326 results about "Inclusion compound" patented technology

The invention belongs to the technical field of flame retardants, and particularly relates to a high-thermal-stability polyphosphate flame retardant and a preparation method thereof. The DOPO is modified through the polyethylene glycol acrylate, methyl methacrylate and dicumyl peroxide composite solution, double bonds of the polyethylene glycol acrylate and P-H bonds of the DOPO can be subjected to nucleophilic addition to form stable C-P bonds, and thermal migration of the DOPO is hindered; dOPO has polymerization double bonds of methyl methacrylate and long carbon chains of polyethylene glycol acrylate, so that the compatibility of the polyphosphate flame retardant and a polymer substrate is improved, and phase separation is avoided; maleic anhydride grafted silicone oil is connected to the surface of an amino modified gamma-cyclodextrin-modified DOPO inclusion compound, so that the polyphosphate flame retardant has high thermal stability and high compatibility after long-chain alkyl modification; amino groups in the modified gamma-cyclodextrin react with maleic anhydride grafted silicone oil to generate an amido bond cross-linked network, so that the thermal migration of DOPO is reduced together, and the high thermal stability of the polyphosphate flame retardant is improved.

The invention discloses a polyrotaxane covalent organic framework material capable of regulating interlayer spacing through cyclodextrin and application of the polyrotaxane covalent organic framework material, and belongs to the technical field of biological medicine. The polyrotaalkylated covalent organic framework material is obtained by taking a cyclodextrin aromatic multi-amino inclusion compound and a (multi-aldehyde bipyridine) ruthenium (II) complex as structural units and carrying out copolymerization; the cyclodextrin aromatic polyamine inclusion compound is a beta-cyclodextrin p-phenylenediamine inclusion compound with a hydroxyl group or without a hydroxyl group; the (multi-aldehyde dipyridyl) ruthenium (II) complex is tris (4, 4 '-diformaldehyde-2, 2'-dipyridyl) ruthenium (II). The interlayer spacing of the polyrotaxane covalent organic framework material is greatly increased by utilizing a cavity of gamma-cyclodextrin, and meanwhile, the material has excellent photo-thermal and photodynamic activity, is positively charged, and can better adsorb negatively charged bacteria; and the hydrogel is good in biocompatibility and free of toxic and side effects, and has an excellent treatment effect on wounds infected with staphylococcus aureus.

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.

The invention relates to a method for increasing the sweetness value of carbohydrates by using an aroma substance containing isoeugenol, which comprises the following steps: mixing the carbohydrates and the aroma substance containing isoeugenol, and exploring the influence on the sweetness response value by using an electronic tongue and a molecular simulation technology. The aroma substance containing isoeugenol comprises isoeugenol or an isoeugenol capsule clathrate compound, the carbohydrate substance comprises cane sugar, and the isoeugenol capsule clathrate compound is an isoeugenol / gamma-cyclodextrin capsule clathrate compound. Compared with the prior art, the sweetening effect of the isoeugenol is obvious under the cane sugar concentration of 7wt%-9wt%; the sweetening effect of the isoeugenol capsule clathrate compound is higher than that of isoeugenol under the same condition, the aroma is more lasting and soft at high temperature, the sweet response value is larger, molecular docking shows that the capsule clathrate compound further strengthens the interaction between sucrose and sweet receptor protein, a theoretical support is provided for precise regulation and control of food flavor, and the isoeugenol capsule clathrate compound has good application prospects. The method can be used for developing novel food and beverage products.

