26 results about "Rectal use" patented technology

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The present disclosure relates to a cannula and an enema composition for rectal administration via the cannula, particularly a liquid enema composition that forms a gel at body temperature. The cannula and enema are suitable for use in the treatment of ulcerative colitis, particularly distal ulcerative colitis (including proctitis and proctosigmoiditis).

The utility model belongs to the technical field of bioequivalence tests, and particularly relates to a rectal administration device in a bioequivalence test, which comprises a mounting box and a medicine delivery component arranged on the outer side of the end part of the mounting box, the medicine feeding assembly comprises a mounting plate, a motor and a rotating disc, and the inner side of one end of the mounting box is fixedly connected with the mounting plate; the release position and depth of the medicine can be accurately controlled through the medicine feeding assembly, it is ensured that the medicine can reach a target area in the rectum, accurate control over the medicine dosage can be achieved through the device, the consistency of the dosage every time is ensured, and according to a traditional rectal administration mode, manual insertion and manual medicine injection are possibly needed; this may cause discomfort or pain of an injected person, while the drug delivery assembly can complete the drug delivery process instantly, thereby reducing the pain of organisms.

The invention discloses mucoprotein nano-selenium gas motor hydrogel as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method of the mucoprotein nano-selenium gas motor hydrogel comprises the following steps: adding a carbonyl compound and selenite into an emulsifier solution, and adding a reducing agent for mixing reaction to obtain a nano-selenium gas motor, oxidized mucoprotein and the nano-selenium gas motor are mixed, then a cross-linking agent is added, the oxidized mucoprotein is subjected to a cross-linking reaction to form gel, and the mucoprotein nano-selenium gas motor hydrogel is obtained. The mucoprotein nano-selenium gas motor hydrogel is constructed by wrapping a gas motor into a mucoprotein hydrogel delivery system, the mucoprotein nano-selenium gas motor hydrogel can be specifically delivered to a colitis disease part through rectal administration, and meanwhile, the safe and controllable release and mucous membrane protection effects of the nano-selenium gas motor are realized; therefore, a new thought is provided for treating enteritis.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The rectal administration device comprises an insertion cylinder, a medicine containing cavity, a handle and a medicine pushing assembly, the insertion cylinder is provided with an insertion end used for being inserted into the rectum and an exposed end located outside the body, and a liquid outlet hole and an adsorption hole are formed in the circumferential side wall of the insertion end; a liquid inlet channel communicated with the liquid outlet hole and an adsorption channel communicated with the adsorption hole are formed in the insertion cylinder, and the liquid inlet channel and the adsorption channel both extend to the exposed end; the medicine containing cavity is formed in the end portion of the insertion end and used for containing solid or semi-solid medicine. The handle is sleeved and fixed at the exposed end of the insertion cylinder; the inserting cylinder is provided with an operation channel extending from the exposed end to the medicine containing cavity in the axial direction, and the medicine pushing assembly is arranged in the operation channel in an axial moving mode and used for pushing out medicine in the medicine containing cavity. The rectal administration device can integrate local cleaning of the rectum and a drug delivery function, so that the operation is simplified, the cleaning pertinence is improved, and the administration effect is ensured.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention relates to the technical field of rectal administration, and discloses a traditional Chinese medicine rectal drip irrigation administration device which comprises a medicine storage cylinder and an installation block, the installation block is located on the right front portion of the medicine storage cylinder, a stabilizing ring is fixedly installed on the outer side of the installation block, and a cover body is movably installed on the inner bottom wall of the medicine storage cylinder. A fixing pipe extending to the inner side of the medicine storage barrel is fixedly installed at the bottom of the cover body, a liquid outlet pipe extending to the bottom of the fixing pipe is movably installed at the top of the fixing pipe, an adjusting pump is fixedly installed at the other end of the liquid outlet pipe, and a connecting pipe is fixedly installed at the output end of the adjusting pump; according to the traditional Chinese medicine rectum drip irrigation administration device, by arranging the administration mechanism and the connecting mechanism, the purpose that the anus tube is convenient to replace is achieved, by arranging the lubricating mechanism, the traditional Chinese medicine rectum drip irrigation administration device is convenient to use, and the traditional Chinese medicine rectum drip irrigation administration device is convenient to use. The purpose of arranging a lubricating structure is achieved.

