69 results about "Corneal surface" patented technology

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The invention provides methods of treating an eye disorder and compositions for use therein, the methods comprising applying a crosslinkable liquid composition onto an anterior corneal surface of said eye using a mold; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a crosslinked composition on the anterior corneal surface of the eye; and correcting the curvature of the crosslinked composition.

The invention discloses a contact lens defocusing amount optimization method and system, electronic equipment and a medium, and relates to the technical field of data processing. The method comprises the following steps: acquiring reference eye optical data of a tested eye through a wavefront aberration instrument, wherein the reference eye optical data comprises the eye axis length, the corneal curvature radius and the reference value of the lens equivalent refractive power; establishing a correlation model of the eye axis length and the corneal curvature and a correlation model of the eye axis length and the lens equivalent refractive power, and determining a change threshold value of the eye axis length. Acquiring an eye axis length acquisition value through an ultrasonic measuring instrument, and calculating the variable quantity of the eye axis length acquisition value and a reference value; and when the variable quantity exceeds a threshold value, substituting the variable quantity into the correlation model to calculate the estimated values of the curvature radius of the cornea surface and the equivalent refractive power of the crystalline lens, and constructing an optical state parameter set of the eye. And finally, based on the parameter set, calculating defocusing amount values of the contact lens at a plurality of radial positions through a ray tracing algorithm. By implementing the technical scheme provided by the invention, the defocusing amount accuracy of the contact lens can be improved.

The present invention relates to a crosslinkable liquid composition for use in a method of treating an eye disease of a subject eye, comprising (i) polyethylene glycol diacrylate (PEGDA), (ii) gelatin or a gelatin-based crosslinkable biomaterial, and (iii) a photoinitiator and optionally a coinitiator, the method comprising applying the crosslinkable liquid composition to the anterior corneal surface of the eye having the eye disease using a mold, crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a composition crosslinked on the anterior corneal surface of the eye, and correcting the curvature of the crosslinked composition.

Methods of treating eyes are described. The method may include administering an agent capable of disrupting corneal cell junctures to a corneal surface of the eye, the corneal surface comprising an intact epithelium and stroma; and administering riboflavin to the corneal surface after or simultaneously with the agent. The riboflavin may diffuse through the eye to penetrate the stroma within 10 minutes of administration of the riboflavin.

A corneal elastic modulus measurement device and method based on magnetic nanoparticle excitation, including a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module, and a data processing module. The soft contact lens is wrapped with a sealing film and attached to the corneal surface, and generates a mechanical response under the controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and its optical path is coaxially adapted with the annular electromagnetic structure to ensure synchronization of imaging and excitation. The data processing module extracts displacement information through multi-stage signal processing, combines the magnetic field force and the correction coefficient to compensate for the influence of corneal geometric parameters, and generates a high-resolution two-dimensional elastic modulus map. The system realizes real-time regional measurement of corneal mechanical properties with micron-level resolution, avoids the inadaptability of traditional technology with millimeter-level deformation, significantly improves the detection accuracy, safety and comfort, and is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

During use, the contact lens (10) forms a hollow space between its concave inner surface and the convex outer surface of the eye, and due to the presence of multiple microprotrusions (13), the contact lens (10) contacts the corneal epithelium only on a portion of its inner surface facing the eye, and the microprotrusions (13) allow the contact lens (10) to be raised a few micrometers relative to the corneal surface.

Disclosed are various systems and methods of using interferometry to measure the tear film for disease prediction and treatment. A point-by-point scan of a corneal surface of an eye is obtained from an interferometry system, including at least an interference signal. Next, a large field-of-view of the corneal surface is obtained from an objective lens with a curved focal plane matched to a curvature of the corneal surface. Subsequently, motion correction is performed on the point-by-point scan. Then, noise is filtered from the interference signal. A tear film lipid layer signal and a precorneal tear film signal are separated from the filtered interference signal. Later, a best fit frequency for the tear film lipid layer signal and the precorneal tear film signal are determined. Then, a thickness of the tear film lipid layer and the precorneal tear film are determined based at least in part on the best fit frequency.

Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.