The invention discloses a method for reducing the content of aged starch and soluble miscellaneous sugar in alpha-cyclodextrin, and belongs to the technical field of alpha-cyclodextrin synthesis, the method comprises the following steps: liquefaction, conversion, primary filtration, inclusion, secondary filtration, complexing agent removal and post-treatment; the conversion comprises the following steps: adding alpha-CGTase and isoamylase into the starch liquefied liquid at 38-42 DEG C, adjusting the pH value to 5.30-5.70, and carrying out conversion to obtain a conversion liquid; the primary filtration comprises the following steps: carrying out enzyme deactivation treatment on the conversion liquid, filtering, washing a filter cake with water, and combining the washing liquid with the filtrate to obtain primary filtrate; and the secondary filtration comprises the following steps: filtering the material liquid containing the complex, taking a filter cake, and washing the filter cake with water to obtain the inclusion compound. The preparation method of the alpha-cyclodextrin is improved, so that the alpha-cyclodextrin with high yield and high stability is obtained, and the industrial controllability is realized.

The invention discloses a novel long-acting bird repellent and a preparation method thereof, and belongs to the technical field of chemical bird repelling. The bird repellent is composed of a core material and a wall material, the core material is a mixture of geraniol, cinnamyl aldehyde and allicin according to the mass ratio of 1: (1.2-1.5): (0.5-0.8), the wall material is modified beta-cyclodextrin and pumpkin seed protein nanoparticles, and the mass ratio of the geraniol, the cinnamyl aldehyde and the allicin is (5-7): (3-5): (1-3). The preparation method comprises the following steps: preparing the quaternary ammonium salt modified beta-cyclodextrin, including the core material, performing high-speed shearing emulsification on the quaternary ammonium salt modified beta-cyclodextrin and the pumpkin seed protein nano dispersion liquid, and performing freeze drying to obtain a final product. According to the invention, a stable and compact'molecular inclusion + physical barrier 'dual slow-release structure is constructed by utilizing the electrostatic interaction between the positively charged modified beta-cyclodextrin and the negatively charged protein nanoparticles, the release time of effective components is remarkably prolonged to 9 months or more, and the composite material has excellent rain wash resistance and ultraviolet resistance, and can be used for preparing a composite material with a good application prospect. And efficient, environment-friendly and long-acting bird repelling is realized.

The invention belongs to the technical field of food preservation, and particularly relates to a chitosan / polyvinyl alcohol film loaded beta-acid / beta-cyclodextrin inclusion compound as well as a preparation method and application thereof. The method comprises the following steps: adding beta-acid / beta-cyclodextrin into distilled water, grinding and centrifuging, and freeze-drying the obtained supernatant to obtain the beta-acid / beta-cyclodextrin inclusion compound. The preparation method comprises the following steps: mixing a PVA solution with a chitosan solution, adding glycerol to obtain a mixed solution, dissolving the beta-acid / beta-cyclodextrin inclusion compound in water, adding the dissolved beta-acid / beta-cyclodextrin inclusion compound into the mixed solution, stirring, standing and drying to obtain the film. The prepared film has good physical properties and stability, has good oxidation resistance and antibacterial activity, can inhibit adhesion of pathogenic microorganisms such as staphylococcus aureus on the surfaces of perishable fruits, and prolongs the shelf life of the perishable fruits.

The invention relates to a dihydroartemisinic acid inclusion compound as well as a preparation method and application thereof. The dihydroarteannuic acid clathrate compound comprises dihydroarteannuic acid and a cyclodextrin compound wrapping the dihydroarteannuic acid. The cyclodextrin compound comprises cyclodextrin and / or a cyclodextrin derivative. According to the invention, the inclusion effect of the cyclodextrin compound on the dihydroarteannuic acid is utilized, so that dihydroarteannuic acid molecules are embedded in the tubular structure of the cyclodextrin compound, and the water solubility of the dihydroarteannuic acid is greatly improved.

The invention discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by salicylic acid, amino acid and a cyclodextrin derivative through non-covalent bond interaction, the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, salicylic acid molecules are included in a cavity of the cross-linked beta-cyclodextrin polymer, and the cross-linked beta-cyclodextrin polymer is a cross-linked beta-cyclodextrin polymer. And meanwhile, guanidyl or carboxyl of an amino acid side chain interacts with hydroxyl outside the cross-linked beta-cyclodextrin polymer or an exposed part of an included salicylic acid molecule. According to the invention, a cross-linked beta-cyclodextrin polymer is used, arginine is introduced as a synergist, a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary clathrate compound is constructed, and through charge neutralization and hydrogen bond network synergistic effect, clathration efficiency is significantly improved, and water solubility of salicylic acid is improved.

