545results about How to "Good clinical efficacy" patented technology

Milling and drilling tools and soft tissue management techniques are provided for arthroplasty that facilitate intraoperative and postoperative efficacy and ease of use. In one embodiment, resiliently biased soft tissue protective sleeves surround a side cutting tool and are interposed along the longitudinal axis of the cutting tool, preferably adjacent each side of the bone. The soft tissue protective sleeves are biased to track along the contour of the side of the bone and prevent the cutting tool from being exposed to soft tissue during the resection. In another embodiment, a pilot drill is initially utilized to create an initial bore in the bone to be resected. The pilot drill preferably has an end cutting arrangement and a non-cutting removal channel that minimizes the tendency of the pilot drill bit to drift off-axis as the initial bore in the bone is created. Once the initial bore is created, the pilot drill bit is withdrawn and a second side cutting tool, such as a milling bit, is then inserted into the bore to perform the desired surface resection.

Alignment guides, cutting guides, cutting tools and soft tissue management techniques for profile based resection (PBR) arthroplasty facilitate intraoperative and postoperative efficacy and ease of use. In one embodiment, a manual alignment guide is provided that permits less invasive incisions by providing soft tissue accommodating contours or reliefs. In another embodiment, a single medial drill guide plate is used for the PBR arthroplasty.

A cutting tool is provided with an arcuate cutting blade that preferably engages a guide tool to create a curved resected surface during an arthorplasty procedure. In one embodiment, a depth of the cutting blade is sufficient to permit the simultaneous creation of resected surfaces on two bones that articulate, such as both the femor and the tibia for a given condyle, without the need to reposition the guide or the leg. In another embodiment, a cutting member has a generally rectangular cross-section along a longitudinal axis with a first and second surface having cutting teeth defined thereon and a third and fourth surface adapted to interface with a cutting guide positioned proximate the bone. In this embodiment, the cutting tool can resect the bone in two different directions without reorienting the cutting member.

Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.

The present invention relates to a medicine preparation with raw material comprising gen-seng, RADIX OPHIOPOGONIS and schizan drin and relates to the methods of preparing and quality control of the invention as well as relates to the quality control method of the raw material comprising gen-seng, radix ophiopogonis and schizan drin. The present invention comprises saponins content of gen-seng, amylase content of gen-seng, saponins content of radix ophiopogonis and neolignan content of schizan drin. Each unit dosage of preparation comprises Rg1 and Re for 0.08 mg-12 mg, polysaccharide of gen-seng for 1mg-460mg, general saponins for 5 mg-800 mg and Schisandrin for 0.036mg-6mg. a medicine functioning as cooperation can be or can not be added in the present invention which can be any acceptable medicine preparation type comprising oral taking solid preparation, oral taking semi-solid preparation, oral taking liquid preparation and injection. The present invention also provides the quality control method of gen-seng, RADIX OPHIOPOGONIS and schizan drin as well as the quality control method of the present invention.

The invention relates to a body position rotating device, which comprises a host machine and at least one bracket, wherein the host machine comprises a transmission mechanism and a rotating device which is driven by the transmission mechanism to rotate, the rotating device comprises at least one rotating shaft, and the bracket is connected with the rotating shaft in a rotation way. The invention also relates to a body position rotating system containing the body position rotating device. During the diagnosis and treatment process, the system can precisely control the variation speed of the patient body position and the space position of the patient, so the diagnosis and the treatment of the semicircular canal dysfunctional diseases are more accurate and more reliable.

