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391 results about "Inclusion compound" patented technology

In host–guest chemistry, an inclusion compound is a complex in which one chemical compound (the "host") has a cavity into which "guest" compound can be accommodated. The interaction between the host and guest involves purely van der Waals bonding. The definition of inclusion compounds is very broad, extending to channels formed between molecules in a crystal lattice in which guest molecules can fit.

Polyphosphate flame retardant with high thermal stability and preparation method thereof

The invention belongs to the technical field of flame retardants, and particularly relates to a high-thermal-stability polyphosphate flame retardant and a preparation method thereof. The DOPO is modified through the polyethylene glycol acrylate, methyl methacrylate and dicumyl peroxide composite solution, double bonds of the polyethylene glycol acrylate and P-H bonds of the DOPO can be subjected to nucleophilic addition to form stable C-P bonds, and thermal migration of the DOPO is hindered; dOPO has polymerization double bonds of methyl methacrylate and long carbon chains of polyethylene glycol acrylate, so that the compatibility of the polyphosphate flame retardant and a polymer substrate is improved, and phase separation is avoided; maleic anhydride grafted silicone oil is connected to the surface of an amino modified gamma-cyclodextrin-modified DOPO inclusion compound, so that the polyphosphate flame retardant has high thermal stability and high compatibility after long-chain alkyl modification; amino groups in the modified gamma-cyclodextrin react with maleic anhydride grafted silicone oil to generate an amido bond cross-linked network, so that the thermal migration of DOPO is reduced together, and the high thermal stability of the polyphosphate flame retardant is improved.
Owner:SHOUGUANG LUYUAN SALINIZATION CO LTD

Polyrotaxane covalent organic framework material for regulating interlayer spacing through cyclodextrin and application of polyrotaxane covalent organic framework material

The invention discloses a polyrotaxane covalent organic framework material capable of regulating interlayer spacing through cyclodextrin and application of the polyrotaxane covalent organic framework material, and belongs to the technical field of biological medicine. The polyrotaalkylated covalent organic framework material is obtained by taking a cyclodextrin aromatic multi-amino inclusion compound and a (multi-aldehyde bipyridine) ruthenium (II) complex as structural units and carrying out copolymerization; the cyclodextrin aromatic polyamine inclusion compound is a beta-cyclodextrin p-phenylenediamine inclusion compound with a hydroxyl group or without a hydroxyl group; the (multi-aldehyde dipyridyl) ruthenium (II) complex is tris (4, 4 '-diformaldehyde-2, 2'-dipyridyl) ruthenium (II). The interlayer spacing of the polyrotaxane covalent organic framework material is greatly increased by utilizing a cavity of gamma-cyclodextrin, and meanwhile, the material has excellent photo-thermal and photodynamic activity, is positively charged, and can better adsorb negatively charged bacteria; and the hydrogel is good in biocompatibility and free of toxic and side effects, and has an excellent treatment effect on wounds infected with staphylococcus aureus.
Owner:WEIFANG MEDICAL UNIV

Composition with effects of protecting liver and resisting oxidation and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.
Owner:BEIJING FUTAIMING BIOTECHNOLOGY CO LTD

Green and environment-friendly pH-responsive corrosion inhibitor as well as preparation method and application thereof

The invention belongs to the technical field of water treatment, and discloses a green and environment-friendly pH-responsive corrosion inhibitor as well as a preparation method and application thereof. The corrosion inhibitor comprises the following raw materials in parts by mass: 25-30 parts of green tea polyphenol, 10-15 parts of graphene oxide nanosheets, 15-25 parts of pH response type polymer corrosion inhibition microcapsules, 5-10 parts of a beta-cyclodextrin / corrosion inhibition salt inclusion compound, 5-10 parts of an amino acid derivative polymer, 3-5 parts of a thickening agent, 180-450 parts of a solvent, and an antioxidant accounting for 0.01-0.05% of the total mass of the raw materials. And a pH regulator is added to regulate the pH of the corrosion inhibitor to 7-8. According to the corrosion inhibitor, plant extracts and non-toxic chemical substances are adopted as main components, the requirements of environment-friendly materials are met, and under the synergistic effect of all the components, the corrosion inhibitor can keep stable in a high-temperature, oxygen-containing and high-salinity environment, and anti-corrosion protection can be provided for a long time.
Owner:武汉钢铁有限公司

