146results about How to "Good bioadhesion" patented technology

The present invention relates to nanoparticles comprising a biodegradable polymer, preferably the vinyl methyl ether and maleic anhydride (PVM/MA) copolymer, and a polyethylene glycol or derivatives thereof. These nanoparticles are easy to produce and provide excellent bioadhesion, size and zeta potential characteristics making them suitable for the administration of active molecules. The selection of the type of polyethylene glycol used in their production allows suitably modulating the characteristics of these nanoparticles, which can be advantageously used according to the type of drug to be carried and/or the method of administration of the pharmaceutical formulation. pegylation is carried out by simple incubation for a short time period of the two macromolecules in question, without needing to have to resort to the use of organic solvents with high toxicity or long and laborious organic synthesis processes. Furthermore, the pegylation process can be associated to the process of encapsulating the biologically active molecule.

The present invention relates to a drug delivery system, in which a drug containing core, either alone or coated with a rate controlling membrane system, is enveloped on its circumference by an optionally bioadhesive coating, thereby yielding a monolithic system that allows for drug release in a regulated manner.

The invention discloses a mussel mucoprotein gel for repairing and reliving itching. The mussel mucoprotein gel is prepared from the following components in percentage by weight: 0.15%-0.2% of mussel mucoprotein, 0.5%-2% of a macromolecule host material, 3%-10% of a humectant, 1%-5% of a surfactant, 0.1%-0.5% of a preservative, 1%-2% of a protein protectant, 0.5%-3% of a stabilizer, 0.5%-1% of a bacteriostatic agent, 0.8%-5.2% of a pH modifier and the balance of purified water. The mussel mucoprotein gel has good biological adhesion, is rapidly and effectively adhered to a wound surface, is capable of rapidly reliving itching and easing pain, and has the advantages of being low in immunogenicity, good in biocompatibility with a human body, convenient to use, free of thrill to skin, safe, nontoxic and free of bad reaction.

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosifies in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

The invention discloses an ultra-multiaperture hydrogel compound, making method and application in pharmacy. It contains cross-linked polymer and Carbomer. At least one unsaturated alkene monomer and polyene cross-linking agent polymerize to develop it. The making steps: mix at least one unsaturated alkene monomer, one polyene cross-linking agent, Carbomer and one foaming agent; the mixture develops it on the condition of polymerizing and foaming. It can be used in stomach floating preparation and protein polypeptide oral medicine supplying system.

The invention provides polymer gel particles, a preparation method thereof, composite gel particles containing the polymer gel particles and an application of the composite gel particles. The Young modulus of the polymer gel particles is 5-5000Pa, the average particle size is 100nm-100[mu]m, the polydispersity index is less than 0.5, and an organic solvent is not contained. The polymer gel particles are obtained by the following steps: performing cross-linking on a polymer aqueous solution to form a hydrogel with a Young modulus of 5-5000Pa, then performing preliminary crushing and refining onthe hydrogel, and using a fluid shearing method to prepare the polymer gel particles. The composite gel particles include the above polymer gel particles, and a functional substance supported on thepolymer gel particles. According to the method provided by the invention, organic solvents or surfactants are not used in the process of preparing the polymer gel particles, the obtained polymer gel particles are safe and reliable, the particle size is controllable in the range from the nanometer to the micrometer, the particle sizes are uniform, and the prepared composite gel particles can be used in the fields of biomedicines and the like.