The invention provides a cornea surface shape construction method and system, and relates to the technical field of cornea surface shape construction.The cornea surface shape construction method includes the steps that original scanning data are obtained by scanning a cornea, and cornea tomography data are obtained according to preset cornea anatomical structure division; removing invalid data points with noise, motion artifacts or signal loss to obtain effective cornea tomography data, and marking the positions of the effective data points based on an equipment space coordinate system to obtain effective cornea tomography data with position information; acquiring initial cornea optical image data, and adjusting image parameters according to the initial cornea optical image data to obtain final image data; and segmenting the final image data to obtain a cornea image, identifying the feature points to obtain three-dimensional coordinates, modeling based on the coordinates, and performing Gaussian smoothing to obtain the cornea surface shape, so that the cornea surface shape can be accurately constructed through a complete process from cornea scanning data processing, optical image optimization to feature point extraction and modeling smoothing, and the cornea surface shape can be accurately constructed. And a reliable morphological basis is provided for related diagnosis and treatment or research of the cornea.

The application belongs to the technical field of ophthalmic medical instruments, and provides a corneal topography measurement method, an instrument, an electronic device and a program product, the corneal topography measurement method obtains the corneal diameter and the corneal vertex of the eye cornea of a detected object; determines the distance between the corneal vertex and the vertex of a Placido disc, determines the eccentricity of the Placido disc; determines the shape of the Placido disc according to the eccentricity of the Placido disc, and determines the ring number of the Placido disc according to the corneal diameter; collects the corneal topography imaging after the concentric ring on the Placido disc is reflected on the corneal surface of the detected object; based on the shape and the ring number of the Placido disc, analyzes a plurality of concentric rings contained in the corneal topography imaging, and obtains the corneal topography data of the detected object. The accuracy of measuring the corneal topography is improved, so that the micro-landscape features of the corneal surface can be more accurately obtained.

The invention discloses a nano-robot based on tear driving, a preparation method of the nano-robot and application of the nano-robot in eye drops. The preparation method comprises the following steps: step 1, loading ophthalmic disease treatment drugs such as amphotericin B, voriconazole and natamycin into nano-particles such as polylactic acid-glycolic acid copolymer, chitosan and sodium alginate; 2, coupling urease on the surfaces of the nano-particles to obtain a nano-robot with autonomous movement ability; step 3, performing morphology characterization on the obtained nanometer robot driven by the tear liquid; and step 4, dispersing the prepared tear-driven nano-robot in a buffer solution to prepare the eye drops. The tear-driven nano-robot can utilize urea in tears as fuel to generate cluster motion on the cornea surface, so that the retention time is remarkably prolonged, the drug retention amount is increased, and the treatment effect is improved. The nano-robot eye drops based on tear driving have biocompatibility and treatment safety, and have wide application prospects in the field of ophthalmic local administration.

The invention provides an infrared eye movement tracking device and eye movement tracking equipment, and relates to the technical field of eye movement tracking. The device comprises a single infrared light emitting diode, a collimating element, a metasurface device, an image sensor and a control processing unit. The metasurface device is arranged on the light emitting path of the collimating element and located between the infrared light emitting diode and the human eye observation area; the metasurface device is a device designed based on a two-dimensional metasurface grating structure and is configured to diffract and modulate an incident light beam into a plurality of illumination light beams separated in space so as to form a plurality of light spots distributed in a concentric ring shape on the cornea surface of a target eyeball; the image sensor is used for collecting a cornea reflection image containing a plurality of light spots; and the control processing unit is in communication connection with the image sensor and is used for outputting sight line direction data based on the relative position relationship between a plurality of light spots in the cornea reflection image and the pupil center, so that the eye movement tracking performance with higher precision and higher reliability is realized while hardware is simplified.

