213 results about "Inclusion compound" patented technology

The invention discloses a method for reducing the content of aged starch and soluble miscellaneous sugar in alpha-cyclodextrin, and belongs to the technical field of alpha-cyclodextrin synthesis, the method comprises the following steps: liquefaction, conversion, primary filtration, inclusion, secondary filtration, complexing agent removal and post-treatment; the conversion comprises the following steps: adding alpha-CGTase and isoamylase into the starch liquefied liquid at 38-42 DEG C, adjusting the pH value to 5.30-5.70, and carrying out conversion to obtain a conversion liquid; the primary filtration comprises the following steps: carrying out enzyme deactivation treatment on the conversion liquid, filtering, washing a filter cake with water, and combining the washing liquid with the filtrate to obtain primary filtrate; and the secondary filtration comprises the following steps: filtering the material liquid containing the complex, taking a filter cake, and washing the filter cake with water to obtain the inclusion compound. The preparation method of the alpha-cyclodextrin is improved, so that the alpha-cyclodextrin with high yield and high stability is obtained, and the industrial controllability is realized.

The invention discloses a novel long-acting bird repellent and a preparation method thereof, and belongs to the technical field of chemical bird repelling. The bird repellent is composed of a core material and a wall material, the core material is a mixture of geraniol, cinnamyl aldehyde and allicin according to the mass ratio of 1: (1.2-1.5): (0.5-0.8), the wall material is modified beta-cyclodextrin and pumpkin seed protein nanoparticles, and the mass ratio of the geraniol, the cinnamyl aldehyde and the allicin is (5-7): (3-5): (1-3). The preparation method comprises the following steps: preparing the quaternary ammonium salt modified beta-cyclodextrin, including the core material, performing high-speed shearing emulsification on the quaternary ammonium salt modified beta-cyclodextrin and the pumpkin seed protein nano dispersion liquid, and performing freeze drying to obtain a final product. According to the invention, a stable and compact'molecular inclusion + physical barrier 'dual slow-release structure is constructed by utilizing the electrostatic interaction between the positively charged modified beta-cyclodextrin and the negatively charged protein nanoparticles, the release time of effective components is remarkably prolonged to 9 months or more, and the composite material has excellent rain wash resistance and ultraviolet resistance, and can be used for preparing a composite material with a good application prospect. And efficient, environment-friendly and long-acting bird repelling is realized.

The invention discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by salicylic acid, amino acid and a cyclodextrin derivative through non-covalent bond interaction, the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, salicylic acid molecules are included in a cavity of the cross-linked beta-cyclodextrin polymer, and the cross-linked beta-cyclodextrin polymer is a cross-linked beta-cyclodextrin polymer. And meanwhile, guanidyl or carboxyl of an amino acid side chain interacts with hydroxyl outside the cross-linked beta-cyclodextrin polymer or an exposed part of an included salicylic acid molecule. According to the invention, a cross-linked beta-cyclodextrin polymer is used, arginine is introduced as a synergist, a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary clathrate compound is constructed, and through charge neutralization and hydrogen bond network synergistic effect, clathration efficiency is significantly improved, and water solubility of salicylic acid is improved.

