37 results about "Inclusion compound" patented technology

The application discloses a modified bromhexine hydrochloride inhalation solution with enhanced stability and a preparation method thereof, and belongs to the technical field of medical preparations. The inhalation solution is mainly prepared from a targeting impurity control modified bromhexine hydrochloride inclusion compound, a special composite buffer mother liquor for inhibiting impurity B, inhalation grade sodium chloride, pharmaceutical grade sodium hydroxide and water for injection, and the pH value of the finished product is 4.5-5.5. The application constructs a three-stage progressive modification system, covalently grafts a mercapto-activated L-cysteine derivative onto hydroxypropyl-gamma-cyclodextrin to prepare a functional carrier, and realizes molecular-level isolation of bromhexine hydrochloride through host-guest inclusion, thereby blocking the generation of impurity B of bromhexine hydrochloride from the whole path, and solving the core pain points of easy impurity exceeding, short effective period and airway irritation of the existing product. The application can realize long-acting stable storage for 36 months, is suitable for the existing industrial production line, and has high clinical application and industrialization values.

This invention relates to pharmaceutical inclusion compounds, their preparation methods, and uses. Specifically, it provides a buggerfuran inclusion compound and its preparation method, wherein the inclusion compound comprises buggerfuran, cyclodextrin compounds, and optionally a high molecular weight polymer. This inclusion compound has a simple composition, high encapsulation efficiency, stability, and high safety, and can be used to prepare various liquid and solid dosage forms.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The invention provides a polyimide film and a preparation method thereof. The preparation method of the polyimide film comprises the following steps: mixing cyclodextrin, an inorganic nano material and water, stirring for a certain time to form an inclusion compound, removing water, and adding a polar aprotic solvent to form an inclusion compound solution I; mixing a polar aprotic solvent containing a diamine monomer with the inclusion compound solution I to obtain an inclusion compound solution II; mixing the inclusion compound solution II with a dianhydride monomer to obtain a reaction system; carrying out polymerization reaction on the reaction system to obtain a polyamide acid solution; and preparing the polyimide film by using the polyamide acid solution. On the basis of ensuring the appearance and mechanical properties of the polyimide film, the thermal expansion coefficient of the polyimide film is reduced, and the thermal stability of the polyimide film is improved.

The application relates to an antibacterial and antifouling reverse osmosis membrane and a preparation method thereof, and comprises the following steps: (1) uniformly dissolving a multiacyl chloride group organic compound in an organic solvent, then adding cyclodextrin, and carrying out ultrasonic treatment to obtain a cyclodextrin-organic acyl chloride inclusion compound solution; dispersing antibacterial nanoparticles in water, then adding an amino silane coupling agent, and stirring and dispersing to obtain a functionalized antibacterial nanoparticle suspension with amino groups on the surface; (2) uniformly coating the cyclodextrin-organic acyl chloride inclusion compound solution to one surface of a prefabricated reverse osmosis membrane, removing the excess solution on the surface after standing, and then coating the functionalized antibacterial nanoparticle suspension with amino groups on the surface on the surface with the cyclodextrin-organic acyl chloride inclusion compound, removing the excess solution on the surface after standing, and carrying out thermal drying to obtain the antibacterial and antifouling reverse osmosis membrane. The reverse osmosis membrane has excellent stability, small membrane sheet water flux attenuation, obviously improved antifouling capacity, and excellent antibacterial capacity.

This application relates to the field of self-healing materials, specifically disclosing a high-toughness self-healing functional material, its preparation method, and its applications. This self-healing functional material is a supramolecular elastomer formed by in-situ free radical polymerization of the tetrad hydrogen-bonded monomer UPy-EMA, a host-guest inclusion complex, and an acrylate monomer under the action of a crosslinking agent and an initiator. The high-toughness self-healing functional material provided in this application is the first to effectively integrate multiple functions of "strength, toughness, self-healing, conductivity, and antibacterial properties," ultimately obtaining a self-repairing material that combines high strength and toughness, rapid self-healing at room temperature, conductivity, and antibacterial properties, with broad application prospects.