A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

The utility model discloses a rectal administration device, which relates to the technical field of rectal administration and comprises a delivery tube, an adsorption part and a push tube. The delivery pipe is hollow, openings are formed in the two ends, and at least part of the delivery pipe is used for entering the rectum of a patient. The adsorption part is used for adsorbing liquid medicine, is movably arranged in the conveying pipe and is connected with a pull wire; the push pipe is at least partially located in the conveying pipe and is in sliding connection with the conveying pipe, and the pull wire penetrates through the push pipe; when the push tube is pushed by one end of the push tube, the other end of the push tube is in contact with the adsorption part in an abutting mode so that the adsorption part can be pushed into the rectum of the patient from the conveying tube. According to the rectal administration device, the liquid medicine can be continuously released after being adsorbed by the adsorption part, and the intestinal wall can be covered by only a small amount of liquid medicine, so that the dosage of the liquid medicine is reduced; the expanded adsorption part is attached to the intestinal wall to form a physical barrier, so that liquid medicine flowing can be inhibited, and leakage is prevented; the patient does not need to keep a specific posture for a long time, operation difficulty is reduced, and operation is convenient.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention relates to a pharmaceutical preparation for local rectal administration, and relates to the technical field of rectal administration preparations. The pharmaceutical preparation comprises an active ingredient compound and pharmaceutically available auxiliary materials, the active ingredient compound comprises a glucoside compound. The pharmaceutical preparation provides a new drug choice for treatment of haemorrhoids.

The invention provides a hollow anus suppository capable of loading multiple active ingredients and application, and relates to the technical field of pharmaceutical preparations, the hollow anus suppository comprises a hollow shell made of a fusible matrix and an active ingredient filler sealed in the hollow shell; a highly universal rectal administration platform is constructed through a special hollow shell, active ingredients are sealed in an independent cavity, physical isolation and effective protection of contents are achieved, and the rectal administration device is particularly suitable for probiotics, chemical drugs, traditional Chinese medicine extracts and other sensitive ingredients which are prone to inactivation or unstable in the rectal environment. By accurately designing the wall thickness of the shell and the matrix formula, the fusion characteristic of the shell and the release behavior of the content can be effectively regulated and controlled, so that various programmed drug release modes from delayed release to colon targeted delivery and the like are realized, and the technical problems that a traditional suppository is too fast in release and non-targeted are solved.

The invention discloses application of a cytisine-N-isoflavone derivative in preparation of a medicine for resisting non-small cell lung cancer, and belongs to the technical field of biological medicine. The derivative is a compound CNI3, and the medicine takes the compound CNI3 or a pharmaceutically acceptable solvate thereof as an active ingredient; the dosage form can be selected from tablets, capsules, granules, dripping pills, suspensions, syrups, enteric preparations, gels, suppositories, ointments, emulsions and injections, and the administration route can be selected from oral administration, injection administration, respiratory tract inhalation administration, local administration, sublingual administration and rectal administration. Experiments in combination with in-vivo cell level and in-vitro animal level prove that the compound CNI3 promotes apoptosis of non-small cell lung cancer, exerts activity of resisting non-small cell lung cancer, has no obvious toxic or side effect on normal tissue cells, is good in safety, and has a good clinical application prospect when being used for preparing the medicine for resisting non-small cell lung cancer.

The present application provides a kind of transvaginal, rectal administration progesterone sustained-release solid composition. Specifically, the composition includes: progesterone 100 parts by weight, cyclodextrin 800-2000 parts by weight, filler 10-30 parts by weight, binder 20-40 parts by weight, optionally preservative 0.5-10 parts by weight, polyoxyethylene 30-300 parts by weight and lubricant 4-30 parts by weight. The composition of the present application is based on progesterone-cyclodextrin inclusion and polyoxyethylene sustained-release synergistic effect for preparing vaginal, rectal administration preparation, not only has the physical properties suitable for vaginal, rectal administration (such as adhesion performance, prevent the preparation from sliding), but also can ensure that progesterone is stably released in vagina for a long time, improve bioavailability, reduce the side effects of progesterone administration.

