10 results about "Doramectin" patented technology

The utility model relates to the technical field of material mixing devices, and discloses a material mixing device for doramectin injection production, which comprises a material mixing box, a plurality of stirring mechanisms I are arranged at the bottom end of a fixing plate, a fan is arranged in a mounting groove, rectangular grooves are formed in the left side end and the right side end of the mounting groove at intervals, and a plurality of stirring mechanisms II are arranged in the rectangular grooves. A plurality of rectangular grooves are formed in the material mixing box, a fan is arranged in each rectangular groove, a limiting mechanism used for fixing the fan is arranged in each rectangular groove, and a second stirring mechanism is arranged between the bottom end of the fixing plate and the bottom end of the material mixing box, so that two-stage stirring of doramectin liquid and other raw material liquid is realized through the arrangement of the first stirring mechanism, the fan and the second stirring mechanism; through the arrangement of a fixed plate and a plurality of conical pipes, doramectin liquid and other raw material liquid can be continuously and uniformly fed, and the problem that the mixing efficiency is low as a large amount of doramectin liquid and other raw material liquid are fed into the mixing box at a time can be avoided.

The utility model discloses a doramectin soluble powder preparation stirring device, which comprises a stirring tank and a feed pipe installed on the top of the stirring tank, the inner wall of the stirring tank is slidably connected with a screening seat, the inner bottom wall of the screening seat is provided with uniformly distributed screening holes, the top of the stirring tank is fixedly provided with a driving motor, and the driving motor is connected with the feeding pipe. An output shaft of the driving motor penetrates through and extends into the stirring tank, and a synchronizing shaft is fixedly connected to the output shaft of the driving motor. After the feeding pipe is used for feeding, the screening seat can effectively block large-particle materials, materials with proper specifications enter the bottom of the stirring tank to be stirred through the screening holes, the uniformity of the materials is guaranteed, the synchronous shaft drives the synchronous seat and the inner gear ring to rotate, the first crushing rod and the second crushing rod which are staggered can crush the large-particle materials in the screening seat, and the quality of the raw materials is improved; in the auxiliary assembly, an electromagnet is intermittently powered on and powered off and cooperates with a spring to enable a screening base to generate inertial motion, screening holes are prevented from being blocked, and stable and efficient operation of the device is guaranteed.

The present invention provides an anti-parasitic composition for use in the treatment or prevention of a parasitic infection in a mammal, the anti-parasitic composition comprising a macrolide, in particular a combination of ivermectin, abamectin and doramectin. The invention also provides a method of treating a parasitic infection in a mammal by administering to the mammal an effective amount of an anti-parasitic composition comprising ivermectin, abamectin, and doramectin, and a method of preparing the anti-parasitic composition.

The present application belongs to the technical field of pesticides, and particularly relates to a kind of insecticidal composition for preventing and treating Dacus oleae. An insecticidal composition for preventing and treating Dacus oleae, wherein the insecticidal composition is prepared by compounding doramectin with spirodurable or flubrocythrinate; the mass ratio of doramectin to spirodurable is 1-15:30-1; the mass ratio of doramectin to flubrocythrinate is 1-20:5-1. When doramectin is compounded with spirodurable or flubrocythrinate, the compound combination shows a joint synergistic effect on Dacus oleae within the mass ratio range of 1-15:30-1 and 1-20:5-1, which indicates that the insecticidal composition of the present application can improve the prevention and treatment effect on Dacus oleae.

A synthesis method for selamectin was developed, where doramectin is oxidized by manganese dioxide, oximated and de-sugared in one-step by an aqueous solution of hydroxylamine hydrochloride, and then selectively reduced in the presence of Wilkinson's catalyst and hydrogen to obtain selamectin. Doramectin is oxidized to a carbonyl group firstly, so that the generation of impurities during the subsequent reaction is reduced; t-butyl alcohol with a larger steric hindrance is used as a solvent, so that transesterification impurities are avoided; the hydrogenation is implemented in the final step, and the crude product is recrystallized before the hydrogenation reaction, so that the cost is greatly reduced. The method of the present application with an overall yield of 57%. The purity of product was 97.11%. All impurities meet the requirements of Pharmacopoeia. The present application is a simpler, more economical and more efficient synthesis method, and is suitable for industrial production.