The invention discloses a high-efficiency anti-blocking synchronous nitration and denitrification hierarchy biological aerated filter, and relates to a biological aerated filter, and the filter is used for solving the problems that the conventional filler is small in specific surface area, small in biomass adhesion, low in reaction efficiency, easy to block, and less in possibility of achieving synchronous nitration and denitrification through a single device. The biological aerated filter comprises a water supply and distribution and denitrification mixing area, a biological filter aerobic reaction area, an aerobic area and a water discharge area, wherein an aeration pipeline and a conventional grain filler are arranged in the biological filter aerobic reaction area; an aeration pipeline and a soft fiber spherical filler are arranged in the aerobic area. The filter adopts the soft fiber spherical filler, and has the advantages that the specific surface area is large, the dissolved oxygen mass transfer performance is good, the biologic adhesion property is good, the oxygen conveying is facilitated, the gas-water uniform distribution is improved, sewage blocking is prevented, adhesion growth of nitrobacteria is facilitated, the blocking is unlikely to happen, and the like, the biomass of the biological filter is effectively improved, the ammonium-nitrogen removal rate is 90%, the total nitrogen removal rate is 85%, that is, the total nitrogen removal rate is increased by 8.5% when being compared with that of the conventional biological aerated filter.

The invention provides eye drops containing tafluprost. The eye drops comprise tafluprost and a hydrophilic polymer, wherein the hydrophilic polymer is selected from polycarbophil or carbomer and the content of the hydrophilic polymer is 0.4-1.0%. Medicament storage formed by the eye drops plays a role of slowly releasing medicaments, prevents medicaments from being rapidly eliminated, and improves the bioavailability. The preparation method of the eye drops is simple and feasible and suitable for industrial production.

The invention discloses a CDI (Capacitive Deionization) based compound type constructed wetland desalination system. The technical scheme of the invention is that a pretreatment system in the compounded type constructed wetland desalination system is connected with a compound vertical flow constructed wetland system by virtue of a pipeline. The pretreatment system is that: the water inlet and the water outlet of a grille (22) are communicated with the water inlet of a corresponding first pressure pump (23) and the water inlet of a CDI device (3) by virtue of pipelines, andthe water outlet of the CDI device (3) is communicated with the water inlet of a compound vertical flow constructed wetland and the water inlet of a salt drying plate (9) respectively through pipelines.A bottom impervious layer (18) of the compound vertical flow constructed wetland system is sequentially provided with a gravel layer (17), a biological ceramisite layer (13), a zeolite layer (12) and a soil layer (11) upwards, the constructedwetland is uniformly separated into 2n+1 vertical flow treatment tanks (7)along the left and right direction, and the tops and the bottoms of the vertical flow treatment tanksare communicated with one another in a staggered manner. The CDI based compound type constructed wetland desalination system disclosed by the invention is environmentallyfriendly, can effectively solve the problem of clogging and saturation of the soil layer of the wetland, and is good in nitrogen and phosphorus removal effect and desalination effect.

The present invention provides a flexible, biocompatible transparent sheet (8) which has high biocompatibility and a high ability to adsorb a biologically relevant substance, which can be used as a novel biomaterial, and which can be used to observe the propagation, differentiation, and/or the like of living cells in real time. The biocompatible transparent sheet (8) is produced in such a manner that a biocompatible ceramic film (2) is formed on a substrate (1) soluble in a solvent (11) incapable of dissolving biocompatible ceramics by using exemplary a laser ablation process, the substrate (1) depositing the film (2) is dipped in the solvent (11) and dissolved off, and the isolated film (2) is then dried. The biocompatible transparent sheet (8) is utilizable of producing a flexible cultured cell sheet which can be directly transplanted to an affected area. The cell sheet can be prepared in such a manner that cells are seeded on the biocompatible transparent sheet (8) and then propagated.

The invention provides silk fibroin nanoparticles and drug-loading silk fibroin nanoparticles. The silk fibroin nanoparticles are prepared by a method comprising the following steps: dissolving silk fibroin in water, and keeping the water in which the silk fibroin is dissolved at 2-6 DEG C for 2-8h, so that a silk fibroin solution is obtained; mixing the silk fibroin solution with an organic solvent at the volume ratio of 1 to (4-8), and implementing stirring so as to obtain a nanoparticle suspension, wherein the organic solvent is selected from ethanol, isopropanol or acetone; implementing centrifugal separation on the nanoparticle suspension, washing the nanoparticle suspension by virtue of de-ionized water, and implementing centrifuging, so that a nanoparticle precipitate is obtained; and dispersing the nanoparticle precipitate by virtue of de-ionized water, so that the silk fibroin nanoparticles are obtained. The drug-loading silk fibroin nanoparticles can improve intake of drugs in cells and prolong retention time of the drugs; the drug-loading silk fibroin nanoparticles have the advantages of being effective, long-acting and targeted in cells and the drug-loading silk fibroin nanoparticles are conducive to the improvement of bioavailability of the drugs; the silk fibroin nanoparticles are excellent in biological adhesion and free from immunogenicity; and the silk fibroin nanoparticles are free from obvious inflammatory response and tissue fibrosis, and are excellent in biocompatibility and safety.

