37 results about "Rectal administration" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The present disclosure relates to a cannula and an enema composition for rectal administration via the cannula, particularly a liquid enema composition that forms a gel at body temperature. The cannula and enema are suitable for use in the treatment of ulcerative colitis, particularly distal ulcerative colitis (including proctitis and proctosigmoiditis).

The invention relates to the technical field of colorectal administration, in particular to a leakage-proof colorectal administration device which comprises a material pushing assembly, an anti-seepage assembly arranged on the material pushing assembly and a quantity-control liquid discharging assembly installed on the anti-seepage assembly, heat supply assemblies are installed in the material pushing assembly and the quantity-control liquid discharging assembly, and the heat supply assemblies penetrate into the anti-seepage assembly; the material pushing assembly comprises a tail end cushion piece. The anti-seepage assembly comprises an external end head installed at the inner end of the tail end cushion piece, by reducing the size of the dosing tool, after the volume-controlled liquid discharging assembly and the anti-seepage assembly are fed into the colorectum in a barrier-free mode, the compression balloon is inflated till the compression balloon is expanded and matched with the inner wall of the colorectum, and at the moment, the anti-seepage assembly is connected with the external end head. By means of the compression balloon, the area of stimulation to the colorectum can be reduced through the expansion area of the compression balloon, effective anti-overflow protection is provided for feeding of liquid medicine, meanwhile, the soft compression balloon can change according to the contraction change of the colorectum mucosa wall, and therefore the anti-overflow protection after medicine feeding is improved.

The utility model belongs to the technical field of bioequivalence tests, and particularly relates to a rectal administration device in a bioequivalence test, which comprises a mounting box and a medicine delivery component arranged on the outer side of the end part of the mounting box, the medicine feeding assembly comprises a mounting plate, a motor and a rotating disc, and the inner side of one end of the mounting box is fixedly connected with the mounting plate; the release position and depth of the medicine can be accurately controlled through the medicine feeding assembly, it is ensured that the medicine can reach a target area in the rectum, accurate control over the medicine dosage can be achieved through the device, the consistency of the dosage every time is ensured, and according to a traditional rectal administration mode, manual insertion and manual medicine injection are possibly needed; this may cause discomfort or pain of an injected person, while the drug delivery assembly can complete the drug delivery process instantly, thereby reducing the pain of organisms.

The invention discloses mucoprotein nano-selenium gas motor hydrogel as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method of the mucoprotein nano-selenium gas motor hydrogel comprises the following steps: adding a carbonyl compound and selenite into an emulsifier solution, and adding a reducing agent for mixing reaction to obtain a nano-selenium gas motor, oxidized mucoprotein and the nano-selenium gas motor are mixed, then a cross-linking agent is added, the oxidized mucoprotein is subjected to a cross-linking reaction to form gel, and the mucoprotein nano-selenium gas motor hydrogel is obtained. The mucoprotein nano-selenium gas motor hydrogel is constructed by wrapping a gas motor into a mucoprotein hydrogel delivery system, the mucoprotein nano-selenium gas motor hydrogel can be specifically delivered to a colitis disease part through rectal administration, and meanwhile, the safe and controllable release and mucous membrane protection effects of the nano-selenium gas motor are realized; therefore, a new thought is provided for treating enteritis.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention relates to the technical field of rectal administration, and provides equipment for rectal administration, the equipment for rectal administration comprises a feeding device, a medicine carrying piece, a medicine pushing piece and a control device, and the medicine carrying piece can be movably connected to the feeding device in the length direction of the feeding device; at least part of the medicine carrying piece protrudes out of one end of the feeding device; the medicine pushing piece can be movably connected to the feeding device in the length direction of the feeding device; at least part of the medicine pushing piece penetrates through the medicine carrying piece; the control device is arranged at the other end of the feeding device; the control device is electrically connected to the feeding device; the control device is used for controlling starting and stopping of the feeding device, and then the medicine carrying piece and the medicine pushing piece are driven to move. According to the equipment for rectal administration, the release position and dosage of the medicine can be accurately controlled, the treatment effect of a local area is enhanced, and the intelligence and automation of the equipment for rectal administration are improved.

