52 results about "Rectal administration" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses an application of indolepropionic acid in preparation of a medicine for preventing or treating ovarian cancer, the medicine takes indolepropionic acid as an active ingredient, the concentration is 0.1-1000 mu M, and the dosage forms comprise tablets, capsules, granules, pills, gels, suppositories, ointments, emulsions, mixtures, suspensions, injections and solutions. Administration routes comprise oral administration, injection administration, respiratory tract inhalation administration, local administration, sublingual administration and rectal administration, and can be combined with chemotherapeutic drugs for use. It is found through experiments that IPA with different concentrations can inhibit cell growth of ovarian cancer cell lines SKOV3 and A2780, cell proliferation of macrophages RAW264.7 is remarkably promoted, and the IPA has a potential immune promotion effect and good biological safety. In addition, the IPA can enhance the sensitivity of chemotherapeutic drugs, and the IPA and the chemotherapeutic drugs are combined to be applied to treatment of ovarian cancer, so that the treatment effect of the drugs can be remarkably improved.

The invention discloses a gastroenterology department rectal administration device combining traditional Chinese medicine and western medicine, and relates to the technical field of medical instruments, the gastroenterology department rectal administration device comprises an injection needle cylinder, the right end of the inner surface of the injection needle cylinder is slidably connected with an injection piston, the left end of the injection needle cylinder is fixedly provided with a connector, and the left end of the connector is fixedly connected with a conveying hose; fixing frames are fixedly connected to the front and rear sides of the left side of the outer surface of the injection needle cylinder, and a pulling lug plate is slidably connected to the right side of the outer surface of the injection needle cylinder. When the dosing device is used, the connecting sleeve is arranged on the connecting pipe in a sleeving mode, so that the left end of an injection needle cylinder can be sleeved with a clamping ring, meanwhile, under the jacking action of a jacking spring, a sliding baffle can limit the clamping ring, and therefore the position of the connecting sleeve can be positioned; therefore, the conveying hose can be prevented from falling off from the left end of the injection needle cylinder during administration, and normal use of the rectal administration device for the department of gastroenterology is guaranteed.

The invention discloses a leakage-proof colorectal administration device. The leakage-proof colorectal administration device comprises an administration tank, a dynamic sealing assembly and an administration plug, the dosing tank is used for storing liquid medicine and pushing the liquid medicine to be output through the matching effect of the piston plate and the plunger rod; the dynamic sealing assembly comprises a medicine injection box, a liquid feeding pipe and an abutting wheel, and the abutting wheel rotates when liquid medicine flows, guides the liquid medicine to smoothly enter the colorectum and is in a closed state when not used, so that the liquid medicine is prevented from flowing back; the dosing plug is inserted into a colorectum opening, a plug head body of the dosing plug is provided with an inner plug ball and a plug sealing part, double limiting and fixing are achieved through inflation and rotation of the expansion plug screw, the inner plug ball is located on the inner side of the colorectum to form internal limiting, the plug sealing part is located on the outer side of the colorectum to form external limiting, and therefore it is guaranteed that the device is stably positioned and effectively sealed, and liquid medicine leakage is prevented. The colorectal administration device is simple in structure and convenient to operate, can improve the safety and stability of colorectal administration, and has a good application prospect.

The present disclosure relates to a cannula and an enema composition for rectal administration via the cannula, particularly a liquid enema composition that forms a gel at body temperature. The cannula and enema are suitable for use in the treatment of ulcerative colitis, particularly distal ulcerative colitis (including proctitis and proctosigmoiditis).

The invention relates to the technical field of colorectal administration, in particular to a leakage-proof colorectal administration device which comprises a material pushing assembly, an anti-seepage assembly arranged on the material pushing assembly and a quantity-control liquid discharging assembly installed on the anti-seepage assembly, heat supply assemblies are installed in the material pushing assembly and the quantity-control liquid discharging assembly, and the heat supply assemblies penetrate into the anti-seepage assembly; the material pushing assembly comprises a tail end cushion piece. The anti-seepage assembly comprises an external end head installed at the inner end of the tail end cushion piece, by reducing the size of the dosing tool, after the volume-controlled liquid discharging assembly and the anti-seepage assembly are fed into the colorectum in a barrier-free mode, the compression balloon is inflated till the compression balloon is expanded and matched with the inner wall of the colorectum, and at the moment, the anti-seepage assembly is connected with the external end head. By means of the compression balloon, the area of stimulation to the colorectum can be reduced through the expansion area of the compression balloon, effective anti-overflow protection is provided for feeding of liquid medicine, meanwhile, the soft compression balloon can change according to the contraction change of the colorectum mucosa wall, and therefore the anti-overflow protection after medicine feeding is improved.

