1403 results about "Inclusion compound" patented technology

A polishing slurry used in chemical mechanical polishing of a barrier layer and an interlayer dielectric film in a semiconductor integrated circuit includes an abrasive, an oxidizer, an anticorrosive, an acid, a surfactant and an inclusion compound. The polishing slurry has a pH of less than 5. The resulting polishing slurry contains a solid abrasive used in barrier CMP for polishing a barrier layer made of a metallic barrier material, has excellent storage stability, achieves a good polishing rate in various films to be polished such as the barrier layer, and is capable of independently controlling the polishing rate with respect to the various films to be polished while further suppressing agglomeration of the abrasive particles.

The invention relates to compounds of structural formula (I) or (III): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein ring A, X1, X2, X3, X5, R1, R4, Y, Z, L, m and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

The invention relates to compounds of structural formula (Ia): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, X4, X6, X10, R1, Y, Z, L, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

The invention relates to a wound treating agent for humans and / or animals which contains a zeolite-iodine inclusion compound, to the use of such wound treating agent for the preparation of wound-stilling materials, especially compresses, plasters and / or dressing material, and to such wound-stilling materials.

The invention relates to compounds of structural formulas (I) and (XVI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, Z, L, L2, R1, R2, R3, R21, n, q, and t are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

A pharmaceutical composition an inclusion complex and methods for treating patients and preparing said complex disclosed for transmucosal delivery comprising an inclusion complex of (a) alprazolam and (b) a water soluble 2-hydroxypropyl-beta-cyclodextrin, and a pharmaceutically acceptable carrier therefor, wherein all the alprazolam is present in ring-closed form.

The present invention is directed to a method of making an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the method comprises the steps of: a)contacting the acylated cyclodextrin host molecule and the guest molecule to form an inclusion complex; and b) precipitating the inclusion complex in an aqueous medium. The present invention is further directed to an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the guest molecule comprises from about 2% (wt.) to about 15% (wt.) of the inclusion complex. Moreover, the present invention relates to a composition comprising a polymer and an inclusion complex, wherein the inclusion complex comprises an acylated cyclodextrin host molecule and a guest molecule and medical devices and solid pharmaceutical compositions comprised thereof.

The invention provides a tamper-resistant dosage form including a therapeutic agent-substrate complex embedded in a thermo-formable matrix; such that the complex includes at least one therapeutic agent bound to at least one substrate to form the therapeutic agent-substrate complex. The at least one substrate is being selected from the group consisting of a polyelectrolyte, an organic counter-ion, a pharmacologically inert organic component of a prodrug, an inclusion compound and an inorganic adsorbent; and the thermo-formable matrix includes one or more thermoplastic polymers and optionally at least one pharmaceutical additive.

This invention provides a soluble inclusion complex formed of a water-insoluble lipophilic compound and an amphiphilic polymer and which demonstrated improved solubility and stability. The lipophilic compound within the inclusion complex may consist of pharmaceutical compounds, food additives, cosmetics, agricultural products and veterinary products. The invention also provides novel methods for preparing the inclusion complex, as well as a novel chemical reactor for forming the inclusion complex.

The invention relates to a preparation method of tobacco extract granules, which comprises the following steps: firstly taking and cutting up tobacco leaves and / or tobacco stalks, taking water or ethanol or ethyl ether as a solvent for extraction, settling and filtering to obtain tobacco extract, then concentrating to the relative density of 1.00-1.30, and controlling the temperature to 20-40 DEGC to obtain tobacco extract concentrate or tobacco extractum; and including beta-cyclodextrin and flavouring essence for tobacco according to the mass ratio of 1-3:1 with the inclusion time of 1 / 5-3 hours to obtain a flavouring essence and beta-cyclodextrin inclusion compound, and then spray drying the flavouring essence for tobacco and beta-cyclodextrin inclusion compound and the tobacco extractconcentrate together to obtain tobacco spray dried powder; or directly spray drying the tobacco extractum to obtain the tobacco spray dried powder; and then adding excipient material to the tobacco spray dried powder for dry method or wet method granulation to obtain the tobacco extract granules. The tobacco extract granules obtained in the method disclosed by the invention are applied to cigarettes to improve the tar and harm reduction effect of the cigarettes, and can be used for aroma compensation, the utilization rate of waste tobacco leaf raw material is improved, and the cost of the cigarettes is reduced.

