21 results about "Corneal limbus" patented technology

A tomographic imaging system, methods to visualize tomographic images, and a ‎stereoscopic calibration procedure for obtaining two-dimensional cross-sectional ‎and three-dimensional volumetric images over the entire anterior eye. The optical ‎system combines stereoscopic imaging with patterned illumination (e.g., slit-‎scanning or array of slits). The captured cross-sectional images can be viewed ‎individually or as a fly-through video. The calibration and reconstruction methods ‎determine the true spatial location of imaged features and record a 3D volumetric ‎representation of the anterior eye. The system can image the entire anterior ‎chamber and contiguous structures, including the corneal limbus, sclera and ‎eyelids. Furthermore, the system can obtain corneal topography. ‎

A method and device are disclosed for determining the position of a flap incision on a cornea and the position of the hinge associated with the flap. The method comprises the steps of: capturing an image of an eye, including at least the pupil and the limbus; determining a region including the outer circumference of the flap incision; determining the position of the flap incision; determining a straight region including the hinge; and determining the position of the hinge.

Glaucoma can be treated by implanting an intraocular shunt in the eye. The implantation can be performed by first determining an entry area below a corneal limbus of an eye. Thereafter, the intraocular shunt can be inserted into eye tissue through the entry area such that an inflow end of the shunt is positioned in the anterior chamber of the eye and an outflow end of the shunt is positioned between layers of Tenon's capsule.

The present disclosure relates to intraocular implants for treating a condition of the eye, wherein the implant is configured to deliver a drug to the eye. The present disclosure also relates to methods of treating a condition of the eye by delivering a drug from intraocular implants to the posterior chamber (e.g., sulcus), iridocorneal angle, sclera, cornea, limbus, and vitreous.

Systems and methods for determining IRA candidacy and optimizing autologous corneal graft location and orientation to standardize and improve IRA procedures. A novel digital virtual model (i.e., a digital twin) of the eye is provided that integrates corneal imaging, pachymetry, topography and limbus / white-to-white measurements, and automates key surgical variables such as trephine size, autologous corneal graft rotations, and curvature and thickness matching, reducing cognitive load on the surgeon and improving accuracy. The embodiments herein provide precise graft placement parameters to maximize the amount of clear cornea in the visual axis. By providing real-time, patient specific guidance, the present embodiments enhance surgical precision and visual outcomes.

The invention belongs to the technical field of biomedical engineering, and particularly relates to human corneal limbus microenvironment cell exosome eye drops as well as a preparation method and application thereof. The invention discloses human corneal limbus microenvironment cell exosome eye drops. The unique active ingredient in the eye drops is human corneal limbus microenvironment cell exosome. The invention aims to provide eye drops containing human corneal limbus microenvironment cell exosomes. The eye drops are suitable for repairing corneal injuries caused by various factors clinically and relieving eye diseases such as visual fatigue, xerophthalmia, corneal limbus stem cell deficiency and immune lesions caused by graft-versus-host diseases.

The application discloses application of a norepinephrine inhibitor in preparation of a medicine for treating or relieving corneal limbal stem cell deficiency, and belongs to the technical field of medicines.The experiment proves that sympathetic nerves are excessively activated in a mouse model of corneal limbal stem cell deficiency, and the release of norepinephrine is increased, and the experiment proves that 6-hydroxydopamine hydrochloride can destroy sympathetic nerves to inhibit the release of norepinephrine, and a tyrosine hydroxylase inhibitor can inhibit the synthesis of norepinephrine, and both can further relieve the symptoms of corneal limbal stem cell deficiency.The norepinephrine inhibitor can improve the corneal limbal microenvironment, reduce corneal neovascularization, reduce corneal epithelialization, enhance corneal transparency and relieve corneal edema, and provides a new direction and a new way for the pathogenic mechanism and intervention target of corneal limbal stem cell deficiency, and has a wide application prospect.