The invention discloses a Chinese medicine composition for treating acute sinusitis. A medicament for oral administration, of Chinese medicine composition comprises the raw ingredients in parts by weight: 10 to 20 parts of spreading hedyotis herb, 10 to 20 parts of pipewort, 10 to 20 parts of fistular onion stalk, 10 to 20 parts of angelica, 10 to 20 parts of siberia cocklebur, 10 to 20 parts of small centipeda herb, 10 to 20 parts of forsythia, 10 to 20 parts of Chinese waxgourd seed, 10 to 20 parts of Sichuan lovage rhizome, 10 to 20 parts of balloonflower root, 10 to 20 parts of cicada slough, 10 to 20 parts of houttuynia cordata, 10 to 20 parts of milkvetch root, 10 to 20 parts of flower bud of lily magnolia, 10 to 20 parts of angelica root, 10 to 20 parts of baikal skullcap root, 10 to 20 parts of dandelion, 10 to 20 parts of reed rhizome and 10 to 20 parts of herba schizonepetae; and a medicament for external application, of the Chinese medicine composition comprises the raw ingredients in parts by weight: 10 to 20 parts of catechu, 10 to 20 parts of small centipeda herb, 10 to 20 parts of angelica root, 10 to 20 parts of honeysuckle, 10 to 20 parts of dandelion, 10 to 20 parts of borneol, 10 to 20 parts of mint, 10 to 20 parts of Manchurian wild ginger, 10 to 20 parts of safflower, 10 to 20 parts of bletilla tuber and 10 to 20 parts of divaricate saposhnikovia root. The Chinese medicine composition disclosed by the invention has the efficacies of dispelling wind for clearing heat, ventilating lung qi for promoting the restoration of consciousness, clearing gallbladder-heat, clearing nasal passage, clearing away heat and promoting diuresis and dissolving turbidity for promoting the restoration of consciousness, and has the advantages of simpleness and convenience for use and easiness for preparation.

The invention relates to a body position rotating device, which comprises a host machine and at least one bracket, wherein the host machine comprises a transmission mechanism and a rotating device which is driven by the transmission mechanism to rotate, the rotating device comprises at least one rotating shaft, and the bracket is connected with the rotating shaft in a rotation way. The invention also relates to a body position rotating system containing the body position rotating device. During the diagnosis and treatment process, the system can precisely control the variation speed of the patient body position and the space position of the patient, so the diagnosis and the treatment of the semicircular canal dysfunctional diseases are more accurate and more reliable.

The present invention relates to one kind of sodium-potassium andrographolide-semisuccinate and its preparations. On the basis of potassium andrographolide-semisuccinate, which is not enough stable and is likely to produce precipitate and negative effect, sodium-potassium andrographolide-semisuccinate is developed and has relatively high stability and less side effect. The sodium-potassium andrographolide-semisuccinate is prepared into injection, powder for injection and other forms.

The invention provides a traditional Chinese medicine composition for treating lumbar muscle strain. A medicine for oral administration of the traditional Chinese medicine composition is prepared from the following raw materials: 10-20 parts of herba epimedii, 10-20 parts of polygonum cuspidatum, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of loranthus parasiticus, 10-20 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of fructus liquidambaris, 10-20 parts of gentiana macrophylla, 10-20 parts of dogwood, 10-20 parts of salvia miltiorrhiza, 10-20 parts of lycopodium clavatum, 10-20 parts of ramulus mori, 10-20 parts of radix dipsaci, 10-20 parts of phryma leptostachya, 10-20 parts of fructus psoraleae, 10-20 parts of davallia mariesii, 10-20 parts of kadsura pepper stem and 10-20 parts of red paeony root; an external-use medicine of the traditional Chinese medicine composition is prepared from the following raw materials: 10-20 parts of artemisia anomala, 10-20 parts of caulis spatholobi, 10-20 parts of radix clematidis, 10-20 parts of asarum, 10-20 parts of prepared frankincense, 10-20 parts of myrrh, 10-20 parts of radix dipsaci, 10-20 parts of saposhnidoviae radix, 10-20 parts of cassia twig, 10-20 parts of davallia mariesii, 10-20 parts of fructus liquidambaris, 10-20 parts of phryma leptostachya,10-20 parts of ground beetle and 10-20 parts of kadsura pepper stem. As a treatment method of invigorating the kidney and replenishing essence, activating blood and removing stasis and activating meridians and stopping pains is clinically utilized, the traditional Chinese medicine composition achieves good clinical curative effects on treatment of lumbar muscle strain.

