A rectal in-situ gel for antipyretic and preparation method thereof

An in-situ gel and gel technology, which is applied to antipyretics, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of high local concentration and uneven distribution, and achieve enhanced Adsorption capacity, reduced drug excretion, good containment effect

Inactive Publication Date: 2011-11-30
陕西医药控股集团新药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The problem to be solved by the present invention is to provide a rectal in-situ gel for antipyretic and its preparation method, and provide a new preparation for antipyretic, which not only retains the advantages of rectal medication, but also overcomes the existing There is a problem of excessive local concentration and uneven distribution of rectal medication

Method used

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  • A rectal in-situ gel for antipyretic and preparation method thereof
  • A rectal in-situ gel for antipyretic and preparation method thereof
  • A rectal in-situ gel for antipyretic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 In situ gel formulation for rectal use containing acetaminophen

[0062]

[0063] According to the above mass percentages, first add 5 g of paracetamol, 2 g of glycerin, 0.5 g of sodium benzoate, and 1 g of phenhol in 50 g of water for injection, stir well and dissolve; then poloxamer (407) 20 g, hydroxypropyl Slowly add 1 g of cellulose to the above solution under the condition of stirring in an ice-water bath, store in low temperature refrigeration until a clear solution is formed, then add 20.5 g of water for injection to make the content of each component reach a predetermined concentration, and obtain acetaminophen-containing The in situ gel preparation for rectal use can be used for reducing fever in children and other special populations.

Embodiment 2

[0064] Example 2 In situ gel formulation for rectum containing ibuprofen

[0065]

[0066] First micronize the ibuprofen raw material into 10g of superfine powder, disperse in 50g of water for injection, stir to disperse evenly, add 0.02g of bromogeramine, 1g of glycerin, 2g of sodium alginate, mix evenly, and slowly Add 18g of poloxamer (407) and 1g of hydroxypropyl cellulose to the above solution, add water for injection to make the content of each component reach the predetermined concentration, store it in low temperature refrigeration, stir it evenly, and pack it separately. The preparation is Pharmaceutical preparations for febrile illnesses.

Embodiment 3

[0067] Example 3: In situ gel formulations containing nimesulide

[0068]

[0069]

[0070] Firstly, the raw material of nimesulide is pulverized into ultra-fine powder, 15g of nimesulide is dispersed in 40g of aqueous solution, stirred to make the dispersion even, add 1g of methylparaben, 5g of propylene glycol, and 2g of laurocapram, mix well, Slowly add 18 g of poloxamer (407) and 3 g of poloxamer (188) to the above solution under stirring in an ice-water bath. Store in low temperature refrigeration, stir well and then pack. The preparation is a pharmaceutical preparation for febrile illnesses.

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Abstract

The invention discloses a rectal in-situ gel for antipyretic and a preparation method thereof, which comprises the following components in terms of mass fraction: 1-20% of antipyretic drug, and 5-30% of in-situ gel matrix , 0.1-10% of tackifier, 0.1-10% of lubricant, 0.1-10% of preservative, 0.1-10% of transdermal absorption regulator, and the balance is water. The rectal in-situ gel for antipyretic provided by the present invention not only has no drug dead angle, but also enhances the adsorption capacity and prolongs the drug effect by adding bioadhesive substances, and reduces the excretion of the drug caused by the stool caused by the solid preparation; it has good Inclusiveness, it can be either a specific medicinal ingredient or an active ingredient of a traditional Chinese medicine extract.

Description

technical field [0001] The invention belongs to the technical field of rectal administration, and relates to a rectal in-situ gel for reducing fever and a preparation method thereof. Background technique [0002] The earliest drug enema therapy can be found in Zhang Zhongjing's "Treatise on Distinguishing Yangming Diseases and Syndromes and Treating them", which records "a big pig bile, diarrhea juice, and a little French vinegar are used to irrigate the valley road. It is very effective to stay and eat evil things." There are similar records in many medical arts in later generations. It is recorded in volume 2882 of Dunhuang posthumous medical volume that the enema method for external treatment is to make a pouch containing medicine from sheepskin, use a bamboo tube as a catheter, and then enema into the anus, and volume 5435 records that a reed tube is used as a catheter for insertion, and sheep bile is enema Treat constipation. There is a similar description in the fam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/38A61K47/36A61K47/34A61K47/32A61P29/00
Inventor 肖志强麻纪斌朱骤海王晓博张琳何俊婷杨建刚翟帆李宗霖
Owner 陕西医药控股集团新药技术开发有限公司
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