The invention discloses a corneal elastic modulus measuring device and method based on magnetic nanoparticle excitation. The corneal elastic modulus measuring device comprises a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module and a data processing module. The soft contact lens is attached to the cornea surface by wrapping magnetic nanoparticles with the sealing film, and generates mechanical response under a controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and an optical path of the OCT module is coaxially matched with the annular electromagnetic structure to guarantee synchronization of imaging and excitation. And the data processing module extracts displacement information through multi-stage signal processing, compensates the influence of cornea geometric parameters in combination with a magnetic field acting force and a correction coefficient, and generates a high-resolution two-dimensional elastic modulus map. According to the system, real-time regionalization measurement of corneal mechanical characteristics is achieved with micron-level resolution, discomfort of millimeter-level deformation in the prior art is avoided, detection precision, safety and comfort are remarkably improved, and the system is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

The invention relates to the technical field of eye movement tracking, in particular to an eye movement tracking method and device based on an optical waveguide near-infrared luminous point, and the method comprises the steps: controlling a near-infrared light machine to generate illumination light in a near-infrared band, and guiding the illumination light to an in-coupling region of a near-infrared light waveguide lens; the illumination light is coupled into the near-infrared light waveguide lens through an in-coupling diffractive optical element arranged in the in-coupling area, so that the illumination light is transmitted in the near-infrared light waveguide lens along a predetermined propagation path and reaches the out-coupling area; in the out-coupling area, an out-coupling diffractive optical element is used for emitting the illumination light from the near-infrared light waveguide lens to form a plurality of near-infrared light-emitting points distributed on the near-infrared light waveguide lens, and the emitting direction of the near-infrared light-emitting points is made to point to the pupil area of the user, so that corresponding cornea reflection light spots are formed on the cornea surface of the user; an infrared eye movement camera is used for collecting an eye image containing a pupil area and a cornea reflection light spot; and performing feature extraction on the eye image to obtain an image coordinate of the pupil center and an image coordinate of the cornea reflection facula, establishing an eyeball geometric model based on a cornea reflection method, and performing calculation to obtain the sight line direction of the user. According to the invention, the problems that the frame is too wide, the view shielding is too large and the wearing comfort is insufficient when the eye movement glasses adopt a cornea reflex method can be solved.

To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

Example embodiments relate to a computer-implemented method for generating an opto-mechanical model of a camera-type eye from ocular biometry parameters that define the anatomy of the camera-type eye; wherein the ocular biometry parameters comprise at least a pupil size (224) and an iris thickness (223). The computer- implemented method comprises obtaining a predetermined iris shape (220) and a predetermined ciliary body shape (230); anchoring (201) one or more data points (221) of an outer edge of the iris shape (220) to one or more reference points of the posterior corneal surface; transforming (202) the iris shape (220) as to respect the pupil size (224) and the iris thickness (223); anchoring (203) a first portion of the outer edge (250) of the ciliary body shape to a portion of an outer edge (225) of the iris shape; transforming (204) the ciliary body shape (230) such that a second portion of an outer edge (231) of the ciliary body shape coincides with a portion of the inner scleral surface (212); and generating (205) one or more polygons (261, 262) indicative for respective zonular fibres, wherein the respective one or more polygons are defined by at least two data points located on the crystalline lens surface (240) and at least two data points located on an inner edge (232) of the ciliary body shape.

Various embodiments are presented for a method of wide-field self-referenced interference for OCT imaging, that allows for a focus on the cornea over a large diameter while reducing the number of artifacts in the signal. To accomplish this, the method includes operating a super luminescent diode to emit a light, using that light to illuminate an interferometer, collimating the light, and coupling the collimated light to an optical scanner and lens to produce a probing beam. The method also includes directing the beam through the lens onto the anterior corneal surface of the cornea and creating an incident angle between the probing beam and the anterior corneal surface. Finally, the method includes using the lens to ensure the beam is perpendicular to the corneal surface with the incident angle at less than two degrees, focusing from the center to the periphery of the corneal surface, aligning the beam with the reflective corneal surface to generate a self-referencing signal, and using the self-referencing signal to generate self-referenced interference. The self-referenced interference is detected with a spectrometer to generate a high-resolution image of the cornea over a large diameter while reducing the number of reflection artifacts experienced in typical OCT system. Additionally, a hybrid dual-path and self-referenced imaging method is disclosed in which an optical shutter in the reference arm enables sequential acquisition of conventional OCT and localized self-reference apex imaging, followed by fusion into a composite artifact-free OCT image.