An anterior chamber maintainer (ACM), which is to be utilized in connection with maintaining physiological intraocular pressure during intraocular surgery, is disclosed and comprises an axially elongated tubular member which is adapted to be fluidically connected at a first end to a supply of balanced salt solution (BSS) for introduction into the anterior chamber of an eye so as to maintain adequate intraocular pressure while performing any intraocular surgery. A second opposite end of the anterior chamber maintainer (ACM) is provided with a sharply pointed end for insertion through a paracentesis incision formed within the limbus region of the eye, and a non-deformable, incompressible, tapered, annular bulbous portion is interposed between the first and second ends such that as the second end passes through the paracentesis incision, the non-deformable, incompressible, tapered, annular bulbous portion will cause the paracentesis incision to deform or expand radially outwardly, and after passing through the paracentesis incision, the non-deformable, incompressible, annular bulbous portion will trap the anterior chamber maintainer (ACM) within the anterior chamber of the eye.

The invention belongs to the technical field of biology, and particularly relates to a cytoskeleton for promoting proliferation of corneal limbal stem cells. The raw materials of the cytoskeleton provided by the invention are chitosan and sodium hyaluronate, and the cytoskeleton has good biocompatibility and biological activity, can simulate the characteristics of an extracellular matrix, provides necessary physical and chemical support for stem cells, and does not cause immune response or cytotoxicity. The addition of the magnetic nanoparticles further enhances the performance of the cytoskeleton. Directional arrangement under the action of a magnetic field can provide structural support closer to an in-vivo microenvironment for cells, and adhesion and proliferation of the cells are promoted. The cell scaffold provided by the invention can provide a good growth microenvironment for the corneal limbus stem cells, and is beneficial to solving the problem that the corneal limbus stem cells are easy to lose activity and function in in-vitro culture.

Disclosed herein is a method of alleviating symptoms of ocular surface discomfort, the method comprising: topically applying a cold slurry adjacent to a corneal limbus of an eye of a patient, wherein the cold slurry comprises water and a freezing point depressant, wherein the topical application of the cold slurry is configured to cause a degree of numbing of a cornea of the eye for a period of time, and wherein an ocular sensation of the eye is restored following the period of time.

The present disclosure relates to intraocular drug-eluting particulate implants and dry particulate formulations comprising a plurality of drug-eluting particulate implants for use in the treatment of conditions of the eye, wherein the implants are configured to deliver a drug to the eye without a carrier. The present disclosure also relates to methods of treating conditions of the eye by delivering one or more drugs from a drug eluting implant or dry particulate formulation to the anterior chamber, posterior chamber (e.g., ciliary sulcus), iris corneal horn, sclera, cornea, limbus, subconjunctival space, subcapsular space, and vitreous body.

Use of a recombinant transforming growth factor beta induced (TGFBI) protein in lattice corneal dystrophy (LCD) is provided, belonging to the technical field of biomedicine. Use of a recombinant TGFBI protein and a recombinant TGFBI protein-expressing reagent in preparation of a medicament for treating LCD are provided. It is confirmed that dropping eye drops of the recombinant TGFBI protein can promote the repair of corneal epithelial damages in an LCD mouse model; corneal intrastromal injection of the recombinant TGFBI protein can promote the repair of corneal epithelial damages in the LCD mouse model; and limbal intrastromal injection of an adeno-associated virus (AAV) vector carrying a Tgfbi gene can promote the repair of epithelial damages in a TGFBI point mutation-carrying mouse. Therefore, the recombinant TGFBI protein-related reagents exhibit a potential to treat the LCD.

The invention relates to a construction method of tissue engineering corneal epithelial cells. The construction method comprises the following steps: obtaining corneal limbus tissue blocks; digesting the tissue block, and separating to obtain epithelial cells of the tissue block; the method comprises the following steps: attaching epithelial cells to ultrathin amniotic membrane-umbilical cord derived mesenchymal stem cells, culturing in an SHEM culture medium, changing the SHEM culture medium once every two days, culturing for a period of time, and culturing the epithelial cells for a period of time by using a gas-liquid interface culture method to promote the multi-layer growth of the epithelial cells, thereby obtaining the tissue engineering corneal epithelial cells. Through a controllable preparation scheme, the amniotic membrane carrier with a certain thickness is obtained so as to increase the transparency of the amniotic membrane carrier, meanwhile, the matrix surface of the amniotic membrane carrier is inoculated with MSC, the healthy corneal limbus matrix microenvironment of a human body is simulated, damaged corneal limbus tissue / corneal epithelium is better repaired or regenerated, and the ocular surface microenvironment is improved. The produced ultrathin amnion combined mesenchymal stem cell carrier can obviously improve the effect of a tissue engineering corneal epithelium transplantation operation.

