Medicament for assisting in treating moderate and severe xerophthalmia through fumigation and washing and treatment method thereof

Abstract

The invention belongs to the field of ophthalmology, and particularly relates to a medicament for treating moderate and severe xerophthalmia through fumigation and washing assistance, which consists of mint, schizonepeta, chrysanthemum, moutan bark, cicada slough, cassia seed and scutellaria baicalensis. The invention further provides a treatment method of the medicament for the fumigation-washing adjuvant therapy of the moderate-severe xerophthalmia, the medicament for the fumigation-washing adjuvant therapy of the moderate-severe xerophthalmia and the treatment method of the medicament can be used for patients with the moderate-severe xerophthalmia, the medicament has the main effects of dispelling wind, clearing heat, removing red spots and improving eyesight, and the medicament has the characteristics of simplicity, convenience, economy, easiness in matching and the like, and meanwhile, the medicament has the effect of treating the moderate-severe xerophthalmia through the fumigation-washing adjuvant therapy of the moderate-severe xerophthalmia. The treatment method is remarkable in treatment effect and efficient.

Description

Technical Field

[0001] The present invention belongs to the field of ophthalmology, and particularly relates to a medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye and its treatment method. Background Art

[0002] Dry eye, this ocular surface disease is usually caused by various factors. Its core problem lies in the abnormal quality and quantity of tears, as well as the instability of the tear film. In daily life, patients often feel discomfort in their eyes, and different degrees of damage will occur on the severe ocular surface. Moderate to severe dry eye not only affects the patient's vision and quality of life, but may also lead to corneal lesions and even vision loss. In recent years, due to the widespread use of electronic devices and the evolution of the working environment, the prevalence of moderate to severe dry eye is gradually increasing. Relevant research shows that in the Asian region, the overall prevalence of dry eye is about 20%-30%, of which moderate to severe dry eye accounts for about 15%-20%. Among different age groups, the prevalence of dry eye in people over 40 years old is significantly higher than that of the younger group, about 30%-40%. In addition, long-term use of electronic devices is closely related to the onset of dry eye. The incidence of dry eye in people who use electronic devices for more than 6 hours a day is about 2 times higher than that of the general population. Therefore, developing effective treatment means to relieve symptoms and improve the ocular surface condition is of great significance for improving the quality of life of patients.

[0003] However, there is currently a lack of efficient treatment medicaments and treatment means, and the conditions of moderate to severe dry eye patients cannot be quickly relieved and cured, causing many inconveniences to daily life and work.

[0004] In summary, the related technology urgently needs to be improved. Summary of the Invention

[0005] The purpose of the present invention is: aiming at the deficiencies of the prior art, to provide a medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye and its treatment method, which can be used for moderate to severe dry eye patients, with the main efficacy of expelling wind and clearing heat, removing redness and improving eyesight, and having the characteristics of simplicity, economy, easy cooperation, etc. At the same time, the treatment effect of the treatment method is remarkable and efficient.

[0006] To achieve the above purpose, the present invention adopts the following technical scheme:

[0007] A medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye, which is prepared from the following components according to the weight ratio:

[0008] 5-10 parts by weight of mint, 10-15 parts by weight of schizonepeta, 10-20 parts by weight of chrysanthemum

[0009] 10-20 parts by weight of moutan bark, 5-10 parts by weight of cicada slough, 15-30 parts by weight of cassia seed

[0010] Scutellaria baicalensis Georgi 10 - 15 parts by weight;

[0011] The treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye syndrome is carried out according to the following steps:

[0012] S1. Take the above-mentioned Mentha haplocalyx Briq., Schizonepeta tenuifolia Briq., Chrysanthemum morifolium Ramat., Paeonia suffruticosa Andr., Cryptotympana pustulata Fabricius, Cassia obtusifolia L. and Scutellaria baicalensis Georgi and put them into a container in sequence, then pour an appropriate amount of clear water into the container and then decoct. After the water boils, decoct for a certain period of time, then take out 400 ml of the decocted liquid, divide the taken-out liquid into 2 packages, let it cool to room temperature and reserve for use. Use one package for each treatment and conduct 2 treatments per day;

[0013] S2. Each time take 150 ml of the liquid medicine in one package and use a traditional Chinese medicine fumigation treatment instrument to fumigate the patient's eyes for treatment;

[0014] S3. Each time take 50 ml of the liquid medicine in one package and use a medical cotton swab to scrub around the patient's eyes for treatment.