The invention relates to the technical field of biology, in particular to silymarin inclusion compound lipidosome and a preparation method and application thereof. The silymarin inclusion compound liposome is prepared from the following components in parts by weight: 10 to 48 parts of silymarin, 10 to 53 parts of phospholipid, 5 to 10 parts of Arabic gum and 25 to 70 parts of cyclodextrin. According to the invention, cyclodextrin and phospholipid are combined to form a double-drug-loading structure; on the basis, Arabic gum is used as a film-forming agent to form a protective film on the surface of the liposome, so that the stability of the system is further improved; the silymarin inclusion compound is encapsulated in a water phase in the liposome, and meanwhile, part of free silymarin is encapsulated in a lipid bilayer. According to the structure, the solubility and the encapsulation efficiency of the silymarin are remarkably improved, the liposome stability is enhanced, the drug release is effectively controlled, and the silymarin inclusion compound lipid is simple in preparation process and suitable for industrial production.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The application relates to the technical field of traditional Chinese medicines, in particular to a uric acid reducing composition and a preparation method thereof. The uric acid reducing composition comprises 35-45 parts of a cyclodextrin inclusion compound, 25-35 parts of nano-liposomes, 20-30 parts of a chicory extract-phospholipid complex and 5-8 parts of an antioxidant complex; the preparation method of the cyclodextrin inclusion compound comprises the following steps: step 1, adding beta-cyclodextrin into water, stirring and dissolving, adding pueraria extract, drying after inclusion reaction, and obtaining inclusion compound a; step 2, adding hydroxypropyl-gamma-cyclodextrin into water, stirring, adding mulberry leaf extract, drying after inclusion, and obtaining inclusion compound b; and step 3, mixing the inclusion compound a and the inclusion compound b, and obtaining the product. The uric acid reducing composition can more comprehensively and efficiently reduce blood uric acid level, and has high safety, high stability and high bioavailability. The preparation method is simple, easy to industrialize and beneficial to large-scale industrial production.

The present application provides a rhodiolide composition with a core-shell-shell structure, a preparation method thereof comprising the steps of: 1) EGCG inclusion: adding beta-cyclodextrin and EGCG into water, ultrasonic, forming an inclusion compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, dissolving in chloroform to form a uniform solution; weighing rhodiolide, dissolving in the uniform solution, rotary evaporation to remove chloroform, then adding the inclusion compound and PBS buffer into the container, hydrating, forming a liposome wrapping rhodiolide and inclusion compound; 3) shell loading: weighing collagen, mixing with chitosan solution uniformly to form a complex; adding the complex into the liposome, the complex is coated on the outer layer of the liposome, centrifugal purification, obtaining a rhodiolide composition with a core-shell-shell structure. The present application belongs to the technical field of cosmetic raw materials, and the rhodiolide composition provided has the advantages of high stability, good transdermal effect, and significant anti-aging effect.

The invention discloses a covalent organic framework antibacterial material with NO light-controlled release as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The covalent organic framework antibacterial material is a porous polymer taking a cyclodextrin inclusion compound and a porphyrin metal coordination compound as structural units; a plurality of porphyrin metal coordination compounds surround the cyclodextrin inclusion compound in each structural unit, and the porphyrin metal coordination compounds are not on the same plane; the cyclodextrin inclusion compound is obtained by inclusion of BNN6 with beta-cyclodextrin; the porphyrin metal coordination compound is a coordination compound of porphyrin and copper. The preparation method comprises the following steps: firstly preparing a cyclodextrin porphyrin porous polymer, then matching the cyclodextrin porphyrin porous polymer with copper and entrapping BNN6 to obtain a covalent organic framework antibacterial material, utilizing NO release and combining simulated photo-thermal, photodynamic, peroxidase and glutathione peroxidase to achieve synergistic antibacterial effect, and remarkably accelerating the recovery of bacterial infected wounds.

The invention belongs to the technical field of functional condiments, and provides a functional minced garlic sauce based on fermentation engineering and a preparation method thereof.According to the functional minced garlic sauce based on fermentation engineering and the preparation method thereof, the design that a lactic acid fermentation minced garlic matrix is combined with a double-layer structure functional microcapsule dispersion phase is adopted, and an inner core layer is composed of a clathrate compound formed by gamma cyclodextrin and allicin; an outer shell is formed by compounding protein and high-methoxyl pectin under a specific pH condition and is subjected to calcium ion cross-linking stabilization, and an immobilized gamma-glutamyltransferase conversion and a lactobacillus plantarum and lactobacillus rhamnosus co-fermentation process are adopted; the microcapsule has the advantages that the content of S-allyl L-cysteine is larger than or equal to 220 mg / kg, the particle size D50 of the microcapsule is 5-10 micrometers, and the viable bacterium stability is good under the low-salt condition, the technical problems that allicin retention and stability of minced garlic seasoning products are insufficient, and functional ingredient enrichment and viable bacterium stability are difficult to consider under the low-salt condition are solved, and the technical effects that the content of S-allyl L-cysteine is larger than or equal to 220 mg / kg and the particle size D50 of the microcapsule is 5-10 micrometers are achieved. And the method has a wide industrial application value.

