148results about How to "Good bioadhesion" patented technology

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with / without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

The present invention relates to nanoparticles comprising a biodegradable polymer, preferably the vinyl methyl ether and maleic anhydride (PVM / MA) copolymer, and a polyethylene glycol or derivatives thereof. These nanoparticles are easy to produce and provide excellent bioadhesion, size and zeta potential characteristics making them suitable for the administration of active molecules. The selection of the type of polyethylene glycol used in their production allows suitably modulating the characteristics of these nanoparticles, which can be advantageously used according to the type of drug to be carried and / or the method of administration of the pharmaceutical formulation. pegylation is carried out by simple incubation for a short time period of the two macromolecules in question, without needing to have to resort to the use of organic solvents with high toxicity or long and laborious organic synthesis processes. Furthermore, the pegylation process can be associated to the process of encapsulating the biologically active molecule.

The present invention relates to a drug delivery system, in which a drug containing core, either alone or coated with a rate controlling membrane system, is enveloped on its circumference by an optionally bioadhesive coating, thereby yielding a monolithic system that allows for drug release in a regulated manner.

The invention discloses a mussel mucoprotein gel for repairing and reliving itching. The mussel mucoprotein gel is prepared from the following components in percentage by weight: 0.15%-0.2% of mussel mucoprotein, 0.5%-2% of a macromolecule host material, 3%-10% of a humectant, 1%-5% of a surfactant, 0.1%-0.5% of a preservative, 1%-2% of a protein protectant, 0.5%-3% of a stabilizer, 0.5%-1% of a bacteriostatic agent, 0.8%-5.2% of a pH modifier and the balance of purified water. The mussel mucoprotein gel has good biological adhesion, is rapidly and effectively adhered to a wound surface, is capable of rapidly reliving itching and easing pain, and has the advantages of being low in immunogenicity, good in biocompatibility with a human body, convenient to use, free of thrill to skin, safe, nontoxic and free of bad reaction.

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosifies in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

The invention discloses an ultra-multiaperture hydrogel compound, making method and application in pharmacy. It contains cross-linked polymer and Carbomer. At least one unsaturated alkene monomer and polyene cross-linking agent polymerize to develop it. The making steps: mix at least one unsaturated alkene monomer, one polyene cross-linking agent, Carbomer and one foaming agent; the mixture develops it on the condition of polymerizing and foaming. It can be used in stomach floating preparation and protein polypeptide oral medicine supplying system.

The invention provides polymer gel particles, a preparation method thereof, composite gel particles containing the polymer gel particles and an application of the composite gel particles. The Young modulus of the polymer gel particles is 5-5000Pa, the average particle size is 100nm-100[mu]m, the polydispersity index is less than 0.5, and an organic solvent is not contained. The polymer gel particles are obtained by the following steps: performing cross-linking on a polymer aqueous solution to form a hydrogel with a Young modulus of 5-5000Pa, then performing preliminary crushing and refining onthe hydrogel, and using a fluid shearing method to prepare the polymer gel particles. The composite gel particles include the above polymer gel particles, and a functional substance supported on thepolymer gel particles. According to the method provided by the invention, organic solvents or surfactants are not used in the process of preparing the polymer gel particles, the obtained polymer gel particles are safe and reliable, the particle size is controllable in the range from the nanometer to the micrometer, the particle sizes are uniform, and the prepared composite gel particles can be used in the fields of biomedicines and the like.

The invention discloses a cysteine functionalized hyaluronic acid conjugate, a synthetic method and an application in preparation of injectable in-situ hydrogel thereof. According to the method, a hydroxy of hyaluronic acid is modified to obtain the cysteine functionalized hyaluronic acid conjugate with a stable ether bond, and tetrabutyl ammonium hydroxide is introduced in the reaction process. The new method improves the solubility of hyaluronic acid and increases the reaction efficiency. The obtained cysteine functionalized hyaluronic acid conjugate has a sulfhydryl active group which not only improves the adhesion of hyaluronic acid, but also can be further functionalized. According to the invention, injectable in-situ hydrogel is generated by a native chemical ligation reaction or a Michael addition reaction of the prepared cysteine functionalized hyaluronic acid conjugate with a polyethylene glycol conjugate; rheological research shows that the generated hydrogel has good rheological properties, the gel performance is controllable, and the hydrogel has wide application prospects in the biological medicine field.