Modified epoxidized soybean oil, epoxy resin adhesive and preparation method thereof

The invention discloses modified epoxidized soybean oil, epoxy resin glue and a preparation method thereof. The modified epoxidized soybean oil is obtained through a reaction of a cyclodextrin-epoxidized soybean oil inclusion compound and citric acid, and the cyclodextrin-epoxidized soybean oil inclusion compound is obtained through a reaction of cyclodextrin and epoxidized soybean oil. The epoxy resin adhesive is prepared from bisphenol A epoxy resin, modified epoxidized soybean oil, an anhydride curing agent and a curing accelerator. The modified epoxidized soybean oil is added into the epoxy resin adhesive, so that the epoxy resin adhesive has better tensile strength, elongation at break, impact strength and low-temperature impact strength, and the toughening effect is remarkable.
Owner:GUANGZHOU BAIYUN CHEM IND +1

Method for improving sweetness value of carbohydrates by using aroma substance containing isoeugenol

The invention relates to a method for increasing the sweetness value of carbohydrates by using an aroma substance containing isoeugenol, which comprises the following steps: mixing the carbohydrates and the aroma substance containing isoeugenol, and exploring the influence on the sweetness response value by using an electronic tongue and a molecular simulation technology. The aroma substance containing isoeugenol comprises isoeugenol or an isoeugenol capsule clathrate compound, the carbohydrate substance comprises cane sugar, and the isoeugenol capsule clathrate compound is an isoeugenol / gamma-cyclodextrin capsule clathrate compound. Compared with the prior art, the sweetening effect of the isoeugenol is obvious under the cane sugar concentration of 7wt%-9wt%; the sweetening effect of the isoeugenol capsule clathrate compound is higher than that of isoeugenol under the same condition, the aroma is more lasting and soft at high temperature, the sweet response value is larger, molecular docking shows that the capsule clathrate compound further strengthens the interaction between sucrose and sweet receptor protein, a theoretical support is provided for precise regulation and control of food flavor, and the isoeugenol capsule clathrate compound has good application prospects. The method can be used for developing novel food and beverage products.
Owner:SHANGHAI INST OF TECH

Method for reducing content of aged starch and soluble miscellaneous sugar in alpha-cyclodextrin

PendingCN121087125AFermentationAmylaseSugar
The invention discloses a method for reducing the content of aged starch and soluble miscellaneous sugar in alpha-cyclodextrin, and belongs to the technical field of alpha-cyclodextrin synthesis, the method comprises the following steps: liquefaction, conversion, primary filtration, inclusion, secondary filtration, complexing agent removal and post-treatment; the conversion comprises the following steps: adding alpha-CGTase and isoamylase into the starch liquefied liquid at 38-42 DEG C, adjusting the pH value to 5.30-5.70, and carrying out conversion to obtain a conversion liquid; the primary filtration comprises the following steps: carrying out enzyme deactivation treatment on the conversion liquid, filtering, washing a filter cake with water, and combining the washing liquid with the filtrate to obtain primary filtrate; and the secondary filtration comprises the following steps: filtering the material liquid containing the complex, taking a filter cake, and washing the filter cake with water to obtain the inclusion compound. The preparation method of the alpha-cyclodextrin is improved, so that the alpha-cyclodextrin with high yield and high stability is obtained, and the industrial controllability is realized.
Owner:SHANDONG GUOBANG PHARMA +1

