544results about How to "Good clinical efficacy" patented technology

Milling and drilling tools and soft tissue management techniques are provided for arthroplasty that facilitate intraoperative and postoperative efficacy and ease of use. In one embodiment, resiliently biased soft tissue protective sleeves surround a side cutting tool and are interposed along the longitudinal axis of the cutting tool, preferably adjacent each side of the bone. The soft tissue protective sleeves are biased to track along the contour of the side of the bone and prevent the cutting tool from being exposed to soft tissue during the resection. In another embodiment, a pilot drill is initially utilized to create an initial bore in the bone to be resected. The pilot drill preferably has an end cutting arrangement and a non-cutting removal channel that minimizes the tendency of the pilot drill bit to drift off-axis as the initial bore in the bone is created. Once the initial bore is created, the pilot drill bit is withdrawn and a second side cutting tool, such as a milling bit, is then inserted into the bore to perform the desired surface resection.

Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.

The present invention relates to a medicine preparation with raw material comprising gen-seng, RADIX OPHIOPOGONIS and schizan drin and relates to the methods of preparing and quality control of the invention as well as relates to the quality control method of the raw material comprising gen-seng, radix ophiopogonis and schizan drin. The present invention comprises saponins content of gen-seng, amylase content of gen-seng, saponins content of radix ophiopogonis and neolignan content of schizan drin. Each unit dosage of preparation comprises Rg1 and Re for 0.08 mg-12 mg, polysaccharide of gen-seng for 1mg-460mg, general saponins for 5 mg-800 mg and Schisandrin for 0.036mg-6mg. a medicine functioning as cooperation can be or can not be added in the present invention which can be any acceptable medicine preparation type comprising oral taking solid preparation, oral taking semi-solid preparation, oral taking liquid preparation and injection. The present invention also provides the quality control method of gen-seng, RADIX OPHIOPOGONIS and schizan drin as well as the quality control method of the present invention.

The present invention relates to one kind of sodium-potassium andrographolide-semisuccinate and its preparations. On the basis of potassium andrographolide-semisuccinate, which is not enough stable and is likely to produce precipitate and negative effect, sodium-potassium andrographolide-semisuccinate is developed and has relatively high stability and less side effect. The sodium-potassium andrographolide-semisuccinate is prepared into injection, powder for injection and other forms.

The invention provides a traditional Chinese medicine composition for treating lumbar muscle strain. A medicine for oral administration of the traditional Chinese medicine composition is prepared from the following raw materials: 10-20 parts of herba epimedii, 10-20 parts of polygonum cuspidatum, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of loranthus parasiticus, 10-20 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of fructus liquidambaris, 10-20 parts of gentiana macrophylla, 10-20 parts of dogwood, 10-20 parts of salvia miltiorrhiza, 10-20 parts of lycopodium clavatum, 10-20 parts of ramulus mori, 10-20 parts of radix dipsaci, 10-20 parts of phryma leptostachya, 10-20 parts of fructus psoraleae, 10-20 parts of davallia mariesii, 10-20 parts of kadsura pepper stem and 10-20 parts of red paeony root; an external-use medicine of the traditional Chinese medicine composition is prepared from the following raw materials: 10-20 parts of artemisia anomala, 10-20 parts of caulis spatholobi, 10-20 parts of radix clematidis, 10-20 parts of asarum, 10-20 parts of prepared frankincense, 10-20 parts of myrrh, 10-20 parts of radix dipsaci, 10-20 parts of saposhnidoviae radix, 10-20 parts of cassia twig, 10-20 parts of davallia mariesii, 10-20 parts of fructus liquidambaris, 10-20 parts of phryma leptostachya,10-20 parts of ground beetle and 10-20 parts of kadsura pepper stem. As a treatment method of invigorating the kidney and replenishing essence, activating blood and removing stasis and activating meridians and stopping pains is clinically utilized, the traditional Chinese medicine composition achieves good clinical curative effects on treatment of lumbar muscle strain.