The invention belongs to the technical field of pesticides, and discloses a botanical insecticide and a preparation method thereof. The insecticide is prepared from the following raw materials in percentage by weight: 1%-15% of a datura stramonium extract, 5%-40% of cohundred cinnamyl aldehyde, 0.1%-10% of doramectin, 2%-20% of polyoxyethylene ether, 3%-30% of a lavender laundry detergent, 10%-35% of edible ethanol, 5%-15% of a stabilizer and the balance of distilled water. The preparation method comprises the following steps: firstly, diluting the datura stramonium extract, the clouding cinnamyl aldehyde and the doramectin respectively, and then uniformly stirring and mixing all the components at 20-30 DEG C. Through compounding and synergistic interaction of multiple components, broad-spectrum and efficient prevention and control of pests with chewing and piercing-sucking mouthparts are achieved, the corrected death rate in a room within 48 hours reaches 95% or above, the pest decline rate in a field within 72 hours exceeds 94%, and the insecticidal composition has fast-acting property and persistent effect, is stable, and is kept uniform and free of layered precipitation in hard water for a long time.

The utility model discloses a fermentation tank for preparing doramectin, which comprises a tank body, a stirring piece is arranged on the tank body, a feeding valve is arranged at the top of the tank body, an annular flow guide cavity is arranged in the tank wall of the tank body, flow equalizing connecting pieces are arranged on two sides of the tank body, a vertical positioning cylinder is fixedly arranged at the top of the tank body, and a plurality of flow equalizing connecting pieces are arranged on the positioning cylinder. And a sampling pipe is hermetically and rotatably connected into the vertical positioning cylinder. Doraxine fermentation materials close to the bottom in a deeper position can be pumped through the material pump, then the driving mechanism is started to drive the sampling pipe to rotate by 90 degrees anticlockwise, so that the material guide hole in the middle position is aligned with the through hole in the middle position, extraction is carried out again, then the driving mechanism is driven to drive the sampling pipe to rotate by 90 degrees anticlockwise again, and the sampling pipe is driven to rotate by 90 degrees. And the material close to the top position is extracted again, so that the device has the advantages of continuous layered extraction of doraxine fermentation materials at different depths, more uniform sampling and more accurate data.

The application provides application of doramectin in an NLRP3 inflammasome activation inhibitor, and belongs to the technical field of medicines.The application first discloses that doramectin can directly target NLRP3 protein, inhibit the interaction between NLRP3 and NEK7, inhibit NLRP3 inflammasome assembly, and thus inhibit NLRP3 inflammasome activation; meanwhile, doramectin can improve the occurrence of NLRP3 inflammasome related inflammatory diseases at an animal level.The application provides a theoretical basis and experimental basis for treating NLRP3 inflammasome related inflammatory diseases by using doramectin, and also expands the use field of the drug.

According to the radioisotope tritium labeled selamectin and the preparation method thereof, doramectin is taken as a starting raw material, sodium boron tritide is taken as a tritium source, accurate tritium atom labeling is realized at a specific site of a 16-membered macrolide carbon skeleton through a'directional oxidation-tritiated reduction 'strategy, the defects of an existing labeling technology can be overcome, and the radioisotope tritium labeled selamectin is prepared. And enough high-purity and high-stability radioactive tracer can be provided for related isotope tracing research in time.

The application discloses a doramectin monoclonal antibody, a detection test strip and application thereof, and relates to the field of animal health. 50 The heavy chain and light chain variable regions of the monoclonal antibody have specific complementarity determining region sequences, and the half inhibition concentration IC of the monoclonal antibody to doramectin is as low as 3-5 ng / mL, which shows excellent sensitivity; the cross reaction rates of the monoclonal antibody to abamectin, ivermectin and acetyl abamectin are 75%, 75% and 60% respectively, and the monoclonal antibody has no cross reaction with common antibiotics such as tetracycline and gentamicin. Based on the antibody, the application also develops a colloidal gold immunochromatography test strip, which is simple in operation, rapid in detection, visual in result, and has a detection limit of 5 ng / mL, and is suitable for on-site rapid screening of doramectin and abamectin drug residues in animal-derived food, and has a good application prospect.