Novel long-acting bird repellent and preparation method thereof

The invention discloses a novel long-acting bird repellent and a preparation method thereof, and belongs to the technical field of chemical bird repelling. The bird repellent is composed of a core material and a wall material, the core material is a mixture of geraniol, cinnamyl aldehyde and allicin according to the mass ratio of 1: (1.2-1.5): (0.5-0.8), the wall material is modified beta-cyclodextrin and pumpkin seed protein nanoparticles, and the mass ratio of the geraniol, the cinnamyl aldehyde and the allicin is (5-7): (3-5): (1-3). The preparation method comprises the following steps: preparing the quaternary ammonium salt modified beta-cyclodextrin, including the core material, performing high-speed shearing emulsification on the quaternary ammonium salt modified beta-cyclodextrin and the pumpkin seed protein nano dispersion liquid, and performing freeze drying to obtain a final product. According to the invention, a stable and compact'molecular inclusion + physical barrier 'dual slow-release structure is constructed by utilizing the electrostatic interaction between the positively charged modified beta-cyclodextrin and the negatively charged protein nanoparticles, the release time of effective components is remarkably prolonged to 9 months or more, and the composite material has excellent rain wash resistance and ultraviolet resistance, and can be used for preparing a composite material with a good application prospect. And efficient, environment-friendly and long-acting bird repelling is realized.
Owner:SHANDONG SHENYE ELECTRIC TECH CO LTD

Chitosan / polyvinyl alcohol film loaded beta-acid / beta-cyclodextrin inclusion compound as well as preparation method and application thereof

The invention belongs to the technical field of food preservation, and particularly relates to a chitosan / polyvinyl alcohol film loaded beta-acid / beta-cyclodextrin inclusion compound as well as a preparation method and application thereof. The method comprises the following steps: adding beta-acid / beta-cyclodextrin into distilled water, grinding and centrifuging, and freeze-drying the obtained supernatant to obtain the beta-acid / beta-cyclodextrin inclusion compound. The preparation method comprises the following steps: mixing a PVA solution with a chitosan solution, adding glycerol to obtain a mixed solution, dissolving the beta-acid / beta-cyclodextrin inclusion compound in water, adding the dissolved beta-acid / beta-cyclodextrin inclusion compound into the mixed solution, stirring, standing and drying to obtain the film. The prepared film has good physical properties and stability, has good oxidation resistance and antibacterial activity, can inhibit adhesion of pathogenic microorganisms such as staphylococcus aureus on the surfaces of perishable fruits, and prolongs the shelf life of the perishable fruits.
Owner:NINGXIA MEDICAL UNIVERSITY GENERAL HOSPITAL

Method for preparing microcapsules from beta-cyclodextrin inclusion compound microcrystal stabilized sandalwood essential oil

The invention discloses a method for preparing microcapsules from beta-cyclodextrin inclusion compound microcrystal stabilized sandalwood essential oil, and belongs to the technical field of microcapsule preparation. The method comprises the following steps: preparing sandalwood essential oil / beta-cyclodextrin inclusion compound microcrystals, emulsifying and dispersing the sandalwood essential oil by using the inclusion compound microcrystals as an emulsifier, adding resin, and carrying out a condensation reaction to prepare the microcapsule suspension. According to the preparation method, firstly, beta-cyclodextrin and essential oil are embedded to obtain clathrate microcrystals, then the clathrate microcrystals serve as an emulsifying agent, the emulsifying effect of the essential oil is improved, resin microcapsules are convenient to prepare, and the microcapsules prepared through the method are high in essential oil embedding rate and good in stability; beta-cyclodextrin inclusion compound microcrystals are selected as a Pickering emulsion stabilizer, so that the emulsifying and stabilizing effects are good, and the microcapsule emulsion is not layered.
Owner:INST OF WOOD INDUDTRY CHINESE ACAD OF FORESTRY

Dihydroartemisinic acid inclusion compound as well as preparation method and application thereof

The invention relates to a dihydroartemisinic acid inclusion compound as well as a preparation method and application thereof. The dihydroarteannuic acid clathrate compound comprises dihydroarteannuic acid and a cyclodextrin compound wrapping the dihydroarteannuic acid. The cyclodextrin compound comprises cyclodextrin and / or a cyclodextrin derivative. According to the invention, the inclusion effect of the cyclodextrin compound on the dihydroarteannuic acid is utilized, so that dihydroarteannuic acid molecules are embedded in the tubular structure of the cyclodextrin compound, and the water solubility of the dihydroarteannuic acid is greatly improved.
Owner:YUNNAN YUNKE CHARACTERISTIC PLANT EXTRACTION LABORATORY CO LTD +1

Dry and comfortable antibacterial menstrual period trousers and preparation method thereof