The present invention relates to a diagnostic method and a diagnostic apparatus for differentiating a dry eye type. The method comprises: (a) a step of examining a tear film break-up time point and position, photographing a cornea of an eye of a subject to be examined and examining at least one tear film break-up time point in time series as time elapses, at which a break-up appearance is determined from an image of the photographed cornea reflection; (b) a step of examining a corneal surface temperature, measuring the corneal surface temperature of the subject to be examined using a thermal imaging camera, and examining a change in the surface temperature of the cornea over time in time series, which is performed simultaneously with photographing a tear film of the eye; (c) a step of mapping the at least one tear film break-up time point and the change in the surface temperature of the cornea based on time and comparing a position of the at least one tear film break-up time point with a position of the surface temperature of the cornea; and (d) a step of diagnosing a type of dry eye, in a mapping result of step (c), based on any one position of the at least one tear film break-up time point and a position of a change time point of the surface temperature of the cornea corresponding thereto, a type of dry eye is diagnosed.

This invention provides an animal eye imaging method, apparatus, and electronic device based on SS-OCT. The method involves scanning the eye of a target animal using SS-OCT to acquire three-dimensional volumetric data of a designated region of the eye. The designated region includes at least the area from the anterior corneal surface to the retina. An imaging result of the animal eye is generated based on the three-dimensional volumetric data, and the imaging result includes at least one imaging data morphology. This method uses three-dimensional volumetric data as a unified geometric reference to generate at least one imaging data morphology of the animal eye, thereby achieving accurate imaging of the animal eye.

The invention discloses an ophthalmological diagnostic instrument, and relates to the technical field of medical equipment.The ophthalmological diagnostic instrument comprises a topographic map structure, a crack projection structure, an off-axis imaging structure, a dichroic optical element and a rotating mechanism, opaque circular rings and semitransparent circular rings which are alternately distributed are arranged on the Praxiso disc, the red light source is configured to perform backlight illumination on the semitransparent circular rings, and the first camera is a color sensitive image sensor, is aligned along the visual axis of the eye and is used for capturing a Praxiso pattern reflected by the surface of the cornea and a color image of the anterior segment of the eye; the fissure projection structure comprises a visual axis along the topographic map structure and projects a blue fissure light beam to the anterior segment, the off-axis imaging structure comprises a second camera, the second camera is obliquely arranged relative to the visual axis and is used for capturing an anterior segment cross section image irradiated by the blue fissure light beam, and the dichroic optical element is arranged along the visual axis.

Systems and method for treating corneal ectasias such as keratoconus involve contacting the corneal surface to an aperture-free molding lens under vacuum pressure and cross-linking corneal tissue using UV laser or LED light in the presence of a photosensitive substance such as riboflavin. After release of vacuum, oxygen is applied to the corneal surface to enhance the cross-linking of corneal fibers. Systems may include an imaging system, user interface, vacuum regulator and controller to provide rapid diagnosis and treatment. In some embodiments, the systems may be used to treat glaucoma by applying vacuum without cross-linking of corneal fibers.

A device and method for early detection of eye disease including a corneal topography device configured to measure the elevation of a patient's anterior and posterior corneas sequentially or simultaneously; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography. A quantitative corneal symmetry index that measures the three-dimensional (3D) volume difference between the corneal surfaces of fellow eyes for differentiating between normal and abnormal corneas, including early detection and prognosis of ectatic disorders such as keratoconus and Fuchs dystrophy.

An ophthalmic laser system and related method for performing corneal lenticule incision and extraction for treating hyperopia and mixed astigmatism of the eye are described. Various techniques are used to optimize the procedure for concave lenticule incisions. One technique employs a fast-scan-slow-sweep scanning scheme to form the lenticule incisions, where the sweep angle increment is set to ensure at least double-pass cut for the entire lenticule. Another technique allows for desired distribution of refractive powers between the top and bottom lenticule incisions. Other techniques configure the lenticule such that its edge thickness is a constant; or such that the highest point of the top lenticule incision, located near the lenticule periphery, is at a predefined depth below the anterior corneal surface; or to maximize lenticule thickness for refractive treatment while ensuring that minimum anterior depth and minimum residual bed thickness in the peripheral region of the lenticule are maintained.