This invention discloses a method for preparing an ultrathin ordered macrocyclic molecular membrane. The method involves synthesizing macrocyclic molecules with high polymerization activity and amphiphilic guest molecules. The inclusion complexes formed by the macrocyclic molecules and guest molecules are orderedly assembled using Langmuir-Blodgett (LB) technology. Photopolymerization is then employed to achieve ordered cross-linking of the macrocyclic molecules, resulting in an ultrathin ordered macrocyclic molecular membrane. The macrocyclic molecular membrane prepared by this invention is monomolecular in thickness and possesses good mechanical strength. With the assisted orientation of the amphiphilic guest molecules, the macrocyclic molecules achieve ordered assembly at the water-air interface. The membrane preparation process proposed in this invention is simple, cost-effective, versatile, and easily scalable, making it significant for the field of high-performance separation membranes.

The application provides an iodine-doped starch-based carbon material and a preparation method and application thereof, and relates to the technical field of starch-based carbon materials. The method comprises the following steps: mixing starch, an iodine source and a water-soluble dispersant in a solvent, aging, drying and crushing to obtain a purple red to blue purple inclusion precursor; and then performing gradient carbonization treatment in an inert atmosphere to obtain the iodine-doped starch-based carbon material. The application realizes the inclusion and molecular-level anchoring through the van der Waals force between the spiral cavity of the linear starch and the iodine element, and relies on the water-soluble dispersant to form a physical encapsulation layer on the surface of the starch in situ in the low-temperature carbonization stage, cooperates with the high-temperature carbonization process, and inhibits the volatilization of the iodine element to realize the doping of high iodine content. The obtained material is characterized in that the iodine is embedded in the carbon skeleton in a P-pi conjugate state, the conductivity is significantly enhanced, the carrier concentration is improved, and the sodium ion storage capacity is improved, so that the reversible specific capacity is improved and the first circle coulombic efficiency is improved.

The application discloses a method for detecting benzaldehyde by using a three-dimensional hot spot SERS substrate, and belongs to the field of nanomaterials and biosensing technology, and the method comprises the following steps: detecting benzaldehyde in a to-be-detected sample by using a three-dimensional hot spot SERS substrate, and determining whether the to-be-detected sample contains benzaldehyde or the content of benzaldehyde in the to-be-detected sample by the change of a Raman characteristic peak before and after detection; the structure of the three-dimensional hot spot SERS substrate comprises a substrate and a gold nanosphere superlattice two-dimensional film attached to the substrate, the gold nanosphere superlattice two-dimensional film is modified with a beta-cyclodextrin-p-aminophenylthiophenol inclusion compound and loaded with gold@gold silver hollow nanorods; the SERS substrate has a three-dimensional hot spot superlattice-hollow rod structure. The method has low detection limit, high selectivity and specificity, and lays a foundation for realizing a high-performance and customizable sensing platform.

The application provides a preparation method of a complex in a traditional Chinese medicine compound, and belongs to the technical field of medicine industry. The application directly carries out inclusion on a distillate containing complex components such as paeonol, uses hydroxypropyl betadex as an inclusion agent, optimizes the ratio of the distillate containing complex components such as paeonol and the inclusion agent, and directly prepares paeonol inclusion compounds with good stability and not easy to separate from traditional Chinese medicine compound decoctions by directly freeze-drying. The inclusion rate can reach more than 80%, and the yield of the inclusion compound can reach more than 95%. The preparation method not only simplifies the extraction process of the traditional Chinese medicine compound containing paeonia suffruticosa and reduces the cost, but also has a wide application prospect.

This invention relates to the field of pharmaceutical formulation technology, specifically disclosing a coenzyme Q10 nanoemulsion oral liquid with a dual-stabilized structure and its continuous preparation method. It solves technical problems such as the extremely poor water solubility of raw materials, easy oxidation and degradation of coenzyme Q10 during storage, unstable solutions prone to stratification, precipitation, and crystallization, low bioavailability, and imperfect production processes during the preparation of coenzyme Q10 oral liquid. This invention constructs a dual-stabilized system of "cyclodextrin inclusion complex core + nanoemulsion encapsulation shell," with the nanoemulsion particle size controlled at 50-200 nm. Verification shows excellent stability, high retention rate of active ingredients, and bioavailability 2-3 times higher than conventional oral liquids. The process is environmentally friendly and safe, employing aseptic positive pressure conveying or negative pressure extraction of materials during preparation, enabling large-scale continuous aseptic industrial production.

A 4-carboxyamino isoindoline-1,3-dione compound represented by formula (I), or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate (e.g. hydrate) thereof, or a clathrate thereof, or a racemate thereof, or an isotopically-labeled material thereof, or a nitroxide thereof; and pharmaceutical compositions and uses thereof. The compound has good anti-multiple myeloma activity, and can effectively treat and / or prevent the growth of multiple myeloma.