[0015] Preferably, the medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye syndrome of the present invention is a medicament prepared from the following components according to the weight ratio:

[0016] Mentha haplocalyx Briq. 10 parts by weight, Schizonepeta tenuifolia Briq. 15 parts by weight, Chrysanthemum morifolium Ramat. 15 parts by weight

[0017] Paeonia suffruticosa Andr. 15 parts by weight, Cryptotympana pustulata Fabricius 6 parts by weight, Cassia obtusifolia L. 15 parts by weight

[0018] Scutellaria baicalensis Georgi 20 parts by weight.

[0019] Preferably, in the treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye syndrome of the present invention, in step S1, the dosage of the clear water is 500 - 1000 ml.

[0020] Preferably, in the treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye syndrome of the present invention, step S1 is carried out according to the following steps:

[0021] T1. First, take an appropriate amount of Schizonepeta tenuifolia Briq., Paeonia suffruticosa Andr., Cryptotympana pustulata Fabricius, Cassia obtusifolia L. and Scutellaria baicalensis Georgi and put them into a container, then pour an appropriate amount of clear water into the container and then decoct. After the water boils, decoct for 20 minutes;

[0022] T2. Then put Mentha haplocalyx Briq. and Chrysanthemum morifolium Ramat. into the container and decoct with the previous traditional Chinese medicine for 5 - 10 minutes.

[0023] The medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye syndrome of the present invention and its treatment method can be used for patients with moderate to severe dry eye syndrome. The main efficacy is to disperse wind and clear heat, remove redness and improve eyesight, and it has the characteristics of simplicity, economy, easy cooperation, etc. At the same time, the treatment effect of the treatment method is remarkable and efficient. Detailed implementation mode

[0024] The following examples will further illustrate the present invention, but do not limit the present invention thereby.

[0025] Example 1 The medicament for adjuvant treatment of moderate and severe dry eye by fumigation and washing according to the present invention and its treatment method are as follows:

[0026] The research subjects selected this time were moderate and severe dry eye patients who visited Dongguan Traditional Chinese Medicine Hospital from June 2022 to June 2023, with a total of 120 cases, and were randomly divided into a control group (n = 60 cases) and an adjuvant treatment group (n = 60 cases).

[0027] (1) Control group: ① 23 males / 37 females; ② The average age was (45.67 ± 7.89) years old, and the age range was 22 - 67 years old; ③ The average disease course was (5.32 ± 2.18) months, and the disease course range was 1 - 24 months; ④ The average BMI was (23.56 ± 2.47) kg / m 2 , and the BMI range was (18.50 - 29.90) kg / m 2 ; ⑤ There were 23 moderate dry eye patients and 37 severe dry eye patients.

[0028] (2) Adjuvant treatment group: ① 24 males / 36 females; ② The average age was (45.58 ± 8.02) years old, and the age range was 21 - 68 years old; ③ The average disease course was (5.21 ± 2.09) months, and the disease course range was 1 - 24 months; ④ The average BMI was (23.48 ± 2.39) kg / m 2 , and the BMI range was (18.50 - 29.90) kg / m 2 ; ⑤ There were 24 moderate dry eye patients and 36 severe dry eye patients.

[0029] The two groups of patients were comparable in all aspects of baseline information (P > 0.05).

[0030] Inclusion criteria:

[0031] ① According to the "Chinese Dry Eye Expert Consensus: Definition and Classification (2020)" standard, patients diagnosed with moderate and severe dry eye; ② Voluntarily participated in this study and signed an informed consent form; ③ Were able to complete the treatment and follow-up according to the research protocol.

