22 results about "Laurocapram" patented technology

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

The invention relates to a skin moistening composition for a mask and a preparation method thereof, and belongs to the technical field of skin care products, the skin moistening composition is composed of sodium polyglutamate, saccharide isomeride, prunus amygdalus dulcis oil, cajeput leaf oil, an auxiliary natural extract, a permeation enhancing component, a dispersing component, a thickening component, an antiseptic component and deionized water, the auxiliary natural extract comprises a dracocephalum dracocephalum extract and a roselle extract, the permeation enhancing component is at least one of laurocapram and isopropyl myristate, the dispersing component comprises polyglycerol-10 myristate and polyglycerol-6 octoate, the thickening component comprises carbomer and hydroxyethyl cellulose, and the stabilizing component comprises a stabilizing component and a stabilizing component. According to the skin moistening composition, the preservative components comprise sodium ethylparaben and sodium methyl paraben, although the active components of the skin moistening composition are all natural source components, the skin moistening performance is still excellent, the skin moistening and moistening effects are excellent, and the skin care advantages of mildness and strong effect are shown.

The application provides a dexmedetomidine hydrochloride soluble microneedle; the dexmedetomidine hydrochloride soluble microneedle comprises a substrate and a drug-loaded needle body, the drug-loaded needle body comprises dexmedetomidine hydrochloride and a penetration enhancer; the penetration enhancer comprises at least two of laurocapram, polyvinylpyrrolidone and polysorbate; the weight average molecular weight of the polyvinylpyrrolidone is 2000 Da to 13000 Da. The dexmedetomidine hydrochloride soluble microneedle provided by the application can significantly improve the peak drug concentration after transdermal delivery under the promotion of the penetration enhancer, has a short onset time and a long duration, and can achieve the effects of rapid release, rapid onset and sustained effectiveness.

The invention relates to amitriptyline gel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides amitriptyline gel. The amitriptyline gel is prepared from the following components in parts by mass: 2 to 8 parts of amitriptyline hydrochloride, 16 to 24 parts of glycerol, 2 to 8 parts of hydroxypropyl methylcellulose, 16 to 24 parts of 70 to 80 percent ethanol solution, 0.05 to 0.15 part of ethylparaben, 0.2 to 0.8 part of laurocapram and 36 to 64 parts of water. The amitriptyline gel plaster prepared from the amitriptyline gel can effectively relieve postherpetic neuralgia, and compared with traditional oral tablets, the amitriptyline gel plaster can effectively reduce side effects.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The invention provides a ceftiofur injection as well as a preparation method and application thereof, and belongs to the technical field of veterinary drug preparations. The ceftiofur injection prepared by the invention takes propylene glycol as a solvent, and every 1000 mL of the ceftiofur injection is prepared from the following components: 80 to 120 g of ceftiofur hydrochloride, 50 to 80 g of hydroxypropyl-beta-cyclodextrin, 180 to 220 mL of polyethylene glycol 400, 40 to 60 mL of medicinal glycerol, 2 to 5 mL of laurocapram and 0.8 to 1.2 g of ascorbyl palmitate. The ceftiofur injection prepared by the invention has the advantages that the plasma concentration peak reaching time is obviously shortened, the drug concentration of an infected part is obviously improved, the drug action time is effectively prolonged, the drug resistance risk of bacteria is reduced, the survival rate of piglets can be obviously improved, and the death risk caused by bacterial infection is effectively reduced; the method is suitable for prevention and control of secondary bacterial infection of the porcine reproductive and respiratory syndrome in large-scale pig

The present application provides a long-term stable S-2-(2-fluoro-4-biphenyl) propionic acid-containing pharmaceutical composition, and a S-2-(2-fluoro-4-biphenyl) propionic acid-containing patch and a preparation method thereof, the pharmaceutical composition comprising: S-2-(2-fluoro-4-biphenyl) propionic acid or a pharmaceutically acceptable salt thereof, menthol oil and a stabilizer, the stabilizer being selected from at least one of isopropyl myristate, crotamiton and laurocapram. The S-2-(2-fluoro-4-biphenyl) propionic acid-containing pharmaceutical composition of the present application, with at least one of isopropyl myristate, crotamiton and laurocapram as a stabilizer added to the composition of S-2-(2-fluoro-4-biphenyl) propionic acid and menthol oil, can significantly improve the storage stability of the composition, compared with the prior art, the content of the active ingredient S-2-(2-fluoro-4-biphenyl) propionic acid is further inhibited from decreasing over time.

