35 results about "Praziquantel" patented technology

The present invention relates to a composition comprising tigolaner and, optionally endoparasiticidal agents, a method for its manufacture and its use as a medicament for controlling parasites. Compositions can include tigolaner and 1,2-isopropylideneglycerol, or the composition can include praziquantel, emodepside a solvent component, and tigolaner. The composition can be used in the treatment and / or prevention of parasite infections in animals.

The present invention relates to a composition comprising tigolaner and, optionally endoparasiticidal agents, a method for its manufacture and its use as a medicament for controlling parasites. Compositions can include tigolaner and 1,2-isopropylideneglycerol, or the composition can include praziquantel, emodepside a solvent component, and tigolaner. The composition can be used in the treatment and / or prevention of parasite infections in animals.

The invention belongs to the technical field of medicine treatment, and particularly relates to application of combination of an organic small molecule compound and bivalent copper ions in preparation of a medicine for treating schistosomiasis japonicas. The invention provides an application of combination of an organic small molecule compound and bivalent copper ions in preparation of a medicine for treating schistosomiasis japonicas. The organic small molecule compound is selected from one or more of a compound with a structure as shown in a formula 1-1, a compound with a structure as shown in a formula 2-2 and a compound with a structure as shown in a formula 3. According to the invention, development of schistosoma japonicum at multiple juvenile stages in vivo can be blocked in a targeted manner through combination, the schistosoma load and the spawning rate are reduced, compared with praziquantel, the drug has better schistosoma killing activity, and preparation and application of the drug for treating schistosoma japonicum with efficient insect killing can be realized.

The invention relates to the technical field of tapeworm identification, and provides a kit for identifying five target tapeworms by using specific primers and application of the kit. All mainstream genotypes of genes of Echinococcus granulosus, Echinococcus multilocularis, Taenia vesicula, Taenia multiceps and Taenia canis are compared, and a primer pair capable of universally detecting nucleic acids of five tapeworms is obtained by taking conserved regions of the genes as diagnostic targets. The rapid detection of the five pathogens is realized by combining with a digoxin-labeled nucleic acid lateral chromatography test paper. A product obtained by isothermal amplification is detected by a nucleic acid detection test strip and then is directly observed by eyes, and the result is interpreted within 15-20 minutes, so that the operation is simple and convenient. The method provided by the invention has wide application prospects in the aspects of large-scale screening and detection of whether dogs are infected with echinococcus granulosus, echinococcus multilocularis, taenia vesicula, taenia multiceps and tapestoma dogs or not in pasturing areas, especially in areas with epidemic echinococcosis, and evaluation of the insect expelling effect of the dogs fed with praziquantel on the tapeworms.

The invention belongs to the technical field of biological medicines, and discloses a praziquantel dry suspension for mixed drinking of poultry, which is prepared from the following components in parts by weight: 12-25 parts of praziquantel, 50-76 parts of a suspending aid and 12-25 parts of a dispersing agent. The invention also discloses a compound praziquantel effervescent dry suspension for mixed drinking of poultry. The compound praziquantel effervescent dry suspension is prepared from the following components in parts by weight: 0.3-0.5 part of ivermectin, 12-25 parts of praziquantel, 18-25 parts of a suspending aid, 8-14 parts of a dispersing agent, 25-35 parts of an effervescing agent acidic substance, 5.4-6.5 parts of an effervescing agent alkaline substance and 8-14 parts of a deflocculating agent. According to the compound praziquantel effervescent dry suspension prepared by compatibility of praziquantel and ivermectin, a new dosage form which is high in dispersity, uniform in absorption, quick in effect, high in bioavailability, capable of being drunk in a mixed mode and administrated in a group mode, stable in storage and good in physical state is developed, and a new scheme is provided for treatment of drug-resistant parasite infection and parasite mixed infection; and a basis is provided for development of new dosage forms and clinical application of veterinarians.