The utility model belongs to the technical field of bioequivalence tests, and particularly relates to a rectal administration device in a bioequivalence test, which comprises a mounting box and a medicine delivery component arranged on the outer side of the end part of the mounting box, the medicine feeding assembly comprises a mounting plate, a motor and a rotating disc, and the inner side of one end of the mounting box is fixedly connected with the mounting plate; the release position and depth of the medicine can be accurately controlled through the medicine feeding assembly, it is ensured that the medicine can reach a target area in the rectum, accurate control over the medicine dosage can be achieved through the device, the consistency of the dosage every time is ensured, and according to a traditional rectal administration mode, manual insertion and manual medicine injection are possibly needed; this may cause discomfort or pain of an injected person, while the drug delivery assembly can complete the drug delivery process instantly, thereby reducing the pain of organisms.

The invention discloses mucoprotein nano-selenium gas motor hydrogel as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method of the mucoprotein nano-selenium gas motor hydrogel comprises the following steps: adding a carbonyl compound and selenite into an emulsifier solution, and adding a reducing agent for mixing reaction to obtain a nano-selenium gas motor, oxidized mucoprotein and the nano-selenium gas motor are mixed, then a cross-linking agent is added, the oxidized mucoprotein is subjected to a cross-linking reaction to form gel, and the mucoprotein nano-selenium gas motor hydrogel is obtained. The mucoprotein nano-selenium gas motor hydrogel is constructed by wrapping a gas motor into a mucoprotein hydrogel delivery system, the mucoprotein nano-selenium gas motor hydrogel can be specifically delivered to a colitis disease part through rectal administration, and meanwhile, the safe and controllable release and mucous membrane protection effects of the nano-selenium gas motor are realized; therefore, a new thought is provided for treating enteritis.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention relates to the technical field of rectal administration, and provides equipment for rectal administration, the equipment for rectal administration comprises a feeding device, a medicine carrying piece, a medicine pushing piece and a control device, and the medicine carrying piece can be movably connected to the feeding device in the length direction of the feeding device; at least part of the medicine carrying piece protrudes out of one end of the feeding device; the medicine pushing piece can be movably connected to the feeding device in the length direction of the feeding device; at least part of the medicine pushing piece penetrates through the medicine carrying piece; the control device is arranged at the other end of the feeding device; the control device is electrically connected to the feeding device; the control device is used for controlling starting and stopping of the feeding device, and then the medicine carrying piece and the medicine pushing piece are driven to move. According to the equipment for rectal administration, the release position and dosage of the medicine can be accurately controlled, the treatment effect of a local area is enhanced, and the intelligence and automation of the equipment for rectal administration are improved.

The invention belongs to the field of medical and health appliances, and particularly relates to a rectal administration tube sealing assembly, an excrement receiving bag, an enema auxiliary appliance and a method for collecting excrement after enema. A rectal administration tube sealing assembly comprises a through hole for a rectal administration tube to pass through an administration nozzle, and a sealing ring layer is arranged on the inner wall of the through hole. By means of the sealing ring layer, the conveying section and the dosing section of the rectal dosing tube are isolated, and basic conditions are provided for installing an excrement receiving bag. The excrement receiving bag fixing device comprises a fixing base, a drain hole is formed in the middle of the fixing base, and limiting protrusions are arranged on at least two sides of the periphery of the drain hole. According to the clysis excrement collection method, the clysis auxiliary tool is used for collecting excrement. The disposable excrement receiving bag is fixed to the anus opening of a patient, and excrement can be conveniently collected while enema operation is carried out. A medical worker can insert the rectal administration tube into the anus of a patient through the administration nozzle, and after the enema process is completed, the patient can excrete excrement into the excrement receiving bag by himself / herself.

