The invention belongs to the technical field of
medicine preparation, and particularly relates to application of hydroxypropyl-beta-
cyclodextrin in preparation of a Velciguat
solid preparation, the
solid preparation and a preparation method. The key protection of the invention is as follows: hydroxypropyl-beta-
cyclodextrin is applied to the formation of a Vilciguat-
cyclodextrin inclusion compound with Vilciguat, and then the
inclusion compound is combined with other raw materials to prepare the Vilciguat
solid preparation with excellent solubilizing effect, the average substitution degree of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the
viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the
viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, the
viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5, and the viscosity of the hydroxypropyl-beta-cyclodextrin is 3.5-5.5. This is one of the keys of the invention. According to the present invention, a large number of experiments are performed, different types of beta-cyclodextrin and beta-cyclodextrin with different substitution degrees are compared, and finally hydroxypropyl-beta-cyclodextrin with an average substitution degree of 3.5-5.5 is selected to clathrate viriciguat, such that compared with hydroxypropyl-beta-cyclodextrin with other substitution degrees or other solubilizers, the solubilizing effect is excellent, and the solubilizing effect is good. Meanwhile, the stability is good, and the total
impurity is almost unchanged after acceleration for 3 months.