The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula:or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula:with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent.In one embodiment, the present invention is a method of synthesis of a compound of formula (IA)or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA)with an oxidizing agent, thereby producing a compound of formula (IA).The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula:or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula:in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

Disclosed herein is a regioselective synthesis of compounds represented by formula (I):or a salt, solvate, clathrate, or prodrug thereof, wherein X, Y, R2, R3, R4, R7, R8, R9, R10, m and n are defined as within.

The invention relates to a drug-loaded contact lenses and a corresponding preparation method. The drug-loaded contact lenses are obtained firstly through UV-curing or heat-curing and then through drug-liquid immersion. The drug-loaded contact lenses can be particularly defined as a combination of a contact lenses material containing cyclodextrin and drug molecules and comprise the contact lenses formed by combining a crosslinked polymer hydrogel formed by copolymerizing mono-substituted cyclodextrin monomers, polymerization monomers and crosslinkers with one kind or a plurality of acetazolamide, methazolamide, puerarin or prostaglandin. The characteristic of forming inclusion compounds between the cyclodextrin molecules and drug molecules is adopted to increase the quantity of loaded drugs so as to reduce the stimulation to eyes by drugs and control the drug release speed for eye diseases of curing glaucoma, etc.

The invention belongs to the technical field of medicaments, and relates to TS-1 granules for treating advanced gastric cancer and a preparation method thereof. The method comprises the following steps of: preparing active medicaments tegafur, gimeracil and potassium oxonate into a cyclodextrin inclusion compound; and sieving the inclusion compound, uniformly mixing the sieved inclusion compound and pharmaceutically acceptable auxiliary materials and performing wet granulation or dry granulation to prepare the granules. The granules have the advantages of increasing the water solubility and stability of the medicaments, covering the bitter taste of the tegafur, prolonging the action time, improving the medication compliance of patients with cancer, greatly improving the bioavailability of the medicaments and reducing the toxic or side effect of the medicaments.

The invention discloses application of an inclusion technology in preparing animal medicines, and an animal medicine inclusion compound. The animal medicine inclusion compound can increase the dissolution velocity and the solubility of indissolvable medicines, improve the stability of the medicines which are changeable in the presence of lights or moistures and the like, and facilitate the storage of medicines. The invention also provides a method for preparing the animal medicine inclusion compound, and the method is simple in operation, can reduce the use of organic solvent, lower the cost, reduce the poisonous side effects of the medicines, and can be applied to the preparation of animal medicines.

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD / AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD / AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light / temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.

The invention discloses a preparation method and application of a medicament-cyclodextrin inclusion compound self-emulsifying composition. The composition is prepared through the following steps: preparing a medicament-cyclodextrin inclusion compound by combining a medicament and cyclodextrin; mixing the medicament-cyclodextrin inclusion compound, an oil phase, an emulsifier, an assistant emulsifier, a stabilizer and an additive; and completely dissolving the materials through magnetic stirring or ultrasonic; and uniformly mixing. The composition has the advantages that the defects of low solubility of poorly water-soluble drugs, low bioavailability, low drug-loading rate and the like are overcome, the medicament stability is greatly improved, the problems of poor emulsifier stability, large storage volume and the like caused by a water phase are solved, and the effect of sustaining medicament release can be achieved. The preparation method has the advantages of simplicity, developed process, high yield of the composition and suitability for industrial production.

