58 results about "Moxidectin" patented technology

PCT No. PCT/NZ96/00099 Sec. 371 Date Mar. 25, 1998 Sec. 102(e) Date Mar. 25, 1998 PCT Filed Sep. 19, 1996 PCT Pub. No. WO97/11709 PCT Pub. Date Apr. 3, 1997A composition comprising an anthelmintic chosen from the class of macrocyclic lactones including but not limited to the avermectins, ivermectin, doramectin, abamectin, milbemycin and moxidectin, together with a vegetable oil and a co-solvent chosen from the group comprising alcohols having four or more carbons atoms. The compositions of the inventions may be formulated as injections, drenches or for topical administration and are suitable for treating helminthiasis in animals.

The present invention provides a stable veterinary oral composition which comprises one or more surfactants, a water-miscible solvent, optionally an oil and an effective amount of each of a benzimidazole antihelmintic compound, such as triclabendazole and a macrocyclic lactone, such as moxidectin. Said composition is useful for treating and controlling endo- and ectoparasitic infection and infestation in a homeothermic animal.

The invention provides a novel and environmental-friendly Moxidectin pour sprinkling preparation and an industrialized preparation method thereof. The pour sprinkling preparation developed in the invention is prepared by taking Moxidectin as an active ingredient for resisting parasites inside and out of animals and adding an appropriate amount of auxiliaries, such as an antioxidant, a trandermal absorbent, an adhesive, an oil solvent and the like; and the formulation of the preparation is the oily pour sprinkling preparation and belongs to the field of novel veterinary medicinal antiparasitic preparations. The pour sprinkling preparation does not contain an aromatic compound with a low flash point and the potential safety hazard in industrial production. In order to improve medicinal effect, the trandermal absorbent is selected through an in-vitro trandermal absorption test so as to improve the bioavailability of the Moxidectin pour sprinkling preparation in the animals. The environmental-friendly Moxidectin pour sprinkling preparation which has a long-term effect, and is safe and easy to industrially produce is prepared finally.

The invention provides compound moxidectin drops as well as a preparation method and application thereof. The compound moxidectin drops have the advantages that moxidectin and ingredients with insecticidal effect, such as imidacloprid, are compounded and used, so that the drops have good insecticidal effect; meanwhile, in the drops, propylene glycol, moringa seed oil and eucalyptus oil are taken as transdermal agents, wherein the moringa seed oil and the eucalyptus oil are natural plant essential oil with fragrance and can cover up peculiar smell in the drops and improve sense of a user; and further the drops can be used for killing endoparasite and ectoparasite of animals due to good insecticidal effect. In the preparation method, the components of the drops are taken as raw materials and mixed to prepare corresponding drops, so that the preparation method provided by the invention has the advantages of simplicity, high efficiency, good insecticidal effect of the obtained drops, and the like.

The invention discloses a method for removing by-product dimethyl sulfide in a moxidectin production process, and belongs to the technical field of chemical industry production. The method comprises the following steps: in the production process of moxidectin, after oxidation reaction steps are ended, adding excessive water quenching reaction liquid to oxidation reaction liquid; transferring a by-product dimethyl sulfide generated in the oxidation step and used solvent to a sodium hypochlorite absorption kettle through a condenser in a manner of advocating gas desolvation or negative pressure desolvation; oxidizing and absorbing dimethyl sulfide through a sodium hypochlorite solution in the sodium hypochlorite absorption kettle and recovering a reaction solvent, wherein the content of dimethyl sulfide contained in oxidation reaction can be quickly reduced to 1.0% or less, the solvent recovery rate is greater than 60%, and the method has the advantages of low raw material cost, simple absorption process and the like.

The invention discloses a method for separating and purifying moxidectin. The method comprises the step of carrying out separation and purification to obtain the moxidectin of which the purity is 96% or above, wherein a supercritical fluid chromatographic system is adopted, a silica-gel-based filler is used as a stationary phase, supercritical CO2 is used as a mobile phase, and a mixture of methanol, ethanol and acetonitrile is used as an entrainer. The method for separating and purifying moxidectin is simple to operate; and more importantly, by using the supercritical CO2 as the mobile phase, only small amounts of organic solvents are added, thereby reducing the environmental pollution caused by organic solvents, and being green and environment-friendly.

