58 results about "Corneal limbus" patented technology

Surgical apparatus and surgical methods are proposed for the prevention of age-related macular degeneration (AMD) and choroidal neovascularization (CNV), and other eye diseases such as glaucoma by removal of the sclera tissue to reduce its rigidity and increase the flood flow and decrease pressure in the choriocapillaris. The disclosed preferred embodiments of the system consists of a tissue ablation means and a control means of ablation patterns and a fiber delivery unit. The basic laser beam includes UV lasers and infrared lasers having wavelength ranges of (0.15-0.36) microns and (0.5-3.2) microns and diode lasers of about 0.98, 1.5 and 1.9 microns. AMD and CNV are prevented, delayed or reversed by using an ablative laser to ablate the sclera tissue in a predetermined patterns outside the limbus to increase the elasticity of the sclera tissue surrounding the eye globe The surgery apparatus also includes non-laser device of radio frequency wave, electrode device, bipolar device and plasma assisted device

Eye wall anchored fixtures each including at least one elongated anchor member for driven lengthwise insertion into an eye's eye wall in a transverse direction to its thickness for supporting an intraocular device in the eye's vitreous cavity. Fixtures are preferably anchored in circumferential incisions in a human adult eye's pars plana preferably 3.5 mm posterior to its corneal limbus, and perpendicular to a circumferential incision. The fixtures are either generally L-shaped with a single elongated anchor member designed for withdrawal from an eye wall or self-anchoring thereinto, or generally T-shaped with a pair of oppositely directed self-anchoring elongated anchor members for sealing a throughgoing incision. Intraocular devices can be designed for intraocular drug delivery, for acquiring intraocular physiological measurements, and the like.

Eye wall anchored fixtures each including at least one elongated anchor member for driven lengthwise insertion into an eye's eye wall in a transverse direction to its thickness for supporting an intraocular device in the eye's vitreous cavity. Fixtures are preferably anchored in circumferential incisions in a human adult eye's pars plana preferably 3.5 mm posterior to its corneal limbus, and perpendicular to a circumferential incision. The fixtures are either generally L-shaped with a single elongated anchor member designed for withdrawal from an eye wall or self-anchoring thereinto, or generally T-shaped with a pair of oppositely directed self-anchoring elongated anchor members for sealing a throughgoing incision. Intraocular devices can be designed for intraocular drug delivery, for acquiring intraocular physiological measurements, and the like.

The present invention relates to a sterile ophthalmic composition comprising castor oil and a medium chain triglyceride, to its use in medicine, in particular for the treatment and / or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, floppy eyelid syndrome, thyroid ophthalmopathy, pterygium, conjunctivochalasis, epithelial damage induced by preservatives, epithelial or anterior chamber damage induced by ocular surgery, limbal cell deficiency, corneal ulcers induced by physical or chemical agents, keratitis, episcleritis and uveitis.

The invention discloses a method for preparing a decellularized lamellar cornea matrix sheet. The method comprises the steps of disinfecting a fresh animal eyeball; treating with filter paper dipped with alcohol after disinfecting, and then erasing an epithelial cell layer; incising the corneal limbus under an operation microscope, stretching into an iris restorer to separate the anterior cornea, and then shearing the anterior cornea with corneal scissors; drilling the lamellar cornea with a corneal annulus; soaking the fresh lamellar cornea into serum, and then rinsing or performing ice-bath electrophoresis treatment; performing gradient dehydration after the treatment to obtain a non-dried lamellar tissue engineering corneal frame, sterilizing with ethylene oxide, and preserving for later use; drying the non-dried cornea matrix sheet in a 24-pore plate to obtain dried decellularized lamellar cornea; and sterilizing the dried sample with cobalt 60, and performing rehydration treatment to obtain a rehydrated lamellar cornea matrix sheet. The obtained cornea matrix sheet is high in transparency, low in structural destroy, good in biocompatibility, close to fresh cornea in performance and thorough in decellularization.

A multi-function surgical instrument for facilitating ophthalmic surgery of the eye (3) by laser means, included are a lower ring (1) and an upper ring (2). One or two intermediate rings may also be included. The lower ring (1) includes a central aperture (11) to capture the limbus and aid in positioning of the eye (3). Protuberances on the lower surface (18) of said ring (1), application of vacuum between the lower surface (18) of the ring (1) and the eye (3), or both may be used to more firmly grip the eye (3). Ports (14) disposed on the upper surface (13) of the lower ring (1) and connected to a vacuum source may be used to control hydration of the surgical field. Attached to structures of the lower ring (1) is a sterile platform (17) for reposing temporarily removed tissues (32) during the administration of laser pulses to other tissues. The upper ring (2) is disposed above the surgical bed. Ports (22) disposed along said upper ring (2) and connected to a vacuum source may be used to control smoke and splatters resulting from the ablative procedure and create additional airflow to further control hydration of the surgical field.

The invention relates to a stainless steel device for permanent insertion into the sclerocorneal limbus, with different drainage and anchorage systems, enabling the aqueous humour to discharge through one or more virtual spaces from the anterior chamber to an intrascleral space in cases of simple glaucoma or to the equatorial episclera in cases of complex glaucoma, such as neovascular glaucoma. The space is virtual, not real, as in the case of the tubular device. It enables the aqueous humour to discharge slowly and continuously, minimizing the possibility of the chamber being flat or of germs penetrating through the device. Furthermore, the anchorage system is less aggressive, thus reducing the possibility of bleeding.