The invention provides a dual-phase capsule for preventing and treating chronic pelvic inflammation and a preparation method and a detection method thereof. The dual-phase capsule for preventing and treating chronic pelvic inflammation is prepared by extracting 20g of Chinese pulsatilla root, 20g of nutgrass galingale rhizome, 12g of twotooth achyranthes, 12g of Chinese atractylodes, 8g of amur corktree bark and 8g of selinum japenious seed serving as bulk pharmaceuticals, adding a proper amount of superfine silica powder and low-substituted hydroxypropyl cellulose, and adding 80 percent ethanol as a wetting agent. Aiming at the defects in the prior art, a preparation process of the dual-phase capsule for preventing and treating chronic pelvic inflammation is optimized, so that the curative effect of the dual-phase capsule on chronic pelvic inflammation is more remarkable. A systematic, complete and effective component identification and content determination method is established, so that the quality of the dual-phase capsule can be controlled effectively, and the clinical curative effect is ensured.

This invention relates to topical pharmaceutical preparations and methods for the treatment of acute and chronic pain and inflammation therewith. The preparations have a saturated solution of an active pharmaceutical ingredient in a solvent therefor in intimate combination and contact with a suspension of nanoparticles of the active pharmaceutical ingredient in the solvent, and a pharmaceutically acceptable carrier therefor, and are administered topically.

Milling and drilling tools and soft tissue management techniques are provided for arthroplasty that facilitate intraoperative and postoperative efficacy and ease of use. In one embodiment, resiliently biased soft tissue protective sleeves surround a side cutting tool and are interposed along the longitudinal axis of the cutting tool, preferably adjacent each side of the bone. The soft tissue protective sleeves are biased to track along the contour of the side of the bone and prevent the cutting tool from being exposed to soft tissue during the resection. In another embodiment, a pilot drill is initially utilized to create an initial bore in the bone to be resected. The pilot drill preferably has an end cutting arrangement and a non-cutting removal channel that minimizes the tendency of the pilot drill bit to drift off-axis as the initial bore in the bone is created. Once the initial bore is created, the pilot drill bit is withdrawn and a second side cutting tool, such as a milling bit, is then inserted into the bore to perform the desired surface resection.

The invention relates to an effector cell combination for preventing and treating tumors. The effector cell combination comprises CIK (cytokine induced killer) cells and MSC (Mesenchymal Stem Cells) which are sequentially injected into a human body in the form of a cell suspension and are extracted and prepared from peripheral blood of exogenous healthy people in non-tumor patients. The invention also discloses a preparation method of the effector cell combination, and the method comprises the following steps of: blood mononuclear cell collection, CIK cell culture and MSC culture. According to the scheme disclosed by the invention, the CIK cells and the MSC are extracted and prepared from the peripheral blood of the exogenous healthy people in the non-tumor patients, thereby breaking the routine treatment of auto-CIK cells, improving the clinical effects of tumor biotherapy and especially the clinical effects of CIK cell therapy, and solving the problems in graft-versus-host reaction (GVHD).

The invention relates to a compound liquorice tablet and a preparation process thereof. The compound liquorice tablet comprises the following raw materials: liquorice root extracts, opium powder, camphor, star anise oil, sodium benzoate, an adsorbent and a corrective. The preparation process comprises the following steps: adding the adsorbent in the raw material composition, and hiding special foul smell of the camphor and the star anise oil by adopting an adsorption method to eliminate the foul smell; adding the corrective in the raw material composition to enable the compound liquorice tablet to have satisfactory mouthfeel. Therefore, the compound liquorice tablet prepared by the invention is suitable for being taken orally, excellent in mouthfeel, good in clinical effects, and high in bioavailability. Meanwhile, through the improvement on the process, especially, a manner of performing direct tabletting on powder is adopted, so that the compound liquorice tablet is remarkably improved in process level, stable in quality and stable in effect; the production cost of the product is further reduced, and the tablet can serve patients better.