The invention belongs to the fields of nanometer materials and antimicrobial packaging materials for foods, and discloses a hydrophobic nanofiber membrane containing plant essential oil and a preparation method and an application thereof. The preparation method comprises the following steps: 1, preparing cinnamon essential oil / [beta]-cyclodextrin inclusion compound; 2, preparing polylactic acid solution with the mass concentration of 5%-25%; 3, adding the cinnamon essential oil / [beta]-cyclodextrin inclusion compound with the mass concentration of 5%-20% into the solution obtained in the step 2, and stirring to obtain spinning solution; 4, sucking the spinning solution into an syringe, installing a syringe needle with the diameter of 0.6-0.8mm, adjusting the distance between the syringe needle and a receiver to be 8-20cm, spinning for 3-6h under conditions that the voltage is 7-25kV and the flow rate of the spinning solution is 1.5-4mL / h, drying and thus obtaining the hydrophobic nanofiber membrane containing plant essential oil. The hydrophobic nanofiber membrane containing plant essential oil has good bactericidal effect, and can well prolong quality guarantee periods of meat products and the like, thus being capable of serving as the packaging material for foods.

A stable inclusion compound for the antistaling purpose of fruit, vegetable, flower, plant, etc. is prepared from 1-methyl cyclopropene, starch and alpha-cyclodextrin or its derivative by using of a reaction system, which is composed of 1-methyl cyclopropene generator, three-pass gas washing unit, inclusion reactor and tail gas absorbing unit.

The invention discloses a dihydromyricetin cyclodextrin inclusion compound, which comprises cyclodextrin and dihydromyricetin, wherein the dihydromyricetin is embedded into a cyclodextrin cavity; and the inclusion compound employing the cyclodextrin as a host molecule and dihydromyricetin as a guest molecule is formed. The dihydromyricetin cyclodextrin inclusion compound has the beneficial effects that 1 the dihydromyricetin cyclodextrin inclusion compound is embedded by the cyclodextrin, and the solubility, the stability and the bioavailability of the dihydromyricetin are improved; 2 the preparation method of the dihydromyricetin cyclodextrin inclusion compound disclosed by the invention is simple in process and suitable for industrialized production; 3 a spray drying process is adopted, the process from spray drying to dust collection is finished within 20 seconds, the problem of product oxidation in the drying process is avoided, the method is simple in process, simple and convenient to operate; the production conditions are easy to control, and the inclusion rate of the dihydromyricetin is high; and 4 the dihydromyricetin used by the dihydromyricetin cyclodextrin inclusion compound is extracted from vitaceae ampelopsis, and the dihydromyricetin in the vitaceae ampelopsis is high in content, and is a natural substance and free of toxicity.

A preparation method of a rose essence beta-cyclodextrin polymer microsphere inclusion compound comprises the following steps: preparing a beta-cyclodextrin polymer microsphere by an inverse emulsion polymerization method; dissolving rose essential oil in a small amount of anhydrous ethanol; including the solution with the beta-cyclodextrin polymer microsphere by a saturated aqueous solution method; and after completion of inclusion, eluting and performing vacuum decompressed drying to obtain an inclusion product. The preparation method of the rose essence beta-cyclodextrin polymer microsphere inclusion compound takes the beta-CD (cyclodextrin) as a matrix which is crosslinked by epichlorohydrin, and uses the beta-CD microsphere which is synthesized by the inverse emulsion polymerization method, so that not only the original cavity structure and the slow-release and controlled-release and identification capabilities of the beta-CD are kept, but also the hydrophobicity of a beta-CD cavity is improved, the inclusion is promoted and the inclusion rate is improved; and due to intermolecular synergistic inclusion after beta-cyclodextrin polymerization, so that rose essence and a substance with similar structure and solubility to the rose essence can be firmly clamped, thus playing a relatively good slow-release effect.