The invention provides a dual-phase capsule for preventing and treating chronic pelvic inflammation and a preparation method and a detection method thereof. The dual-phase capsule for preventing and treating chronic pelvic inflammation is prepared by extracting 20g of Chinese pulsatilla root, 20g of nutgrass galingale rhizome, 12g of twotooth achyranthes, 12g of Chinese atractylodes, 8g of amur corktree bark and 8g of selinum japenious seed serving as bulk pharmaceuticals, adding a proper amount of superfine silica powder and low-substituted hydroxypropyl cellulose, and adding 80 percent ethanol as a wetting agent. Aiming at the defects in the prior art, a preparation process of the dual-phase capsule for preventing and treating chronic pelvic inflammation is optimized, so that the curative effect of the dual-phase capsule on chronic pelvic inflammation is more remarkable. A systematic, complete and effective component identification and content determination method is established, so that the quality of the dual-phase capsule can be controlled effectively, and the clinical curative effect is ensured.

The invention relates to a compound liquorice tablet and a preparation process thereof. The compound liquorice tablet comprises the following raw materials: liquorice root extracts, opium powder, camphor, star anise oil, sodium benzoate, an adsorbent and a corrective. The preparation process comprises the following steps: adding the adsorbent in the raw material composition, and hiding special foul smell of the camphor and the star anise oil by adopting an adsorption method to eliminate the foul smell; adding the corrective in the raw material composition to enable the compound liquorice tablet to have satisfactory mouthfeel. Therefore, the compound liquorice tablet prepared by the invention is suitable for being taken orally, excellent in mouthfeel, good in clinical effects, and high in bioavailability. Meanwhile, through the improvement on the process, especially, a manner of performing direct tabletting on powder is adopted, so that the compound liquorice tablet is remarkably improved in process level, stable in quality and stable in effect; the production cost of the product is further reduced, and the tablet can serve patients better.

The invention discloses a multifunctional carrier based on cytogenic vesicle in body fluid, a preparation method and an application. The method comprises the following steps: (1) collecting human body fluid, performing gradient ultra-centrifugation, removing supernatant and using sterile PBS heavy suspension for precipitating and (2) adding the cytogenic membrane vesicle from the body fluid, ultra-small luminescent material and electroporation buffer solution into an electric shock cup, uniformly mixing, placing onto an electroporation instrument and treating, placing under room temperature and repairing after the ending of electroporation, performing ultra-centrifugation and then using sterile PBS heavy suspension for precipitating, thereby acquiring the multifunctional carrier based on the cytogenic membrane vesicle from the body fluid and marked with the ultra-small luminescent material. The carrier is used for preparing a chemotherapeutic drug or gene therapeutic drug for treating or preventing tumor, has high biocompatibility, is convenient to carry various therapeutic drugs, is capable of effectively restraining tumor growth, is suitable for diagnosis and treatment of various innocent and malignant tumors and especially supplies a choice for the diagnosis and treatment of deep tumors in skull, thoracic cavity and abdominal cavity.

The invention discloses a sweating suppression deodorant composition which comprises the following components in percentage by weight: 0.01-3% of cyperus rotundus root extract, 0.01-3% of farnesol, 0.01-3% of honeysuckle flower extract, 0.01-3% of mulberry leaf extract, 5-30% of antiperspirant, 0.1-3% of essential oil and the balance of auxiliaries. The sweating suppression deodorant composition disclosed by the invention can be prepared into multiple dosage forms; due to the interaction of multiple active components, the sweating suppression deodorant composition has the functions of suppressing sweat gland secretion, suppressing smelly bacteria, eliminating dampness with aromatics and protecting skin and diminishing inflammation; and the sweating suppression deodorant composition is rich in natural plant components and has the characteristics of little toxic and side effect, high effect taking speed, lasting effect and good clinical effect.

