Chinese medicine composition for treating pains and preparation method thereof

Abstract

The invention discloses a Chinese medicine composition for treating pains and a preparation method thereof. The Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals: 300-1200 parts of safflower, 300-1200 parts of peach kernel, 300-900 parts of rhizoma corydalis, 300-900 parts of myrrh, 300-1200 parts of angelica, 300-900 parts of rhizoma ligustici wallichii, 300-1200 parts of achyranthes, 300-900 parts of earthworm, 300-600 parts of notopterygium, 300-600 parts of large-leaved gentian, 300-600 parts of rhizoma cyperi and 300-900 parts of liquoric root. According to the invention, parameters of processes for extracting and purifying the effective ingredients of the bulk pharmaceutical chemicals are optimized, a supercritical CO2 extraction technology is utilized to extract essential oil and macroporous resin adsorption is utilized to purify and enrich pharmaceutical ingredients. The preparation of the Chinese medicine composition provided by the invention has the advantages of good efficacy, short disintegration time, fast dissolution and rapid adsorption speed, high bioavailability and the like, is not easy to absorb moisture and degrade, and does not contain crude drug powder.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating pain and a preparation method thereof, and belongs to the field of traditional Chinese medicine compositions for treating pain. Background technique

[0002] The most typical feature of stasis-blocking meridian syndrome is pain. Pain is a common clinical disease, which can be found in common and difficult diseases in various departments such as internal medicine, surgery, gynecology, children, orthopedics, nerves, facial features, etc. In clinical practice, severe or persistent pain often leads to mental and mental distress of patients. Physical secondary injuries seriously affect the patient's health and quality of life. More than one-third of the world's population suffers from persistent or recurrent pain, and there are about 100 million pain patients in my country. Two-thirds of patients who visit the hospi...

Examples

Embodiment 1

[0045] The preparation of embodiment 1 capsule

[0046] (1) Accurately weigh 900g of safflower, 900g of peach kernel, 600g of Yuanhu, 300g of myrrh, 900g of angelica, 600g of Chuanxiong, 900g of Achyranthes bidentata, 600g of earthworm, 300g of notopterygium, 300g of genus chinensis, and 300g of Cyperus cyperus after selection and purification. , Radix Glycyrrhizae 600g; The above-mentioned crude drug is pulverized, and set aside.

[0047] (2) Ligusticum chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus cyperi were placed in HA221-40-48 supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 30MPa, extraction temperature 35°C, extraction time 120min, entrainer is acetone, CO 2 The flow rate is 25L / h, the extracted medicinal residues are used for later use, and the volatile oil is collected. Each ml of volatile oil is clathrated with 6g o...

Embodiment 2

[0051] The preparation of embodiment 2 capsules

[0052] (1) Accurately weigh 300g of safflower, 300g of peach kernel, 300g of rhubarb, 300g of myrrh, 300g of angelica, 300g of chuanxiong, 300g of Achyranthes bidentata, 300g of earthworm, 300g of notopterygium, 300g of genus chinensis, and 300g of Cyperus cyperus after selection and purification. , Radix Glycyrrhizae 300g; The above-mentioned crude drug is pulverized, set aside;

[0053] (2) Ligusticum chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus cyperi were placed in supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 35MPa, extraction temperature 30°C, extraction time 90min, entrainer is acetone, CO 2 The flow rate is 20L / h, the extracted medicinal residues are used for later use, the volatile oil is collected, 8g of cyclodextrin is used for clathrate with saturated aqueous so...

Embodiment 3

[0057] The preparation of embodiment 3 capsules

[0058] (1) Accurately weigh 1200g of safflower, 1200g of peach kernel, 900g of pedicel, 900g of myrrh, 1200g of angelica, 900g of Chuanxiong, 1200g of Achyranthes bidentata, 900g of earthworm, 600g of notopterygium, 600g of Gentiana chinensis, Cyperus cyperi 600g, licorice 900g; pulverize the above-mentioned raw materials, set aside.