The invention discloses azithromycin ophthalmic in-situ gel. The azithromycin ophthalmic in-situ gel comprises the following components in percentage by weight: 0.1 to 5 percent of azithromycin, 0.05to 5 percent of cationic polysaccharide, 0.05 to 5 percent of sodium alga acid, 10 to 30 percent of poloxamer 407, 0.1 to 15 percent of poloxamer 188, 0.05 to 5 percent of cosolvent and buffer salt thereof, 0.01 to 5 percent of a tackifier, 0.01 to 5 percent of an antioxidant, 0.1 to 10 percent of an osmotic pressure regulator and 0.001 to 2 percent of a preservative. The prepared azithromycin ophthalmic in-situ gel still has proper solution-gel phase conversion ability when being used and diluted by tear, has excellent mucous membrane permeability and biological adhesive force, overcomes thedefects in the prior art, increases the ocular bioavailability of the medicine, improves corneal permeability, reduces eye irritant irritation and improves compliance of patients. The invention also discloses a preparation method of the gel, wherein the process is simple.

Provided are a bioadhesive hydrogel including surface-treated nanofibers, a preparation method thereof, and use of thereof. The hydrogel including surface-treated nanofibers provided in the present invention may have excellent bioadhesive strength, thereby being widely applied to a bioadhesive, a scaffold for tissue engineering, a carrier for drug delivery, etc.

The invention discloses a deodorization composite biological stuffing as well as a preparation method and application of the same. The deodorization composite biological stuffing comprises a stuffing main body and an adhesion agent, wherein the adhesion agent takes account for 10-40% of the stuffing main body in usage amount by weight percentage; in percent by weight, the stuffing main body comprises 70-80% of calcium carbonate, 5-10% of diammonium phosphate, 10-20% of bark powder, 0-5% of urea and 0-5% of the soybean meal; and in percent by weight, the adhesion agent comprises one or more of 30-100% of ethylene/ vinyl acetate, and 20-70% of Na2O nSiO2/K2O nSiO. By the steps of mixing, extrusion forming, drying and the like, the stuffing main body and the adhesion agent are prepared to the deodorization composite biological stuffing. The stuffing is matched with deodorization microorganism for use, second fermentation liquor obtained from the deodorization microorganism which is subject to seed cultivation and fermenter cultivation is uniformly scattered on the stuffing, and after growing, the microorganism can be used for deodorization work. The deodorization composite biological stuffing has the advantages of being excellent in deodorization effect and long in using time which is improved by 30% compared with that of the way using bark as stuffing.

The invention relates to a high-bioavailability rapamycin composition and a preparation method thereof. The drug release of the solid drug composition in a gastrointestinal tract has pH sensitivity. The high dispersivity of the drug in a carrier can obviously increase the absorption of rapamycin in the gastrointestinal tract or improve other properties of the drug, thereby obviously improving bioavailability, being capable of lowering administration dosage, namely reducing the usage of the raw materials in the preparation, and further saving the production cost greatly. The rapamycin composition can be processed into various oral solid dosage forms and has simple preparation process.

A medicine targeting to colon for treating colitis is prepared through dispersing 5-aminosalicylic acid in chitosan solution, adding the oil-phase substance containing surfactant, stirring, adding the aqueous solution of ammonium sulfate, stirring, depositing, separating, washing and vacuum drying.