The invention discloses a traditional Chinese medicine preparation for treating ulcerative colitis. The traditional Chinese medicine preparation comprises the following raw materials: bletilla striata, pericarpium granati, membranous milkvetch root, white paeony root, common yam rhizome, costustoot, skyblue broomrape herb, largehead atractylodes rhizome, Indian buead, divaricate saposhnikovia root, common macrocarpium fruit, Chinese magnoliavine fruit, golden thread and tangerine peel. Chinese pulsatilla root, dahurian patrinia herb and amur corktree bark are added for people with heavy dampness and heat and incessant dysentery. Officinal magnolia bark, bitter orange, kudzuvine root, charred malt, charred hawthorn fruit and charred medicated leaven are added for people with intestine and stomach dyspepsia, stomachache, abdominal distension and less ache after diarrhea. Chicken's gizzard-membrane, nutmeg and malaytea scurfpea fruit are added for people with incoordination between the liver and the spleen and heavy cold dampness in phlegm. Through the application of the traditional Chinese medicine preparation for treating ulcerative colitis, the purposes of checking diarrhea and reducing inflammation, resolving tetany and relieving pain, modifying local blood circulation and metabolism, enhancing the intestinal immune function and promoting the healing of ulcer can be reached. And through the application of the traditional Chinese medicine preparation for treating ulcerative colitis, the medicine can directly act on nidus; and meanwhile, the traditional Chinese medicine preparation for treating ulcerative colitis can be used for local washing and cleaning, and is simple and convenient in production process, less in toxic and side effects, convenient to apply, easy to produce, low in cost, short in healing time and relapse-free after healing.

The invention discloses a Chinese medicinal composition for treating children chronic sinusitis. The oral taken medicine comprises the following active ingredients in part by weight: 10 to 20 parts of Chinese angelica, 10 to 20 parts of xanthium sibiricum, 10 to 20 parts of nutgrass galingale rhizome, 10 to 20 parts of weeping forsythia, 10 to 20 parts of wax gourd seed, 10 to 20 parts of Szechuan lovage rhizome, 10 to 20 parts of platycodon root, 10 to 20 parts of sargent gloryvine, 10 to 20 parts of heartleaf houttuynia herb, 10 to 20 parts of astragalus, 10 to 20 parts of biond magnolia flower, 10 to 20 parts of angelica dahurica, 10 to 20 parts of baical skullcap root, 10 to 20 parts of Mongolian dandelion herb, 10 to 20 parts of honeysuckle and 10 to 20 parts of fineleaf schizonepetaherb; the external application medicine comprises the following active ingredients in part by weight: 10 to 20 parts of honeysuckle, 10 to 20 parts of nutgrass galingale rhizome, 10 to 20 parts of borneol, 10 to 20 parts of mint, 10 to 20 parts of manchurian wildginger, 10 to 20 parts of chrysanthemum, 10 to 20 parts of safflower, 10 to 20 parts of bletilla striata, 10 to 20 parts of divaricate saposhnikovia root and 10 to 20 parts of frankincense. The Chinese medicinal composition makes a nasal part lesion subjected to benign simulation so as to clear the meridians, dispel blood block, accelerate blood smoothness and achieve an effect of strengthening body resistance and eliminating evil, and has a better clinical effect through combined treatment of oral administration and external application.

The invention discloses a multifunctional carrier based on cytogenic vesicle in body fluid, a preparation method and an application. The method comprises the following steps: (1) collecting human body fluid, performing gradient ultra-centrifugation, removing supernatant and using sterile PBS heavy suspension for precipitating and (2) adding the cytogenic membrane vesicle from the body fluid, ultra-small luminescent material and electroporation buffer solution into an electric shock cup, uniformly mixing, placing onto an electroporation instrument and treating, placing under room temperature and repairing after the ending of electroporation, performing ultra-centrifugation and then using sterile PBS heavy suspension for precipitating, thereby acquiring the multifunctional carrier based on the cytogenic membrane vesicle from the body fluid and marked with the ultra-small luminescent material. The carrier is used for preparing a chemotherapeutic drug or gene therapeutic drug for treating or preventing tumor, has high biocompatibility, is convenient to carry various therapeutic drugs, is capable of effectively restraining tumor growth, is suitable for diagnosis and treatment of various innocent and malignant tumors and especially supplies a choice for the diagnosis and treatment of deep tumors in skull, thoracic cavity and abdominal cavity.

