectin; the production cost is reduced and extra equipment and manpower do not need to be increased; the fermentation level of the doramectin can be relatively greatly improved and the production method is relatively suitable for commercial large-scale production.

The invention provides a method for preparing hexahydrophthalic anhydride, belonging to the field of synthesis of fine chemicals. The method comprises the steps: phthalic anhydride is heated to 50 DEG C and injected into a phthalic anhydride dissolving tower, the phthalic anhydride is dissolved with a solvent, the temperature of the dissolving tower is 50-70 DEG C, the dissolved phthalic anhydride solution is pressurized and injected into a constant-pressure reaction kettle or a fixed bed reactor filled with a selective hydrogenation catalyst to carry out selective hydrogenation reaction, the product directly enters a solvent recovery column after hydrogenation reaction, the solvent is distilled off at the tower top, the materials at the tower bottom enter a hexahydrophthalic anhydride rectifying tower, the hexahydrophthalic anhydride is obtained at the tower bottom, and a mixture of phthalide, o-toluic acid and o-methyl cyclohexanecarboxylic acid is obtained at the tower top; and the mixture obtained at the top of the rectifying tower is recrystallized to crystallize phthalide. The method has the advantages of simple operation, favorable economic benefit and industrial application prospects.

The invention discloses a preparation method of an amide polypropylene beta crystal form nucleating agent by taking p-phenylenediamine as a skeleton. The preparation method disclosed by the invention comprises the following steps of putting p-phenylenediamine into a flask, adding a solvent and an acid-binding agent in sequence, carrying out the temperature in an ice-water bath, dropping cyclohexanecarboxylic acid chloride, controlling the dropping temperature, increasing the temperature to reflux temperature after dropping, keeping the temperature for three hours, evaporating out the solvent, and washing through hot water and alcohol to obtain N-N'-1,4 benzene dicyclohexyl formamide. The preparation method disclosed by the invention has the benefits that raw materials are easily obtained, the process operation is simple, and the prepared product is high in yield and purity, has a good nucleating effect and is easy for industrialization.

The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.

The present invention relates to compounds trans-4-[1-(3-chlorphenyl)-7-methoxy-2, 4-dioxo-pyrimido [5, 4-c] quinoline-3-yl] cyclohexanecarboxylic acid, pharmaceutically acceptable salts thereof, andtheir use as therapeutic agents, including in the treatment of inflammatory disorders.

The invention discloses a multi-component content determination method of Miao medicine Laportea bulbifera. The method comprises the following steps: S100, preparation of mixed reference solution, respectively and accurately weighing right amount of reference substances of Gallocatechin, neochlorogenic acid, Epigallocatechin, catechinic acid, chlorogenic acid, Cyclohexanecarboxylic acid, epicatechin, rutin, isoquercitrin, kaempferol-3-0-rutinoside and quercitrin; and simultaneously determining contents of eleven components including the Gallocatechin, the neochlorogenic acid, the Epigallocatechin, the catechinic acid, the chlorogenic acid, the Cyclohexanecarboxylic acid, the epicatechin, the rutin, the isoquercitrin, the kaempferol-3-0-rutinoside and the quercitrin. The method is simple, efficient, highly sensitive and excellent in specificity, and can provide baisis for quality control of Laportea bulbifera medicinal materials. Compared with the ordinary liquid phase, the method has the advantages of being accurate, reliable and highly sensitive, and having lower specificity detection limit and quantification limit, and is more effective in medicinal material component content analysis through a liquid chromatography-mass spectrometry analysis technology.

The invention discloses a palladium-carbon filtering and recycling system and method, the palladium-carbon filtering and recycling system comprises a hydrogenation reaction kettle (1), a filter (2) connected with the hydrogenation reaction kettle (1), a nitrogen back flushing mechanism, a drainage system and a cyclohexanecarboxylic acid crude product tank (3) which are connected with the filter (2), a palladium-carbon suction filter (4) connected with the filter (2), and a pure water pipe and a tail gas buffer tank (5) which are communicated with the filter (2), the palladium-carbon filteringand recycling method comprises the following steps: after the reaction is finished, replacing residual gas in the hydrogenation reaction kettle (1) with nitrogen, and conveying crude product cyclohexanecarboxylic acid obtained by the reaction to the cyclohexanecarboxylic acid crude product tank (3); when the activity of a catalyst becomes low and the catalyst cannot be continuously used, discharging filter residues from the filter (2) after the filter residues are filtered by the filter (2), starting pure water flushing until no palladium-carbon and cyclohexanecarboxylic acid residues exist ina pipeline and the filter (2), and enabling the filter residues and cleaning water to enter the palladium-carbon suction filter (4); and recycling the filter residues after vacuum filtration and dehydration through the palladium-carbon suction filter (4).

The invention provides synthetic ester lubricating oil base oil with a high viscosity index and a preparation method thereof. The synthetic ester lubricating oil base oil is prepared by taking pyromellitic acid, triethanolamine, dihydroxy polyether, 1,10-decanediol, tetraethylene glycol, n-octanoic acid, cyclohexanecarboxylic acid and an organic solvent as main raw materials and carrying out sub-step esterification reaction. The synthetic ester lubricating oil base oil provided by the invention has a very high viscosity index and a relatively low pour point and the pour point can reach -45 DEGC; in a lubricating oil formula, a viscosity index modifier does not need to be additionally added and the requirements on high-viscosity lubricating oil can be met.

The invention relates to a synthesis process of corresponding hydroxy-cyclohexanecarboxylic acid from cycloalkyl formic acid. The method is characterized by performing halogenation on cyclohexanecarboxylic acid, subjecting the cyclohexanecarboxylic acid to hydrolization in an alkaline condition, and obtaining a corresponding hydroxy-cyclohexanecarboxylic acid product through acid neutralization, extraction and distillation. According to the preparation method, usage of highly toxic product of sodium cyanide is avoided and the synthesis process of hydroxy-cyclohexanecarboxylic acid is suitable for industrial application.

The present invention relates to a one-pot process for the preparation of trans-4-amino-l-cyclohexanecarboxylic acid derivatives where the trans ratio is more than 75% by reaction of a 4-aminobenzoicacid derivative using an appropriate catayst and an appropriate solvent or solvent mixture under basic conditions. The process uses low hydrogen pressure and is therefore suitable for industrial application.

The invention discloses a method and equipment for separating cyclohexanecarboxylic acid (CCA) slurry. The equipment mainly comprises a metal film penetrating separator; and a film pipe is arranged in the separator, and is provided with a stainless steel metal film with the aperture of 0.50 to 50 mu m. The method comprises the following steps of: introducing palladium-carbon catalyst-containing reaction mixed solution into an enclosed separator for separation through a buffer tank; and directly discharging the separated light phase into the next production procedure, concentrating the heavy phase in the separator, stopping feeding when the catalyst concentration reaches 10-30 weight percent, performing nitrogen stirring and clear liquid backwashing, and returning to a reactor. The separated light phase CCA product has the purity of 98-99 percent, and the catalyst content of zero. The separating process is automatically continuously carried out, power equipment is not required, the catalyst is not worn, the consumption of the catalyst is low, and the service life of the catalyst is long. The separating equipment is easy to operate, convenient to maintain, safe, environment-friendly and pollution-free.