The present application provides a milbemycin oxime praziquantel-based parasitic expelling drug, which comprises the following components in parts by mass: modified milbemycin oxime 10-30 parts, nano-coated praziquantel 20-50 parts, compound synergist 5-15 parts, flavoring agent 3-8 parts, and disintegrating agent 2-5 parts. The application of the milbemycin oxime praziquantel-based parasitic expelling drug is used for preparing a preparation for preventing or treating mixed parasitic infection of dogs and cats, wherein the parasites include tapeworms, nematodes, trematodes and Demodex. Through the integrated innovation of chemical modification (succinylated milbemycin oxime), nanotechnology (HPMC-coated praziquantel) and compound synergy (non-ban Tai'er-beta cyclodextrin), the comprehensive advantages of broad-spectrum parasitic expelling, long-acting stability, safety and low toxicity are realized, and the pain points such as poor palatability, high metabolic burden and weak environmental adaptability in the prior art are solved, and the application is suitable for the prevention and treatment of mixed parasitic infection of dogs and cats.

The invention relates to the technical field of biochemical engineering and medicinal chemistry, and provides a method for improving the resolution efficiency of a praziquantel racemoid by an enzyme method, which comprises the following steps: S1, preparing oxidase, selectively oxidizing dextropraziquantel by the oxidase, and basically not oxidizing levo praziquantel; s2, contacting oxidase with the racemic praziquantel mixture in a Tris-HCl buffer system with the pH value of 7.5-8.5, adding Fe as a cofactor, and reacting at the temperature of 35-39 DEG C for 4-6 hours; and S3, separating and purifying the reaction mixture obtained in the step S2 to obtain the high-purity levo-praziquantel. The problem of low resolution efficiency of the praziquantel racemate is successfully solved through an enzymatic resolution technology with high efficiency, strong specificity and mild conditions.

The invention provides a method for detecting the content of compound selamectin drops, which adopts high performance liquid chromatography for detection, and comprises the following specific steps: sequentially preparing a blank solution, a blank auxiliary material solution, a contrast solution and a test solution, sequentially and respectively injecting the blank solution, the blank auxiliary material solution, the contrast solution and the test solution into a high performance liquid chromatograph, an octadecyl silane bonded silica gel column is used as a chromatographic column, a formic acid solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, and gradient elution is carried out. According to the method disclosed by the invention, the three active ingredients, namely the selamectin, the fluralan and the praziquantel, in the compound selamectin drops can be effectively detected, the quality detection result is accurate and reliable, and the three active ingredients in the compound selamectin drops can be accurately quantified, so that the product quality of the compound selamectin drops can be better controlled.

The invention provides a long-acting slow-release compound preparation for preventing and treating schistosomiasis. The compound preparation comprises two active ingredients, namely niclosamide and praziquantel, the niclosamide accounts for 10-90% of the weight of the compound preparation; praziquantel accounts for 10%-90% of the weight of the compound preparation; the coating further comprises a biodegradable high polymer material and a dispersion medium. Optionally, a wetting agent; the biodegradable high polymer material accounts for 12.5%-14.3%; the dispersion medium accounts for 50.0%-57.1%; and the wetting agent accounts for 0-5.7%. The compound preparation can maintain long-acting slow release after being administrated once, has excellent prevention and control and treatment effects on schistosomiasis, particularly has good prevention and treatment effects on larvae and / or adults of schistosomiasis, blocks a transmission chain of the schistosomiasis, protects human beings and animals from schistosomiasis infection, and has huge economic benefits and social benefits.

Praziquantel may be formulated to enhance its pharmacokinetic, toxicity, and palatability properties. It can be stored and / or dispensed as a liquid, powder, or tablet. Reduction in the most common side effects improves patient compliance and satisfaction. Altered taste profile improves patient compliance and satisfaction. Once formulated it can be used to treat a variety of blood flukes and worms in human and veterinary subjects.

The invention discloses a formula and a preparation method of a stomach-invigorating parasite-expelling tablet for livestock. The parasite expelling tablet is formed by compounding and tabletting parasite expelling core enteric particles A and stomach invigorating and relieving quick-release particles B. The particles A contain praziquantel and levamisole or salts thereof, and are coated with enteric materials, so that the parasite expelling activity is limited in gastric segment release and is quickly released in intestinal segment; the particles B contain a cortex meliae extract, a fructus quisqualis extract, pericarpium citri reticulatae, fried malt and fructus crataegi, are compounded with mucous membrane protection or adsorption stimulation components such as sodium alginate / pectin / montmorillonite and the like, and are subjected to post-treatment adsorption through essence, so that the taste covering stability is improved. The preparation method comprises the following steps: plant extraction, wet granulation in two ways, enteric coating of particles A, essence post-treatment of particles B, and compounding, lubricating and tabletting. According to the scheme, the insect expelling effect is guaranteed, gastrointestinal stimulation is reduced, the voluntary ingestion rate and administration compliance are improved, and the composition is suitable for dogs, cats and livestock to expel insects by oral administration.