The invention relates to the technical field of medical instruments, in particular to a transanal probiotic colonization enema device and method.The transanal probiotic colonization enema device comprises a transparent scale liquid storage bag and an annular bag belt, the outer wall of the transparent scale liquid storage bag is sleeved with the annular bag belt, and the inner wall of the annular bag belt is fixedly connected with a constant-temperature heater; the outer wall of the transparent scale liquid storage bag is wrapped with a paraffin-based composite layer, the lower surface of the transparent scale liquid storage bag is fixedly connected with a medical silica gel catheter through a Luer taper, gastric acid and bile inactivation barriers are bypassed through rectal administration, the survival rate of probiotics is greatly increased, the probiotics directly reach the colon diseased region in a targeted mode, and the survival rate of the probiotics is increased. High-concentration florae are in accurate contact with intestinal mucosa, the colonic colonization rate is increased, the symptom relieving period is shortened, the device is easy and convenient to assemble and suitable for families and basic medical scenes, double leakage prevention is achieved through the annular bag, the funnel-shaped abutting piece and the leakage-proof and backflow-proof valve, leakage is eradicated, tissue damage is reduced through the arc-shaped tip design, and the use comfort is improved through self-adaptive sealing.

The invention belongs to the technical field of medicines, and particularly relates to a troxerutin suppository and a preparation method thereof. The invention provides a troxerutin suppository. The troxerutin suppository is prepared from the following raw materials in percentage by mass: 20-40% of troxerutin, 25-35% of cocoa butter and 35-45% of mixed fatty glyceride. According to the troxerutin suppository, the cocoa butter and the mixed fatty glyceride are adopted as auxiliary materials of the suppository, meanwhile, the cocoa butter and the mixed fatty glyceride are optimized to be matched with the troxerutin in a proper mass ratio, the obtained troxerutin suppository has good stability, and the release degree meets the standard. Meanwhile, the troxerutin suppository provided by the invention can realize rectal administration, reduces gastrointestinal irritation, is long in acting time, improves bioavailability, is suitable for patients who cannot take orally or are difficult to take orally, and improves drug compliance.

The utility model discloses a painless bolt pushing device used after anorectal operation, which relates to the technical field of medical instruments and comprises a painless bolt pushing device shell, a push rod is arranged in the painless bolt pushing device shell, a piston is fixedly mounted at the bottom of the push rod, a handle is fixedly mounted at the top of the push rod, and a handle is fixedly mounted at the bottom of the handle. An auxiliary extension is fixedly installed on the upper portion of the outer surface of the painless bolt pushing device shell, a lining is fixedly installed in the painless bolt pushing device shell, a suppository customized to be particularly long and thin is placed in the lining, and a thin film is arranged at the bottom of the painless bolt pushing device shell. The outer surface of the shell of the painless suppository pusher is subjected to super-smooth treatment, the suppository customized to be particularly slender is placed in the lining, the painless suppository pusher can be used for rectal administration after an anorectal small operation similar to haemorrhoids, and the problems that due to the fact that fingers are too thick, the suppository is slippery when a haemorrhoids suppository is plugged, and the suppository is not prone to being plugged by a patient repeatedly are solved.

1. The name of the design product: hemorrhoid suppository. 2. The use of the design product: the design product is applied to the suppository medicine for treating hemorrhoids, and directly acts on the anal rectal mucosa through rectal administration. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design. 6. Other conditions that need to be explained: when in use, the suppository part of the head enters the anal rectum and is separated from the push part of the tail.

Provided are a rectal administration tube sealing assembly, a collection bag, an enema auxiliary device, and a method for post-enema excreta collection. The rectal administration tube sealing assembly comprises: a through hole (1) for a rectal administration tube to pass through an administration nozzle, and a sealing ring layer (2) arranged on the inner wall of the through hole (1) and configured to separate a delivery section and an administration section of the rectal administration tube. A collection bag securing device comprises a securing base (14), a defecation hole (15) arranged in the middle part of the securing base (14), and limiting protrusions (16) arranged on two sides of the defecation hole (15). The method for enema excreta collection uses the enema auxiliary device to collect excreta. The medical staff can complete the enema process by means of the rectal administration tube and collect the feces.