Methods, systems and computer program products for combining atrial defibrillation treatment techniques include techniques for reducing the discomfort associated with defibrillation and / or reducing the defibrillation threshold. Techniques include timing the defibrillation shock to reduce discomfort based on a sensed signal, giving the shock relatively early during atrial fibrillation, therapeutic drugs, administering more than one shock in succession, pacing the heart before, after, or during the defibrillation shock or shocks, and placing the shock electrodes in locations that may reduce discomfort.

The invention discloses a sweating suppression deodorant composition which comprises the following components in percentage by weight: 0.01-3% of cyperus rotundus root extract, 0.01-3% of farnesol, 0.01-3% of honeysuckle flower extract, 0.01-3% of mulberry leaf extract, 5-30% of antiperspirant, 0.1-3% of essential oil and the balance of auxiliaries. The sweating suppression deodorant composition disclosed by the invention can be prepared into multiple dosage forms; due to the interaction of multiple active components, the sweating suppression deodorant composition has the functions of suppressing sweat gland secretion, suppressing smelly bacteria, eliminating dampness with aromatics and protecting skin and diminishing inflammation; and the sweating suppression deodorant composition is rich in natural plant components and has the characteristics of little toxic and side effect, high effect taking speed, lasting effect and good clinical effect.

The invention relates to the technical field of traditional Chinese medicines, and provides application of quercetin in preparing a medicine for treating polycystic ovarian syndrome. A test is performed on a rat model with polycystic ovarian syndrome by adopting quercetin, and discovers that the quercetin has a remarkable treatment effect and can remarkably reverse insulin resistance. Quercetin does not have liver or kidney toxicity, is small in side effect, has a good clinical application prospect, does not have drug resistance, can avoid operative wounds, and obtains an excellent clinical effect in PCOS (polycystic ovary syndrome) treatment.

The invention discloses a preparation method for a fructus lycii extract, relates to a preparation method for an extract of a traditional Chinese medicinal material fructus lycii and aims to solve the problems of incomplete extraction of effective components, low extraction rate, low oral bioavailability and waste of resources in a conventional fructus lycii extract preparation method. The preparation method disclosed by the invention comprises the following steps of 1, purifying fructus lycii medicinal materials; 2, pulverizing the medicinal materials through a freezing pulverizer; 3, performing supercritical CO2 extraction; 4, performing alcohol extraction on herb residues; 5, recycling an alcohol extraction solution; 6, performing water extraction on residues; 7, concentrating a water extraction solution, and combining medicine liquids; 8, performing low-temperature depression drying on the combined medicine liquid; 9, pulverizing a dry extract through gas flow; 10, uniformly mixing the dry extract powder. The preparation method disclosed by the invention can be used for fully extracting the effective components, which can be absorbed by a human body, in the fructus lycii medicinal materials; the oral bioavailability is high; the clinical application treating effect is good; the resources cannot be wasted; the extraction rate is increased by about 30 percent than that in the conventional normal extraction method. The preparation method is mainly applied to the field of natural medicine extract preparation.

The invention discloses a preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation, prepared from creeping dichondra, berchemia lineate, verbena, stephania root, herba patriniae, herba epimedii, milk vetch, red peony root, salviae miltiorrhizae and auxiliary materials. According to the preparation method disclosed by the invention, a preparation process is optimized according to properties of each medicine in a formula of creeping dichondra-berchemia lineata-verbena Gantai granules and the effect of the medicine in the formula; and compared with the prior art, the preparation method disclosed by the invention has the advantages that content of active ingredients of a product prepared by the preparation method disclosed by the invention is high and clinical effect is good.

An oral liquid for promoting digestion and its preparation method. The liquid is prepared from chinese feveruine, hawkthorn,wheat germ, medicated leaven, betelnut, dried tangerine peel and weeping forsythia.