[0059] (2), put Chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus in supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 40MPa, extraction temperature 35°C, extraction time 120min, entrainer acetone, CO 2 The flow rate is 25L / h, the extracted medicinal residues are used for later use, and the volatile oil is collected, and 4g of cyclodextrin is used for inclusion of each ml of volatile oil by ultrasonic method, and the inclusion compound is dried at 37°...

technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating pain and a preparation method thereof, and belongs to the field of traditional Chinese medicine compositions for treating pain. Background technique

[0002] The most typical feature of stasis-blocking meridian syndrome is pain. Pain is a common clinical disease, which can be found in common and difficult diseases in various departments such as internal medicine, surgery, gynecology, children, orthopedics, nerves, facial features, etc. In clinical practice, severe or persistent pain often leads to mental and mental distress of patients. Physical secondary injuries seriously affect the patient's health and quality of life. More than one-third of the world's population suffers from persistent or recurrent pain, and there are about 100 million pain patients in my country. Two-thirds of patients who visit the hospi...

Examples

Embodiment 1

[0045] The preparation of embodiment 1 capsule

[0046] (1) Accurately weigh 900g of safflower, 900g of peach kernel, 600g of Yuanhu, 300g of myrrh, 900g of angelica, 600g of Chuanxiong, 900g of Achyranthes bidentata, 600g of earthworm, 300g of notopterygium, 300g of genus chinensis, and 300g of Cyperus cyperus after selection and purification. , Radix Glycyrrhizae 600g; The above-mentioned crude drug is pulverized, and set aside.

[0047] (2) Ligusticum chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus cyperi were placed in HA221-40-48 supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 30MPa, extraction temperature 35°C, extraction time 120min, entrainer is acetone, CO 2 The flow rate is 25L / h, the extracted medicinal residues are used for later use, and the volatile oil is collected. Each ml of volatile oil is clathrated with 6g o...

Embodiment 2

[0051] The preparation of embodiment 2 capsules

[0052] (1) Accurately weigh 300g of safflower, 300g of peach kernel, 300g of rhubarb, 300g of myrrh, 300g of angelica, 300g of chuanxiong, 300g of Achyranthes bidentata, 300g of earthworm, 300g of notopterygium, 300g of genus chinensis, and 300g of Cyperus cyperus after selection and purification. , Radix Glycyrrhizae 300g; The above-mentioned crude drug is pulverized, set aside;

[0053] (2) Ligusticum chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus cyperi were placed in supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 35MPa, extraction temperature 30°C, extraction time 90min, entrainer is acetone, CO 2 The flow rate is 20L / h, the extracted medicinal residues are used for later use, the volatile oil is collected, 8g of cyclodextrin is used for clathrate with saturated aqueous so...

Embodiment 3

[0057] The preparation of embodiment 3 capsules

[0058] (1) Accurately weigh 1200g of safflower, 1200g of peach kernel, 900g of pedicel, 900g of myrrh, 1200g of angelica, 900g of Chuanxiong, 1200g of Achyranthes bidentata, 900g of earthworm, 600g of notopterygium, 600g of Gentiana chinensis, Cyperus cyperi 600g, licorice 900g; pulverize the above-mentioned raw materials, set aside.

[0059] (2), put Chuanxiong, safflower, notopterygium, myrrh, angelica and Cyperus in supercritical CO 2 In the extractor (Nantong Huaan Supercritical Extraction Co., Ltd.), supercritical CO 2 Extract volatile oil, the extraction conditions are: extraction pressure 40MPa, extraction temperature 35°C, extraction time 120min, entrainer acetone, CO 2 The flow rate is 25L / h, the extracted medicinal residues are used for later use, and the volatile oil is collected, and 4g of cyclodextrin is used for inclusion of each ml of volatile oil by ultrasonic method, and the inclusion compound is dried at 37°...

Images