The invention belongs to the fields of intelligent bionic materials, high-molecular materials and biomedical engineering, and concretely relates to a polydopamine particles-doped star-shaped polymer of a multi-responsive self-healing hydrogel, and the self-healing hydrogel and a preparation method thereof. In the present invention, the polydopamine nanoparticles and the star-shaped polymer SPDMAEMA-AA are prepared first; and the polydopamine nanoparticles, SPDMAEMA-AA and branched polyethyleneimine are mixed in proportion to form a crosslinked network by forming a dynamic reversible enamine bond through the acetoacetate on SPDMAEMA-AA and an amino group in the PEI molecules to obtain the hydrogel. The self-healing hydrogel material prepared by the invention has good near-infrared responsiveness, biocompatibility and high self-healing efficiency, and has potential applications in the fields of solid-state band-aids, drug slow release, cell culture, and a double-layer drive.

The invention discloses a high-efficiency anti-blocking synchronous nitration and denitrification hierarchy biological aerated filter, and relates to a biological aerated filter, and the filter is used for solving the problems that the conventional filler is small in specific surface area, small in biomass adhesion, low in reaction efficiency, easy to block, and less in possibility of achieving synchronous nitration and denitrification through a single device. The biological aerated filter comprises a water supply and distribution and denitrification mixing area, a biological filter aerobic reaction area, an aerobic area and a water discharge area, wherein an aeration pipeline and a conventional grain filler are arranged in the biological filter aerobic reaction area; an aeration pipeline and a soft fiber spherical filler are arranged in the aerobic area. The filter adopts the soft fiber spherical filler, and has the advantages that the specific surface area is large, the dissolved oxygen mass transfer performance is good, the biologic adhesion property is good, the oxygen conveying is facilitated, the gas-water uniform distribution is improved, sewage blocking is prevented, adhesion growth of nitrobacteria is facilitated, the blocking is unlikely to happen, and the like, the biomass of the biological filter is effectively improved, the ammonium-nitrogen removal rate is 90%, the total nitrogen removal rate is 85%, that is, the total nitrogen removal rate is increased by 8.5% when being compared with that of the conventional biological aerated filter.

The invention provides eye drops containing tafluprost. The eye drops comprise tafluprost and a hydrophilic polymer, wherein the hydrophilic polymer is selected from polycarbophil or carbomer and the content of the hydrophilic polymer is 0.4-1.0%. Medicament storage formed by the eye drops plays a role of slowly releasing medicaments, prevents medicaments from being rapidly eliminated, and improves the bioavailability. The preparation method of the eye drops is simple and feasible and suitable for industrial production.

The invention discloses a CDI (Capacitive Deionization) based compound type constructed wetland desalination system. The technical scheme of the invention is that a pretreatment system in the compounded type constructed wetland desalination system is connected with a compound vertical flow constructed wetland system by virtue of a pipeline. The pretreatment system is that: the water inlet and the water outlet of a grille (22) are communicated with the water inlet of a corresponding first pressure pump (23) and the water inlet of a CDI device (3) by virtue of pipelines, andthe water outlet of the CDI device (3) is communicated with the water inlet of a compound vertical flow constructed wetland and the water inlet of a salt drying plate (9) respectively through pipelines.A bottom impervious layer (18) of the compound vertical flow constructed wetland system is sequentially provided with a gravel layer (17), a biological ceramisite layer (13), a zeolite layer (12) and a soil layer (11) upwards, the constructedwetland is uniformly separated into 2n+1 vertical flow treatment tanks (7)along the left and right direction, and the tops and the bottoms of the vertical flow treatment tanksare communicated with one another in a staggered manner. The CDI based compound type constructed wetland desalination system disclosed by the invention is environmentallyfriendly, can effectively solve the problem of clogging and saturation of the soil layer of the wetland, and is good in nitrogen and phosphorus removal effect and desalination effect.