The utility model discloses a novel vitreous cavity injector capable of being positioned, which comprises a guiding and positioning mechanism and an injector, the guiding and positioning mechanism comprises an outer cylinder and a positioning ring, the positioning ring is arranged at the front end of the outer cylinder, the positioning ring and the outer cylinder are of an integrated structure which is concentrically arranged, and a concentric annular silica gel gasket is arranged on the front end face of the positioning ring. The silica gel gasket is positioned on the flat part of the ciliary body behind the cornea sclera edge of the eyeball of the patient; and a metal needle catheter is arranged in the center of the front end surface of the outer cylinder. The silica gel gasket of the positioning ring at the front end of the outer cylinder is tightly attached to the cornea sclera edge and makes flexible contact with the eyeball, and the needle head can be directly positioned on the flat portion of the ciliary body of a patient; after the needle head is inserted into the eyeball of a patient, the positioning ring at the front end of the outer cylinder provides certain supporting force, so that unnecessary damage to the eyeball of the patient caused by shaking of the hand, slippage of the needle head and the like during medicine injection is prevented; the positioning ring is suitable for the outer diameter radians of various eyeballs, and can accurately position a 4 mm injection point behind the corneal limbus.

Disclosed herein is a method of alleviating symptoms of ocular surface discomfort, the method comprising: topically applying a cold slurry adjacent to a corneal limbus of an eye of a patient, wherein the cold slurry comprises water and a freezing point depressant, wherein the topical application of the cold slurry is configured to cause a degree of numbing of a cornea of the eye for a period of time, and wherein an ocular sensation of the eye is restored following the period of time.

The invention discloses an intraoperative extracorporeal Schlemm tube positioning method and application of the intraoperative extracorporeal Schlemm tube positioning method in a glaucoma surgery, and the intraoperative extracorporeal Schlemm tube positioning method comprises the steps that a conjunctival flap with a dome as a base is manufactured, a full-thickness bulbar conjunctiva is cut off along the corneal limbus radian through a conjunctival shear, and the cut-off length is 8 + / -2 mm; performing blunt separation by clinging to the sclera surface to form a rectangular sclera area; the method comprises the following steps: manufacturing a superficial sclera flap taking limbus corneae as a substrate, forwards sectioning a sclera to a transparent cornea area, placing a mitomycin cotton piece under the sclera flap, staying for 3 minutes, and flushing; a light ring and a shadow ring are observed to be formed on the whole corneal limbus by means of irradiation of the positioning optical fiber device, and lineation marking is carried out; carrying out 1mm * 2mm deep sclera flap sectioning in the direction from 1mm behind the marking line to the limbus corneae until the limbus corneae is transparent; in the sectioning process, 0.3 mm-0. 5 mm in front of the marking line is the rear edge of the outer path Schlemm tube, the outer wall of the outer path Schlemm tube can be opened by conducting conventional fine sectioning on the outer path Schlemm tube at the position, positioning is accurate, and the surgical success rate can be improved.