The invention discloses a composition capable of efficiently killing a greedy meimeria disease and application of the composition. The composition is prepared from 0.1 mg / mL to 0.9 mg / mL of astragalus polysaccharide, 0.005 mg / mL to 0.015 mg / mL of carvacrol, 0.05 mg / mL to 0.15 mg / mL of praziquantel and 0.4 mg / mL to 1.5 mg / mL of herba epimedii. The invention finds that after the astragalus polysaccharide, carvacrol, praziquantel and epimedium are combined for use, a remarkable synergistic effect is generated, and the effect of killing the greedy Michamei insect can be remarkably improved within the same time at the dosage which is far lower than the effective concentration of each single component of the astragalus polysaccharide, the carvacrol, the praziquantel and the epimedium. The dosage of four drugs is greatly reduced, the method has the advantages of being efficient, low in cost, capable of reducing drug residues and the like, and a new scheme can be provided for prevention and treatment of the greedy Michameiasis of the large yellow croakers.

The invention provides a parasite expelling drug based on milbemycin oxime praziquantel, and the parasite expelling drug comprises the following components in parts by mass: 10-30 parts of modified milbemycin oxime, 20-50 parts of nano-coated praziquantel, 5-15 parts of a compound synergist, 3-8 parts of a flavoring agent, and 2-5 parts of a disintegrating agent. According to the application of the parasite expelling medicine based on milbemycin oxime praziquantel, the medicine is used for preparing a preparation for preventing or treating mixed parasite infection of dogs and cats, and parasites comprise tapeworms, nematodes, flukes and vermiform mites. Through integrated innovation of chemical modification (succinylated milbemycin oxime), a nanotechnology (HPMC-coated praziquantel) and compounding cooperation (febantel-beta cyclodextrin), the comprehensive advantages of broad-spectrum parasite expelling, long-acting stability, safety and low toxicity are achieved, meanwhile, the problems that in the prior art, palatability is poor, the metabolic burden is high, and environmental adaptability is weak are solved, and the application has good application prospects. The composition is suitable for preventing and treating mixed parasite infection of dogs and cats.

The present invention is aimed at a pharmaceutical formulation or composition and a method of manufacture or production thereof, wherein the pharmaceutical composition includes fluralaner, moxidectin and praziquantel for the treatment of parasitic infestations in animals, wherein the composition may be in tablet form, more particularly as a chewable tablet and more preferably as a soft chewable tablet that manages to mask the bitter taste of the active ingredient praziquantel based on an association of bitter taste receptor blockers.

The invention provides a long-acting slow-release compound preparation for preventing and treating echinococcosis. The compound preparation comprises praziquantel serving as a first active ingredient and oxfendazole serving as a second active ingredient, praziquantel accounts for 5-95% of the weight of the compound preparation; the oxfendazole accounts for 5-95% of the weight of the compound preparation; the coating further comprises a biodegradable high polymer material and a dispersion medium. The biodegradable high polymer material accounts for 11.1%-14.9% of the weight of the compound preparation; and the dispersion medium accounts for 42.5%-44.4% of the weight of the compound preparation. The compound preparation has a long-acting slow-release effect, can maintain long-term prevention and control and treatment effects after being administered once, has a good treatment effect on echinococcosis prevention and control, especially adults and / or larvae of echinococcus, protects animals from being infected by pathogens in infection seasons or even longer time, controls parasitic disease transmission, and has a good application prospect in prevention and control of echinococcosis. And a transmission chain of parasites transmitted by animals is blocked.