The present invention provides a flexible, biocompatible transparent sheet (8) which has high biocompatibility and a high ability to adsorb a biologically relevant substance, which can be used as a novel biomaterial, and which can be used to observe the propagation, differentiation, and / or the like of living cells in real time. The biocompatible transparent sheet (8) is produced in such a manner that a biocompatible ceramic film (2) is formed on a substrate (1) soluble in a solvent (11) incapable of dissolving biocompatible ceramics by using exemplary a laser ablation process, the substrate (1) depositing the film (2) is dipped in the solvent (11) and dissolved off, and the isolated film (2) is then dried. The biocompatible transparent sheet (8) is utilizable of producing a flexible cultured cell sheet which can be directly transplanted to an affected area. The cell sheet can be prepared in such a manner that cells are seeded on the biocompatible transparent sheet (8) and then propagated.

The invention provides silk fibroin nanoparticles and drug-loading silk fibroin nanoparticles. The silk fibroin nanoparticles are prepared by a method comprising the following steps: dissolving silk fibroin in water, and keeping the water in which the silk fibroin is dissolved at 2-6 DEG C for 2-8h, so that a silk fibroin solution is obtained; mixing the silk fibroin solution with an organic solvent at the volume ratio of 1 to (4-8), and implementing stirring so as to obtain a nanoparticle suspension, wherein the organic solvent is selected from ethanol, isopropanol or acetone; implementing centrifugal separation on the nanoparticle suspension, washing the nanoparticle suspension by virtue of de-ionized water, and implementing centrifuging, so that a nanoparticle precipitate is obtained; and dispersing the nanoparticle precipitate by virtue of de-ionized water, so that the silk fibroin nanoparticles are obtained. The drug-loading silk fibroin nanoparticles can improve intake of drugs in cells and prolong retention time of the drugs; the drug-loading silk fibroin nanoparticles have the advantages of being effective, long-acting and targeted in cells and the drug-loading silk fibroin nanoparticles are conducive to the improvement of bioavailability of the drugs; the silk fibroin nanoparticles are excellent in biological adhesion and free from immunogenicity; and the silk fibroin nanoparticles are free from obvious inflammatory response and tissue fibrosis, and are excellent in biocompatibility and safety.

The invention discloses azithromycin ophthalmic in-situ gel. The azithromycin ophthalmic in-situ gel comprises the following components in percentage by weight: 0.1 to 5 percent of azithromycin, 0.05to 5 percent of cationic polysaccharide, 0.05 to 5 percent of sodium alga acid, 10 to 30 percent of poloxamer 407, 0.1 to 15 percent of poloxamer 188, 0.05 to 5 percent of cosolvent and buffer salt thereof, 0.01 to 5 percent of a tackifier, 0.01 to 5 percent of an antioxidant, 0.1 to 10 percent of an osmotic pressure regulator and 0.001 to 2 percent of a preservative. The prepared azithromycin ophthalmic in-situ gel still has proper solution-gel phase conversion ability when being used and diluted by tear, has excellent mucous membrane permeability and biological adhesive force, overcomes thedefects in the prior art, increases the ocular bioavailability of the medicine, improves corneal permeability, reduces eye irritant irritation and improves compliance of patients. The invention also discloses a preparation method of the gel, wherein the process is simple.

Provided are a bioadhesive hydrogel including surface-treated nanofibers, a preparation method thereof, and use of thereof. The hydrogel including surface-treated nanofibers provided in the present invention may have excellent bioadhesive strength, thereby being widely applied to a bioadhesive, a scaffold for tissue engineering, a carrier for drug delivery, etc.

The invention discloses a deodorization composite biological stuffing as well as a preparation method and application of the same. The deodorization composite biological stuffing comprises a stuffing main body and an adhesion agent, wherein the adhesion agent takes account for 10-40% of the stuffing main body in usage amount by weight percentage; in percent by weight, the stuffing main body comprises 70-80% of calcium carbonate, 5-10% of diammonium phosphate, 10-20% of bark powder, 0-5% of urea and 0-5% of the soybean meal; and in percent by weight, the adhesion agent comprises one or more of 30-100% of ethylene / vinyl acetate, and 20-70% of Na2O nSiO2 / K2O nSiO. By the steps of mixing, extrusion forming, drying and the like, the stuffing main body and the adhesion agent are prepared to the deodorization composite biological stuffing. The stuffing is matched with deodorization microorganism for use, second fermentation liquor obtained from the deodorization microorganism which is subject to seed cultivation and fermenter cultivation is uniformly scattered on the stuffing, and after growing, the microorganism can be used for deodorization work. The deodorization composite biological stuffing has the advantages of being excellent in deodorization effect and long in using time which is improved by 30% compared with that of the way using bark as stuffing.