This invention discloses a method for preparing a cyclodextrin-ammonium acetate-naproxen ternary inclusion complex, comprising the following steps: mixing β-cyclodextrin, naproxen, and ammonium acetate in a molar ratio of 0.8-1.3:0.9-1.1:0.8-2.5 with a solvent; stirring the resulting mixture at 35-45°C for 0.5-2 hours; and then removing the solvent by evaporation, standing, and freeze-drying to obtain the ternary complex. This invention prepares a ternary inclusion complex using β-cyclodextrin, naproxen, and ammonium acetate, which significantly improves drug stability and water solubility, thus helping to enhance the bioavailability of naproxen and expand its application areas.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a rivaroxaban tablet, a preparation method and use. The rivaroxaban tablet comprises a rivaroxaban inclusion compound, lactose, starch, low-substitution hydroxypropyl cellulose and magnesium stearate. The rivaroxaban is packaged by using trimethylamine modified methyl cellulose as a packaging material, and the preparation process is optimized. The problem of low drug loading and low encapsulation efficiency of the rivaroxaban inclusion compound in the prior art is solved. The rivaroxaban tablet with a rivaroxaban inclusion compound with high drug loading and high encapsulation efficiency is provided, and the delivery efficiency of the rivaroxaban inclusion compound is improved. Through verification, the rivaroxaban tablet provided by the application has high dissolution rate, few impurities and stability.

The application discloses an aerogel with humidity responsiveness, and preparation raw materials comprise cellulose nanocrystals, 4-terpenol / hydroxypropyl-BETA-cyclodextrin inclusion compound and starch; compared with the prior art, the aerogel prepared has the advantages of water absorption, antibiosis and humidity response slow release, and after being applied to the preservation of ice-fresh salmon at 4 DEG C, the shelf life of the ice-fresh salmon is remarkably prolonged.

The present disclosure teaches methods, materials, and structures for encapsulating probiotic microorganisms in a biocompatible encapsulation compound. The encapsulation compound may be a cyclodextrin macrocyclic molecule that has a hollow, cone-shaped, central cavity. Probiotic microorganisms are then encapsulated partially, or completely, inside of the hollow, central cavity of the cyclodextrin molecule to make a cyclodextrin inclusion complex. The resulting encapsulated probiotic assembly provides enhanced stability and bioavailability of the probiotic microorganisms during storage and after ingestion, as well as offering protection against environmental stressors, such as heat, moisture, and oxygen. The sugar-like cyclodextrin encapsulant material may also serve a prebiotic function of supporting beneficial gut flora proliferation and improved probiotic viability in the gastrointestinal tract. The cyclodextrin macrocyclic molecule may be an α-cyclodextrin, β-cyclodextrin, and / or γ-cyclodextrin molecule, and / or combinations thereof. Other biocompatible encapsulation compounds may be used, including polysaccharides, liposomes, alginates, chitosans, gelatins, and polyvinyl alcohols.

The present application provides a kind of transvaginal, rectal administration progesterone sustained-release solid composition. Specifically, the composition includes: progesterone 100 parts by weight, cyclodextrin 800-2000 parts by weight, filler 10-30 parts by weight, binder 20-40 parts by weight, optionally preservative 0.5-10 parts by weight, polyoxyethylene 30-300 parts by weight and lubricant 4-30 parts by weight. The composition of the present application is based on progesterone-cyclodextrin inclusion and polyoxyethylene sustained-release synergistic effect for preparing vaginal, rectal administration preparation, not only has the physical properties suitable for vaginal, rectal administration (such as adhesion performance, prevent the preparation from sliding), but also can ensure that progesterone is stably released in vagina for a long time, improve bioavailability, reduce the side effects of progesterone administration.

A 4-carbonylamino isoindolin-1-one compound represented by formula (I), or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate (e.g. hydrate) thereof, or a clathrate thereof, or a racemate thereof, or an isotopically-labeled material thereof, or a nitroxide thereof; and pharmaceutical compositions and uses thereof. The compound has good anti-multiple myeloma activity, and can effectively treat and / or prevent the growth and reproduction of multiple myeloma.