The rectal administration device comprises an insertion cylinder, a medicine containing cavity, a handle and a medicine pushing assembly, the insertion cylinder is provided with an insertion end used for being inserted into the rectum and an exposed end located outside the body, and a liquid outlet hole and an adsorption hole are formed in the circumferential side wall of the insertion end; a liquid inlet channel communicated with the liquid outlet hole and an adsorption channel communicated with the adsorption hole are formed in the insertion cylinder, and the liquid inlet channel and the adsorption channel both extend to the exposed end; the medicine containing cavity is formed in the end portion of the insertion end and used for containing solid or semi-solid medicine. The handle is sleeved and fixed at the exposed end of the insertion cylinder; the inserting cylinder is provided with an operation channel extending from the exposed end to the medicine containing cavity in the axial direction, and the medicine pushing assembly is arranged in the operation channel in an axial moving mode and used for pushing out medicine in the medicine containing cavity. The rectal administration device can integrate local cleaning of the rectum and a drug delivery function, so that the operation is simplified, the cleaning pertinence is improved, and the administration effect is ensured.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention relates to the technical field of rectal administration, and discloses a traditional Chinese medicine rectal drip irrigation administration device which comprises a medicine storage cylinder and an installation block, the installation block is located on the right front portion of the medicine storage cylinder, a stabilizing ring is fixedly installed on the outer side of the installation block, and a cover body is movably installed on the inner bottom wall of the medicine storage cylinder. A fixing pipe extending to the inner side of the medicine storage barrel is fixedly installed at the bottom of the cover body, a liquid outlet pipe extending to the bottom of the fixing pipe is movably installed at the top of the fixing pipe, an adjusting pump is fixedly installed at the other end of the liquid outlet pipe, and a connecting pipe is fixedly installed at the output end of the adjusting pump; according to the traditional Chinese medicine rectum drip irrigation administration device, by arranging the administration mechanism and the connecting mechanism, the purpose that the anus tube is convenient to replace is achieved, by arranging the lubricating mechanism, the traditional Chinese medicine rectum drip irrigation administration device is convenient to use, and the traditional Chinese medicine rectum drip irrigation administration device is convenient to use. The purpose of arranging a lubricating structure is achieved.

A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

This invention relates to the field of rectal drug delivery system preparation, specifically to a method for preparing a novel rectal gel based on hydroxybutyl chitosan and graphene oxide, and its application. First, HBC is prepared via homogeneous synthesis. Then, GO is prepared using a modified Hummers method, and the anticancer model drug PYM is loaded onto its surface to obtain GO@PYM. Finally, GO@PYM is crosslinked with HBC to obtain HBC / GO@PYM. This invention improves upon the shortcomings of in-situ thermosensitive gels by introducing the nanomaterial GO, increasing drug loading and mechanical strength, enhancing drug release and bioavailability, and exhibiting a significant sustained-release effect. This invention provides a new method to solve the problems of insufficient mechanical strength, low drug loading, and low bioavailability of in-situ thermosensitive gels for rectal drug delivery.

The utility model discloses a rectal administration device, which relates to the technical field of rectal administration and comprises a delivery tube, an adsorption part and a push tube. The delivery pipe is hollow, openings are formed in the two ends, and at least part of the delivery pipe is used for entering the rectum of a patient. The adsorption part is used for adsorbing liquid medicine, is movably arranged in the conveying pipe and is connected with a pull wire; the push pipe is at least partially located in the conveying pipe and is in sliding connection with the conveying pipe, and the pull wire penetrates through the push pipe; when the push tube is pushed by one end of the push tube, the other end of the push tube is in contact with the adsorption part in an abutting mode so that the adsorption part can be pushed into the rectum of the patient from the conveying tube. According to the rectal administration device, the liquid medicine can be continuously released after being adsorbed by the adsorption part, and the intestinal wall can be covered by only a small amount of liquid medicine, so that the dosage of the liquid medicine is reduced; the expanded adsorption part is attached to the intestinal wall to form a physical barrier, so that liquid medicine flowing can be inhibited, and leakage is prevented; the patient does not need to keep a specific posture for a long time, operation difficulty is reduced, and operation is convenient.