The invention discloses a self-assembled hydrogel for treating ulcerative colitis and a preparation method and application thereof.The SPV-GA hydrogel with pH responsiveness and temperature-sensitive injectability is formed by dissolving and mixing evergreen gelsemine (SPV) and glycyrrhizic acid (GA) according to a certain molar ratio at the high temperature and conducting self-assembly at the temperature of 4 DEG C. The hydrogel can be rapidly degraded to release medicine in the intestinal pH environment (pH 7.4), and the hydrogel can be used for treating ulcerative colitis. The intestinal inflammation and barrier injury of ulcerative colitis are improved in a targeted manner, and the proinflammatory factor level is remarkably reduced; the temperature-sensitive injectable property is adapted to rectal administration, so that the problem of first-pass effect of a traditional oral preparation is solved, meanwhile, the preparation process is simple, the biocompatibility is excellent, and a novel targeted treatment strategy is provided for ulcerative colitis.

The present invention is directed to compositions containing exosomes isolated from milk and methods and uses thereof for treating inflammatory bowel disease (IBD) and conditions related thereto. In particular, disclosed are exosomes derived from milk and enteral formulations supplemented therewith for use in treating IBD. The compositions are preferably formulated for rectal administration and the exosomes comprise one or more miRNA molecules and TGF-β.

The utility model discloses a leakage-proof closed drainage device for fecal incontinence. The leakage-proof closed drainage device comprises a base plate, a transparent long bag, a multifunctional long tube and a drainage bag, an anus hole is formed in the middle of the base plate, one end of the transparent long bag is connected with the wall face of the base plate, the other end of the transparent long bag is connected with the outer wall of the multifunctional long pipe, and the multifunctional long pipe freely stretches out and draws back in the transparent long bag. The multifunctional long tube internally comprises a large cavity and a small cavity, the front ends of the double cavities of the multifunctional long tube are both provided with openings, the tail end of the large cavity is provided with a first connector and a second connector in a forked mode, the tail end of the first connector is connected with the drainage bag, and rectal administration is conducted through the second connector on one side; a third connector arranged at the tail end of the small cavity channel is used for being connected with a connector of an infusion apparatus, then anus wrinkles at the uncovered position of the base plate are flushed, pasty excrement is diluted, drainage is facilitated, pollution and infection caused by fecal incontinence can be effectively prevented, meanwhile, drainage, flushing and rectal administration are facilitated, and the nursing efficiency and the comfort degree of a patient are improved.

This invention belongs to the field of pharmaceutical formulations and relates to a drug nanocrystal using a low-molecular-weight weak acid salt as a stabilizer and its preparation method. This invention uses a low-molecular-weight weak acid salt as a stabilizer for nanoscale drug crystal particles, resulting in a simple formulation and good safety profile. The preparation method described in this invention is based on media grinding and can be further freeze-dried to obtain a lyophilized product that can be reconstituted to the nanoscale, facilitating large-scale preparation and long-term storage. The formulation described in this invention can be administered via mucosal routes such as intravenous injection, local injection, oral administration, vaginal administration, intranasal administration, oral administration, rectal administration, and intraocular administration, as well as inhalation administration, intravesical instillation, or surgical margin administration.

The present application provides a preparation that can be used for colitis, comprising arctiin; chitosan; and arctiin and chitosan connected via a diselenide bond. A method for preparing the aforementioned preparation is also provided. Compared to other existing technologies with complex preparation processes and inconvenient administration methods, the preparation method of the present application is simple, has a stable yield, and is convenient and quick to synthesize in only two steps. The prepared hydrogel also uses a safe and non-toxic natural non-toxic cross-linking agent as a cross-linking agent, has good efficacy, can be administered orally, and has better patient compliance than rectal administration. It has significant advantages and extremely high development potential for clinical development and use.

A method of generating a microbial composition is disclosed. The method comprises: (a) culturing at least one food source under conditions that promote native microbial growth; (b) separating resulting microbes from the cultured food to obtain a composition comprising at least 80% of the distinct microbial species present in the microbiota of the cultured food; and (c) processing the microbes by formulating the composition for oral, endoscopic, colonoscopic or rectal administration. Microbial compositions generated thereby and uses thereof are also disclosed.