The application discloses an environment-friendly long-acting mildew-proof silicone sealant and a preparation method thereof. The environment-friendly long-acting mildew-proof silicone sealant comprises the following raw material components in parts by mass: 100 parts of alpha, omega dihydroxypolydimethylsiloxane, 5-15 parts of CDs-SiO2, 3-50 parts of dimethyl silicone oil, 70-160 parts of inorganic filler, 3-7 parts of crosslinking agent, 1-3 parts of coupling agent and 3-6 parts of catalyst. The CDs-SiO2 is made of cyclodextrin inclusion compound, silane coupling agent and porous silicon dioxide, the porous silicon dioxide is obtained by reacting tetrabutyl silicate in a mixed medium of alcohol and water under the action of an amine catalyst and a pore former; and the cyclodextrin inclusion compound is made of monochlorotriazine-cyclodextrin and natural mildew-proof agent. The silicone sealant has excellent long-acting mildew-proof effect and mechanical properties.

This invention relates to a method for preparing an extract of Camellia yunnanensis flower, its product, and its applications. The preparation method includes: mixing Camellia yunnanensis flower raw material with water and an enzyme, performing enzymatic hydrolysis, and then inactivating the enzyme; subjecting the enzymatic hydrolysis solution to ultrasonic treatment, performing solid-liquid separation, concentrating and drying the supernatant to obtain a crude extract; mixing the crude extract with an aqueous two-phase extractant for extraction, concentrating and drying the supernatant to obtain the Camellia yunnanensis flower extract. This extraction process can maximize the yield of extracts with tyrosinase inhibitory activity at lower temperatures; the use of aqueous two-phase extraction enriches multiple target active ingredients, ensuring that the extracted product has superior tyrosinase inhibitory activity. This invention also develops a formulation with excellent stability containing the aforementioned Camellia yunnanensis flower extract, wherein the Camellia yunnanensis flower extract is encapsulated in cyclodextrin, the inclusion complex is loaded in a liposome structure, and the addition of Camellia yunnanensis seed oil and Prickly pear fruit oil can further improve the stability of the obtained formulation.

The application discloses an antibacterial and deodorant composite EVA shoe material and a manufacturing process, and relates to the technical field of shoe materials.The shoe material takes ethylene-vinyl acetate copolymer as a matrix, and the matrix is dispersed with a functional unit of a modified multi-level pore biochar loaded with a beta-cyclodextrin inclusion compound; the modified multi-level pore biochar is prepared through carbonization, activation and surface oxidation treatment, the beta-cyclodextrin inclusion compound is formed by the inclusion of beta-cyclodextrin and a natural antibacterial agent and is loaded in the pore channel of the biochar, and the manufacturing process comprises corresponding two-stage mixing and two-stage mold foaming.The application realizes humidity-responsive release of the antibacterial agent, long-term and stable antibacterial and deodorant effects, high biological safety, good mechanical properties, and can be formed into shoe midsoles or outsoles, and is suitable for the production and application of shoe materials.

A clathrate of 1-methylcyclopropene with α-cyclodextrin, obtained as a solid particulate product, is modified by comminuting, classifying, or both to obtain a modified particulate. When subjected to identical atmospheric disgorgement conditions of humidity and temperature, identical masses of the modified and unmodified particulates exhibit different rates of 1-methylcyclopropene disgorgement. Specifically, we have found that a smaller mean particle size is inversely related to a greater rate of 1-methylcyclopropene release.

The application discloses a simplified SERS nanoparticle preparation method and application in pesticide residue detection, and belongs to the technical field of spectral analysis and detection. The preparation method comprises the following steps: taking gold nanoparticles as initial nanoparticles, then reducing AgNO3 under alkaline conditions by using beta-CD, so as to form Au-Ag Janus. The beneficial effects are as follows: the beta-CD modified silver-coated gold nanoparticles are Janus structure, the size of which can be adjusted according to requirements; the beta-CD comprises a hydrophobic inner cavity and a hydrophilic outline, so that hydrophobic organic small molecules can be captured in the cavity and stable host-guest inclusion compounds are formed, macromolecular recognition is realized, and the detection sensitivity of SERS is greatly improved. The preparation method of the Au-Ag Janus nano material is simple, fast, stable, reproducible and high in sensitivity, and the SERS detection method adopted is simple and fast.

The application discloses an environment-friendly long-acting mildew-proof silane modified polyether sealant and a preparation method thereof. The silane modified polyether sealant comprises the following raw material components in parts by weight: MS-polymer prepolymer 100 parts, cyclodextrin polyether polyol inclusion compound 4-16 parts, reinforcing filler 180-450 parts, thixotropic agent 1-8 parts, plasticizer 50-400 parts, hydroxyl scavenger 4-16 parts, coupling agent 2-9 parts, and organic tin catalyst 0.1-0.6 parts; the cyclodextrin polyether polyol inclusion compound is obtained by cyclodextrin polyether polyol inclusion natural mildew-proof agent; the cyclodextrin polyether polyol is obtained by reaction of cyclodextrin, diethylene glycol and an oxacyclic compound under alkaline conditions; and the oxacyclic compound is at least one of oxirane, oxetane and tetrahydrofuran. The environment-friendly long-acting mildew-proof silane modified polyether sealant has excellent long-acting mildew-proof effect and mechanical properties.