The invention relates to a method for detecting the encapsulation efficiency of an injection of a cytomegalovirus inhibitor. Comprising the following steps: mixing an injection of the cytomegalovirus inhibitor with diethyl ether according to a certain volume ratio, carrying out extraction separation, and carrying out quantitative analysis by using high performance liquid chromatography after separation. The detection method is simple and rapid, and can ensure the accuracy of the detection result of the encapsulation efficiency without using a complex instrument and almost without damaging the structure of the inclusion compound. Meanwhile, the method meets the requirements of accuracy and repeatability.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine micro-powder capsule based on functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain. 0.8%-1.2% of scorpion; 0.8%-1.2% of Chinese polyphaga; 0.8%-1.2% of safflower carthamus; 0.8%-1.2% of peach kernels; 0.8%-1.2% of zaocys dhumnade; 0.8% to 1.2% of frankincense; 0.8%-1.2% of ligusticum wallichii; 0.8%-1.2% of cortex moutan; 0.8% to 1.2% of myrrh; 0.8%-1.2% of notopterygium root; 0.8%-1.2% of radix angelicae pubescentis; 0.8%-1.2% of fructus lycii; 0.8%-1.2% of centipede; 15%-25% of a functional auxiliary material: 3%-5% of a nano dispersion carrier; and 3%-5% of an inclusion compound. By adopting a beta-cyclodextrin inclusion technology, volatile oil and a humid and hot environment can be effectively isolated, the stability of the volatile oil can be enhanced, by taking ligustrazine as an example, under an accelerated test condition, the retention rate of the ligustrazine in 6 months is up to 89.5%, and compared with a non-inclusion condition, the retention rate is improved, the degradation rate is reduced by 3.1 times, and the stability of the core component for promoting blood circulation to remove blood stasis in the storage and use process is ensured.

The invention relates to the technical field of materials, in particular to light-cured aluminum oxide ceramic slurry and a preparation method thereof. The preparation method of the light-cured aluminum oxide ceramic slurry comprises the following preparation steps: preparation of alkenyl chitosan nanofibers, preparation of modified monomers, preparation of clathrate powder, preparation of a photosensitive resin premixed solution, preparation of clathrate powder and preparation of the light-cured aluminum oxide ceramic slurry. According to the preparation method, by introducing the alkenyl chitosan nanofiber and the inclusion compound powder, the rheological property, the sintering compactness and the mechanical property of the light-cured aluminum oxide ceramic slurry are remarkably improved, meanwhile, the apparent porosity and the shrinkage rate are reduced, and the preparation method is suitable for preparing the high-performance ceramic core.

The invention provides a preparation method for a reverse osmosis membrane resistant to a high-temperature water environment, comprising: synthesizing an α-cyclodextrin@polyethylene glycol supramolecular inclusion complex by a saturated aqueous solution coprecipitation method; preparing an aqueous phase solution containing m-phenylenediamine, D(+) camphorsulfonic acid and triethylamine; preparing an oil phase solution containing trimesoyl chloride; preparing a secondary aqueous solution containing α-cyclodextrin@polyethylene glycol powder and triethylamine; forming an ultrathin polyamide separation layer on a base membrane by interfacial polymerization; and performing secondary interfacial polymerization to form an α-CD@PEG polyester protection layer, and storing a prepared reverse osmosis membrane in ultrapure water.

