369 results about "Xerophthalmia" patented technology

The invention relates to a comprehensive diagnostic apparatus for xerophthalmia. The comprehensive diagnostic apparatus comprises an upper computer, a controller, a Placido disc, a near-infrared light illuminating system, a white light illuminating system, and an imaging system, wherein the white light illuminating system comprises a diffuse reflection plate and a white light LED array, the imaging system comprises an industrial camera, an automatic focusing lens, an optical filter wheel disc, a motor and a gear, the diagnostic apparatus respectively measures the tear meniscus height, the area of a tiny blood vessel of a conjunctiva, the structural and morphological parameters of meibomian glands, the breakup time of a tear film, and the thickness of a lipid layer of the tear film according to the principles of visible light / near-infrared light imaging measurement, structured light imaging measurement and white light interferometry, so as to provide objective diagnostic evidences and preliminary diagnostic result for the diagnosis of the xerophthalmia. The diagnostic apparatus can replace a series of separated diagnosis items during the clinical diagnosis of the xerophthalmia, the diagnosis flow of the xerophthalmia is simplified, the diagnosis time is shortened, and the objectivity and the repeatability of the diagnosis result are improved.

The invention provides a method and a device for protecting eyesight. The method comprises the following steps that: a mobile terminal detects acquired eye image information, wherein the eye image information comprises opening state information of eyes; and when the condition that the opening states of the eyes keep a first preset period of time is detected, the mobile terminal performs eyesight protection operation. Due to the adoption of the technical scheme provided by the invention, the problems that xerophthalmia or hypopsia and the like can be caused by asthenopia which is easy to cause because a user watches a screen of the mobile terminal for a long time when using a certain application program of the mobile terminal, for example, the user does not blink the eyes for a long time when playing games or reading electronic books in the prior art are solved, so that the effect that the eyesight of the user can be protected when the mobile terminal is used by the user is achieved, the mobile terminal is more humanized and user experience effects are improved.

The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating xerophthalmia. The composition comprises chrysanthemums, medlar, phellodendron, red sage roots, pearls, borneol and menthol. The medicinal composition preferably comprises the following in part by weight: 2.5 to 3 parts of chrysanthemums, 2.5 to 3 parts of medlar, 2.5 to 3 parts of phellodendron, 1.5 to 2 parts of red sage roots, 0.08 to 0.1 parts of pearls, 0.08 to 0.1 parts of borneol and 0.15 to 0.2parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the effects of clearing heat, releasing toxin and moistening dryness, enables people to feel cool and comfortable after using the composition, and has the advantages of no toxic or side effects, easy absorption, quick response, good curative effect and good application prospects.

The invention discloses novel application for Ectoine, namely application of the Ectoine in preparing medicines of treating xerophthalmia. The effective dosage range of the Ectoine is 0.1 to 100 mg / kg of body weight, preferably 8 to 50 mg / kg of the body weight. When in use, the Ectoine can be used independently, or can be combined with medically and pharmaceutically acceptable carriers for use. The inventor of the application makes related experimental research; and the experiment proves that the Ectoine can effectively protect the stability of a tear film, maintain normal tear secretion, and reduce the water evaporation of cornea / conjunctiva, thereby relieving and treating the xerophthalmia.

The invention belongs to a pharmaceutical composition, in particular a pharmaceutical composition for treating xerophthalmia. The pharmaceutical composition provided by the invention is prepared from effective amounts of radix rehmanniae, figwort, ophiopogon root, dendrobium, rhizoma anemarrhenae, radix trichosanthis, chrysanthemum, mulberry leaf, pipewort, radix sileris and other raw medicines. The invention solves the problems of short action time, limited treatment, poor treatment effect and the like in the prior art. The pharmaceutical composition has the advantages of small drug toxicity, obvious treatment effect and the like.