The invention discloses a traditional Chinese medicine plugging agent for treating rhinitis, and relates to the technical field of medicines, the traditional Chinese medicine plugging agent comprises traditional Chinese medicine compound compatibility of dahurian angelica root, mint, ligusticum wallichii, magnolia flower, centipeda minima, borneol and spina gleditsiae, the traditional Chinese medicine compound compatibility is combined with a biodegradable matrix PLGA (poly (lactic-co-glycolic acid)) for forming, and stable release of the medicine is realized through a slow release technology. The preparation method comprises the steps of superfine grinding of traditional Chinese medicine powder, suspension preparation, microsphere forming, vacuum drying and the like. The plugging agent is conical, smooth in surface, soft in texture, convenient to insert into the nasal cavity, not prone to falling off and suitable for treating acute and chronic rhinitis. By adjusting the proportion of the PLGA and adding a penetration enhancer laurocapram, the drug release and permeability are optimized. The defects of existing traditional Chinese medicine preparations in dosage form adaptability, targeted delivery and drug release controllability are overcome, the treatment effect and use comfort are remarkably improved, and clinical requirements are met.

The invention discloses a preparation method of a skin freckle-removing and whitening composite film spraying agent, which comprises the following steps: S1, preparing a sodium alginate solution with the content of sodium alginate being 1-1.5%; s2, sodium hyaluronate, whitening components, propylene glycol and azone are added into the sodium alginate solution to be dissolved, the mass ratio of sodium alginate to sodium hyaluronate to propylene glycol to azone is 1: (0.5-1): (0.5-1): 1, and a compound film forming solution is obtained; and S3, uniformly spreading the compound film-forming solution prepared in the step S2 in a vessel, uniformly spraying the uniform cross-linking solution in the vessel, and after a layer of film is formed, taking out the film to obtain the freckle-removing and whitening type composite film spraying agent for the skin. The prepared skin freckle-removing and whitening composite film spraying agent has the effects of no irritation to skin, strong medicine infiltration capacity, high mechanical strength, moisture retention and oil control.

The invention relates to the technical field of external medicine preparations, discloses skin antibacterial gel and a preparation method thereof, and aims to solve the technical problems that in the prior art, extraction of multi-polar active ingredients of Mongolian medicine is insufficient, and when natural extracts and chemical bacteriostatic agents are compounded, uneven dispersion, high irritation and poor stability are prone to occurring. The skin antibacterial gel is composed of Mongolian medicine extract, polyvinyl alcohol, xanthan gum, triclosan, glycerin, nicotinamide and other auxiliary materials. The preparation method is characterized in that the Mongolian medicine is extracted by adopting a gradient process combining ultrasonic water extraction and microwave alcohol extraction, so that active ingredients with different polarities are fully reserved; the triclosan is subjected to composite microencapsulation treatment through a trehalose and sodium hyaluronate compounded wall material; according to the preparation method, polyvinyl alcohol and xanthan gum are used for constructing an interpenetrating network matrix, laurocapram is introduced for optimizing the transdermal performance, the Mongolian medicine ingredient extraction efficiency is improved, and the obtained gel is reliable in antibacterial effect, stable in long-term storage performance, low in skin irritation and capable of meeting the skin antibacterial nursing requirement.

Topical compositions and kits are provided for hair regrowth, hair loss prevention, and scalp health improvement. These formulations contain at least one active (e.g., finasteride, minoxidil, dutasteride, and latanoprost), at least one penetration enhancer (e.g., Transcutol®, laurocapram), stabilizers, and anti-inflammatory agents like retinoic acid, hydrocortisone, and aloe vera. They utilize optimized particle sizes (D90 ≤8.5 μm, span ≤1.7) and may include bioadhesive polymers or nanoparticles for enhanced follicular delivery and extended residence. Modular kits offer multi-chambered packaging, calibrated droppers, and app- or sensor-guided dispensing for customizable ingredient mixing and regimen personalization. These innovations improve active stability, minimize irritation, and yield superior clinical outcomes (hair density and quality) over traditional therapies. Methods include treating varied alopecia types, with or without device-assisted delivery (microneedling, light therapy), alongside digital monitoring, compliance tracking, and optional diagnostic or conditioning tools for individualized scalp and hair care.

The present invention discloses a skin care composition, comprising a first active component and a second auxiliary component. The first active component is selected from one or more of tetrahydrocurcumin, ergothioneine, phloretin, arbutin, resveratrol, vitamin C, dipotassium glycyrrhizinate, ceramide, Aloe vera polysaccharide, Opuntia dillenii polysaccharide, Astragali radix polysaccharide, Dendrobii caulis polysaccharide, Cucumis metuliferus polysaccharide, fucoidan, small-molecule hyaluronic acid, pearl powder, collagen, tea tree essential oil, thearubigins, salicylic acid, retinol, glycoxyl, carnosine; the second auxiliary component is selected from one or more of tetrahydropiperine, laurocapram, PEG-75 shea butter glycerides, hydrogenated castor oil, glycerol, lauric acid, sucrose laurate, butanediol, polysorbate, hydroxyethyl cellulose, 1,2-pentanediol, ethoxydiglycol. The skin care composition of the present invention can be used for whitening, anti-inflammatory, anti-glycation, moisturizing, skin firming, anti-bacterial and / or anti-aging.