[0032] Exclusion criteria:

[0033] ① Complicated with other eye diseases or systemic diseases; ② Allergic to any component in the treatment plan of this study; ③ With eye structure changes or recent eye surgery history.

[0034] For the control group: The conventional traditional Chinese medicine acupuncture treatment method was adopted

[0035] The patients in the control group received standardized traditional Chinese medicine acupuncture treatment: ① The selected acupoints included periorbital acupoints such as Jingming, Cuanzhu, and Yuyao, and the even reinforcing-reducing method was applied to each acupoint; ② Each treatment lasted for 30 minutes and was carried out 3 times a week; ③ All acupuncture operations were performed by experienced traditional Chinese medicine doctors, ensuring the safety and effectiveness of the treatment.

[0036] For the adjuvant treatment group: The adjuvant traditional Chinese medicine fumigation and washing treatment method was adopted.

[0037] On the basis of the conventional traditional Chinese medicine acupuncture treatment, the adjuvant treatment group added traditional Chinese medicine fumigation and washing as an adjuvant treatment method. The traditional Chinese medicine fumigation and washing formula used was Juqin Qingmu Fang (Fumigating Eyes Formula No. 1). Its prescription was taken according to the weight ratio of 5-10 parts by weight of Mentha haplocalyx, 10-15 parts by weight of Schizonepeta tenuifolia, 10-20 parts by weight of Chrysanthemi Flos, 10-20 parts by weight of Moutan Cortex, 5-10 parts by weight of Cicadae Periostracum, 15-30 parts by weight of Cassiae Semen, and 10-15 parts by weight of Scutellaria baicalensis. It was composed of medicinal materials such as Chrysanthemi Flos (15g), Scutellaria baicalensis (20g), Schizonepeta tenuifolia (15g), Moutan Cortex (15g), Cicadae Periostracum (6g), Mentha haplocalyx (10g), and Cassiae Semen (15g). Chrysanthemi Flos was used as the main drug in the formula, combined with Scutellaria baicalensis and Schizonepeta tenuifolia to strengthen the effects of expelling wind, clearing heat, and drying dampness; Moutan Cortex and Cicadae Periostracum were used for cooling blood and removing redness, while Mentha haplocalyx and Cassiae Semen cleared heat and improved eyesight, jointly exerting the therapeutic effect. The specific usage was as follows: ① First, take appropriate amounts of Schizonepeta tenuifolia, Moutan Cortex, Cicadae Periostracum, Cassiae Semen, and Scutellaria baicalensis and put them into a container (decocting pot, model: MD-JYC3002, manufacturer: Midea Group Co., Ltd.), then pour 500-1000 ml of clear water into the container and then decoct. Preferably, pour 800 ml of clear water and then decoct. After the water boils, decoct for another 20 minutes. ② Then put Mentha haplocalyx and Chrysanthemi Flos into the container and decoct with the previous traditional Chinese medicine for 5-10 minutes. ③ Then take out 400 ml of the decocted medicinal liquid, and divide the taken-out medicinal liquid into 2 packages and let it cool to room temperature for later use. One package was used for each treatment, and the treatment was carried out 2 times a day. ④ Each time, take 150 ml of the medicinal liquid from one package and use a traditional Chinese medicine fumigation treatment instrument (eye protection hot compress eye mask, model: S600-B14, manufacturer: Dongguan Tianzi Technology Co., Ltd.) to fumigate the patient's eyes for treatment; then take 50 ml of the medicinal liquid from one package and use a medical cotton swab to scrub the patient's periorbital area for treatment. ⑤ It was necessary to track whether the patient had allergic reactions, such as redness, itching, blisters, etc., and the medicine should be stopped immediately.

[0038] Both groups of patients needed to implement the corresponding clinical treatment methods for 4 weeks.

[0039] The observation indicators were as follows

[0040] 1. Traditional Chinese medicine syndrome score

[0041] ① The main symptoms include dryness and lack of luster, and the secondary symptoms include visual fatigue, foreign body sensation, photophobia, and injection of the sclera; ② Symptom scoring criteria: 0 points (none), 1 - 3 points (mild), 4 - 6 points (moderate), 7 - 10 points (severe); ③ The higher the score, the more severe the condition.