The invention discloses a comprehensive analysis system for xerophthalmia. The comprehensive analysis system comprises an imaging system, an analyzing system and a video terminal, wherein the imaging system comprises a lighting source, an imaging assembly, a control panel and a camera shooting module, the lighting source penetrates through the imaging assembly and irradiates the eyes of a patient, and the camera shooting module carries out imaging on the eyes of the patient, and transmits the generated image to a PC machine through a USB interface; the analyzing system is arranged at the PC machine end, and comprises a communication module, an image data collecting module, a tear film breakup time check module, a lacrimal rivus height measuring module, a meibomian gland image collecting and enhancing module, a lipid layer analyzing module, a data analyzing module and an information management output module; the video terminal is connected with the analyzing system. With the comprehensive analysis system for xerophthalmia provided by the invention, the functions of tear film breakup time statistics checking, lacrimal rivus height measurement, meibomian gland image collection and enhancement, human eye lipid layer analysis, and the like are realized, a basis is provided for the clinical diagnosis for xerophthalmia, and the comprehensive analysis system is applied to the medical treatment in the relevant fields of clinical diagnosis of the ophtalmology department.

The present invention relates to a vitamin A liposome artificial tears eye drops for preventing and curing xerophthalmia and ophthalmokopia. Its composition includes fat-soluble vitamin A, liposome encapsulating material, vitamin E and artificial tears hydrated liquor, in which the fat-soluble vitamin A is vitamin A palmitate or vitamin A acetate, the liposome encapsulating material is soya bean lecithin and cholesterol, and the composition of artificial tears hydrated liquor includes sodium hydrogen carbonate, sodium chloride, glucose, potassium chloride, calcium chloride and water. Besides, according to requirements one or several kinds of auxiliary components of menthanol, PVP and HPMC, etc. also can be added.

The invention relates to a cyclosporine-containing composition and a preparation method thereof. The compound eye drops are prepared from cyclosporine, anti-inflammatory or antibiotic drugs, a surfactant, a stabilizer, a thickener, an isoosmotic adjusting agent, a pH adjusting agentr and water or oil, the preparation is a mixed suspension agent or an emulsion, and one or two of a high pressure homogenization method and a wet grinding technique is / are combined for use in the preparation method. The cyclosporine compound eye drops have the advantages that the ophthalmic tolerance is excellent, the drug utilization degree is high, the tear secretion of people suffering from xerophthalmia can be effectively improved, the tear film is stabilized, the anti-inflammation function of the anti-inflammatory or antibiotic drugs and the immunoregulation function of cyclosporine can be synergistically exerted, xerophthalmia can be effectively treated, and the compound eye drops have a better treatment effect compared with the separate application of cyclosporine.

The present invention provides pharmaceuticals for the prevention or treatment of diseases associated with decrease in tear. That is, the present invention provides pharmaceuticals for the prevention or treatment of diseases associated with decrease in tear such as dry eye, dry disorders of cornea and conjunctiva, disorders of the keratoconjunctival epithelium, syndrome with decrease in tear secretion, xerophthalmia, dry eye due to aging, opthalmopathy in Stevens-Johnson syndrome, opthalmopathy in Sjögren's syndrome, keratoconjunctival ulcer, dryness in wearing of contact lens or the like, which comprises a β3 adrenoceptor stimulant. The present invention also provides a combination pharmaceutical comprising a β3 adrenoceptor stimulant and a β2 adrenoceptor stimulant.

The invention discloses a composition for preventing xerophthalmia, an eye mask with the composition and a preparation method of the eye mask. The composition comprises an effective dosage of gamma-polyglutamic acid and a cell growth factor. The composition for preventing the xerophthalmia comprises an effective dosage of gamma-polyglutamic acid and the cell growth factor which are used as main active ingredients; and the active ingredients can be mutually complemented with each other on function, so that the xerophthalmia can be effectively prevented. The eye mask manufactured by the technical scheme can be widely applied to eye protection of people and is particularly applicable to eye protection of groups who look at computers for a long tine or work by other terminal displays, people who wear contact lenses and diabetes patients.