The invention relates to a high-bioavailability rapamycin composition and a preparation method thereof. The drug release of the solid drug composition in a gastrointestinal tract has pH sensitivity. The high dispersivity of the drug in a carrier can obviously increase the absorption of rapamycin in the gastrointestinal tract or improve other properties of the drug, thereby obviously improving bioavailability, being capable of lowering administration dosage, namely reducing the usage of the raw materials in the preparation, and further saving the production cost greatly. The rapamycin composition can be processed into various oral solid dosage forms and has simple preparation process.

The invention relates to a tourmaline / chitosan hydrochloride compound spray-type aqueous dressing and belongs to the technical field of compound aqueous wound dressings. In order to solve the technical problems, the invention provides the compound spray-type aqueous dressing which is suitable for the field of the wound dressings. In the compound spray-type aqueous dressing provided by the invention, chitosan hydrochloride plays a role of blood coagulation and hemostasis, antibiosis antiphlogosis and film formation; tourmaline plays a role of launching far infrared rays, generating negative ions and promoting cell growth and wound healing; and polyvinylpyrrolidone (PVP) in a small number of PVP alcohol solution as an auxiliary material plays a role of a film-forming agent, a dispersing agent and a binding agent. The prepared compound spray-type aqueous dressing is convenient in use, slight in skin irritation and high in film-forming speed, has good effects of antibiosis antiphlogosis and blood coagulation and hemostasis, can be used for launching the far infrared rays, generating the negative ions and promoting the cell growth and the wound healing, is good in air permeability and moisture permeability after the film is formed and can be used as a biological wound dressing.

The invention discloses a method for quickly improving biological adhesiveness of a laser patterned PDMS surface. A microstructure can be formed on the PDMS surface after laser action, so that a good environment is provided for cell adhesion and growth; or the PDMS surface after laser action is chemically modified or structurally modified, so that biological adhesiveness is improved; the microstructure can fix protein, cell growth factors, enzyme and nucleic acid; a laser device generates high-energy pulse laser beams which focus to the PDMS surface through a convex lens after going through a reflection mirror, and under action of high energy and impact force caused by radiation of the high-energy pulse laser beams, the PDMS surface occurs photothermal action and photochemical action and is instantly vaporized or splashes so as to form the microstructure on the PDMS surface. Laser action is utilized for material surface modification or forming the surface microstructure, modification step of the PDMS surface is simplified without having influence on a non-modified area surface, and the PDMS surface is patterned, so that preparation efficiency is improved greatly.

The invention discloses deodorizing composite biological stuffing special for dyeing and finishing wastewater treatment and a preparing method thereof. The stuffing comprises a component A and a component B. The mass ratio of the component A to the component B is 3:(6-8); the component A is prepared from dried sludge, converter slag, coal ash and clay, and the mass ratio of the dried sludge to the converter slag to the coal ash to the clay is (5-8):(5-7):(2-3):(3-5); the component B is prepared from, by mass, 10-20% of bark powder, 5-20% of saw dust, 50-60% of calcium carbonate and 20-30% of adhesive. The component A is prepared at first and then mixed with the component B to obtain the stuffing. The stuffing provides good adhesion space for growth of microorganisms, and provides a stable survival environment for growth of the microorganisms. Compared with inorganic stuffing like volcanic rock and natural or manual organic stuffing such as bark and synthetic resin, the stuffing has the advantages of being low in production cost, better in effect, stable in continuous use time, and beneficial for application to industrialized biological filter tank deodorization.