The utility model discloses a mouse rectal administration fixed anesthesia device, which relates to the technical field of scientific research experiments, and comprises an outer tube and an inner tube, the inner tube is arranged inside the outer tube, the left end of the outer tube is fixedly connected with a first adjustable fan blade ventilation device, and the inside of the outer tube and the left side of the inner tube are fixedly connected with a second adjustable fan blade ventilation device. An anesthetic containing area is formed by the first adjustable fan blade ventilation device, the second adjustable fan blade ventilation device and the interior of the outer pipe, anesthetic cotton balls are arranged in the anesthetic containing area, a first rat tail groove is formed in the right end of the upper side of the outer pipe, and a second rat tail groove is formed in the position, corresponding to the first rat tail groove, of the right end of the upper side of the inner pipe. The device has the advantages that the ventilatory capacity of inhaled anesthetic is controlled in real time according to the anesthesia condition and physiological status of a mouse, the mouse is prevented from escaping through the first mouse tail groove formed in the outer side of the outer tube, the second mouse tail groove formed in the outer side of the inner tube and the limiting clamping bolt, and rectal administration operation is conveniently carried out after the mouse tail is fixed and the anus is exposed.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a topiramate children preparation and a preparation method thereof. The topiramate children preparation is a rectum enema liquid, and is prepared from the following components in percentage by mass: 1-5% of topiramate, 0.01-0.25% of a preservative and the balance of a solvent, wherein the solvent comprises glycerol, and the solvent is anhydrous. The topiramate anhydrous rectal enema provided by the invention adopts rectal administration, so that the problem of poor taste of an oral preparation is avoided; meanwhile, no water is contained, so that the problem of poor stability caused by hydrolysis can be avoided.

The rectal administration device comprises an insertion cylinder, a medicine containing cavity, a handle and a medicine pushing assembly, the insertion cylinder is provided with an insertion end used for being inserted into the rectum and an exposed end located outside the body, and a liquid outlet hole and an adsorption hole are formed in the circumferential side wall of the insertion end; a liquid inlet channel communicated with the liquid outlet hole and an adsorption channel communicated with the adsorption hole are formed in the insertion cylinder, and the liquid inlet channel and the adsorption channel both extend to the exposed end; the medicine containing cavity is formed in the end portion of the insertion end and used for containing solid or semi-solid medicine. The handle is sleeved and fixed at the exposed end of the insertion cylinder; the inserting cylinder is provided with an operation channel extending from the exposed end to the medicine containing cavity in the axial direction, and the medicine pushing assembly is arranged in the operation channel in an axial moving mode and used for pushing out medicine in the medicine containing cavity. The rectal administration device can integrate local cleaning of the rectum and a drug delivery function, so that the operation is simplified, the cleaning pertinence is improved, and the administration effect is ensured.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention relates to the technical field of rectal administration, and discloses a traditional Chinese medicine rectal drip irrigation administration device which comprises a medicine storage cylinder and an installation block, the installation block is located on the right front portion of the medicine storage cylinder, a stabilizing ring is fixedly installed on the outer side of the installation block, and a cover body is movably installed on the inner bottom wall of the medicine storage cylinder. A fixing pipe extending to the inner side of the medicine storage barrel is fixedly installed at the bottom of the cover body, a liquid outlet pipe extending to the bottom of the fixing pipe is movably installed at the top of the fixing pipe, an adjusting pump is fixedly installed at the other end of the liquid outlet pipe, and a connecting pipe is fixedly installed at the output end of the adjusting pump; according to the traditional Chinese medicine rectum drip irrigation administration device, by arranging the administration mechanism and the connecting mechanism, the purpose that the anus tube is convenient to replace is achieved, by arranging the lubricating mechanism, the traditional Chinese medicine rectum drip irrigation administration device is convenient to use, and the traditional Chinese medicine rectum drip irrigation administration device is convenient to use. The purpose of arranging a lubricating structure is achieved.