The invention provides a composition containing an effective dose of antofloxacin or a pharmaceutically acceptable salt thereof or / and an effective dose of an anti-inflammatory steroid or non-steroidanti-inflammatory medicine or / and an effective dose of a water-retaining or wetting agent or an anti-xerophthalmia medicine, and an application of the composition in the preparation of an externally used antofloxacin medicine for local eyes or ears or noses or skins, used for preventing or treating conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitisexterna, otitis media, folliculitis and impetigo in humans or mammals. The medicine obtained in the invention has good curative effects or good therapeutic compliance.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating xerophthalmia, characterized by comprising the following medicinal raw materials: 6-9g of astragalus root, 8-10g of coix seed, 3-6g of peony, 6-9g of angelica, 6-9g of prepared rehmannia root, 3-6g of dodder, 4-6g of sealwort, 5-6g of magnolia vine fruit, 6-9g of figwort, 3-6g of rehmannia root, 3-6g of tree peony bark, 3-6g of lily, 3-6g of root of straight ladybell, 3-6g of ophiopogon root, 3-6g of polygonatum and 3-6g of licorice. Chinese traditional treatment for the disease has the therapeutic principles of nourishing the liver, tonifying the kidney, eliminating pathogenic heat from the blood, nourishing yin and moistening dryness, and diagnosis and treatment are based on an overall analysis of the illness and the condition of a patient according to different symptoms clinically. The medicine is simple to prepare and convenient to use, and has low cost, wide medicine sources, quick curative effect, high cure rate and no toxic side effect.

The present invention provides a liquid preparation composition comprising a solvent and a surfactant dissolving in the solvent, the surface tension of the liquid preparation composition is less than 60mN / m, and the pH of the liquid preparation composition is 5.0-7.4. The present invention also discloses a preparation method of the liquid preparation composition and use of the liquid preparation composition in treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses. The present invention also discloses a preparation comprising the liquid preparation composition. The liquid preparation composition can effectively relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

The invention discloses a traditional Chinese medicine eye care mask and relates to the technical field of eye care masks. A preparation method of the traditional Chinese medicine eye care mask comprises the steps that ganoderma, flos chrysanthemi indici, licorice roots, cassia seeds, radix angelicae dahuricae, cortex phellodendri, Chinese wolfberry fruits, radix ophiopogonis, flos lonicerae, rehmannia roots, folium mori, chuanxiong rhizomas, kudzu vine roots and mint leaves are placed in distilled water with the weight five times that of the medicine mixture for soaking, then the mixture is decocted for 30-40 minutes, filtrate is filtered, and the filtrate is subjected to reduced pressure concentration, so that a concentrated solution is obtained for use; silk patch cloth is cut to be oval and then soaked into the concentrated solution, high temperature sterilization and disinfection are conducted, then each piece of the silk patch cloth is encapsulated into an aluminum plastic film-coated bag together with the concentrated solution, sealing is conducted, and the traditional Chinese medicine eye care mask is obtained. According to the traditional Chinese medicine eye care mask, traditional Chinese medicine constituents which have the functions of invigorating blood circulation, dispelling wind, clearing away heat, calming the liver and improving eyesight are added to the formula, and multiple effects of treating pseudomyopia, preventing and treating xerophthalmia, protecting eyes, improving eyesight and the like are achieved. Meanwhile, such asthenopia symptoms as visual impairment, eye tiredness, photaesthesia, ache, tears-down, foreign body sensation, dry eyes and eye spasm can be improved or alleviated, and compared with traditional medicinal treatment, the eye care mask is more convenient and faster to use.

The invention provides an application of etimicin and pharmacologically acceptable salt or inclusion compounds thereof in preparation of a local eye medicine or medicine composition for preventing ortreating eye diseases, xerophthalmia or dry eye syndromes, caused by conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma and sensitive bacterium infection, of people or mammals. Eye preparations comprise eye drops, eye gel and the like. The medicine has better safety and effectiveness in a certain range.