The present invention relates to a preparation method of floatation-bioadhesion synergistic type microgranules. Said preparation method includes the following steps: firstly, utilizing drying system in the water to prepare ethyl cellulose floatation microspheres, then using sodium alginate to make coating in the emulsification system, finally the sodium alginate and ethyl cellulose microparticles are dispersed in chitosan solution to produce ion gelatification and form chitosan film so as to obtain the invented floatation-bioadhesion synergistic type microgranules.

The invention provides diacerein injection type thermo-sensitive gel. The diacerein injection type thermo-sensitive gel comprises diacerein, poloxamer 407, poloxamer 188 and HPMC (hydroxypropyl methylcelluloses). A concentration ratio (w / v) of the diacerein to the P-407 to the P-188 to the HPMC is 0.5%:17-22%:1-5%:0.3-1.0%. A method for preparing the diacerein injection type thermo-sensitive gelincludes preparation steps of swelling the HPMC by the aid of water at the room temperature to obtain HPMC solution; uniformly scattering the poloxamer P-407 and the poloxamer P-188 on the surface ofthe HPMC solution and carrying out overnight swelling and dissolving to obtain blank thermo-sensitive gel solution; sufficiently dissolving the diacerein by the aid of DMSO (dimethyl sulfoxide) to obtain diacerein solution and then adding the diacerein solution into the blank thermo-sensitive gel solution to obtain diacerein thermo-sensitive gel solution. The diacerein injection type thermo-sensitive gel and the method have the advantages that the diacerein injection type thermo-sensitive gel prepared by the aid of the method is prepared from water-soluble high-polymer materials, is excellentin histocompatibility and bio-adhesion, is long in detention time at medication positions, can be slowly released and is long-acting, and the purpose of reducing side effects on gastrointestinal tracts can be achieved.

A medicine targeting to colon for treating colitis is prepared through dispersing 5-aminosalicylic acid in chitosan solution, adding the oil-phase substance containing surfactant, stirring, adding the aqueous solution of ammonium sulfate, stirring, depositing, separating, washing and vacuum drying.

The invention relates to a temperature-sensitive gel type nano-silver foam aerosol for women, which comprises a gel system and a propellant dimethyl ether evenly mixed in the gel system, wherein the gel system contains nano-silver colloidal particles, a temperature-sensitive high molecular polymer and a diluting agent. The volume of the propellant the dimethyl ether is 8 to 15 percent of that of the gel system. An ejected matter is foam during the use of the temperature-sensitive gel type nano-silver foam aerosol, the deep administration can be performed, and a medicine can quickly swell and comprehensively contacts a focus after reaching the focus, and is dispersed evenly and permeated fully in a cavity; and at the same time, the nano-silver foam aerosol forms semisolid shaped gel in special physiological environment of a drug application position, has strong adhesiveness, is convenient for vagina mucosa to absorb to play effect, and effectively improves the compliance of patients and the bioavailability of nano-silver. The temperature-sensitive gel type nano-silver foam aerosol for the women has the advantages of convenient use, exact therapeutic effect, and no drug dependence.

The invention provides a preparation method of an injectable self-adaptive natural hydrogel adhesive. The preparation method comprises the following steps: firstly, synthesizing gelatin-phenylboronic acid from carboxyl phenylboronic acid and gelatin through an amidation reaction, or synthesizing polysaccharide-phenylboronic acid from amino phenylboronic acid and natural polysaccharide; synthesizing gelatin-dopamine or polysaccharide-dopamine from dopamine and gelatin or natural polysaccharide through an amidation reaction; and dissolving the gelatin-phenylboronic acid / polysaccharide-phenylboronic acid in a phosphate buffer solution, dissolving the gelatin-dopamine / polysaccharide-dopamine in a phosphate buffer solution containing natural polyphenol substances, and uniformly mixing two obtained solutions to realize a spontaneous esterification reaction of phenylboronic acid and polyphenol so as to generate reversible boric acid ester bonds, thereby finally preparing the injectable self-adaptive natural hydrogel adhesive. The hydrogel adhesive disclosed by the invention has good biological adhesion and antibacterial and anti-inflammatory effects, and is attached to the surface of a tissue to play a repairing role; and the hydrogel adhesive has good mechanical self-adaptive performance and can be matched with deformation and frequency of different dynamic tissues.