The invention provides a rapid detection method for non-pralazone illegally added in food, and belongs to the technical field of medicine detection. The method comprises the following steps: respectively carrying out secondary extraction on a food sample by adopting a strong polar extraction agent and a non-polar extraction agent to obtain extracted supernate; removing the non-polar extraction agent in the supernate by adopting a nitrogen blowing method; eluting the supernate subjected to nitrogen blowing treatment by adopting a strong polar solvent to prepare a to-be-detected solution; and sequentially adding the metal sol and the inorganic salt flocculant into the to-be-detected solution, uniformly mixing, and detecting by using a Raman spectrometer. The detection method provided by the invention has the advantages of high sensitivity, low detection limit and low cost, and can realize rapid detection of non-pralazone illegally added in food.

The invention provides a rare earth chelate as well as a preparation method and application thereof, and relates to the technical field of rare earth materials. The rare earth chelate is formed by coordination of rare earth elements and organic ligands, and the organic ligands are praziquantel and derivatives thereof. The rare earth chelate disclosed by the invention has relatively good insect repelling and insect resisting effects.

A veterinary extruded soft chew has as active pharmaceutical ingredients (APIs), milbemycin oxime or one of its salts, and praziquantel or one of its salts. The APIs are uniformly dispersed in a matrix having one or more fillers, a polyethylene glycol (PEG), a non-animal based palatant, a disintegrant, a humectant, an oil, water, and preservatives. Neither the milbemycin oxime or one of its salts, nor the praziquantel or one of its salts is coated, granulated or physically separated from the other APIs within the matrix. More importantly, the soft chew does not comprise any palatant of animal origin.

The invention discloses an application of baicalin in preparation of a medicine for inhibiting and / or treating schistosomiasis japonicas. The invention further discloses a medicine for inhibiting and / or treating schistosomiasis. Experiments prove that after praziquantel kills schistosoma japonicum adults, baicalin is used for treatment, so that liver and spleen injuries caused by schistosoma japonicum infection are effectively relieved, the liver function of a host is protected, the influence of eggs in the host and schistosoma japonicum egg protein secreted by the eggs on the host is reduced, and the survival rate of schistosoma japonicum adults is increased. The treatment effect of the praziquantel is obviously better than that of the existing praziquantel

The invention discloses a praziquantel derivative PT-28 as well as a preparation method and application thereof. According to the praziquantel derivative PT-28, a thymol precursor and amino-praziquantel react to generate the derivative. The praziquantel derivative PT-28 can be used as a drug for resisting third-generation insect diseases, and compared with the national standard anti-parasitic drug praziquantel, the safety index-therapeutic index (TI value) of the drug is improved by 8.89 times. The compound has the characteristics of being safe to fishes, low in toxicity and good in killing effect on third-generation insects, and has wide application prospects in development of novel insect-resistant fishery drugs.

The utility model relates to the technical field of process wastewater treatment devices, and provides a praziquantel production process process wastewater treatment device which comprises a treatment bin, and two groups of first sliding grooves are transversely formed in the treatment bin from top to bottom; when the device is used, firstly, process wastewater is added into the treatment bin through the arranged feeding hopper, firstly, the process wastewater passes through the coarse screen, large-particle impurities in the wastewater can be removed, then, the process wastewater passes through the fine screen, and therefore suspended solids and colloidal substances can be further removed; according to the sewage treatment device disclosed by the invention, the sewage treatment device is arranged, so that a better effect of subsequent treatment steps can be ensured, then a worker starts a motor, an electric heating rod and an ultraviolet lamp through a control panel, the filtered wastewater can be heated and stirred, and then irradiation of the ultraviolet lamp is synchronized, so that pathogenic microorganisms in the wastewater can be killed; therefore, the treatment effect on the process wastewater is further enhanced.

Preparation method for a compound as shown in formula (I) and levo-praziquantel. A racemate of ester of the compound of formula (I) is used as a substrate, and reaction is performed under the catalysis of immobilized lipase to produce the compound of formula (I); a circulating fluidized bed reactor is used, the circulating fluidized bed reactor includes an external circulation system and a reaction column, the immobilized lipase is arranged in the reaction column, the substrate solution is circulated many times between the external circulation system and the reaction column, the reaction is performed in the reaction column. The preparation of levo-praziquantel includes the described preparation steps of the formula (I). The preparation method of formula (I) can significantly improve the utilization rate of enzyme and reduce the use ratio of enzyme / substrate, and has mild reaction conditions, strong stereoselectivity, high reaction efficiency.