The invention relates to an eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method, wherein the system can directly serve as artificial tears to be applied to the treatment of xerophthalmia and other ophthalmology diseases. The system may also include other active constituents.

The invention relates to a meibomian gland heating and fumigating device for xerophthalmias. The meibomian gland heating and fumigating device comprises a wearable assembly, a temperature control assembly and a medicine assembly. The meibomian gland heating and fumigating device is simple in operation, the temperature is controllable in a meibomian gland hot compressing process, and the guarantee of controlling the skin around eyes at a relatively appropriate temperature in a working process is realized, so that the problems that an existing physical hot compressing method is great in temperature fluctuation and the hot compressing time and temperature are difficult to control are avoided, and the hot compressing effect is improved. Heating power generated by infrared rays can permeate through the deep layer of the skin, so that the blood circulation is quickened; the operating temperature of an infrared heating plate is controlled at 38-42 DEG C; the therapy of the infrared heating plate is a non-invasive therapy, safe and convenient, and is free of toxic and side effects; the heating temperature and time can be individually selected according to the conditions of each patient. Meanwhile, the device provided by the invention contains traditional Chinese medicine fumigation; medicine absorption and availability can be promoted while pipes of meibomian glands are open; the device is suitable for different types of xerophthalmias, and the therapeutic safety and effectiveness for the xerophthalmias are improved.

The invention discloses a contact lens for treating xerophthalmia. The contact lens is a ball coronary-shaped corneal contact lens (1) which is mainly composed of a soft layer (7) and a hard layer (8), wherein the two parts are made in manners of plane bonding and hot-press molding; a micro-fluid channel (3) and a hollow cavity (4) are formed inside the contact lens; the hollow cavity (4) is filled with a liquid medicine (5); one end of the micro-fluid channel (3) is communicated with the hollow cavity (4); and the other end of the micro-fluid channel (3) is communicated with a liquid outlet (2), and thus the micro-fluid channel (3) is communicated with outside of the corneal contact lens (1). Through reasonable arrangement and improvement of materials of contact lenses and internal structures of lens pieces, the contact lens is used as a medicine delivery system, and compared with a conventional treatment mode of eye drops, the contact lens has the advantages that multiple inconveniences of conventional eye drop treatment modes are overcome, the biological utilization rates of medicines are effectively increased, the retention times of the medicines on corneas are prolonged, and automatic and long-lasting medicine administration treatment on patients suffering from xerophthalmia is achieved.

The invention provides a pair of autonomous atomization wet chamber spectacles, which comprises a spectacles frame, water storage tanks, an elastic eyeshade, ultrasonic transduction sheets, a micro-control circuit board and a lithium battery, wherein the spectacles frame comprises a frame body, spectacles legs and lenses; atomizing nozzles are formed at the bottom of the frame body; grooves are formed in the left outer side and the right outer side of the frame body; the water storage tanks are mounted in the grooves and can be dismounted; the elastic eyeshade is mounted on one side, close to human eyes, of the frame body and can be dismounted; the micro-control circuit board is mounted in the spectacles leg on one side and controls the ultrasonic transduction sheets to operate via a program. The pair of spectacles takes effect quickly, and can quickly alleviate a xerophthalmia symptom; the water storage tank can be replaced to avoid bacterial stemming; water in the water storage tank is directly in contact with the ultrasonic transduction sheets; guide tubes are not required to further avoid the bacterial stemming.