The invention discloses dry and comfortable antibacterial menstrual period pants and a preparation method thereof, and belongs to the technical field of female hygienic products, and the preparation method comprises the following steps: beta-cyclodextrin and sophocarpidine are utilized to form a superfine capsular inclusion compound, the superfine capsular inclusion compound is adsorbed on the surface of macroporous super absorbent resin to form antibacterial composite resin powder, and the antibacterial composite resin powder is sprayed on the surface of a composite aerogel sheet; when meeting blood, the affinity of water molecules to external hydroxyl groups of cyclodextrin is enhanced, so that the binding force of matrine and beta-cyclodextrin is weakened, and matrine is released; the antibacterial composite resin powder expands when encountering water, compresses and promotes the release of the nano antibacterial inclusion compound loaded on the surface, so that the release of the matrine contained in the antibacterial composite resin powder is accelerated, and a rapid and highly-targeted antibacterial effect is realized; the composite aerogel sheet can improve the resilience force of the menstrual period trousers, has an extremely high specific surface area, a nanoscale hole structure and an extremely low heat conductivity coefficient, and can effectively prevent heat transfer and improve air permeability.
Owner:AIFU (SHANGHAI) BIOTECHNOLOGY CO LTD

Salicylic acid-cyclodextrin-amino acid ternary inclusion compound as well as preparation method and application thereof

The invention discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by salicylic acid, amino acid and a cyclodextrin derivative through non-covalent bond interaction, the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, salicylic acid molecules are included in a cavity of the cross-linked beta-cyclodextrin polymer, and the cross-linked beta-cyclodextrin polymer is a cross-linked beta-cyclodextrin polymer. And meanwhile, guanidyl or carboxyl of an amino acid side chain interacts with hydroxyl outside the cross-linked beta-cyclodextrin polymer or an exposed part of an included salicylic acid molecule. According to the invention, a cross-linked beta-cyclodextrin polymer is used, arginine is introduced as a synergist, a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary clathrate compound is constructed, and through charge neutralization and hydrogen bond network synergistic effect, clathration efficiency is significantly improved, and water solubility of salicylic acid is improved.
Owner:AIXIMEI (ZHUHAI) BIOTECHNOLOGY CO LTD

Detection method for injection encapsulation efficiency of cytomegalovirus inhibitor

The invention relates to a method for detecting the encapsulation efficiency of an injection of a cytomegalovirus inhibitor. Comprising the following steps: mixing an injection of the cytomegalovirus inhibitor with diethyl ether according to a certain volume ratio, carrying out extraction separation, and carrying out quantitative analysis by using high performance liquid chromatography after separation. The detection method is simple and rapid, and can ensure the accuracy of the detection result of the encapsulation efficiency without using a complex instrument and almost without damaging the structure of the inclusion compound. Meanwhile, the method meets the requirements of accuracy and repeatability.
Owner:SHANGHAI HANHERUI PHARM TECH CO LTD

Traditional Chinese medicine micro-powder capsule for promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine micro-powder capsule based on functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain. 0.8%-1.2% of scorpion; 0.8%-1.2% of Chinese polyphaga; 0.8%-1.2% of safflower carthamus; 0.8%-1.2% of peach kernels; 0.8%-1.2% of zaocys dhumnade; 0.8% to 1.2% of frankincense; 0.8%-1.2% of ligusticum wallichii; 0.8%-1.2% of cortex moutan; 0.8% to 1.2% of myrrh; 0.8%-1.2% of notopterygium root; 0.8%-1.2% of radix angelicae pubescentis; 0.8%-1.2% of fructus lycii; 0.8%-1.2% of centipede; 15%-25% of a functional auxiliary material: 3%-5% of a nano dispersion carrier; and 3%-5% of an inclusion compound. By adopting a beta-cyclodextrin inclusion technology, volatile oil and a humid and hot environment can be effectively isolated, the stability of the volatile oil can be enhanced, by taking ligustrazine as an example, under an accelerated test condition, the retention rate of the ligustrazine in 6 months is up to 89.5%, and compared with a non-inclusion condition, the retention rate is improved, the degradation rate is reduced by 3.1 times, and the stability of the core component for promoting blood circulation to remove blood stasis in the storage and use process is ensured.
Owner:周士清

Toothpaste with biological activity and deodorization function and preparation method thereof