[0042] 2. Ocular symptom scoring

[0043] ① Ocular Surface Disease Index (OSDI) assessment; ② 12 questions, covering ocular discomfort, blurred vision, and the degree of impact on daily life; ③ 0 - 100 points, the higher the score, the more severe the ocular symptoms.

[0044] 3. Clinical efficacy assessment

[0045] ① Clinical efficacy assessment includes three grades: marked effect, effective, and ineffective; ② Marked effect criteria: the reduction of traditional Chinese medicine syndrome score is ≥ 70%, BUT > 10 seconds, NI BUT > 10 seconds, and corneal fluorescein staining disappears; ③ Effective criteria: the reduction of traditional Chinese medicine syndrome score is ≥ 40%, BUT and NI BUT increase compared with before treatment, and corneal fluorescein staining decreases compared with before; ④ Ineffective criteria: not meeting the above criteria.

[0046] Statistical methods

[0047] Performed using SPSS 25.0 software. Measurement data are expressed as and compared between groups using the t - test. Count data are expressed as [n(%)] and compared between groups using χ 2 test. P < 0.05 indicates statistical significance.

[0048] The treatment results are as follows

[0049] 1. Comparative analysis of traditional Chinese medicine syndrome scores

[0050] The traditional Chinese medicine syndrome scores of the adjuvant treatment group are better than those of the control group (P < 0.05), as shown in Table 1.

[0051] Table 1 Results of traditional Chinese medicine syndrome scores

[0052]

[0053] 2. Comparative analysis of ocular symptom scores

[0054] After treatment, the ocular symptom scores of both groups of patients decreased significantly. The ocular symptom score of the adjuvant treatment group was (21.4 ± 3.2) points, significantly lower than that of the control group (28.6 ± 3.5) points, (P < 0.05), as shown in Table 2.

[0055] Table 2 Results of ocular symptom scores

[0056]

[0057] 3. Comparative Analysis of Clinical Treatment Effects of Diseases

[0058] The total effective rate of the adjuvant treatment group was 93.33% (56 / 60), which was significantly higher than 76.67% (46 / 60) of the control group (x 2 = 21.49, P < 0.05), as shown in Table 3.

[0059] Table 3 Results of Clinical Treatment Effects [n(%)]

[0060]

[0061] Summarized as follows:

[0062] Dry eye disease belongs to a long-term ocular surface disorder, which is mainly manifested by abnormal quality and quantity of tears, as well as instability of the tear film, often causing ocular discomfort and damage to the ocular surface. Moderate to severe dry eye disease not only affects vision and quality of life, but may also cause corneal lesions and even lead to vision loss. At present, traditional Chinese medicine acupuncture and Chinese medicine fumigation therapy have been widely studied and applied due to their unique treatment advantages. In this study, 120 patients with moderate to severe dry eye disease were randomly grouped and treated for 4 weeks. The adjuvant treatment group added Chinese medicine fumigation therapy on the basis of conventional traditional Chinese medicine acupuncture treatment. The results showed that the adjuvant treatment group was significantly superior to the control group in terms of traditional Chinese medicine syndrome scores and ocular symptom scores, and the total effective rate was also significantly improved. Analyzing the reasons, from the perspective of modern medicine, the possible synergistic mechanism of Chinese medicine fumigation and acupuncture is as follows: Under the action of hot steam, the components of Chinese medicine can better penetrate the ocular surface cells and regulate the physiological functions of the ocular surface cells. For example, certain components of Chinese medicine may promote cell metabolism, enhance the antioxidant capacity and repair ability of cells by activating specific receptors on the ocular surface cells, thereby reducing the ocular surface inflammatory response and improving the ocular surface microenvironment. At the same time, acupuncture stimulation of acupoints can affect the autonomic nervous system and endocrine system through the neuro-humoral regulation mechanism, and then regulate the secretory function of the lacrimal gland, increasing the production and secretion of tears. In addition, acupuncture can also improve the blood circulation of the eyes, promote the nutrient supply of ocular tissues and the excretion of metabolic wastes, providing good conditions for the repair of the ocular surface tissues and the maintenance of tear stability. This synergistic effect of Chinese medicine fumigation and acupuncture can not only improve the ocular surface condition locally, but also regulate the physiological functions of the body as a whole, thus more effectively alleviating the symptoms of dry eye disease, improving the treatment effect and quality of life of patients. In addition, the results of this study are consistent with the positive effects of previous studies on the treatment of dry eye disease with Chinese medicine fumigation and acupuncture, further verifying the clinical value of these two traditional therapies. Especially the addition of Chinese medicine fumigation provides a new perspective and method for the treatment of dry eye disease. Through the physical action of hot steam and the chemical action of drugs, it directly acts on the ocular surface, which may better promote the repair of the ocular surface and the maintenance of tears. Compared with single acupuncture therapy, the comprehensive treatment plan shows better treatment effects. This may be related to the synergistic effect of the two treatment methods. On the one hand, acupuncture improves the qi and blood circulation of the eyes by stimulating acupoints, and on the other hand, Chinese medicine fumigation directly acts on the ocular surface, providing necessary moisture and nutrition, jointly promoting the healthy state of the ocular surface. In summary, this study confirmed the effectiveness and safety of Chinese medicine fumigation in the adjuvant treatment of moderate to severe dry eye disease, providing a new option for clinical treatment and worthy of popularization and application in a wider patient population.

Claims

1. A medicament for adjuvant fumigation and washing in the treatment of moderate and severe dry eye, characterized in that, It is made up of the following components according to the weight ratio: 5 - 10 parts by weight of mint, 10 - 15 parts by weight of schizonepeta, 10 - 20 parts by weight of chrysanthemum 10 - 20 parts by weight of moutan bark, 5 - 10 parts by weight of cicada slough, 15 - 30 parts by weight of cassia seed 10 - 15 parts by weight of scutellaria baicalensis; The treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate to severe dry eye is carried out according to the following steps: S1. Put the above-mentioned mint, schizonepeta, chrysanthemum, moutan bark, cicada slough, cassia seed and scutellaria baicalensis into a container in sequence, then pour an appropriate amount of clear water into the container and then decoct. After the water boils, decoct for a certain time. Then take out 400 ml of the decocted liquid, divide the taken-out liquid into 2 packages, let it cool to room temperature and reserve for use. Use one package for each treatment and conduct 2 treatments every day; S2. Each time, take 150 ml of the liquid in one package and use a traditional Chinese medicine fumigation treatment instrument to fumigate the patient's eyes for treatment; S3. Each time, take 50 ml of the liquid in one package and use a medical cotton swab to scrub around the patient's eyes for treatment.

2. The medicament for adjuvant fumigation and washing treatment of moderate and severe dry eye according to claim 1, characterized in that It is made up of the following components according to the weight ratio: 10 parts by weight of mint, 15 parts by weight of schizonepeta, 15 parts by weight of chrysanthemum 15 parts by weight of moutan bark, 6 parts by weight of cicada slough, 15 parts by weight of cassia seed 20 parts by weight of scutellaria baicalensis.

3. The treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate and severe dry eye according to claim 2, characterized in that: In step S1, the amount of the clear water used is 500 - 1000 ml.

4. The treatment method of the medicament for adjuvant fumigation and washing in the treatment of moderate and severe dry eye according to claim 1 or 3, characterized in that, In step S1, it is carried out according to the following steps: T1. First, take an appropriate amount of schizonepeta, moutan bark, cicada slough, cassia seed and scutellaria baicalensis and put them into a container, then pour an appropriate amount of clear water into the container and then decoct. After the water boils, decoct for 20 minutes; T2. Then put the mint and chrysanthemum into the container and decoct with the previous traditional Chinese medicine for 5 - 10 minutes.

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