Provided is a composition comprising microalgae and clay, formulated for ingestion, application to skin, an oral cavity, or administration rectally to a mammal. Also provided is a method of treating a mammal. The method comprises administering the above composition to the mammal.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention relates to a pharmaceutical preparation for local rectal administration, and relates to the technical field of rectal administration preparations. The pharmaceutical preparation comprises an active ingredient compound and pharmaceutically available auxiliary materials, the active ingredient compound comprises a glucoside compound. The pharmaceutical preparation provides a new drug choice for treatment of haemorrhoids.

The invention provides a hollow anus suppository capable of loading multiple active ingredients and application, and relates to the technical field of pharmaceutical preparations, the hollow anus suppository comprises a hollow shell made of a fusible matrix and an active ingredient filler sealed in the hollow shell; a highly universal rectal administration platform is constructed through a special hollow shell, active ingredients are sealed in an independent cavity, physical isolation and effective protection of contents are achieved, and the rectal administration device is particularly suitable for probiotics, chemical drugs, traditional Chinese medicine extracts and other sensitive ingredients which are prone to inactivation or unstable in the rectal environment. By accurately designing the wall thickness of the shell and the matrix formula, the fusion characteristic of the shell and the release behavior of the content can be effectively regulated and controlled, so that various programmed drug release modes from delayed release to colon targeted delivery and the like are realized, and the technical problems that a traditional suppository is too fast in release and non-targeted are solved.

The invention discloses a novel rectum self-foaming drug delivery system and application, and belongs to the technical field of medicine. The novel rectum self-foaming drug delivery system comprises a carrier material, a foaming agent and a foaming agent, when the drug delivery system or device is used for a rectum drug delivery route, particles carrying drugs can penetrate through an intestinal mucous layer and further penetrate through or directly act on mucous membranes, and the treatment effect is improved.

The invention discloses application of a cytisine-N-isoflavone derivative in preparation of a medicine for resisting non-small cell lung cancer, and belongs to the technical field of biological medicine. The derivative is a compound CNI3, and the medicine takes the compound CNI3 or a pharmaceutically acceptable solvate thereof as an active ingredient; the dosage form can be selected from tablets, capsules, granules, dripping pills, suspensions, syrups, enteric preparations, gels, suppositories, ointments, emulsions and injections, and the administration route can be selected from oral administration, injection administration, respiratory tract inhalation administration, local administration, sublingual administration and rectal administration. Experiments in combination with in-vivo cell level and in-vitro animal level prove that the compound CNI3 promotes apoptosis of non-small cell lung cancer, exerts activity of resisting non-small cell lung cancer, has no obvious toxic or side effect on normal tissue cells, is good in safety, and has a good clinical application prospect when being used for preparing the medicine for resisting non-small cell lung cancer.

The present application provides a kind of transvaginal, rectal administration progesterone sustained-release solid composition. Specifically, the composition includes: progesterone 100 parts by weight, cyclodextrin 800-2000 parts by weight, filler 10-30 parts by weight, binder 20-40 parts by weight, optionally preservative 0.5-10 parts by weight, polyoxyethylene 30-300 parts by weight and lubricant 4-30 parts by weight. The composition of the present application is based on progesterone-cyclodextrin inclusion and polyoxyethylene sustained-release synergistic effect for preparing vaginal, rectal administration preparation, not only has the physical properties suitable for vaginal, rectal administration (such as adhesion performance, prevent the preparation from sliding), but also can ensure that progesterone is stably released in vagina for a long time, improve bioavailability, reduce the side effects of progesterone administration.