The invention discloses application of a composition containing uridine or a derivative thereof and praziquantel in preparation of a medicine for preventing or treating liver injury. Uridine or derivatives thereof and praziquantel cooperate to further inhibit hepatic stellate cell activation, so that the uridine or derivatives thereof and praziquantel can be used as a medicine for inhibiting hepatic stellate cell activation and preventing or treating liver injury. Particularly, the compound can be used for preparing medicines for treating hepatic fibrosis caused by schistosomiasis.

The invention discloses an artificial domestication method for odontobutis suchneri. The method comprises the steps of fishing, temporary rearing in a net cage, running water transportation, indoor temporary rearing and quarantine treatment and culture in a culture pond. According to the method, the dissolved oxygen condition, the pH water temperature, the photoperiod and other environmental regulation and control means in the domestication process are controlled, a three-stage medicated bath scheme of citric acid, glutaraldehyde benzalkonium bromide and oxytetracycline is adopted, and praziquantel is adopted for targeted parasite expelling, that is, environmental stimulation is effectively reduced through environmental regulation and control and use of animal protection products, loss caused by stress and fight is reduced, and the economic benefit is increased. Meanwhile, physical damage caused in the fishing and transporting processes can be effectively treated. In addition, in consideration of the fact that food of the humping head fishes mainly comprises small invertebrates such as shells, snails, crabs and shrimps, bait conversion is completed through specially-made artificial feed and a domestication material management technology in the artificial domestication process. Therefore, the artificial domestication of the wild odontella schuchnoi is realized.

The invention discloses 10-[7-(2-decyloxy) coumarin] praziquantel and a preparation method and application thereof.The praziquantel derivative 10-[7-(2-decyloxy) coumarin] praziquantel is obtained by connecting coumarin to the 10-site of an aromatic ring through an alkyl chain on the basis of the structure of praziquantel, and after insect-resistant evaluation and safety evaluation, the 10-[7-(2-decyloxy) coumarin] praziquantel derivative can be used for preparing the praziquantel derivative. The 10-[7-(2-decyloxy) coumarin] praziquantel provided by the invention can be used as a drug for resisting monocoloniasis, and shows activity and safety superior to those of praziquantel.

The present invention provides a method for preparing praziquantel, especially (R)-praziquantel and its analogs, in a stereoselective manner. One method involves the asymmetric hydrogenation of the following intermediate compound (I) and subsequent cyclization:

A veterinary extruded soft chew has as active pharmaceutical ingredients (APIs), milbemycin oxime or one of its salts, and praziquantel or one of its salts. The APIs are uniformly dispersed in a matrix having one or more fillers, a polyethylene glycol (PEG), a non-animal based palatant, a disintegrant, a humectant, an oil, water, and preservatives. Neither the milbemycin oxime or one of its salts, nor the praziquantel or one of its salts is coated, granulated or physically separated from the other APIs within the matrix. More importantly, the soft chew does not comprise any palatant of animal origin.

The present disclosure provides novel chemotypes, pharmaceutical compositions thereof, and method of use thereof for treating parasitic infection, including infection caused by parasitic flatworms. The present compounds may be useful as alternatives to praziquantel and may have improved activities against parasitic infections, particularly parasitic flatworm infections.

The present invention discloses a pharmaceutical formulation or composition and a method for manufacturing or producing same, wherein the pharmaceutical composition comprises fluralaner, moxidectin and praziquantel for treating parasitic infestations in animals. The composition may be in tablet form, more particularly as a chewable tablet, and more preferably as a soft chewable tablet that masks the bitter flavour of the active ingredient praziquantel based on a series of bitter taste receptor blockers.

The present invention is aimed at a pharmaceutical formulation or composition and a method of manufacture or production thereof, wherein the pharmaceutical composition includes fluralaner, moxidectin and praziquantel for the treatment of parasitic infestations in animals, wherein the composition may be in tablet form, more particularly as a chewable tablet and more preferably as a soft chewable tablet that manages to mask the bitter taste of the active ingredient praziquantel based on an association of bitter taste receptor blockers.