The invention discloses a traditional Chinese medicine bowel relaxing suppository, belongs to the technical field of biological pharmacy, and ensures the safety and obvious curative effect of the product through scientific preparation. The composition combines a nourishing and intestine moistening mixture and a modern preparation technology, and can quickly relieve constipation and adjust intestinal functions. Compared with oral administration and rectal administration, the suppository provided by the invention is more convenient to use, can be directly brought into the anus, and avoids complex operation and discomfort. In addition, the traditional Chinese medicine composition is helpful for preventing complications such as anal fissure and haemorrhoids possibly caused by long-term constipation, and the living quality of patients is The traditional Chinese medicine theory is inherited and developed, the modernization process of traditional Chinese medicine is promoted, and a new example is provided for internationalized development. Meanwhile, the traditional Chinese medicine composition has high market potential and social value, the cognition of the public on traditional Chinese medicine can be improved, healthy industry development is promoted, and contribution is made to reasonable allocation of social medical resources.

A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

This invention relates to the field of rectal drug delivery system preparation, specifically to a method for preparing a novel rectal gel based on hydroxybutyl chitosan and graphene oxide, and its application. First, HBC is prepared via homogeneous synthesis. Then, GO is prepared using a modified Hummers method, and the anticancer model drug PYM is loaded onto its surface to obtain GO@PYM. Finally, GO@PYM is crosslinked with HBC to obtain HBC / GO@PYM. This invention improves upon the shortcomings of in-situ thermosensitive gels by introducing the nanomaterial GO, increasing drug loading and mechanical strength, enhancing drug release and bioavailability, and exhibiting a significant sustained-release effect. This invention provides a new method to solve the problems of insufficient mechanical strength, low drug loading, and low bioavailability of in-situ thermosensitive gels for rectal drug delivery.

The utility model discloses a rectal administration device, which relates to the technical field of rectal administration and comprises a delivery tube, an adsorption part and a push tube. The delivery pipe is hollow, openings are formed in the two ends, and at least part of the delivery pipe is used for entering the rectum of a patient. The adsorption part is used for adsorbing liquid medicine, is movably arranged in the conveying pipe and is connected with a pull wire; the push pipe is at least partially located in the conveying pipe and is in sliding connection with the conveying pipe, and the pull wire penetrates through the push pipe; when the push tube is pushed by one end of the push tube, the other end of the push tube is in contact with the adsorption part in an abutting mode so that the adsorption part can be pushed into the rectum of the patient from the conveying tube. According to the rectal administration device, the liquid medicine can be continuously released after being adsorbed by the adsorption part, and the intestinal wall can be covered by only a small amount of liquid medicine, so that the dosage of the liquid medicine is reduced; the expanded adsorption part is attached to the intestinal wall to form a physical barrier, so that liquid medicine flowing can be inhibited, and leakage is prevented; the patient does not need to keep a specific posture for a long time, operation difficulty is reduced, and operation is convenient.

Provided is a composition comprising microalgae and clay, formulated for ingestion, application to skin, an oral cavity, or administration rectally to a mammal. Also provided is a method of treating a mammal. The method comprises administering the above composition to the mammal.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention relates to a pharmaceutical preparation for local rectal administration, and relates to the technical field of rectal administration preparations. The pharmaceutical preparation comprises an active ingredient compound and pharmaceutically available auxiliary materials, the active ingredient compound comprises a glucoside compound. The pharmaceutical preparation provides a new drug choice for treatment of haemorrhoids.

The present disclosure relates to a cannula and an enema composition for rectal administration via the cannula, particularly a liquid enema composition that forms a gel at body temperature. The cannula and enema are suitable for use in the treatment of ulcerative colitis, particularly distal ulcerative colitis (including proctitis and proctosigmoiditis).

The invention provides a hollow anus suppository capable of loading multiple active ingredients and application, and relates to the technical field of pharmaceutical preparations, the hollow anus suppository comprises a hollow shell made of a fusible matrix and an active ingredient filler sealed in the hollow shell; a highly universal rectal administration platform is constructed through a special hollow shell, active ingredients are sealed in an independent cavity, physical isolation and effective protection of contents are achieved, and the rectal administration device is particularly suitable for probiotics, chemical drugs, traditional Chinese medicine extracts and other sensitive ingredients which are prone to inactivation or unstable in the rectal environment. By accurately designing the wall thickness of the shell and the matrix formula, the fusion characteristic of the shell and the release behavior of the content can be effectively regulated and controlled, so that various programmed drug release modes from delayed release to colon targeted delivery and the like are realized, and the technical problems that a traditional suppository is too fast in release and non-targeted are solved.

