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Praziquantel long-acting sustained release injection and preparing method thereof

A sustained-release injection, praziquantel technology, applied in the field of broad-spectrum anti-parasitic drug-praziquantel long-acting sustained-release injection and its preparation, which can solve the problems of no long-term anti-parasitic activity and short drug effect time , to achieve the effect of convenient storage and transportation, less animal irritation and stable release

Inactive Publication Date: 2008-07-30
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the defects and deficiencies in the prior art, the object of the present invention is to provide a long-acting sustained-release injection of praziquantel suitable for veterinary clinical application, which solves the problem of short drug effect time and no The problem of long-term anti-parasitic activity, and the injection has a sustained-release effect, which can be released in animals for a long time, stably and slowly, and has the dual effect of preventing and treating parasitic infection in animals

Method used

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  • Praziquantel long-acting sustained release injection and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 10 hours. Heat the swollen white pasty mixture to 130°C while stirring, and keep it for 20 minutes to make it completely dissolved. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.

[0020] (2) Get 20 parts of praziquantel bulk drug, dissolve it in 200 parts of dehydrated ethanol at 50°C, filter with a 0.45 μm microporous membrane, and then mix the filtrate with 100 parts of aluminum monostearate castor Mix sesame oil and gelatin evenly, stir and evaporate all absolute ethanol at 50°C, heat up to 80°C to form a light yellow transparent viscous liquid, and pack it into sterilized glass vials after cooling to obtain pyridine with a content of 20%. Quinone long-acting sustai...

Embodiment 2

[0022] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2.5 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 12 hours. Heat the swollen white pasty mixture to 150°C while stirring, and keep it for 20 minutes to make it dissolve completely. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.

[0023] (2) Get 25 parts of praziquantel bulk drug, dissolve it in 300 parts of dehydrated ethanol at 50°C, filter with a 0.45 μm microporous membrane, and then mix the filtrate with 100 parts of aluminum monostearate castor Mix sesame oil and gum evenly, stir and evaporate all the absolute ethanol at 60°C, heat up to 100°C to form a light yellow transparent viscous liquid, pack it into sterilized glass vials after cooling, and obtain pyridine with a content of 25%. Quinone long-acting sustai...

Embodiment 3

[0025] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2.5 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 11 hours. Heat the swollen white pasty mixture to 140°C while stirring, and keep it for 20 minutes to make it completely dissolved. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.

[0026] (2) Get 2 parts of praziquantel bulk drug, dissolve it in 20 parts of dehydrated ethanol at 50°C, filter it with a 0.45 μm microporous membrane, then mix the filtrate with 100 parts of aluminum monostearate Mix sesame oil and gum evenly, stir and evaporate all the absolute ethanol at 55°C, heat up to 90°C to form a light yellow transparent viscous liquid, and pack it into sterilized glass vials after cooling to obtain 25% praquine Ketone long-acting sustained-release injection.

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Abstract

The invention discloses a praziquantel long-acting sustained-release injection, following materials are formed with a certain mass fraction into 2 to 25 units of praziquantel, 20 to 250 units of ethanol, 0.5 to 2.5 units of aluminum monostearatenf, and 100 units of castor oil used for injection, the processing method is that first, oil glue of aluminum monostearatenf and castor oil is made, then, when the temperature is 50 to 60 DEG C, praziquantel is distributed into the oil glue of monostearatenf and castor oil through solvent evaporation, when the temperature is raised to 80 to 100 DEG C, light yellowish transparent thick liquid will be formed, after being cold and in split charging, the invention can be finished, the processing method of the invention is simple, and the storing process is stable, the invention can not only retain the wide anti-insect property and the strong activity of the traditional type of praziquantel but also be released slowly, stably in the body of animals for a long time, the control effect can be kept for three to four months after using the invention for once, and the invention adds a new dosage form, which solves the problems of traditional form such as the short sustained time and a plurality of times for medication.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a broad-spectrum antiparasitic drug-praziquantel long-acting sustained-release injection and a preparation method thereof. Background technique [0002] Praziquantel is an ideal new broad-spectrum anti-tapeworm and anti-schistosomal drug, which is widely used all over the world. The drug has high safety and is highly effective against most tapeworms of sheep and goats. The dose of 10-15mg / kg is 100% effective against Taenia extensa Monitz, Monitz beinzii, Taenia globosa and G. % of killing effect. In addition, the drug has a good effect on schistosomiasis of cattle and cysticercosis of pigs. [0003] In veterinary clinics, the commonly used preparations of this drug mainly include tablets, capsules, etc. These preparations are generally administered orally, but because praziquantel is absorbed rapidly after oral administration, the peak value of the drug in blood generally oc...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/00A61K31/4985A61K47/12A61P33/12A61P33/00
Inventor 欧阳五庆张文娟
Owner NORTHWEST A & F UNIV
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