The invention relates to the technical field of oral medicine preparations, in particular to a compound preparation special for periodontitis and having analgesic and anti-inflammatory effects and a preparation method of the compound preparation. Comprising 0.01 wt% to 0.05 wt% of capsaicin, 0.5 wt% to 1.5 wt% of propyl gallate, 0.3 wt% to 0.8 wt% of berberine hydrochloride, 2.0 wt% to 5.0 wt% of chitosan quaternary ammonium salt, 1.0 wt% to 3.0 wt% of hydroxypropyl methylcellulose K4M, 0.5 wt% to 1.2 wt% of azone, 5.0 wt% to 10.0 wt% of glycerinum, 0.5 wt% to 1.0 wt% of citric acid-sodium citrate buffer solution and the balance purified water for injection. Through combination of capsaicin (analgesic), propyl gallate (anti-inflammatory) and berberine hydrochloride (bacteriostatic), 'pain relief-inflammation control-pathogenic bacteria removal 'are synchronously carried out, an adhesion-controlled release system is formed by chitosan quaternary ammonium salt and HPMC, so that the retention time of a medicine in a periodontal pocket reaches 8-12 hours, the in-vitro release rate in 24 hours is greater than or equal to 85%, and the effect is remarkable. The local drug concentration is 4-6 times that of common gel, and frequent drug administration is avoided.

The application belongs to the technical field of medicine, and particularly relates to a preparation method of laurocapram aripiprazole suspension, which comprises the following steps: (a) obtaining a mother liquor by mixing laurocapram aripiprazole, a first surfactant and water; (b) homogenizing the mother liquor to form an intermediate suspension with D90 of 10-25 microns; (c) heating the intermediate suspension; (d) when the intermediate suspension obtained in step (c) is cooled to room temperature, mixing with a standby solution containing a second surfactant to obtain laurocapram aripiprazole suspension.

The invention relates to a skin care composition which comprises a first active component and a second auxiliary component, the first active component is selected from tetrahydrocurcumin, ergothioneine, phloretin, arbutin, resveratrol, vitamin C, dipotassium glycyrrhizinate, ceramide, aloe polysaccharide, cactus polysaccharide, astragalus polysaccharide, dendrobe polysaccharide, cucumis metuliferus polysaccharide, fucoidan, micromolecular hyaluronic acid, pearl powder, collagen, tea tree essential oil, thearubigin, salicylic acid, retinol and tannin; one or more of carnosine; and the second auxiliary agent component is selected from one or more of tetrahydropiperine, laurocapram, PEG-75 shea butter glyceride, hydrogenated castor oil, glycerol, lauric acid, sucrose laurate, butanediol, polysorbate, hydroxyethyl cellulose, 1, 2-pentanediol and ethoxydiethylene glycol. The skin care composition can be used for whitening, resisting inflammation, resisting sugar, moisturizing, tightening skin, resisting bacteria and / or resisting ageing.

The present application relates to the technical field of traditional Chinese medicine, and relates to a targeted drug introduction treatment paste for treating Gouty Arthritis, and also relates to a preparation method of the treatment paste and application thereof. The targeted drug introduction treatment paste for treating Gouty Arthritis is prepared from the following components in parts: Radix Rehmanniae 15-30 parts, Radix Sophorae 15-30 parts, Radix Angelicae Pubescentis 15-30 parts, Radix Hedysari 15-30 parts, Ramulus Cinnamomi 15-30 parts, Herba Epimedii 30-60 parts, Radix Saposhnikoviae 10-20 parts, Radix Clematidis 15-30 parts, Radix Paeoniae Alba 15-30 parts, Radix Curculiginis 15-30 parts, Radix Cibotii 15-30 parts, Radix Pyrolae 15-30 parts, Carthami Flos 10-20 parts, Radix Angelicae Dahuricae 10-20 parts, and Borneolum Syntheticum 3-6 parts. The targeted drug introduction treatment paste for treating Gouty Arthritis further comprises a transdermal penetration enhancer, and the transdermal penetration enhancer is a combination of 1,2-propanediol, oleic acid and laurocapram (AGone). The treatment paste is combined with intelligent targeted drug treatment technology, so that the drug can directly reach deep lesions, reduce drug toxicity and side effects, maintain a high drug concentration at the lesion site, reduce the frequency of drug administration, improve the curative effect, shorten the treatment course, and greatly improve patient compliance.

