14 results about "Rectal use" patented technology

The invention discloses mucoprotein nano-selenium gas motor hydrogel as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method of the mucoprotein nano-selenium gas motor hydrogel comprises the following steps: adding a carbonyl compound and selenite into an emulsifier solution, and adding a reducing agent for mixing reaction to obtain a nano-selenium gas motor, oxidized mucoprotein and the nano-selenium gas motor are mixed, then a cross-linking agent is added, the oxidized mucoprotein is subjected to a cross-linking reaction to form gel, and the mucoprotein nano-selenium gas motor hydrogel is obtained. The mucoprotein nano-selenium gas motor hydrogel is constructed by wrapping a gas motor into a mucoprotein hydrogel delivery system, the mucoprotein nano-selenium gas motor hydrogel can be specifically delivered to a colitis disease part through rectal administration, and meanwhile, the safe and controllable release and mucous membrane protection effects of the nano-selenium gas motor are realized; therefore, a new thought is provided for treating enteritis.

The rectal administration device comprises an insertion cylinder, a medicine containing cavity, a handle and a medicine pushing assembly, the insertion cylinder is provided with an insertion end used for being inserted into the rectum and an exposed end located outside the body, and a liquid outlet hole and an adsorption hole are formed in the circumferential side wall of the insertion end; a liquid inlet channel communicated with the liquid outlet hole and an adsorption channel communicated with the adsorption hole are formed in the insertion cylinder, and the liquid inlet channel and the adsorption channel both extend to the exposed end; the medicine containing cavity is formed in the end portion of the insertion end and used for containing solid or semi-solid medicine. The handle is sleeved and fixed at the exposed end of the insertion cylinder; the inserting cylinder is provided with an operation channel extending from the exposed end to the medicine containing cavity in the axial direction, and the medicine pushing assembly is arranged in the operation channel in an axial moving mode and used for pushing out medicine in the medicine containing cavity. The rectal administration device can integrate local cleaning of the rectum and a drug delivery function, so that the operation is simplified, the cleaning pertinence is improved, and the administration effect is ensured.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention relates to the technical field of rectal administration, and discloses a traditional Chinese medicine rectal drip irrigation administration device which comprises a medicine storage cylinder and an installation block, the installation block is located on the right front portion of the medicine storage cylinder, a stabilizing ring is fixedly installed on the outer side of the installation block, and a cover body is movably installed on the inner bottom wall of the medicine storage cylinder. A fixing pipe extending to the inner side of the medicine storage barrel is fixedly installed at the bottom of the cover body, a liquid outlet pipe extending to the bottom of the fixing pipe is movably installed at the top of the fixing pipe, an adjusting pump is fixedly installed at the other end of the liquid outlet pipe, and a connecting pipe is fixedly installed at the output end of the adjusting pump; according to the traditional Chinese medicine rectum drip irrigation administration device, by arranging the administration mechanism and the connecting mechanism, the purpose that the anus tube is convenient to replace is achieved, by arranging the lubricating mechanism, the traditional Chinese medicine rectum drip irrigation administration device is convenient to use, and the traditional Chinese medicine rectum drip irrigation administration device is convenient to use. The purpose of arranging a lubricating structure is achieved.

A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

The utility model discloses a rectal administration device, which relates to the technical field of rectal administration and comprises a delivery tube, an adsorption part and a push tube. The delivery pipe is hollow, openings are formed in the two ends, and at least part of the delivery pipe is used for entering the rectum of a patient. The adsorption part is used for adsorbing liquid medicine, is movably arranged in the conveying pipe and is connected with a pull wire; the push pipe is at least partially located in the conveying pipe and is in sliding connection with the conveying pipe, and the pull wire penetrates through the push pipe; when the push tube is pushed by one end of the push tube, the other end of the push tube is in contact with the adsorption part in an abutting mode so that the adsorption part can be pushed into the rectum of the patient from the conveying tube. According to the rectal administration device, the liquid medicine can be continuously released after being adsorbed by the adsorption part, and the intestinal wall can be covered by only a small amount of liquid medicine, so that the dosage of the liquid medicine is reduced; the expanded adsorption part is attached to the intestinal wall to form a physical barrier, so that liquid medicine flowing can be inhibited, and leakage is prevented; the patient does not need to keep a specific posture for a long time, operation difficulty is reduced, and operation is convenient.

Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

The invention provides a hollow anus suppository capable of loading multiple active ingredients and application, and relates to the technical field of pharmaceutical preparations, the hollow anus suppository comprises a hollow shell made of a fusible matrix and an active ingredient filler sealed in the hollow shell; a highly universal rectal administration platform is constructed through a special hollow shell, active ingredients are sealed in an independent cavity, physical isolation and effective protection of contents are achieved, and the rectal administration device is particularly suitable for probiotics, chemical drugs, traditional Chinese medicine extracts and other sensitive ingredients which are prone to inactivation or unstable in the rectal environment. By accurately designing the wall thickness of the shell and the matrix formula, the fusion characteristic of the shell and the release behavior of the content can be effectively regulated and controlled, so that various programmed drug release modes from delayed release to colon targeted delivery and the like are realized, and the technical problems that a traditional suppository is too fast in release and non-targeted are solved.