The invention relates to the technical field of biology, in particular to silymarin inclusion compound lipidosome and a preparation method and application thereof. The silymarin inclusion compound liposome is prepared from the following components in parts by weight: 10 to 48 parts of silymarin, 10 to 53 parts of phospholipid, 5 to 10 parts of Arabic gum and 25 to 70 parts of cyclodextrin. According to the invention, cyclodextrin and phospholipid are combined to form a double-drug-loading structure; on the basis, Arabic gum is used as a film-forming agent to form a protective film on the surface of the liposome, so that the stability of the system is further improved; the silymarin inclusion compound is encapsulated in a water phase in the liposome, and meanwhile, part of free silymarin is encapsulated in a lipid bilayer. According to the structure, the solubility and the encapsulation efficiency of the silymarin are remarkably improved, the liposome stability is enhanced, the drug release is effectively controlled, and the silymarin inclusion compound lipid is simple in preparation process and suitable for industrial production.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The invention belongs to the technical field of coatings, and particularly relates to a high-flash-point phenolic anticorrosive coating as well as a preparation method and application thereof. The high-flash-point phenolic anticorrosive paint is prepared from the following raw materials in parts by mass: 40 to 70 parts of xylene phenolic resin, 30 to 60 parts of hyperbranched polyester modified phenolic resin, 10 to 15 parts of silicone acrylic emulsion, 5 to 10 parts of modified glass fiber, 5 to 10 parts of pigment, 3 to 8 parts of solvent, 3 to 8 parts of light stabilizer-beta-cyclodextrin inclusion compound and 1 to 3 parts of drier. A coating layer obtained by the phenolic anticorrosive paint provided by the invention has good adhesive force, flexibility, long-term salt fog resistance, weather resistance and heat and humidity resistance.

The application relates to the technical field of traditional Chinese medicines, in particular to a uric acid reducing composition and a preparation method thereof. The uric acid reducing composition comprises 35-45 parts of a cyclodextrin inclusion compound, 25-35 parts of nano-liposomes, 20-30 parts of a chicory extract-phospholipid complex and 5-8 parts of an antioxidant complex; the preparation method of the cyclodextrin inclusion compound comprises the following steps: step 1, adding beta-cyclodextrin into water, stirring and dissolving, adding pueraria extract, drying after inclusion reaction, and obtaining inclusion compound a; step 2, adding hydroxypropyl-gamma-cyclodextrin into water, stirring, adding mulberry leaf extract, drying after inclusion, and obtaining inclusion compound b; and step 3, mixing the inclusion compound a and the inclusion compound b, and obtaining the product. The uric acid reducing composition can more comprehensively and efficiently reduce blood uric acid level, and has high safety, high stability and high bioavailability. The preparation method is simple, easy to industrialize and beneficial to large-scale industrial production.

The present application provides a rhodiolide composition with a core-shell-shell structure, a preparation method thereof comprising the steps of: 1) EGCG inclusion: adding beta-cyclodextrin and EGCG into water, ultrasonic, forming an inclusion compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, dissolving in chloroform to form a uniform solution; weighing rhodiolide, dissolving in the uniform solution, rotary evaporation to remove chloroform, then adding the inclusion compound and PBS buffer into the container, hydrating, forming a liposome wrapping rhodiolide and inclusion compound; 3) shell loading: weighing collagen, mixing with chitosan solution uniformly to form a complex; adding the complex into the liposome, the complex is coated on the outer layer of the liposome, centrifugal purification, obtaining a rhodiolide composition with a core-shell-shell structure. The present application belongs to the technical field of cosmetic raw materials, and the rhodiolide composition provided has the advantages of high stability, good transdermal effect, and significant anti-aging effect.

The invention discloses a covalent organic framework antibacterial material with NO light-controlled release as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The covalent organic framework antibacterial material is a porous polymer taking a cyclodextrin inclusion compound and a porphyrin metal coordination compound as structural units; a plurality of porphyrin metal coordination compounds surround the cyclodextrin inclusion compound in each structural unit, and the porphyrin metal coordination compounds are not on the same plane; the cyclodextrin inclusion compound is obtained by inclusion of BNN6 with beta-cyclodextrin; the porphyrin metal coordination compound is a coordination compound of porphyrin and copper. The preparation method comprises the following steps: firstly preparing a cyclodextrin porphyrin porous polymer, then matching the cyclodextrin porphyrin porous polymer with copper and entrapping BNN6 to obtain a covalent organic framework antibacterial material, utilizing NO release and combining simulated photo-thermal, photodynamic, peroxidase and glutathione peroxidase to achieve synergistic antibacterial effect, and remarkably accelerating the recovery of bacterial infected wounds.

