Praziquantel long-acting sustained release injection and preparing method thereof
A sustained-release injection, praziquantel technology, applied in the field of broad-spectrum anti-parasitic drug-praziquantel long-acting sustained-release injection and its preparation, which can solve the problems of no long-term anti-parasitic activity and short drug effect time , to achieve the effect of convenient storage and transportation, less animal irritation and stable release
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Embodiment 1
[0019] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 10 hours. Heat the swollen white pasty mixture to 130°C while stirring, and keep it for 20 minutes to make it completely dissolved. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.
[0020] (2) Get 20 parts of praziquantel bulk drug, dissolve it in 200 parts of dehydrated ethanol at 50°C, filter with a 0.45 μm microporous membrane, and then mix the filtrate with 100 parts of aluminum monostearate castor Mix sesame oil and gelatin evenly, stir and evaporate all absolute ethanol at 50°C, heat up to 80°C to form a light yellow transparent viscous liquid, and pack it into sterilized glass vials after cooling to obtain pyridine with a content of 20%. Quinone long-acting sustai...
Embodiment 2
[0022] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2.5 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 12 hours. Heat the swollen white pasty mixture to 150°C while stirring, and keep it for 20 minutes to make it dissolve completely. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.
[0023] (2) Get 25 parts of praziquantel bulk drug, dissolve it in 300 parts of dehydrated ethanol at 50°C, filter with a 0.45 μm microporous membrane, and then mix the filtrate with 100 parts of aluminum monostearate castor Mix sesame oil and gum evenly, stir and evaporate all the absolute ethanol at 60°C, heat up to 100°C to form a light yellow transparent viscous liquid, pack it into sterilized glass vials after cooling, and obtain pyridine with a content of 25%. Quinone long-acting sustai...
Embodiment 3
[0025] (1) Put 100 parts of castor oil for injection into a dissolver, then weigh 2.5 parts of aluminum monostearate into the castor oil, stir to form a white uniform paste, put it in an oven at 50°C, and swell for 11 hours. Heat the swollen white pasty mixture to 140°C while stirring, and keep it for 20 minutes to make it completely dissolved. After dissolving, filter it with a vertical melting funnel, and after the filtrate is cooled, aluminum monostearate castor oil is obtained. glue.
[0026] (2) Get 2 parts of praziquantel bulk drug, dissolve it in 20 parts of dehydrated ethanol at 50°C, filter it with a 0.45 μm microporous membrane, then mix the filtrate with 100 parts of aluminum monostearate Mix sesame oil and gum evenly, stir and evaporate all the absolute ethanol at 55°C, heat up to 90°C to form a light yellow transparent viscous liquid, and pack it into sterilized glass vials after cooling to obtain 25% praquine Ketone long-acting sustained-release injection.
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