The invention provides a salidroside composition with a core-shell-shell structure, and a preparation method of the salidroside composition comprises the following steps: 1) EGCG (epigallocatechin gallate) clathration: adding beta-cyclodextrin and EGCG into water, and carrying out ultrasonic treatment to form a clathrate compound; 2) liposome assembly: weighing soybean phospholipid and cholesterol, and dissolving in chloroform to form a uniform solution; the preparation method comprises the following steps: weighing salidroside, dissolving the salidroside in a uniform solution, carrying out rotary evaporation to remove chloroform, then adding an inclusion compound and a PBS (Phosphate Buffer Solution) into a container, and hydrating to form lipidosome wrapping the salidroside and the inclusion compound; 3) shell loading: weighing collagen, and uniformly mixing the collagen with the chitosan solution to form a compound; the salidroside composition with the core-shell-shell structure is obtained by dropwise adding the compound into the lipidosome, coating the outer layer of the lipidosome with the compound and carrying out centrifugal purification. The invention belongs to the technical field of cosmetic raw materials, and provides a salidroside composition which has the advantages of high stability, good transdermal effect, remarkable anti-aging effect and the like.

This invention discloses a method for preparing a detergency-removing composite solution and its gel membrane, as well as its applications. Based on the host-guest inclusion mechanism of cyclodextrin, its hydrophobic cavity is achieved by "encapsulating" hydrophobic molecules or their hydrophobic portions. The volume of the hydrophobic portion / functional group of the complexing agent molecule is smaller than the volume of the cyclodextrin cavity. The complexing agent forms a complex with cyclodextrin, thus dispersing well in the solution. Furthermore, complexing agents with good coordination ability for radioactive ions can almost always form inclusion complexes with cyclodextrin. The polysaccharide molecular chains used in this invention are rich in hydrophilic functional groups such as hydroxyl and amino groups, giving the gel membrane good hydrophilicity, low ion transport resistance, and short equilibrium time. The hydroxyl and amino functional groups also participate in the coordination process of radioactive ions, further improving the adsorption capacity of the gel membrane. The method and application of this invention have strong universality, can simultaneously remove multiple radioactive ions, and can be used on a large scale.

The application discloses a modified bromhexine hydrochloride inhalation solution with enhanced stability and a preparation method thereof, and belongs to the technical field of medical preparations. The inhalation solution is mainly prepared from a targeting impurity control modified bromhexine hydrochloride inclusion compound, a special composite buffer mother liquor for inhibiting impurity B, inhalation grade sodium chloride, pharmaceutical grade sodium hydroxide and water for injection, and the pH value of the finished product is 4.5-5.5. The application constructs a three-stage progressive modification system, covalently grafts a mercapto-activated L-cysteine derivative onto hydroxypropyl-gamma-cyclodextrin to prepare a functional carrier, and realizes molecular-level isolation of bromhexine hydrochloride through host-guest inclusion, thereby blocking the generation of impurity B of bromhexine hydrochloride from the whole path, and solving the core pain points of easy impurity exceeding, short effective period and airway irritation of the existing product. The application can realize long-acting stable storage for 36 months, is suitable for the existing industrial production line, and has high clinical application and industrialization values.