The invention belongs to the technical field of functional condiments, and provides a functional minced garlic sauce based on fermentation engineering and a preparation method thereof.According to the functional minced garlic sauce based on fermentation engineering and the preparation method thereof, the design that a lactic acid fermentation minced garlic matrix is combined with a double-layer structure functional microcapsule dispersion phase is adopted, and an inner core layer is composed of a clathrate compound formed by gamma cyclodextrin and allicin; an outer shell is formed by compounding protein and high-methoxyl pectin under a specific pH condition and is subjected to calcium ion cross-linking stabilization, and an immobilized gamma-glutamyltransferase conversion and a lactobacillus plantarum and lactobacillus rhamnosus co-fermentation process are adopted; the microcapsule has the advantages that the content of S-allyl L-cysteine is larger than or equal to 220 mg / kg, the particle size D50 of the microcapsule is 5-10 micrometers, and the viable bacterium stability is good under the low-salt condition, the technical problems that allicin retention and stability of minced garlic seasoning products are insufficient, and functional ingredient enrichment and viable bacterium stability are difficult to consider under the low-salt condition are solved, and the technical effects that the content of S-allyl L-cysteine is larger than or equal to 220 mg / kg and the particle size D50 of the microcapsule is 5-10 micrometers are achieved. And the method has a wide industrial application value.

The invention provides a salidroside composition with a core-shell-shell structure, and a preparation method of the salidroside composition comprises the following steps: 1) EGCG (epigallocatechin gallate) clathration: adding beta-cyclodextrin and EGCG into water, and carrying out ultrasonic treatment to form a clathrate compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, and dissolving in chloroform to form a uniform solution; the preparation method comprises the following steps: weighing salidroside, dissolving the salidroside in a uniform solution, carrying out rotary evaporation to remove chloroform, then adding an inclusion compound and a PBS (Phosphate Buffer Solution) into a container, and hydrating to form lipidosome wrapping the salidroside and the inclusion compound; 3) shell loading: weighing collagen, and uniformly mixing the collagen with the chitosan solution to form a compound; the salidroside composition with the core-shell-shell structure is obtained by dropwise adding the compound into the lipidosome, coating the outer layer of the lipidosome with the compound and carrying out centrifugal purification. The invention belongs to the technical field of cosmetic raw materials, and provides a salidroside composition which has the advantages of high stability, good transdermal effect, remarkable anti-aging effect and the like.

The invention provides a dual-response antibacterial nanofiber membrane and a preparation method thereof, an antibacterial aminated gelatin nano inclusion compound is loaded into a polyvinyl alcohol-chitosan matrix through an electrostatic spinning technology to prepare a nanofiber membrane, citral is further loaded in a closed adsorption mode, and the dual-response antibacterial nanofiber membrane is prepared. The antibacterial nanofiber membrane with the humidity and gelatinase dual responsiveness is obtained. The antibacterial nanofiber membrane disclosed by the invention can directly wrap the periphery of a meat product, and citral is adaptively released by increasing the environmental humidity so as to inhibit the proliferation of microorganisms; besides, when endogenous or exogenous microorganisms infect the surfaces of the meat products, gelatinase secreted by the microorganisms is used as a sensor to further release antibacterial substances, the antibacterial substances can be released according to actual fresh-keeping requirements in the storage, transportation and circulation process of the meat products, the problems that antibacterial components are released too early and the timeliness is short are solved, the storage time of the meat products can be remarkably prolonged, and the safety of the meat products is improved. And the spoilage is delayed.