An incisional instrument and method of use for creating accurate, reproducible surgical incisions. An exemplary embodiment includes an incisional instrument configured for attachment to a patient's eye and for use performing arcuate limbal relaxing incisions (LRIs). The incisional instrument is made up of two coaxial, interconnecting pieces: a docking piece and a cutting piece. The docking piece includes a suction mechanism and is configured for being secured to a patient's eye just outside the corneal limbus. The cutting piece is configured to fit flush within the docking piece and includes cutting blades and one or more handles for rotating the cutting piece relative to the docking piece. When assembled, the cutting blades extend beyond the proximal end of the docking piece by a length equal to the desired depth of LRIs to be cut. The incisional instrument further includes measurement markings for properly positioning and measuring incisions.

An incisional instrument and method of use for creating accurate, reproducible surgical incisions. An exemplary embodiment includes an incisional instrument configured for attachment to a patient's eye and for use performing arcuate limbal relaxing incisions (LRIs). The incisional instrument is made up of two coaxial, interconnecting pieces: a docking piece and a cutting piece. The docking piece includes a suction mechanism and is configured for being secured to a patient's eye just outside the corneal limbus. The cutting piece is configured to fit flush within the docking piece and includes cutting blades and one or more handles for rotating the cutting piece relative to the docking piece. When assembled, the cutting blades extend beyond the proximal end of the docking piece by a length equal to the desired depth of LRIs to be cut. The incisional instrument further includes measurement markings for properly positioning and measuring incisions.

The invention relates to the biology field, and concretely discloses a recombinant plasmid pAdTrack-CMV-VEGF165-PolyA-promoter-Ang of VEGF165 and Ang-1 as well as a recombinant plasmid pAdTrack-CMV-VEGF165-IRES- Ang-1 of VEGF165 and Ang-1, wherein the preservation numbers are CCTCC No: M 2010221, CCTCC NO: M 2010220. The invention also discloses a homologous recombination of the plasmid and adenovirus and a recombinant adenovirus incased and generated from a QBI-293A cell. The invention also provides a fibroin film modified by transgenic marrow stromal cells. Rabbit corneal limbus injected with the recombination adenovirus provided in the invention is capable of successfully inducing the formation of corneal neovascularization; after the fibroin film modified by transgenic cells is implanted in a rabbit cornea layer, the neovascularization can be grown in a cornea of a fibroin film implanted area and the density of blood vessels is obviously increased, therefore, VEGF165, Ang-1, CD34 can be successfully expressed in a rabbit cornea layer. Wound repairing experiments of rats prove that the fibroin film modified by transgenic marrow stromal cells of the invention is capable of promoting the blood vessel generation of the wound organization and repairing wound, so that the recombinant adenovirus and the fibroin film modified by transgenic marrow stromal cells of the invention have medical application value.

The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are capable of forming embryoid-like bodies when placed in suspension culture. Thus, these cells possess multi-lineage differentiation potential and self-renewing capability. ELSCs may be a promising therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries.

The invention discloses serum-free cultured corneal limbus stromal stem cells and a method for inducing differentiation and stem cell balling of the corneal limbus stromal stem cells. The invention further provides a culture medium combination for inducing corneal limbus stromal stem cells to be pelletized or differentiated into corneal limbus stromal cells in vitro. The serum-free culture mediumcombination used in the invention can provide sufficient nutrition and a good environment required by cell growth and proliferation, can stably carry out in-vitro amplification culture on corneal limbus stromal stem cells, and can ensure that the dryness and specificity of the corneal limbus stromal stem cells are still maintained after amplification culture. Meanwhile, a system for inducing and differentiating into corneal limbus stromal cells is successfully constructed, can be used for experimental research of the corneal limbus stromal stem cells, cell treatment of corneal lesions and transplantation of corneal injuries, and the serum-free cultured corneal limbus stromal stem cells has wide scientific benefits and social and economic benefits.

Techniques for estimating blepharoptosis from an image of a face are disclosed. The image is captured by a camera. Histogram of Oriented Gradients and Linear Classifiers are used to predict the location of the face and eyes. An Ensemble of Regression Trees is used to detect points on each eyelid and the canthi. The location of the iris is ascertained by thresholding HLS values of individual pixels and applying a sliding window algorithm. Using regression, the eyelid shape curve is approximated. The eyelid shape curve function is used to measure the MRD1 value and distance below the limbus after detecting the Purkinje image / corneal light reflex. Finally, the intensity of blepharoptosis is estimated by categorizing the measured MRD1 and distance-from-Limbus values.

An incisional instrument and method of use for creating accurate, reproducible surgical incisions. An exemplary embodiment includes an incisional instrument configured for attachment to a patient's eye and for use performing arcuate limbal relaxing incisions (LRIs). The incisional instrument is made up of two coaxial, interconnecting pieces: a docking piece and a cutting piece. The docking piece includes a suction mechanism and is configured for being secured to a patient's eye just outside the corneal limbus. The cutting piece is configured to fit flush within the docking piece and includes cutting blades and one or more handles for rotating the cutting piece relative to the docking piece. When assembled, the cutting blades extend beyond the proximal end of the docking piece by a length equal to the desired depth of LRIs to be cut. The incisional instrument further includes measurement markings for properly positioning and measuring incisions.