A method for producing an inclusion complex drug includes the following steps: adding cyclodextrin to an aqueous solution of ibuprofen sodium salt at a saturation concentration at a first temperature, then placing it in an electrodialysis apparatus to obtain a first crystallization solution; then removing it and adding acid to adjust the pH to 6.0-6.5, controlling the temperature at a second temperature to obtain a second crystallization solution; placing the second crystallization solution in an electrodialysis apparatus to obtain a third crystallization solution; then removing it and continuing to add acid to adjust the pH to below 3.0 to obtain a fourth crystallization solution; filtering and recovering the fourth crystallization solution, and rinsing to obtain the ibuprofen inclusion complex. This application uses pre-added cyclodextrin, with cyclodextrin and the ibuprofen sodium salt obtained from the reaction as feedstock, then obtaining the second crystallization solution through electrodialysis acidification and acid treatment, followed by electrodialysis to obtain raw materials that can be used as nucleation sites for crystallization, and finally adding acid for final crystallization. The entire crystallization process is controllable.

The invention belongs to the technical field of medical dressings, and provides a hydrocolloid acne patch and a preparation method thereof. According to the invention, beta-cyclodextrin functionalized gelatin and adamantane functionalized hyaluronic acid are subjected to inclusion interaction to form a reversible cross-linked network, and hydroxypropyl trimethyl ammonium chloride chitosan and sodium carboxymethyl cellulose are subjected to electrostatic interaction to form a polyelectrolyte cross-linked network; the genipin is combined with a primary amine group amido bond to form a triple cross-linked network structure design of a covalent cross-linked network, and antibacterial components such as a gamma-cyclodextrin-salicylic acid inclusion compound are loaded, so that the excellent properties that the self-healing recovery rate is 90-95%, the water vapor transmission rate is 500-900g. M <-2 >. 24h <-1 >, and the peel strength is greater than or equal to 1.0 N / 25mm are realized; the technical problem that an existing hydrocolloid acne patch is insufficient in antibacterial persistence and self-healing and repairing capacity is solved, and wide application value is achieved.

The invention discloses a scheme design of a temperature and humidity dual-response eupatorium extract slow-release pillow filler, and belongs to the technical field of functional home textile materials. The problems that an existing eupatorium pillow is single in filler response, fast in effective component loss, poor in signal transmission and insufficient in comfort level are solved. According to the technical scheme, the preparation method comprises the following steps: preparing an eupatorium volatile oil-hydroxypropyl-beta-cyclodextrin inclusion compound (the inclusion rate is 88-92%), and loading the inclusion compound on gradient pore activated ceramic balls (the surface layer is 5-8 [mu] m, the transition layer is 8-10 [mu] m and the core layer is 15-20 [mu] m); coating a composite coating of a beewax-sunflower wax-coconut fat temperature-sensitive matrix (phase change is 32-33 DEG C) and hydroxypropyl methyl cellulose-sodium alginate humidity-sensitive gel (50%-70% RH expansion is 150%-200%); and a three-layer composite bag (3 mm silica gel salient points are arranged on the inner layer) is matched. The 24-hour release rate of the filler during double-signal triggering is 68-72%, the day time is less than or equal to 15%, the service life is 9 months, and the filler is mainly applied to sleep-aiding pillows to improve the sleep quality and comfort.

The invention provides a long-acting microsphere sustained release preparation and a preparation method thereof, and belongs to the technical field of sustained release preparations, the long-acting microsphere sustained release preparation is prepared from the following raw materials of effective components: 9.5 to 10.5 parts of antipsychotic drug, 48 to 50 parts of hydroxypropyl-beta-cyclodextrin, 50 to 52 parts of polylactic acid-glycolic acid copolymer, 1.25 to 1.3 parts of glycerol triacetate and 10 to 11 parts of polyvinyl alcohol. The preparation method comprises the following steps: firstly, the hydroxypropyl-beta-cyclodextrin is used for clathration of the antipsychotic drug, the obtained clathrate compound is further clathrated by the polylactic acid-glycolic acid copolymer, and the long-acting microsphere sustained release preparation is obtained. According to the invention, the double-valve design of beta-CD and PLGA synergistic inclusion is utilized, so that the preparation can realize two-stage release; the macroscopic slow release characteristic of the PLGA is combined with the microcosmic express characteristic of the hydroxypropyl-beta-cyclodextrin, so that the technical limitation of a single carrier is broken through.