The invention relates to the technical field of toothpaste, and discloses toothpaste with biological activity and deodorization and a preparation method thereof, the toothpaste comprises the following raw materials: sucralose, glycerin, sorbitol, benzyl alcohol, sodium dihydrogen phosphate, water, hydrated silica, sodium carboxymethyl cellulose, xanthan gum, a deodorization modification material, a vitamin E inclusion compound, a foaming agent and essence; wherein the deodorizing modified material is obtained by modifying an antibacterial agent triclosan on the surface of tourmaline powder, so that the toothpaste is endowed with excellent antibacterial and deodorizing performance; the vitamin E clathrate compound is a protamine derivative coating vitamin E. In the use process, positive charges carried by protamine and mucous membranes with negative charges are utilized to generate an electrostatic adsorption effect, and the vitamin E clathrate compound is adhered to ulcers, so that the effects of positioning, slow-release and targeting are achieved, ulcer healing is promoted, and the healthy environment in the oral cavity is protected.
Owner:YIWU AISHANG COMMODITY

Nanometer needling instrument and preparation method and application thereof

The invention discloses a nanometer needling instrument and a preparation method and application thereof. The nanoneedle comprises an acupuncture needle with the surface modified with host molecules, and the host molecules comprise annular molecules capable of forming an inclusion compound structure. According to the acupuncture needle, the surface of the acupuncture needle is ingeniously modified to form annular molecules (such as cyclodextrin) of an inclusion compound structure, a cavity can be formed, the acupuncture needle is endowed with the capacity of loading and releasing functional molecules, and the dual effects of acupuncture and medicine delivery are effectively achieved.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

Coenzyme Q10 phospholipid-cyclodextrin double-layer inclusion compound and preparation method thereof

The invention discloses a coenzyme Q10 phospholipid-cyclodextrin double-layer inclusion compound and a preparation method thereof, and particularly relates to the technical field of food raw materials. A preparation form of double-layer inclusion of phospholipid on the inner layer and cyclodextrin on the outer layer is adopted, so that the solubility and bioavailability of the coenzyme Q10 are remarkably improved, and good stability is shown. Meanwhile, the preparation process is simple, the used organic solvent is relatively safe and single, and the method is suitable for industrial mass production.
Owner:NANJING AURORA BOREALIS BIOTECHNOLOGY CO LTD

Photo-cured aluminum oxide ceramic slurry and preparation method thereof

InactiveCN120157461AOxide ceramicNanofiber
The invention relates to the technical field of materials, in particular to light-cured aluminum oxide ceramic slurry and a preparation method thereof. The preparation method of the light-cured aluminum oxide ceramic slurry comprises the following preparation steps: preparation of alkenyl chitosan nanofibers, preparation of modified monomers, preparation of clathrate powder, preparation of a photosensitive resin premixed solution, preparation of clathrate powder and preparation of the light-cured aluminum oxide ceramic slurry. According to the preparation method, by introducing the alkenyl chitosan nanofiber and the inclusion compound powder, the rheological property, the sintering compactness and the mechanical property of the light-cured aluminum oxide ceramic slurry are remarkably improved, meanwhile, the apparent porosity and the shrinkage rate are reduced, and the preparation method is suitable for preparing the high-performance ceramic core.
Owner:JIYUAN GENGXIN PORCELAIN

Degradation control agent, refracturing controllable degradation plugging agent and preparation method

The invention discloses a degradation control agent, a refracturing controllable degradation plugging agent and a preparation method. The degradation control agent is an inclusion compound of cyclodextrin and benzoyl peroxide; the controllable degradation plugging agent for refracturing comprises the degradation control agent; the cyclodextrin molecule has an annular cavity structure, an internal cavity is non-polar, and benzoyl peroxide serving as an organic gel breaker can enter the cavity to form an inclusion compound; when a liquid rubber plug formed by the refracturing controllable degradation plugging agent is in a release medium, benzoyl peroxide molecules are released, inclusion balance is destroyed, deinclusion is carried out to carry out gel breaking degradation, and then the purpose of controllable degradation of the refracturing plugging agent is achieved by controlling the dosage of the degradation control agent.
Owner:DAQING OILFIELD CO LTD +1