The invention discloses a preparation method for a fructus lycii extract, relates to a preparation method for an extract of a traditional Chinese medicinal material fructus lycii and aims to solve the problems of incomplete extraction of effective components, low extraction rate, low oral bioavailability and waste of resources in a conventional fructus lycii extract preparation method. The preparation method disclosed by the invention comprises the following steps of 1, purifying fructus lycii medicinal materials; 2, pulverizing the medicinal materials through a freezing pulverizer; 3, performing supercritical CO2 extraction; 4, performing alcohol extraction on herb residues; 5, recycling an alcohol extraction solution; 6, performing water extraction on residues; 7, concentrating a water extraction solution, and combining medicine liquids; 8, performing low-temperature depression drying on the combined medicine liquid; 9, pulverizing a dry extract through gas flow; 10, uniformly mixing the dry extract powder. The preparation method disclosed by the invention can be used for fully extracting the effective components, which can be absorbed by a human body, in the fructus lycii medicinal materials; the oral bioavailability is high; the clinical application treating effect is good; the resources cannot be wasted; the extraction rate is increased by about 30 percent than that in the conventional normal extraction method. The preparation method is mainly applied to the field of natural medicine extract preparation.

The invention discloses a preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation, prepared from creeping dichondra, berchemia lineate, verbena, stephania root, herba patriniae, herba epimedii, milk vetch, red peony root, salviae miltiorrhizae and auxiliary materials. According to the preparation method disclosed by the invention, a preparation process is optimized according to properties of each medicine in a formula of creeping dichondra-berchemia lineata-verbena Gantai granules and the effect of the medicine in the formula; and compared with the prior art, the preparation method disclosed by the invention has the advantages that content of active ingredients of a product prepared by the preparation method disclosed by the invention is high and clinical effect is good.

The invention discloses a Chinese patent medicament for treating aplastic anemia. The Chinese patent medicament comprises the following Chinese herbal medicines: prepared rehmannia root, figwort root, dwarf lilyturf tuber, oriental waterplantain rhizome, mulberry, India madder root, gardenia, tree paeony bark, lalang grass rhizome and the like. The Chinese patent medicament contains fewer ingredients according to a formula, is mixed scientifically, does not have toxic or side effect, and has an obvious treatment effect on acute and chronic aplastic anemia. By the treatment with the Chinese patent medicament, the effective rate of the aplastic anemia is over 90 percent, and the cure rate is over 80 percent. The Chinese patent medicament has a good clinical treatment effect on aplastic anemia and has the high safety of clinical administration, and bone marrow transplantation is prevented, so the treatment cost is low.

The invention provides a tumor model for screening an anti-tumor treatment protocol, a method for preparing the tumor model and a method for screening the anti-tumor treatment protocol by virtue of the tumor model. The tumor model is derived from a tumor tissue formed in a first organism, and is obtained by proliferating the tumor tissue formed in the first organism in a second organism, wherein the first organism is different from the second organism. By the tumor model, therapy for the first organism can be effectively screened.

The invention discloses a human antibody sample molecular TEM8-Fc based on tumor endothelium marker 8 (TEM8) and the application thereof in tumor therapy and pertains to the biological pharmaceutical field. TEM8-Fc fusion protein is recombinant dimer fusion protein by the linkage of the 1-227 amino acid at extracellular domain of the TEM8, fc fragment, heavy chain constant region 2 and heavy chain constant region 3 of human immunoglobulin IgG1; mature single strand TEM8-Fc has 432 amino acid residues and the dimer has 864 amino acid residues. The invention has the advantages of small side effect, high specificity and wide indication. Animal experiments show that TEM8-Fc can not only effectively inhibit growth of tumor cells such as breast cancer, colorectal cancer, liver cancer, etc. in nude mice, but also can inhibit metastasis of cancer cells such as breast cancer, colorectal cancer, liver cancer, etc., and the angiogenesis in tumor tissues and reverse tumor cells phenotype.