The invention belongs to the technical field of food packaging materials, and discloses a photodynamic antibacterial modified atmosphere film as well as a preparation method and application thereof. The antibacterial modified atmosphere membrane is obtained by drying a membrane casting solution, the membrane casting solution comprises the following components in percentage by mass: 80-95% of anionic waterborne polyurethane emulsion, 5-20% of cationic quaternized nanocellulose and an antibacterial agent inclusion compound which accounts for 1-10% of the total mass of the components, and the antibacterial agent inclusion compound is a curcumin-cyclodextrin inclusion compound. The transparent film which has good compatibility and obviously improved air conditioning performance and mechanical performance is successfully prepared, the film has excellent antioxidant and photodynamic antibacterial functions, and the defect that an existing film is single in function is overcome. When the functional waterborne polyurethane film is applied to strawberry preservation, the oxidation and corruption process of strawberries is effectively delayed, the purpose of prolonging the preservation period is achieved, reliable support is provided for preparation of the functional waterborne polyurethane film and food preservation application, and the functional waterborne polyurethane film has important theoretical and practical significance.

The invention relates to the technical field of food beverages, and discloses a jasmine flower essential oil beta-cyclodextrin inclusion compound and a preparation method thereof. The method comprises the following steps: dissolving beta-cyclodextrin in water to obtain a wall material solution; dissolving jasmine flower essential oil in absolute ethyl alcohol to prepare a core material solution; slowly dropwise adding the core material solution into the wall material solution, and stirring to form an emulsion; and performing vacuum freeze drying on the emulsion to obtain the inclusion compound. Furthermore, Tween 60 and other emulsifiers can be added into the core material solution to improve the dispersity, and the quality of the powder is improved through program control of sectional type pre-freezing, main drying and post-drying. The obtained clathrate compound is solid powder, the particle size is 0.7-4.6 microns, the clathrate compound is in an irregular shape, secondary particles are attached to the surfaces of the particles, and the clathrate compound has a certain pore structure. Compared with the prior art, the preparation method has the advantages that the food-grade beta-cyclodextrin is used as a unique wall material, a large number of surfactants and a complex process are avoided, the preparation is simple and convenient, the cost is low, and the obtained product has higher jasmine essential oil embedding rate, aroma retentivity and water solubility.

The invention discloses a perianal care solution containing herbaceous plants and hyaluronic acid and a preparation method of the perianal care solution, and belongs to the technical field of care solutions, the preparation method comprises the following steps: preparing a decolorizing agent, preparing a composite inclusion compound, extracting and mixing; the preparation method of the composite clathrate compound comprises the following steps: mixing hydroxypropyl-beta-cyclodextrin and pure water, stirring at room temperature until the hydroxypropyl-beta-cyclodextrin and the pure water are completely dissolved, adding ethyl lauroyl arginate hydrochloride, stirring at 55-60 DEG C, adding small molecular hyaluronic acid, stirring at room temperature, refrigerating at-22 DEG C to-18 DEG C, freeze-drying at-80 DEG C to-75 DEG C, and grinding to obtain the composite clathrate compound. The perianal care solution prepared by the invention contains the herbaceous plant extract and the hyaluronic acid, and is good in oxidation resistance, good in care effect, free of precipitation and good in storage resistance.