Preparation method for reverse osmosis membrane resistant to high-temperature water environment

The invention provides a preparation method for a reverse osmosis membrane resistant to a high-temperature water environment, comprising: synthesizing an α-cyclodextrin@polyethylene glycol supramolecular inclusion complex by a saturated aqueous solution coprecipitation method; preparing an aqueous phase solution containing m-phenylenediamine, D(+) camphorsulfonic acid and triethylamine; preparing an oil phase solution containing trimesoyl chloride; preparing a secondary aqueous solution containing α-cyclodextrin@polyethylene glycol powder and triethylamine; forming an ultrathin polyamide separation layer on a base membrane by interfacial polymerization; and performing secondary interfacial polymerization to form an α-CD@PEG polyester protection layer, and storing a prepared reverse osmosis membrane in ultrapure water.
Owner:ZHEJIANG JINMO ENVIRONMENT TECH CO LTD

Application of hydroxypropyl-beta-cyclodextrin in preparation of Vilciguat solid preparation, solid preparation and preparation method

The invention belongs to the technical field of medicine preparation, and particularly relates to application of hydroxypropyl-beta-cyclodextrin in preparation of a Velciguat solid preparation, the solid preparation and a preparation method. The key protection of the invention is as follows: hydroxypropyl-beta-cyclodextrin is applied to the formation of a Vilciguat-cyclodextrin inclusion compound with Vilciguat, and then the inclusion compound is combined with other raw materials to prepare the Vilciguat solid preparation with excellent solubilizing effect, the average substitution degree of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, and the viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5. This is one of the keys of the invention. According to the present invention, a large number of experiments are performed, different types of beta-cyclodextrin and beta-cyclodextrin with different substitution degrees are compared, and finally hydroxypropyl-beta-cyclodextrin with an average substitution degree of 3.5-5.5 is selected to clathrate viriciguat, such that compared with hydroxypropyl-beta-cyclodextrin with other substitution degrees or other solubilizers, the solubilizing effect is excellent, and the solubilizing effect is good. Meanwhile, the stability is good, and the total impurity is almost unchanged after acceleration for 3 months.
Owner:JINAN LIMIN PHARMA

Silymarin inclusion compound liposome as well as preparation method and application thereof

The invention relates to the technical field of biology, in particular to silymarin inclusion compound lipidosome and a preparation method and application thereof. The silymarin inclusion compound liposome is prepared from the following components in parts by weight: 10 to 48 parts of silymarin, 10 to 53 parts of phospholipid, 5 to 10 parts of Arabic gum and 25 to 70 parts of cyclodextrin. According to the invention, cyclodextrin and phospholipid are combined to form a double-drug-loading structure; on the basis, Arabic gum is used as a film-forming agent to form a protective film on the surface of the liposome, so that the stability of the system is further improved; the silymarin inclusion compound is encapsulated in a water phase in the liposome, and meanwhile, part of free silymarin is encapsulated in a lipid bilayer. According to the structure, the solubility and the encapsulation efficiency of the silymarin are remarkably improved, the liposome stability is enhanced, the drug release is effectively controlled, and the silymarin inclusion compound lipid is simple in preparation process and suitable for industrial production.
Owner:EFFEPHARM (SHANGHAI) CO LTD

Pterostilbene-based stability enhanced antioxidant as well as preparation method and application thereof

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.
Owner:WANG SHUHE BIOMEDICINE (WUHAN) CO LTD

Phenolic anticorrosive paint with high flash point as well as preparation method and application of phenolic anticorrosive paint

ActiveCN119875462AAnti-corrosive paintsCyclodextrin coatingsXylyleneGlass fiber
The invention belongs to the technical field of coatings, and particularly relates to a high-flash-point phenolic anticorrosive coating as well as a preparation method and application thereof. The high-flash-point phenolic anticorrosive paint is prepared from the following raw materials in parts by mass: 40 to 70 parts of xylene phenolic resin, 30 to 60 parts of hyperbranched polyester modified phenolic resin, 10 to 15 parts of silicone acrylic emulsion, 5 to 10 parts of modified glass fiber, 5 to 10 parts of pigment, 3 to 8 parts of solvent, 3 to 8 parts of light stabilizer-beta-cyclodextrin inclusion compound and 1 to 3 parts of drier. A coating layer obtained by the phenolic anticorrosive paint provided by the invention has good adhesive force, flexibility, long-term salt fog resistance, weather resistance and heat and humidity resistance.
Owner:无锡市造漆厂有限公司