The utility model provides a personalized corneal contact lens microneedle device for treating corneal dilation diseases, which comprises a fixing device and a drug delivery device, the drug delivery device comprises a drug delivery main body and a drug delivery microneedle arranged on the drug delivery main body; the fixing device surrounds the periphery of the drug delivery main body and is concentric with the drug delivery main body and embedded with the drug delivery main body; wherein the fixing device fixes the whole corneal contact lens microneedle device on the surface of a cornea through the fixing microneedle, a biomechanical effect is generated around the cornea to control the corneal curvature progress, and meanwhile, the medicine delivery microneedle is fixed in the center of the cornea; the drug delivery microneedle is used for penetrating through the cornea epithelium to reach the cornea stroma layer, so that the drug on the drug delivery main body permeates into the cornea stroma layer, and finally, the thickness and hardness of the cornea stroma layer are increased in combination with ultraviolet irradiation, and the disease progress is controlled. The treatment mode of the device is safe and efficient, and nano-drugs are not needed.

The invention relates to the technical field of medical supplies for ophthalmology, and particularly discloses a cornea surface protective agent based on a compound polysaccharide synergistic effect and a preparation method of the cornea surface protective agent. The protective agent comprises chitosan quaternary ammonium salt, trehalose and recombinant human collagen as core active components, and a specific buffer system is supplemented. Through the specific proportioning combination of the core components, the protective agent can quickly form a stable and light-transmitting protective film on the cornea surface, and provides the comprehensive effects of long-acting moisturizing, epithelial repair promotion and inflammation resistance. Experiments show that the moisturizing time of the protective agent can reach more than 90 minutes, the light transmittance exceeds 98%, and corneal epithelium injury repair can be remarkably accelerated. The invention further provides a preparation method of the protective agent, and the preparation method is simple in process and suitable for industrial production.

The present disclosure is directed to contact lenses for the correcting a refractive error, particularly astigmatism, and other corneal irregularities. An exemplary lens comprises an inner portion, a peripheral portion, and a juncture therebetween. The inner portion provides optical correction for an eye. The peripheral portion conforms to a corneal surface of the eye. The juncture is a structurally flexible portion of the ophthalmic lens such that deformation of the peripheral portion in response to conforming to an astigmatism or higher order aberration of the corneal surface does not substantially deform the inner portion. When the lens is placed on the eye, the inner portion vaults over the corneal surface to form a lenticular volume. The optical correction is provided by a combination of the inner portion and the lenticular volume.

The present application belongs to the field of eye optometry technology, and discloses a hard gas-permeable corneal contact lens for myopia prevention and control. The hard gas-permeable corneal contact lens for myopia prevention and control comprises a lens body, a central optical zone, a defocus zone, a defocus stabilization zone and a front surface peripheral zone are sequentially and concentrically arranged on the front surface of the lens body from the center to the edge, a base curve zone, a positioning zone and a rear surface peripheral zone are sequentially and concentrically arranged on the rear surface of the lens body from the center to the edge, the positioning zone comprises a plurality of interconnected sub-positioning zones, the longitudinal section shape of the positioning surface of the sub-positioning zone is linear, and the rear surface peripheral zone comprises at least two interconnected sub-peripheral zones. The hard gas-permeable corneal contact lens for myopia prevention and control provided by the present application can be adjusted according to actual needs to improve the fitting degree of the hard gas-permeable corneal contact lens for myopia prevention and control and the cornea, so that the positioning is more accurate.

Disclosed herein is a soft contact lens for masking astigmatism and other optical aberrations. The soft contact lens has a lens body having a front surface, a rear surface, and at least one aperture penetrating the surfaces. The aperture facilitates or facilitates the flow of tear fluid into the lens volume above the corneal surface of the eye and below the rear surface of the lens body. The tear in the lens volume forms a tear lens to mask astigmatism or other optical aberrations. Further described herein are arrangements, sizes, and geometries of at least one aperture to optimally promote or facilitate tear flow to form a tear lens. The aperture may be configured to optimize tear flow from the eye near a tear meniscus.