The invention discloses an external traditional Chinese medicine composition for treating xerophthalmia and a preparation method thereof. The external traditional Chinese medicine composition for treating xerophthalmia is prepared from Baikal skullcap root, mint, radix trichosanthis, chrysanthemum flower, rhizoma polygonati and borneol. The preparation method comprises the following steps: addingwater to extract Baikal skullcap root, mint, radix trichosanthis, rhizoma polygonati and chrysanthemum flower, merging the extracting solutions, filtering, concentrating the filtrate into paste, mixing the borneol and paste, and adding conventional auxiliary materials to prepare the clinically acceptable preparation formulation. The traditional Chinese medicine composition disclosed by the invention is a pure traditional Chinese medicine external preparation, has the advantages of no toxic or side effect and quick effect taking, and can be absorbed easily; and the traditional Chinese medicinecomposition can prlong the tear break-up time, increase the tear flow, improve conjunctivitis, effectively relieve the symptoms of xerophthalmia, and the like, thereby performing the functions of xerophthalmia treatment and eye health care.

The invention discloses an external spraying agent and / or eye drop of compound oil nano-emulsion as well as preparation method thereof. The pH value of the spraying agent and / or eye drop is 3-9. The spraying agent and / or eye drop comprise the following components according to the weight portion: 5-15 of compound oil, 0.5-2.0 of phospholipid, 0.5-3.0 of propanetriol, sodium hydroxide and medicinal water, wherein the compound oil comprises the following components: (1) zedoary turmeric oil and / or peppermint oil, and (2) soybean oil and / or castor oil. The mass ratio of the (1) and the (2) in the compound oil is 1:99-30:70. The spraying agent of the compound oil nano-emulsion, which is prepared by the invention, is used for antibiosis, inflammation diminishing and wound healing in the process of curing burn and scald. The eye drop of the compound oil nano-emulsion is used for curing eye strain, xerophthalmia and eye inflammation.

The invention provides application of a pharmaceutical composition containing recombinant human prothymosin beta4 in preparation of a medicine for treating eye diseases and particularly application in the treatment of xerophthalmia. The pharmaceutical composition is characterized in that the concentration of the recombinant human prothymosin beta4 is 1ug / mL-1000ug / mL. The invention further provides the pharmaceutical composition containing pharmaceutically acceptable carriers.

The invention discloses an eye patch. The eye patch comprises the following constituents of, by weight, 0.002 to 5 parts of xanthophylls, 0.002 to 5 parts of coix seeds, 0.002 to 5 parts of cassia seeds, 0.002 to 5 parts of ginseng stems and leaves, 0.002 to 5 parts of pearl powder, 0.002 to 5 parts of carthamus tinctorius, 0.002 to 5 parts of tree peony bark, 0.002 to 5 parts of salvia miltiorrhiza, 0.002 to 5 parts of golden cypress, 0.002 to 5 parts of spica prunella, 0.002 to 5 parts of chrysanthemum extract, 0.002 to 5 parts of mint, 0.002 to 5 parts of borneol, 0.002 to 5 parts of glycerinum, 0.001 to 1 part of sodium hyaluronate, 0.001 to 4 parts of propylene glycol, 0.001 to 1 part of metal complexes and 0.001 to 1 part of essence. The constituents are evenly emulsified in an emulsification tank and the formed eye patch is filled with the constituents, so that the eye patch is obtained. The eye patch is pasted to the corresponding eye and xanthophylls is directly absorbed through the eye skin; the sodium hyaluronate is added to a formula to serve as a skin penetration enhancer, so that the skin penetration absorption rate of the xanthophylls is increased. Meanwhile, the constituents with the blood invigorating function, the gout disperse and heat removing function and the liver fire removing and eyesight improving functions are added to the formula, the constituents with the water replenishing and moisture maintaining function are added at the same time, and therefore the multiple effects of treating pseudomyopia and preventing and treating xerophthalmia, cataract and age-related macular degeneration, protecting the eyes and improving the eyesight are achieved.