The invention discloses a method for loading a hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber. The method comprises the following steps of: (1) preparing the hydrophobic medicament-beta cyclodextrin inclusion compound; (2) dissolving the hydrophobic medicament-beta cyclodextrin inclusion compound into water to prepare solution with the mass concentration of 1.0 to 4.0 percent; (3) dissolving the hydrophilic polymer raw material into water to prepare solution with the mass concentration of 3.0 to 10.0 percent; and (4) mixing the solution uniformly to obtain electrospinning liquid, and preparing the electrospinning nanofiber by using an electrostatic spinning instrument under the conditions of the voltage of 15 to 20 kV, the spinning temperature of between 50 and 60 DEG C and the propelling speed of 0.001 to 0.003 mm / s. By the method, the hydrophobic medicament molecules are loaded in the hydrophilic polymer electrospinning nanofiber uniformly and controlled to release.

It is to improve the storage stability of a sealant, to retain the flowability of the sealant when sealing, and to achieve an effective curing rate of the sealant by heating to be applicable as a sealant for delicate semiconductors.It is an epoxy resin composition for sealing a semiconductor, comprising the following component (A) and component (B).(A) an epoxy resin,(B) a clathrate complex comprising(b1) an aromatic carboxylic acid compound, and(b2) at least one imidazole compound represented by formula (II)(wherein R2 represents a hydrogen atom, etc.; R3 to R5 represent a hydrogen atom, etc.).

The invention provides a berberine organic acid salt, a berberine organic acid salt inclusion compound and preparations method thereof. The berberine organic acid salt consists of an alkali base and a salt ligand, wherein the alkali base is a jamaicin alkali base; the salt ligand is an acid radical of organic acid; the mole ratio of the alkali base to the acid radical of organic acid is 1:1; and the berberine organic acid salt inclusion compound consists of an inclusion base material and the berberine organic acid salt. The method for preparing the berberine organic acid salt comprises the following steps of: neutralizing solution of jamaicin and solution of organic acid into salt; crystallizing the salt; and filtering, leaching and drying the crystallized salt so as to obtain the berberine organic acid salt. The method for preparing the berberine organic acid salt inclusion compound comprises the following steps of: dissolving the inclusion base material; adding the berberine organic acid salt into the dissolved inclusion base material for dissolving and inclusion; cooling and standing reaction liquid to separate coprecipitate out; leaching the coprecipitate with acetone; and drying a filter cake so as to obtain the berberine organic acid salt inclusion compound. The berberine organic acid salt and the berberine organic acid salt inclusion compound provided by the invention have the advantages of high bioactivity, small dosage and high dissolubility. The preparation methods have the advantages of simple process, high product purity, easy operation control, simple equipment and easy realization of industrialized production.

The invention relates to the technical field of the cleaning of daily necessities, and discloses an air conditioner cleaning agent and a manufacturing method thereof. The air conditioner cleaning agent is characterized by comprising the following raw materials in percentage by weight: 1-5% of a surfactant, 5-15% of an environment-friendly organic solvent, 1-5% of a co-solvent, 2-7% of cyclodextrin, 0.1-2% of a sterilizing agent, 0.1-2% of a corrosion inhibitor, 0.1-0.5% of sodium pyrophosphate, 1-5% of sodium carbonate, 1-5% of sodium bicarbonate, 1-5% of sodium chloride, 0.5-1% of ethylene diamine tetraacetic acid, 0.1-0.5% of essence and the balance of deionized water. Compared with the prior art, the air conditioner cleaning agent disclosed by the invention has the advantages that (1) the co-solvent is added in the cleaning agent to increase the solubility of the raw materials in the solvent; cyclodextrin is added in the cleaning agent to reduce the irritations of the surfactant to the skin, and can be used for forming a stable inclusion compound with pollutants, thus reducing the environment pollution; and (2) the cleaning agent has good cleaning performances, can be used for cleaning the dirt completely, is low in cost and small in environment pollution, does not damage the air conditioner, and is convenient in use.

The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.