The invention discloses a Chinese patent medicament for treating aplastic anemia. The Chinese patent medicament comprises the following Chinese herbal medicines: prepared rehmannia root, figwort root, dwarf lilyturf tuber, oriental waterplantain rhizome, mulberry, India madder root, gardenia, tree paeony bark, lalang grass rhizome and the like. The Chinese patent medicament contains fewer ingredients according to a formula, is mixed scientifically, does not have toxic or side effect, and has an obvious treatment effect on acute and chronic aplastic anemia. By the treatment with the Chinese patent medicament, the effective rate of the aplastic anemia is over 90 percent, and the cure rate is over 80 percent. The Chinese patent medicament has a good clinical treatment effect on aplastic anemia and has the high safety of clinical administration, and bone marrow transplantation is prevented, so the treatment cost is low.

The invention provides a tumor model for screening an anti-tumor treatment protocol, a method for preparing the tumor model and a method for screening the anti-tumor treatment protocol by virtue of the tumor model. The tumor model is derived from a tumor tissue formed in a first organism, and is obtained by proliferating the tumor tissue formed in the first organism in a second organism, wherein the first organism is different from the second organism. By the tumor model, therapy for the first organism can be effectively screened.

The invention discloses a Chinese medicine composition for treating pains and a preparation method thereof. The Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals: 300-1200 parts of safflower, 300-1200 parts of peach kernel, 300-900 parts of rhizoma corydalis, 300-900 parts of myrrh, 300-1200 parts of angelica, 300-900 parts of rhizoma ligustici wallichii, 300-1200 parts of achyranthes, 300-900 parts of earthworm, 300-600 parts of notopterygium, 300-600 parts of large-leaved gentian, 300-600 parts of rhizoma cyperi and 300-900 parts of liquoric root. According to the invention, parameters of processes for extracting and purifying the effective ingredients of the bulk pharmaceutical chemicals are optimized, a supercritical CO2 extraction technology is utilized to extract essential oil and macroporous resin adsorption is utilized to purify and enrich pharmaceutical ingredients. The preparation of the Chinese medicine composition provided by the invention has the advantages of good efficacy, short disintegration time, fast dissolution and rapid adsorption speed, high bioavailability and the like, is not easy to absorb moisture and degrade, and does not contain crude drug powder.

The invention discloses a human antibody sample molecular TEM8-Fc based on tumor endothelium marker 8 (TEM8) and the application thereof in tumor therapy and pertains to the biological pharmaceutical field. TEM8-Fc fusion protein is recombinant dimer fusion protein by the linkage of the 1-227 amino acid at extracellular domain of the TEM8, fc fragment, heavy chain constant region 2 and heavy chain constant region 3 of human immunoglobulin IgG1; mature single strand TEM8-Fc has 432 amino acid residues and the dimer has 864 amino acid residues. The invention has the advantages of small side effect, high specificity and wide indication. Animal experiments show that TEM8-Fc can not only effectively inhibit growth of tumor cells such as breast cancer, colorectal cancer, liver cancer, etc. in nude mice, but also can inhibit metastasis of cancer cells such as breast cancer, colorectal cancer, liver cancer, etc., and the angiogenesis in tumor tissues and reverse tumor cells phenotype.

The invention discloses propranolol hydrochloride submicron emulsion gel and a preparation method and application thereof. The propranolol hydrochloride submicron emulsion gel comprises propranolol hydrochloride and pharmaceutical acceptable medicinal excipients, wherein the medicinal excipients comprise oil, a surfactant, a cosurfactant, a penetration enhancer, a gel substrate, a pH conditioning agent and the balance water. The propranolol hydrochloride submicron emulsion gel can efficiently deliver the propranolol hydrochloride to skin tissue to enable drugs to be released slowly, skin targeted drug delivery treatment on superficial infantile hemangioma is achieved, and the problems that for an existing drug, the curative effect is low, the side effect is large, and the transdermal absorption ratio is low are effectively solved.