A composition for reducing uric acid and a method for preparing the same

ActiveCN120771238BOrganic active ingredientsPowder deliveryAscophyllum nodosum extractPhospholipid complex
The application relates to the technical field of traditional Chinese medicines, in particular to a uric acid reducing composition and a preparation method thereof. The uric acid reducing composition comprises 35-45 parts of a cyclodextrin inclusion compound, 25-35 parts of nano-liposomes, 20-30 parts of a chicory extract-phospholipid complex and 5-8 parts of an antioxidant complex; the preparation method of the cyclodextrin inclusion compound comprises the following steps: step 1, adding beta-cyclodextrin into water, stirring and dissolving, adding pueraria extract, drying after inclusion reaction, and obtaining inclusion compound a; step 2, adding hydroxypropyl-gamma-cyclodextrin into water, stirring, adding mulberry leaf extract, drying after inclusion, and obtaining inclusion compound b; and step 3, mixing the inclusion compound a and the inclusion compound b, and obtaining the product. The uric acid reducing composition can more comprehensively and efficiently reduce blood uric acid level, and has high safety, high stability and high bioavailability. The preparation method is simple, easy to industrialize and beneficial to large-scale industrial production.
Owner:SHANGHAI HQL TECH DEV CO LTD

Salidroside composition with core-shell-shell structure and preparation method and use thereof

The present application provides a rhodiolide composition with a core-shell-shell structure, a preparation method thereof comprising the steps of: 1) EGCG inclusion: adding beta-cyclodextrin and EGCG into water, ultrasonic, forming an inclusion compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, dissolving in chloroform to form a uniform solution; weighing rhodiolide, dissolving in the uniform solution, rotary evaporation to remove chloroform, then adding the inclusion compound and PBS buffer into the container, hydrating, forming a liposome wrapping rhodiolide and inclusion compound; 3) shell loading: weighing collagen, mixing with chitosan solution uniformly to form a complex; adding the complex into the liposome, the complex is coated on the outer layer of the liposome, centrifugal purification, obtaining a rhodiolide composition with a core-shell-shell structure. The present application belongs to the technical field of cosmetic raw materials, and the rhodiolide composition provided has the advantages of high stability, good transdermal effect, and significant anti-aging effect.
Owner:PEPTIDE SOURCE (GUANGZHOU) BIOTECHNOLOGY CO LTD +1

A kind of encapsulated supramolecular oil-controlling and antibacterial composition, preparation method and application thereof

The present invention discloses an encapsulated supramolecular oil control and antibacterial composition, a preparation method and its application. The encapsulated supramolecular oil control and antibacterial composition is composed of an organic acid, a basic amino acid and a cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, capryloyl glycine, azelaic acid and succinic acid, wherein the organic acid and the basic amino acid are connected by hydrogen bonds to form a supramolecular organic acid, and the composition contains a cyclodextrin inclusion complex formed by encapsulating the organic acid supramolecular. The oil control and antibacterial composition of the present invention encapsulates the organic acid supramolecular by cyclodextrin molecules, has good water solubility, low irritation, easy compatibility, high bioavailability, and the active components are not easy to precipitate. The combination of organic acids can also produce a synergistic effect, and the oil control and antibacterial effect is better.
Owner:NANJING HUASHI NEW MATERIAL CO LTD

Resin composition and molding thereof

PendingJP2025024679APolymer sciencePolypropylene
To provide a polybutene resin composition from which a molding excellent in initial elongation can be obtained, and a molding thereof.SOLUTION: The resin composition contains a polybutene resin and an additive and has a heat of crystal fusion in the range of 60-140°C of 37.0 mJ / mg or less as measured by a differential scanning calorimeter. The additive is, for example, at least one selected from the group consisting of methyl-cyclodextrin and clathrate compounds containing methyl-cyclodextrin and a polypropylene wax.SELECTED DRAWING: None
Owner:SEKISUI CHEMICAL CO LTD