The invention discloses a novel rectum self-foaming drug delivery system and application, and belongs to the technical field of medicine. The novel rectum self-foaming drug delivery system comprises a carrier material, a foaming agent and a foaming agent, when the drug delivery system or device is used for a rectum drug delivery route, particles carrying drugs can penetrate through an intestinal mucous layer and further penetrate through or directly act on mucous membranes, and the treatment effect is improved.

The utility model relates to the technical field of rectal administration auxiliary equipment, in particular to a suppository extrusion device with adjustable administration depth, an adjustable depth setting mechanism comprises an in-vitro stopping sheet and a depth adjusting rod, the in-vitro stopping sheet is movably sleeved on a suppository extrusion mechanism, the depth adjusting rod is a thin screw rod, and the thin screw rod is sleeved on the suppository extrusion mechanism. The in-vitro stopping piece is installed on the suppository extrusion mechanism in a threaded fit mode, one end of the depth adjusting rod is rotatably installed on the in-vitro stopping piece, and the other end of the depth adjusting rod is in threaded connection with the suppository extrusion mechanism so that the position of the in-vitro stopping piece on the suppository extrusion mechanism can be adjusted by rotating the depth adjusting rod. Further, the depth of the suppository extrusion mechanism inserted into the anus is adjusted; and the suppository mounting and lubricating mechanism can also lubricate the suppository. In this way, medicine application can be conducted according to different intra-anus medicine application depths without replacing medicine loading devices of different lengths, the suppository can be lubricated, and discomfort of a patient is reduced.

Rectal administration device, comprising a rod-shaped member having a top end and a bottom end, an auxiliary member, and a drug passage for delivering drugs, the drug passage being provided with at least one drug inlet and at least one drug outlet, the auxiliary member being conformally fitted over the rod-shaped member, at least the auxiliary member entering the rectum having a lower material hardness than the rod-shaped member, the auxiliary member being provided with depressions for accommodating drugs and / or fecal matter, and at least one opening being provided in the depressions.

The invention discloses application of a cytisine-N-isoflavone derivative in preparation of a medicine for resisting non-small cell lung cancer, and belongs to the technical field of biological medicine. The derivative is a compound CNI3, and the medicine takes the compound CNI3 or a pharmaceutically acceptable solvate thereof as an active ingredient; the dosage form can be selected from tablets, capsules, granules, dripping pills, suspensions, syrups, enteric preparations, gels, suppositories, ointments, emulsions and injections, and the administration route can be selected from oral administration, injection administration, respiratory tract inhalation administration, local administration, sublingual administration and rectal administration. Experiments in combination with in-vivo cell level and in-vitro animal level prove that the compound CNI3 promotes apoptosis of non-small cell lung cancer, exerts activity of resisting non-small cell lung cancer, has no obvious toxic or side effect on normal tissue cells, is good in safety, and has a good clinical application prospect when being used for preparing the medicine for resisting non-small cell lung cancer.

The present application provides a kind of transvaginal, rectal administration progesterone sustained-release solid composition. Specifically, the composition includes: progesterone 100 parts by weight, cyclodextrin 800-2000 parts by weight, filler 10-30 parts by weight, binder 20-40 parts by weight, optionally preservative 0.5-10 parts by weight, polyoxyethylene 30-300 parts by weight and lubricant 4-30 parts by weight. The composition of the present application is based on progesterone-cyclodextrin inclusion and polyoxyethylene sustained-release synergistic effect for preparing vaginal, rectal administration preparation, not only has the physical properties suitable for vaginal, rectal administration (such as adhesion performance, prevent the preparation from sliding), but also can ensure that progesterone is stably released in vagina for a long time, improve bioavailability, reduce the side effects of progesterone administration.