The present application provides a kind of water dispersion type 25-hydroxyvitamin D3 Powder inclusion compound, it is characterized in that, including 25-hydroxyvitamin D3, β-cyclodextrin, malt dextrin, wherein, the mass ratio of β-cyclodextrin and 25-hydroxyvitamin D3 is 3-6:1, the mass ratio of malt dextrin and 25-hydroxyvitamin D3 is 10-20:1, in the inclusion compound, β-cyclodextrin, malt dextrin jointly as inclusion compound's inclusion shell, 25-hydroxyvitamin D3 as inclusion compound's content.

The invention belongs to the technical field of food processing, and particularly relates to high-stability theanine soft sugar and a preparation method thereof. The preparation method comprises the following steps: S1, uniformly mixing theanine and a carboxylate polymer in water, adjusting the temperature to 30-40 DEG C and the pH value to 4-5, carrying out a heat preservation reaction for 25-35 min, and then carrying out vacuum drying, grinding and sieving to obtain a theanine inclusion compound; s2, mixing syrup prepared by heating and dissolving carbohydrates with the gel after swelling and gelatinizing, and boiling to form a sugar solution; and S3, fully mixing the theanine inclusion compound with the sugar solution, controlling the temperature at 65-75 DEG C, adding a metal compound buffer solution, uniformly stirring and mixing, carrying out injection molding, cooling and shaping, and drying to obtain the theanine soft sugar. By means of the collaborative design of inclusion protection and ion collaborative gel strengthening, the activity stability of theanine can be guaranteed, the gel strength and texture of the soft sweets are optimized, and the market competitiveness of products is improved.

The invention discloses an antibacterial emulsion for skin and a preparation method thereof, and belongs to the technical field of emulsion medicines. The antibacterial emulsion is prepared from the following raw materials in parts by weight: 3 to 5 parts by weight of modified chitosan, 10 to 20 parts by weight of cross-linked oxidized cyclodextrin inclusion compound, 0.1 to 0.15 part by weight of genipin, 60 to 70 parts by weight of water phase matrix and 10 to 15 parts by weight of oil phase matrix. The antibacterial emulsion prepared by the preparation method disclosed by the invention has a good antibacterial effect and a transdermal effect.

This invention relates to pharmaceutical inclusion compounds, their preparation methods, and uses. Specifically, it provides a buggerfuran inclusion compound and its preparation method, wherein the inclusion compound comprises buggerfuran, cyclodextrin compounds, and optionally a high molecular weight polymer. This inclusion compound has a simple composition, high encapsulation efficiency, stability, and high safety, and can be used to prepare various liquid and solid dosage forms.

The invention discloses a compound disinfectant based on single-chain and double-chain quaternary ammonium salt and plant essential oil and a preparation method thereof, and the preparation method comprises the following steps: firstly, carrying out molecular inclusion on the plant essential oil and cyclodextrin in a water phase to form an inclusion compound; then respectively preparing a first cation solution of double-chain quaternary ammonium salt and a second cation solution of single-chain quaternary ammonium salt; then adding the clathrate compound into a first cation solution, and mixing to form a primary compound solution; slowly adding the second cation solution into the primary compound solution by controlling the dropping rate to complete compounding; and finally, adding a non-ionic high-molecular thickening agent, and stirring to form a uniform and transparent gelatinous disinfectant. By utilizing the characteristic that double-chain quaternary ammonium salt cannot be embedded into a cyclodextrin cavity due to steric hindrance, competitive replacement of single-chain quaternary ammonium salt on an essential oil inclusion compound is blocked from a molecular level, and inclusion stability and slow release performance of the essential oil are ensured; and through step-by-step compounding and accurate control of process parameters, system instability caused by overhigh local concentration is avoided.