The present application provides a kind of transvaginal, rectal administration progesterone sustained-release solid composition. Specifically, the composition includes: progesterone 100 parts by weight, cyclodextrin 800-2000 parts by weight, filler 10-30 parts by weight, binder 20-40 parts by weight, optionally preservative 0.5-10 parts by weight, polyoxyethylene 30-300 parts by weight and lubricant 4-30 parts by weight. The composition of the present application is based on progesterone-cyclodextrin inclusion and polyoxyethylene sustained-release synergistic effect for preparing vaginal, rectal administration preparation, not only has the physical properties suitable for vaginal, rectal administration (such as adhesion performance, prevent the preparation from sliding), but also can ensure that progesterone is stably released in vagina for a long time, improve bioavailability, reduce the side effects of progesterone administration.

The invention relates to the technical field of medical instruments, in particular to a transanal probiotic colonization enema device and method.The transanal probiotic colonization enema device comprises a transparent scale liquid storage bag and an annular bag belt, the outer wall of the transparent scale liquid storage bag is sleeved with the annular bag belt, and the inner wall of the annular bag belt is fixedly connected with a constant-temperature heater; the outer wall of the transparent scale liquid storage bag is wrapped with a paraffin-based composite layer, the lower surface of the transparent scale liquid storage bag is fixedly connected with a medical silica gel catheter through a Luer taper, gastric acid and bile inactivation barriers are bypassed through rectal administration, the survival rate of probiotics is greatly increased, the probiotics directly reach the colon diseased region in a targeted mode, and the survival rate of the probiotics is increased. High-concentration florae are in accurate contact with intestinal mucosa, the colonic colonization rate is increased, the symptom relieving period is shortened, the device is easy and convenient to assemble and suitable for families and basic medical scenes, double leakage prevention is achieved through the annular bag, the funnel-shaped abutting piece and the leakage-proof and backflow-proof valve, leakage is eradicated, tissue damage is reduced through the arc-shaped tip design, and the use comfort is improved through self-adaptive sealing.

The invention belongs to the technical field of medicines, and particularly relates to a troxerutin suppository and a preparation method thereof. The invention provides a troxerutin suppository. The troxerutin suppository is prepared from the following raw materials in percentage by mass: 20-40% of troxerutin, 25-35% of cocoa butter and 35-45% of mixed fatty glyceride. According to the troxerutin suppository, the cocoa butter and the mixed fatty glyceride are adopted as auxiliary materials of the suppository, meanwhile, the cocoa butter and the mixed fatty glyceride are optimized to be matched with the troxerutin in a proper mass ratio, the obtained troxerutin suppository has good stability, and the release degree meets the standard. Meanwhile, the troxerutin suppository provided by the invention can realize rectal administration, reduces gastrointestinal irritation, is long in acting time, improves bioavailability, is suitable for patients who cannot take orally or are difficult to take orally, and improves drug compliance.

1. The name of the design product: hemorrhoid suppository. 2. The use of the design product: the design product is applied to the suppository medicine for treating hemorrhoids, and directly acts on the anal rectal mucosa through rectal administration. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design. 6. Other conditions that need to be explained: when in use, the suppository part of the head enters the anal rectum and is separated from the push part of the tail.

The utility model discloses a leakage-proof closed drainage device for fecal incontinence. The leakage-proof closed drainage device comprises a base plate, a transparent long bag, a multifunctional long tube and a drainage bag, an anus hole is formed in the middle of the base plate, one end of the transparent long bag is connected with the wall face of the base plate, the other end of the transparent long bag is connected with the outer wall of the multifunctional long pipe, and the multifunctional long pipe freely stretches out and draws back in the transparent long bag. The multifunctional long tube internally comprises a large cavity and a small cavity, the front ends of the double cavities of the multifunctional long tube are both provided with openings, the tail end of the large cavity is provided with a first connector and a second connector in a forked mode, the tail end of the first connector is connected with the drainage bag, and rectal administration is conducted through the second connector on one side; a third connector arranged at the tail end of the small cavity channel is used for being connected with a connector of an infusion apparatus, then anus wrinkles at the uncovered position of the base plate are flushed, pasty excrement is diluted, drainage is facilitated, pollution and infection caused by fecal incontinence can be effectively prevented, meanwhile, drainage, flushing and rectal administration are facilitated, and the nursing efficiency and the comfort degree of a patient are improved.

A method of generating a microbial composition is disclosed. The method comprises: (a) culturing at least one food source under conditions that promote native microbial growth; (b) separating resulting microbes from the cultured food to obtain a composition comprising at least 80% of the distinct microbial species present in the microbiota of the cultured food; and (c) processing the microbes by formulating the composition for oral, endoscopic, colonoscopic or rectal administration. Microbial compositions generated thereby and uses thereof are also disclosed.