The invention relates to an application of a limonene inclusion compound solution in bacteriostasis or insect killing. According to the limonene inclusion compound solution prepared by the invention, starch is used as a main raw material, and the conversion rate of cyclodextrin is effectively improved through an enzymolysis technology of a synergistic effect of dextrin debranching enzyme and beta-CGT enzyme. The limonene molecules can be uniformly dispersed in the aqueous solution in various stable forms, so that the solubility of the limonene molecules is remarkably improved, the biological activity of the limonene is effectively reserved, and the problem that the traditional solid powder aqueous solution is limited in part of application fields is solved. Compared with a conventional limonene product, the limonene inclusion compound solution has a remarkable prevention and treatment effect on various pests, shows broad-spectrum antibacterial performance and has a good inhibition effect on various bacteria such as escherichia coli and bacillus subtilis. Besides, the limonene inclusion compound solution also shows good stability and durability when applied to the fields of medicine, food or agriculture, and has wide market prospects and application values.

The invention discloses a catechin-beta-cyclodextrin oleate nanoparticle inclusion compound (CAT-CDO) and a preparation method thereof.The preparation method comprises the steps that a 75% ethanol water solution is added into beta-cyclodextrin oleate (CAT), catechin is dissolved in 20 mL of ethanol solution, the catechin solution is dropwise added into a CAT solution at the temperature of 30 DEG C in a dark place, and a reaction is conducted under stirring; centrifuging the mixed solution to remove undissolved solids, so as to obtain a supernatant which is an inclusion compound solution; and freeze-drying the inclusion compound solution to obtain inclusion compound solid powder. The CAT-CDO prepared by the invention has a good solubilizing effect on CAT, and the antioxidant stability, the release performance, the photo-thermal stability and the cytotoxicity of the CAT are effectively improved. Besides, catechin can be replaced by any other phenolic compounds, and the phenolic compounds and CDO are prepared into a nanoparticle inclusion compound, so that the effects of solubility, antioxidant stability and the like of phenolic substances are improved, and the application performance of the phenolic substances in various fields is further improved.

This invention discloses a method for preparing a detergency-removing composite solution and its gel membrane, as well as its applications. Based on the host-guest inclusion mechanism of cyclodextrin, its hydrophobic cavity is achieved by "encapsulating" hydrophobic molecules or their hydrophobic portions. The volume of the hydrophobic portion / functional group of the complexing agent molecule is smaller than the volume of the cyclodextrin cavity. The complexing agent forms a complex with cyclodextrin, thus dispersing well in the solution. Furthermore, complexing agents with good coordination ability for radioactive ions can almost always form inclusion complexes with cyclodextrin. The polysaccharide molecular chains used in this invention are rich in hydrophilic functional groups such as hydroxyl and amino groups, giving the gel membrane good hydrophilicity, low ion transport resistance, and short equilibrium time. The hydroxyl and amino functional groups also participate in the coordination process of radioactive ions, further improving the adsorption capacity of the gel membrane. The method and application of this invention have strong universality, can simultaneously remove multiple radioactive ions, and can be used on a large scale.

The application discloses a modified bromhexine hydrochloride inhalation solution with enhanced stability and a preparation method thereof, and belongs to the technical field of medical preparations. The inhalation solution is mainly prepared from a targeting impurity control modified bromhexine hydrochloride inclusion compound, a special composite buffer mother liquor for inhibiting impurity B, inhalation grade sodium chloride, pharmaceutical grade sodium hydroxide and water for injection, and the pH value of the finished product is 4.5-5.5. The application constructs a three-stage progressive modification system, covalently grafts a mercapto-activated L-cysteine derivative onto hydroxypropyl-gamma-cyclodextrin to prepare a functional carrier, and realizes molecular-level isolation of bromhexine hydrochloride through host-guest inclusion, thereby blocking the generation of impurity B of bromhexine hydrochloride from the whole path, and solving the core pain points of easy impurity exceeding, short effective period and airway irritation of the existing product. The application can realize long-acting stable storage for 36 months, is suitable for the existing industrial production line, and has high clinical application and industrialization values.