The invention discloses a preparation method of moxidectin. The preparation method comprises the following steps: 1) inoculating a strain in a strain culture medium for culture to obtain spore suspension M1; 2) inoculating the spore suspension M1 in a seed culture medium for culture to obtain seed solution M2; 3) inoculating the seed solution M2 in a fermentation culture medium for culture to obtain primary extract solution M3; 4) performing protection reaction, oxidation reaction, deprotection reaction and oximation reaction to the primary extract solution M3 to obtain the moxidectin, wherein the strain is Streptomyces cyaneogriseus and/or Streptomyces hygroscopicus. By adopting the method, the total yield of the prepared moxidectin is enabled to be obviously higher and thus the effects of simpler and more convenient production manner and higher yield are realized.

The invention provides a purification method for moxidectin. The purification method comprises the steps: mixing a moxidectin crude product with a solvent and adding an antioxidant; stirring the mixture at 60-80 DEG C to prepare a solution; and then adding a solventing-out reagent and finally drying mixture under the vacuum condition through cooling crystallization to obtain high purity moxidectin with the purity being over 96%. The purification method for moxidectin provided by the invention has the advantages of short crystallization time, low cost and high yield and provides a novel method for improving the purity of moxidectin.

The invention discloses an imidacloprid and moxidectin dihydric alcohol plastid and a preparation method and application thereof. An insect repellent preparation is prepared from the following components: imidacloprid, moxidectin, soybean lecithin, dihydric alcohol (including ethanol and propylene glycol), polysorbate-80 and a phosphate buffer solution. It is confirmed by animal experiments that the imidacloprid and moxidectin dihydric alcohol plastid preparation has the effect of resisting in-vivo and in-vitro parasite infection in dogs and cats. Meanwhile, compared with an imidacloprid and moxidectin compound transdermal agent, the toxicity of the imidacloprid and moxidectin dihydric alcohol plastid preparation is greatly reduced, and the advantages such as good skin permeability, biologically slow release, longer action time and comparatively excellent treatment effect are achieved.

The invention relates to a purification method of a crude moxidectin product. The purification method comprises the following process steps: dissolving the crude moxidectin product, performing resin adsorption, crystallizing and drying to obtain a pure moxidectin product. By the purification method, moxidectin is extracted and purified through the resin adsorption, impurities in the moxidectin are removed to the maximum extent, the finished product content of the moxifloxacin is effectively increased, the finished product content thereof reaches 97% or above, and the product quality accords with the quality standard specified in European Pharmacopoeia; meanwhile, by the purification method, the process is simple, the production cycle is short, the production cost is low, and improvement on the competitiveness of the mothocetin in the international market is facilitated.

A monodose veterinary composition for topical application (spot on) for canines, the said composition comprising: (a) Imidacloprid, between 8.18 and 10.00%, (b) Moxidectin, between 2.86 and 3.50%, (c) Praziquantel, between 8.18 and 10.00%, and (d) an aprotic solvent selected from Dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMAC), N,N-dimethylformamide (DMF) and their mixtures, between 65.45 and 80.00%; together with excipients acceptable from the veterinary viewpoint, where the percentages are related to the composition's total weight. The use of an effective amount of (a) Imidacloprid, (b) Moxidectin; (c) Praziquantel; and (d) an aprotic solvent selected from Dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMAC), N,N-dimethylformamide (DMF) and mixtures of these, together with veterinary acceptable excipients, for the preparation of a monodose veterinary composition for the treatment, control and prevention of ecto and endoparasitoses in canines, where the said veterinary composition is adapted to be administered topically (spot on).