1. Name of the product in this design: Rectal drug delivery device. 2. Purpose of this design: To accurately deliver medication into the rectum. 3. The key design features of this product are the combination of shape and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.

A medication delivery device for rectal delivery of medication includes a barrel, a tip, and a plunger. The barrel consists of rigid material. The tip has a first tip portion that is cylindrical and a second tip portion is in the form of a truncated cone. The second tip portion includes a discharge orifice that has a diameter smaller than the diameter of the first tip portion. The tip consists of a flexible, stretchable material. The plunger is insertable into the barrel through the opening in the second barrel end. The plunger includes a plunger shaft, a plunger head, and a plunger handle. The plunger head is disk shaped. The plunger handle is T-shaped and positioned perpendicular to the plunger shaft.

The invention relates to the technical field of medical instruments, in particular to a transanal probiotic colonization enema device and method.The transanal probiotic colonization enema device comprises a transparent scale liquid storage bag and an annular bag belt, the outer wall of the transparent scale liquid storage bag is sleeved with the annular bag belt, and the inner wall of the annular bag belt is fixedly connected with a constant-temperature heater; the outer wall of the transparent scale liquid storage bag is wrapped with a paraffin-based composite layer, the lower surface of the transparent scale liquid storage bag is fixedly connected with a medical silica gel catheter through a Luer taper, gastric acid and bile inactivation barriers are bypassed through rectal administration, the survival rate of probiotics is greatly increased, the probiotics directly reach the colon diseased region in a targeted mode, and the survival rate of the probiotics is increased. High-concentration florae are in accurate contact with intestinal mucosa, the colonic colonization rate is increased, the symptom relieving period is shortened, the device is easy and convenient to assemble and suitable for families and basic medical scenes, double leakage prevention is achieved through the annular bag, the funnel-shaped abutting piece and the leakage-proof and backflow-proof valve, leakage is eradicated, tissue damage is reduced through the arc-shaped tip design, and the use comfort is improved through self-adaptive sealing.

The invention belongs to the technical field of medicines, and particularly relates to a troxerutin suppository and a preparation method thereof. The invention provides a troxerutin suppository. The troxerutin suppository is prepared from the following raw materials in percentage by mass: 20-40% of troxerutin, 25-35% of cocoa butter and 35-45% of mixed fatty glyceride. According to the troxerutin suppository, the cocoa butter and the mixed fatty glyceride are adopted as auxiliary materials of the suppository, meanwhile, the cocoa butter and the mixed fatty glyceride are optimized to be matched with the troxerutin in a proper mass ratio, the obtained troxerutin suppository has good stability, and the release degree meets the standard. Meanwhile, the troxerutin suppository provided by the invention can realize rectal administration, reduces gastrointestinal irritation, is long in acting time, improves bioavailability, is suitable for patients who cannot take orally or are difficult to take orally, and improves drug compliance.

The utility model discloses a painless bolt pushing device used after anorectal operation, which relates to the technical field of medical instruments and comprises a painless bolt pushing device shell, a push rod is arranged in the painless bolt pushing device shell, a piston is fixedly mounted at the bottom of the push rod, a handle is fixedly mounted at the top of the push rod, and a handle is fixedly mounted at the bottom of the handle. An auxiliary extension is fixedly installed on the upper portion of the outer surface of the painless bolt pushing device shell, a lining is fixedly installed in the painless bolt pushing device shell, a suppository customized to be particularly long and thin is placed in the lining, and a thin film is arranged at the bottom of the painless bolt pushing device shell. The outer surface of the shell of the painless suppository pusher is subjected to super-smooth treatment, the suppository customized to be particularly slender is placed in the lining, the painless suppository pusher can be used for rectal administration after an anorectal small operation similar to haemorrhoids, and the problems that due to the fact that fingers are too thick, the suppository is slippery when a haemorrhoids suppository is plugged, and the suppository is not prone to being plugged by a patient repeatedly are solved.