The utility model provides a biological amnion cornea surface transplantation device which comprises a fixing body which is a circular ring and is matched with the corneal limbus of a human body. The fixing support piece at least comprises a fixing loop, and the fixing loop is a metal wire made of shape memory metal; one end of the fixing loop is fixedly connected with the fixing main body, and the other end of the fixing loop is far away from the diameter direction of the fixing main body passing through the connection point of the fixing loop and the fixing main body; and at least two fixing support pieces are arranged on the periphery of the fixing main body. Deformation and recovery of the memory metal and structural characteristics of human eyeballs are ingeniously utilized, the fixing loops are clamped to penetrate through the amniotic membrane and the corneal limbus conjunctiva and then are loosened, the memory metal recovers deformation in the gap between the conjunctiva and the sclera, the at least two fixing loops form a clamping jaw in the gap between the conjunctiva and the sclera along the corneal limbus radian, and the clamping jaw is clamped by the memory metal. Therefore, the amniotic membrane is pressed on the surface of the cornea by the fixing main body. The device is simple in structure, low in cost and easy to operate, trauma in an operation is small, and postoperative recovery is fast.

The present invention relates to a sterile ophthalmic composition comprising castor oil and medium-chain triglycerides; to the use of said composition in medicine, in particular for the treatment and / or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, lax eye lid syndrome, thyroid eye disease, pterygium, conjunctival laxity, epithelial damage caused by preservatives, epithelial or anterior chamber damage caused by ocular surgery, corneal limbal cell deficiency, corneal ulceration caused by physical or chemical agents, keratitis, sub-scleritis and uveitis.

An incisional instrument and method of use for creating accurate, reproducible surgical incisions. An exemplary embodiment includes an incisional instrument configured for attachment to a patient's eye and for use performing arcuate limbal relaxing incisions (LRIs). The incisional instrument is made up of two coaxial, interconnecting pieces: a docking piece and a cutting piece. The docking piece includes a suction mechanism and is configured for being secured to a patient's eye just outside the corneal limbus. The cutting piece is configured to fit flush within the docking piece and includes cutting blades and one or more handles for rotating the cutting piece relative to the docking piece. When assembled, the cutting blades extend into a patient's eye a desired LRI depth. An embodiment further includes an arcuate guide template with stoppers for providing lateral, arcuate stops for precise cuts in the desired LRI locations. An LRI method includes the steps of utilizing the incisional instrument in an ophthalmologic LRI procedure.

The invention discloses a femtosecond laser refraction operation cornea center positioning marking device in the technical field of cornea refraction positioning in the ophthalmology department. The device comprises a positioning module, an acquisition module, a processing module, a control module, a prompting module and a plurality of light sources. The positioning module is composed of an inner ring and an outer ring, the outer ring is used for being aligned with the corneal limbus, and the inner ring is used for being aligned with the corneal central visual area and provided with a dyeing marking mechanism. And the light sources are circumferentially distributed around the fixation lamp. The acquisition module acquires a two-dimensional cornea image. The processing module integrates the images into a three-dimensional visual area image. And the control module generates a reflective point guide curve based on a reflective point area in the three-dimensional visual area image, and judges whether the cornea central visual area is accurately positioned or not. And the prompt module sends prompt information to an operator. Based on the three-dimensional visual area image and the reflective point guide curve, whether positioning of the inner ring and the outer ring is accurate or not is accurately judged, and the accuracy of cornea center positioning is improved.

The invention provides application of vasoactive intestinal peptide VIP in preparation of a medicine for preventing and / or treating corneal epithelium lesion, and belongs to the technical field of biological medicine preparation. The invention discloses application of vasoactive intestinal peptide VIP in preparation of a medicine for preventing and / or treating corneal epithelium lesion. Researches show that diabetes can cause expression down-regulation of VIP and a receptor VIPR1 thereof in corneal limbus tissues, so that proliferation activity of corneal limbus stem cells of diabetic mice is reduced, and healing of corneal epithelium wounds is delayed. The exogenous supplement of VIP can effectively reverse the pathological change, significantly enhance the multiplication capacity of corneal limbal stem cells and accelerate the repair of corneal epithelium wounds; on the contrary, the VIPR1 receptor is knocked out, so that the proliferation activity of the corneal limbal stem cells is reduced, and the epithelium repair is delayed. Based on the results, the invention provides a new application of VIP in preparation of medicines for preventing and / or treating corneal epithelium lesions, and a new effective means is provided for repair treatment of the diseases.