A method for producing an inclusion complex drug includes the following steps: adding cyclodextrin to an aqueous solution of ibuprofen sodium salt at a saturation concentration at a first temperature, then placing it in an electrodialysis apparatus to obtain a first crystallization solution; then removing it and adding acid to adjust the pH to 6.0-6.5, controlling the temperature at a second temperature to obtain a second crystallization solution; placing the second crystallization solution in an electrodialysis apparatus to obtain a third crystallization solution; then removing it and continuing to add acid to adjust the pH to below 3.0 to obtain a fourth crystallization solution; filtering and recovering the fourth crystallization solution, and rinsing to obtain the ibuprofen inclusion complex. This application uses pre-added cyclodextrin, with cyclodextrin and the ibuprofen sodium salt obtained from the reaction as feedstock, then obtaining the second crystallization solution through electrodialysis acidification and acid treatment, followed by electrodialysis to obtain raw materials that can be used as nucleation sites for crystallization, and finally adding acid for final crystallization. The entire crystallization process is controllable.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a cyclodextrin inclusion compound and a preparation method thereof.The cyclodextrin inclusion compound comprises voriconazole, a cosolvent and sulfobutyl-beta-cyclodextrin, by increasing use of the cosolvent polysorbate 80 (II), the use amount of sulfobutyl ether-beta-cyclodextrin in voriconazole for injection is reduced, and the content of the sulfobutyl ether-beta-cyclodextrin in voriconazole for injection is reduced; the invention aims at remarkably reducing cyclodextrin accumulation in the body and provides guarantee for medication safety of patients with moderate to severe renal function impairment. Meanwhile, the preparation process is simple, industrial production is facilitated, and the inclusion effect of the inclusion compound and the stability of the product can be guaranteed.

The invention belongs to the technical field of medical dressings, and provides a hydrocolloid acne patch and a preparation method thereof. According to the invention, beta-cyclodextrin functionalized gelatin and adamantane functionalized hyaluronic acid are subjected to inclusion interaction to form a reversible cross-linked network, and hydroxypropyl trimethyl ammonium chloride chitosan and sodium carboxymethyl cellulose are subjected to electrostatic interaction to form a polyelectrolyte cross-linked network; the genipin is combined with a primary amine group amido bond to form a triple cross-linked network structure design of a covalent cross-linked network, and antibacterial components such as a gamma-cyclodextrin-salicylic acid inclusion compound are loaded, so that the excellent properties that the self-healing recovery rate is 90-95%, the water vapor transmission rate is 500-900g. M <-2 >. 24h <-1 >, and the peel strength is greater than or equal to 1.0 N / 25mm are realized; the technical problem that an existing hydrocolloid acne patch is insufficient in antibacterial persistence and self-healing and repairing capacity is solved, and wide application value is achieved.

The invention discloses a processing method for improving the quality of a surimi product by using a V-type starch-grease inclusion compound. The method comprises the following steps: preparing V-type starch, preparing a V-type starch-grease inclusion compound, blending raw materials, carrying out gradient thermal induction, cooling and shaping, carrying out vacuum exhausting and filling, and sterilizing. The V-type starch-grease inclusion compound is added into the surimi product, and the V-type starch can be embedded into a gel matrix after absorbing water and expanding, so that the flowability of water is effectively limited, the water-holding capacity of the surimi product is further enhanced, and the cooking loss is reduced; and pores in the gel can be physically filled and occupied, so that the gel network structure is more compact, the deformation resistance is improved, and the elasticity and the gel strength of the surimi product are enhanced, thereby optimizing the texture characteristics. The V-type starch-grease inclusion compound also effectively masks characteristic fishy smell substances of the surimi and releases specific flavor components of the starch-grease, so that the surimi product has better flavor characteristics.