The application discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by non-covalent bond interaction of salicylic acid, amino acid and cyclodextrin derivatives, wherein the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, wherein the salicylic acid molecules are included in the cavity of the cross-linked beta-cyclodextrin polymer, and meanwhile, the guanidino group or carboxyl group of the amino acid side chain interacts with the hydroxyl group outside the cross-linked beta-cyclodextrin polymer or the exposed part of the salicylic acid molecules after inclusion. The application uses the cross-linked beta-cyclodextrin polymer and introduces arginine as a synergist to construct a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary inclusion compound, and through charge neutralization and hydrogen bond network synergistic effect, the inclusion efficiency is significantly improved, and the water solubility of salicylic acid is improved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a cyclopentolate injection and a preparation method thereof. The cyclopentolate injection is composed of a cyclopentolate-beta-cyclodextrin inclusion compound, Tween 80, sodium chloride and water for injection. The cyclopentolate is encapsulated by using a cyclodextrin inclusion technology, and meanwhile, the preparation method of the cyclopentolate-beta-cyclodextrin inclusion compound is optimized, so that the encapsulation rate of the cyclopentolate-beta-cyclodextrin inclusion compound is significantly improved, and the stability of the cyclopentolate injection is improved.

The invention discloses a cotton / lyocell composite material for a face towel and a preparation method of the cotton / lyocell composite material, and relates to the technical field of textile fabrics. The cotton fibers and the lyocell fibers are pretreated to form the cotton / lyocell composite fiber net, and then the cotton / lyocell composite fiber net is soaked in the hydrophilic antibacterial finishing agent, so that the cotton / lyocell composite fiber net has the characteristics of being soft, hydrophilic, antibacterial and the like. The hydrophilic antibacterial finishing agent comprises modified polyamide and modified organosilicon quaternary ammonium salt; the modified polyamide contains ether bonds, hydroxyl groups and carboxyl groups and has good hydrophilicity; the modified organosilicon quaternary ammonium salt is further grafted with a compound beta-cyclodextrin inclusion compound, tea polyphenol is included in a cavity of beta-cyclodextrin through a cavity structure of beta-cyclodextrin, then nano-silver is loaded on the surface of beta-cyclodextrin through electrostatic interaction, the antibacterial effect is enhanced through the synergistic effect of nano-silver, tea polyphenol and quaternary ammonium salt, beta-cyclodextrin can efficiently include odor molecules, and the odor removal effect is improved. And a good deodorization effect is achieved.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The application relates to the technical field of inclusion compounds, in particular to a coenzyme Q10-cyclodextrin inclusion compound and a preparation method and application thereof, which comprises the following steps: dissolving coenzyme Q10 in an alcohol aqueous solution to obtain a first solution; performing ultrasonic treatment on the first solution at 40 DEG C-45 DEG C to obtain a second solution; performing cooling treatment on the second solution to obtain a third solution; adding a cyclodextrin derivative solution into the third solution to mix, and obtaining a fourth solution of the coenzyme Q10-cyclodextrin inclusion compound; adding corn starch into the fourth solution, stirring and reacting, removing a solvent, and obtaining a coenzyme Q10-cyclodextrin derivative corn starch inclusion compound. The preparation method has the advantages of simple operation and high encapsulation rate, and the coenzyme Q10-cyclodextrin derivative corn starch inclusion compound has good long-term storage stability.

The invention relates to eye drops containing umbilical cord mesenchymal stem cell exosomes. The eye drops are prepared from the following raw materials: sodium hyaluronate, an L-ascorbyl palmitate / hydroxypropyl-beta-cyclodextrin inclusion compound, panthenol, a solution containing the umbilical cord mesenchymal stem cell exosomes, water and normal saline, the concentration of the sodium hyaluronate is 0.2 to 0.6 mg / mL; the concentration of the L-ascorbyl palmitate / hydroxypropyl-beta-cyclodextrin inclusion compound ranges from 0.1 mg / mL to 0.4 mg / mL; the concentration of the panthenol is 0.2 to 1.0 mg / mL; the concentration of the umbilical cord mesenchymal stem cell exosome is 0.2 * 10 < 10 >-0.6 * 10 < 10 > parts / mL. The eye drops have good effects on treating xerophthalmia and repairing corneal epithelium injury.