This invention belongs to the field of functional food technology, specifically relating to a sleep-aiding composition containing γ-aminobutyric acid (GABA) and its application. The sleep-aiding composition comprises: 2 to 8 parts of fermented soybean extract; 3 to 10 parts of oyster oligopeptide powder; 0.5 to 5 parts of GABA; 1 to 4 parts of Atractylodes macrocephala volatile oil β-cyclodextrin inclusion complex; and 1 to 4 parts of Acanthopanax senticosus extract. This composition is used in the preparation of products with sleep-improving effects. This invention utilizes a two-stage fermentation process to pre-convert soybean isoflavones to estrol and enrich GABA, combined with targeted enzymatic hydrolysis membrane separation to enrich taurine and zinc in oyster oligopeptides to maintain GABA-A receptor sensitivity. The addition of Atractylodes macrocephala volatile oil β-cyclodextrin inclusion complex improves water solubility and stability, achieving stable sleep-aiding effects and minimizing individual differences, while also promoting growth and development.

The application discloses a kind of stable indometacin tablets and its preparation process, belong to pharmaceutical preparation technical field.The tablet is composed of indometacin, hydroxypropyl beta-cyclodextrin, soybean phospholipid, composite stabilizer, binder and lubricant, and the composite stabilizer is compounded by succinylated c14-c18 alkyl sulfonate sodium, N-ethyl-L-glutamine and maltodextrin according to specific mass ratio.Preparation process includes liposome inclusion compound preparation, mixing granulation, drying whole particle, total mixing and tabletting.The application realizes the preparation of high drug loading design, and the composite stabilizer forms a multilayer coating protection system with hydroxypropyl beta-cyclodextrin and soybean phospholipid, which synergistically improves the dissolution performance and stability of the preparation, makes the dissolution rate of the preparation fast, and the content of the main component decreases little during long-term storage, solves the problems of low drug loading, poor stability and dissolution of existing indometacin tablets.

This invention discloses a stable antibody-drug conjugate for radioimmunoassay kits and its preparation method. The antibody-drug conjugate is an aqueous solution system containing hydroxypropyl-β-cyclodextrin, melatonin, L-arginine, tetrahydropyrimidine, polyvinylpyrrolidone, I-125-labeled antibody, and phosphate buffer. Melatonin forms a host-guest inclusion complex within the cavity of the hydroxypropyl-β-cyclodextrin, while L-arginine is distributed at the interface of the inclusion complex. Tetrahydropyrimidine and polyvinylpyrrolidone synergistically construct a highly viscous hydrated matrix. The preparation method employs a stepwise assembly process: first, a concentrated arginine-modified inclusion complex solution and a highly viscous hydrated matrix solution are prepared, mixed and equilibrated, and then the I-125-labeled antibody stock solution is added. This invention utilizes the inclusion complex to scavenge free radicals generated by water radiation decomposition, and prevents non-specific antibody adsorption and denaturation through interface modification and hydration layer construction. This effectively solves the problems of radiation oxidation damage and physical adsorption of I-125-labeled antibodies during liquid storage, significantly extending the shelf life of the kit and ensuring the accuracy of the detection results.

This invention provides a 3D-printed gel composition for sports protective pads and its preparation method, relating to the fields of gel materials and 3D printing technology. The 3D-printed gel composition for sports protective pads of this invention comprises the following materials in parts by weight: 10-25 parts of trimethylolpropane trimethacrylate, 25-35 parts of polyurethane acrylate, 5-15 parts of acrylated eutectic solvent, 1-5 parts of methacrylated-β-cyclodextrin inclusion complex loaded with antibacterial agent, 5-10 parts of amine-modified polyether acrylate, and 0.1-5 parts of additives. This invention aims to solve the problems of poor tear resistance and easy fatigue collapse in existing 3D-printed foam pads due to the physical disruption of the cross-linking network by micropores, while also addressing the issues of traditional pads softening upon absorbing sweat and failing to provide adaptive support and intelligent long-lasting antibacterial properties based on the athlete's sweating state.