A
system and method for locating and modeling eyes in imagery for automated photorefractive screening. The invention includes a
digital camera having a lens-mounted flash for obtaining a
digital image of the face of an individual, and a suitably programmed processor, such as a
general purpose digital computer, for locating an eye of the individual in the
digital image, modeling structures in the eye, analyzing the digitized eyes of the individual for
eye disease, and providing a recommendation for treatment. In one aspect, the invention includes a
system and method for locating a patient's eyes in a
digital image that includes each eye as illuminated by a near-axis flash, including automatically finding light reflexes in the digital images as indicative of the location of each eye. Automatically finding light reflexes includes analyzing such light reflexes to determine possible
pupil and
sclera borders. The invention further includes automatically fitting a corresponding model to such possible
pupil and
sclera borders, analyzing the model of each eye to determine possible abnormalities in each eye; and outputting a possible diagnosis for each eye based on such analyzing. Other aspects of the invention include measuring
retinal reflexes and corneal reflexes from the indicated eye models as an indicator of anomalies in the patient's eyes, and generating a digital image of each of a patient's eyes with a camera having a flash positioned near to a center line of a lens of the camera so as to generate images with bright, sharp light reflexes.