The application relates to the technical field of external drug preparations, and discloses a skin bacteriostatic gel and a preparation method thereof, and aims to solve the technical problems that in the prior art, Mongolian medicine multi-polar active ingredient extraction is insufficient, and when natural extract and chemical bacteriostatic agents are compounded, uneven dispersion, strong irritability and poor stability are prone to occur. The skin bacteriostatic gel is composed of Mongolian medicine extract, polyvinyl alcohol, xanthan gum, triclosan, glycerol, nicotinamide and other auxiliary materials; and the key of the preparation method is that: the Mongolian medicine is extracted by adopting a gradient process combining ultrasonic water extraction and microwave alcohol extraction, so that different polar active ingredients are fully reserved; triclosan is subjected to compound micro-capsulation treatment by being compounded with trehalose and sodium hyaluronate wall materials; an interpenetrating network matrix is constructed by using polyvinyl alcohol and xanthan gum, and laurocapram is introduced to optimize the transdermal performance, so that the extraction efficiency of the Mongolian medicine components is improved; the obtained gel has reliable bacteriostatic effect, stable long-term storage performance and low skin irritability, and can meet the skin bacteriostatic care demand.

This invention discloses a whitening and freckle-removing nano-cream and its preparation method using supergravity technology. The whitening and freckle-removing nano-cream comprises the following raw materials in parts by weight: 2-5 parts of water-in-oil emulsifier, 2-5 parts of oil-in-water emulsifier, 3-5 parts of liquid oil, 1-3 parts of solid oil, 1-3 parts of tocopheryl acetate, 0.5-2 parts of laurocapram, 0.1-0.25 parts of propylparaben, 10-30 parts of glycerin, 0.2-0.3 parts of methylparaben, 0.05-0.1 parts of sodium lauryl sulfate, 0.5-1 parts of antioxidant, 1.8-4 parts of whitening and freckle-removing active ingredients, and deionized water added to a total of 100 parts. The present invention also discloses a method for preparing the whitening and freckle-removing nano-cream. The whitening and freckle-removing nano-cream of the present invention has a particle size between 70-130nm. Under the conditions of storage at room temperature, 40℃ and 4℃ for ≥90 days, the appearance, particle size and content of whitening and freckle-removing active ingredients do not change significantly.

The invention discloses an antifungal compound ointment as well as a preparation method and application thereof. The ointment comprises the following effective components in percentage by mass: 0.1-3% of amorolfen and mangnolia officinalis extract, and the balance of an ointment substrate, the mangnolia officinalis extract is magnolol, and the mass ratio of amorolfen to magnolol is (1: 0.5)-(1: 2). The ointment substrate is an oily substrate containing vaseline, wool fat, liquid paraffin, stearic acid, glycerol monostearate, an antioxidant and laurocapram. According to the compound ointment disclosed by the invention, through the synergistic effect of amorolfen and magnolol, the antifungal effect is remarkably enhanced, and the drug resistance risk is reduced; through cooperation of the optimized matrix and the penetration enhancer laurocapram, the permeability and bioavailability of the medicine to the deck are improved. The ointment can be used for preparing medicines for treating fungal infection such as leuconychia and the like, and has the advantages of good curative effect, high safety and convenience in use.

The invention provides a dexmedetomidine hydrochloride soluble microneedle. The dexmedetomidine hydrochloride soluble microneedle comprises a substrate and a medicine carrying needle body, wherein the medicine carrying needle body contains dexmedetomidine hydrochloride and a penetration enhancer; the penetration enhancer is prepared from at least two of laurocapram, polyvinylpyrrolidone and polysorbate; the weight-average molecular weight of the polyvinylpyrrolidone ranges from 2,000 Da to 1,3,000 Da. According to the dexmedetomidine hydrochloride soluble microneedle provided by the invention, the peak concentration of a drug delivered percutaneously under the promotion action of the penetration enhancer is obviously improved, the onset time is short, the duration time is long, and the effects of quick release, quick onset and continuous effectiveness can be achieved.

The invention provides amitriptyline hydrochloride emulsifiable paste as well as a preparation method and application thereof, and belongs to the technical field of medicines. The amitriptyline hydrochloride emulsion is prepared from the following components in parts by mass: 3 to 8 parts of amitriptyline hydrochloride, 5 to 10 parts of glycerol, 3 to 8 parts of octadecanol, 3 to 8 parts of hexadecanol, 0.5 to 2 parts of ethylparaben, 2 to 5 parts of white vaseline, 0.5 to 2 parts of lauryl sodium sulfate, 12 to 20 parts of dimeticone, 0.5 to 2 parts of laurocapram, 1 to 5 parts of OP-10 and 40 to 67.5 parts of water. When a neuropathic pain model mouse is smeared with the amitriptyline hydrochloride emulsifiable paste, the symptom of the neuropathic pain of the mouse can be improved, the amitriptyline hydrochloride emulsifiable paste can quickly play a role in easing pain, and repair of injured nerves can be promoted through long-term administration.