The invention discloses a medicine composition for treating xerophthalmia. The medicine composition is a preparation prepared from the following crude drugs in weight ratio: 12-18 parts of rhizoma polygonati, 8-12 parts of radix glehniae, 8-12 parts of medlar and 8-12 parts of chrysanthemum. According to the medicine composition disclosed by the invention, the rhizoma polygonati, the radix glehniae, the medlar and the chrysanthemum are reasonably combined, and thus, symptoms, such as dryness, foreign body sensation and hyperemia of bulbar conjunctiva of eyes, can be obviously improved. The medicine composition can be effectively used for treating xerophthalmia caused by video terminals, middle-aged and elderly xerophthalmia or diabetic xerophthalmia. Moreover, the clinical effect of the medicine composition is obviously superior to that of the Western medicine Tears Natural II group and the traditional Chinese medical science acupuncture group. The medicine composition is high in safety and good economic benefit, and a new medicine selection is provided for clinically treating the xerophthalmia.

The present invention provides a composition containing an effective dose of etimicin or a pharmaceutically acceptable salt thereof and an anti-inflammatory effective dose of dexamethasone or a pharmaceutically acceptable derivative thereof, and applications of the composition in preparation of topical ophthalmic or aural or nasal or skin external application drugs for prevention or treatment of human or mammalian conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, otitis externa, otitis media, folliculitis, furuncle, impetigo and the like. According to the present invention, the drug has good safety and good efficacy compared to etimicin.

The invention relates to an application of an HMGCoA reductase inhibitor in preparation of a medicine used for treating xerophthalmia and belongs to the field of medicines. The inventor finds that a frequently-used lipid regulation medicine, the HMGCoA reductase inhibitor, can obviously prolong SIT time and BUT time and obviously reduce an FLS score when being used for treating the xerophthalmia, and the HMGCoA reductase inhibitor is better than ciclosporin or artificial tears in the aspect of improving the indexes, wherein simvastatin and lovastatin have the best treatment effect. The HMGCoA reductase inhibitor also can be prepared into oral preparation used for treatment or adjuvant therapy of the xerophthalmia. The HMGCoA reductase inhibitor has a definite curative effect and less toxic and side effects, compliance of a patient is high, and clinical ophthalmic drugs are further enriched.

The invention relates to an active substance of cordyceps cicadae, a preparation method of the active substance, pharmaceutical composition containing the active substance and application of the active substance. The active substance of the cordyceps cicadae is used for preventing and / or treating xerophthalmia and can be prepared with a method comprising steps as follows: cordyceps cicadae mycelia are taken and cultured on a plate medium for 5-14 days at the temperature of 15-35 DEG C; the cultured cordyceps cicadae mycelia are inoculated into a flask and cultured for a few days under the conditions that the temperature is 15-35 DEG C and the pH is 2-8; the cultured cordyceps cicadae mycelia are inoculated into a fermentation tank and cultured for 3-5 days under the conditions that the temperature is 15-35 DEG C, the pH is 2-8, the tank pressure is 0.5-1.0 kg / cm<2> and the ventilation rate is 0.01-1.5 VVM, and cordyceps cicadae mycelium fermentation broth is formed; the fermentation broth is subjected to freeze drying and ground into powder, and cordyceps cicadae mycelium freeze-dried powder is formed; the freeze-dried powder is extracted with a solvent, and a cordyceps cicadae mycelium extract solution is formed; the extract solution is dried, and the active substance of the cordyceps cicadae is obtained. The active substance of the cordyceps cicadae can be used for preparing the pharmaceutical composition for preventing and / or treating xerophthalmia.

The present invention provides a preparation composition comprising a solvent, a drug component and a surfactant, the preparation composition is emulsion, surfactant-containing liquid droplets are distributed in the solvent, the volume average particle diameter of the liquid droplet is 100mum or less, the drug component comprises one drug or more drugs for treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses, the surface tension of the preparation composition is less than 60mN / m, and the absolute value of the zeta potential is more than 15mV. The present invention also discloses a preparation method and use of the preparation composition. The preparation composition can relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Self-preserving ophthalmic formulations containing norketotifen and methods of making the same and the use thereof in patients suffering from xerophthalmia are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof, self-preserving topical ophthalmic formulations containing norketotifen, free from any added preservative.