1. The name of the design product: hemorrhoid suppository. 2. The use of the design product: the design product is applied to the suppository medicine for treating hemorrhoids, and directly acts on the anal rectal mucosa through rectal administration. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design. 6. Other conditions that need to be explained: when in use, the suppository part of the head enters the anal rectum and is separated from the push part of the tail.

The present invention relates to the technical field of colorectal drug delivery, and specifically to a leak-proof colorectal drug delivery device, comprising a pushing component, an anti-seepage component arranged on the pushing component, and a volume control and liquid discharge component installed on the anti-seepage component, and a heating component is installed in the pushing component and the volume control and liquid discharge component, and the heating component penetrates into the anti-seepage component; the pushing component comprises a tail end pad; the anti-seepage component comprises an external end head installed at the inner end of the tail end pad, by reducing the volume of the drug delivery tool, when the volume control and liquid discharge component and the anti-seepage component are delivered to the interior of the colorectum without obstacle, the compression balloon is inflated until the compression balloon expands and adapts to the inner wall of the colorectum, at this time, the expanded area of ​​the compression balloon can reduce the area of ​​colorectal stimulation and provide effective anti-overflow protection for the feeding of the drug solution, and at the same time, the soft compression balloon can change according to the contraction changes of the colorectal mucosal wall, thereby improving the anti-overflow protection after drug delivery.

Provided are a rectal administration tube sealing assembly, a collection bag, an enema auxiliary device, and a method for post-enema excreta collection. The rectal administration tube sealing assembly comprises: a through hole (1) for a rectal administration tube to pass through an administration nozzle, and a sealing ring layer (2) arranged on the inner wall of the through hole (1) and configured to separate a delivery section and an administration section of the rectal administration tube. A collection bag securing device comprises a securing base (14), a defecation hole (15) arranged in the middle part of the securing base (14), and limiting protrusions (16) arranged on two sides of the defecation hole (15). The method for enema excreta collection uses the enema auxiliary device to collect excreta. The medical staff can complete the enema process by means of the rectal administration tube and collect the feces.

The invention discloses a self-assembled hydrogel for treating ulcerative colitis and a preparation method and application thereof.The SPV-GA hydrogel with pH responsiveness and temperature-sensitive injectability is formed by dissolving and mixing evergreen gelsemine (SPV) and glycyrrhizic acid (GA) according to a certain molar ratio at the high temperature and conducting self-assembly at the temperature of 4 DEG C. The hydrogel can be rapidly degraded to release medicine in the intestinal pH environment (pH 7.4), and the hydrogel can be used for treating ulcerative colitis. The intestinal inflammation and barrier injury of ulcerative colitis are improved in a targeted manner, and the proinflammatory factor level is remarkably reduced; the temperature-sensitive injectable property is adapted to rectal administration, so that the problem of first-pass effect of a traditional oral preparation is solved, meanwhile, the preparation process is simple, the biocompatibility is excellent, and a novel targeted treatment strategy is provided for ulcerative colitis.

The present application relates to the technical field of pharmaceutical compositions, and specifically discloses a phytosphingosine pharmaceutical composition, which comprises an active ingredient and a pharmaceutically acceptable carrier, wherein the active ingredient is phytosphingosine or a pharmaceutically acceptable salt, ester, derivative or prodrug thereof; and the pharmaceutical composition is a colon-targeted drug preparation, an oral enteric-coated preparation or a rectal drug preparation. The present application realizes direct protection of the colon epithelium and breaks through the action limitation of the existing treatment scheme. Phytosphingosine can maintain the integrity of the colon epithelial structure, improve the survival and proliferation of the colon epithelial cells and provide a basis for the repair of the damaged mucosa under the stimulation of inflammation; meanwhile, phytosphingosine can effectively regulate the expression and normal membrane positioning of the tight junction protein of the colon mucosa, repair the damaged intestinal epithelial barrier structure and reduce the intestinal mucosal permeability, thereby breaking the vicious cycle of epithelial damage-inflammation amplification in the pathogenesis of ulcerative colitis from the root.