The invention provides an oily injection containing antiparasitic agent/polyethylene glycol drug-loading microparticles which is prepared by suspending drug-loading microparticles, which are composed of antiparasitic agent and solid polyethylene glycol, in an oily medium. The antiparasitic agent comprises ivermectin, abamectin, eprinomectin, doramectin, milbemycin oxime, moxidectin, albendazole oxide or hydrochloride thereof, oxfendazole or hydrochloride thereof, closantel base or sodium salt thereof; polyethylene glycol with molecular weight of more than 6,000is preferably selected for preparation of the oily injection; and one of isopropyl myristate, injection soybean oil, maize oil and tea seed oil is preferably selected for preparation of the oily injection.

The invention discloses a slow-release gel preparation containing moxidectin for injection and a preparation method of the preparation. The slow-release gel preparation containing moxidectin for injection is prepared by using moxidectin, a slow-release agent, a moisturizer, a preservative and a gel substrate according to a certain ratio and the certain method. The preparation has a high-efficiencykilling effect on the digestive tract nematodes and parasites on the body surfaces of pets such as domestic animals, dogs and cats, especially on nematodes resistant to ivermectin in sheep, and can effectively prevent and control parasitic diseases of the domestic animals, the dogs and the cats in vivo and vitro. The gel preparation provided by the invention has the characteristics of the simplepreparation method, good biocompatibility, slow release and high efficiency, and can be used for subcutaneous and intramuscular local injection to prevent and control the parasitic diseases of the pets such as the domestic animals, the dogs and the cats.

The invention discloses a moxidectin preparation and a preparation method of the moxidectin preparation. The preparation method comprises the following steps: inoculating streptomyces cyaneogriseus sp. noncyanogenus into a culture medium for culturing, thus obtaining a suspension M; carrying out suction filtration on the suspension M to obtain a filter cake N; drying the filter cake N to obtain dry mycelia; mixing the dry mycelia and methanol, and carrying out filtering to obtain leach liquor; carrying out protective reaction, oxidation reaction and oximation reaction on the leach liquor to obtain moxidectin; and mixing water, the moxidectin, methylpropanol, ethyl acetate and a surfactant, thus obtaining the moxidectin preparation. With the adoption of the moxidectin preparation and the preparation method of the moxidectin preparation, the problems that the traditional moxidectin preparation is relatively low in insect killing rate, and has difficulty in volatilizing after use, so that the secondary pollution is easily caused, are solved.

The invention relates to a macrolide biopesticide aqua. The macrolide biopesticide aqua is prepared from the following raw materials by weight: 0.1 to 10 parts of nemadectin or moxidectin, 1 to 30 parts of a surfactant, 0.1 to 10 parts of an osmotic agent, 1 to 10 parts of an antifreezing agent and 1 to 85 parts of water. The surfactant is a mixture of a nonionic surfactant and an anionic surfactant and/or an ampholytic surfactant. The macrolide biopesticide aqua provided by the invention does not need usage of organic solvents for dissolving of nemadectin or moxidectin; through combined usage of the surfactants, the biopesticide aqua is allowed to have stable and uniform properties, which is more beneficial for application of nemadectin or moxidectin in pesticide products.

The invention provides an external use type medicine for preventing and controlling livestock ectoparasite. The external use type medicine is characterized by being prepared from the following components: nisin, moxidectin, herba menthae extract, glycyrrhetinic acid, a surfactant, ethanol, double-distilled water, vaseline and paraffin wax. The external use type medicine for preventing and controlling the livestock ectoparasite, provided by the invention has the beneficial effects that a traditional Chinese medicine and Western medicine combined formula is adopted, and dual advantages of traditional Chinese medicines and Western medicines are expressed; the aim of controlling the livestock ectoparasite to the greatest extent can be realized and the healing rate can reach 100 percent; furthermore, the toxicity of some effective components is relatively small so that the medicine does not cause relatively great pollution to livestock fed by the medicine and the environment and the medicine belongs to an efficient, safe, green and environment-friendly product; the raw materials are easy to purchase, the cost is low and the compatibility is simple; a drug feeding manner is simple and feasible; in actual application, the medicine can realize a prevention or control effect through regulating a proper dosage and the prevention and control effect is greatly improved; the manpower and material resources are saved and the culture benefits are improved.