36 results about "Corneal surface" patented technology

The invention provides methods of treating an eye disorder and compositions for use therein, the methods comprising applying a crosslinkable liquid composition onto an anterior corneal surface of said eye using a mold; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a crosslinked composition on the anterior corneal surface of the eye; and correcting the curvature of the crosslinked composition.

The present invention relates to a crosslinkable liquid composition for use in a method of treating an eye disease of a subject eye, comprising (i) polyethylene glycol diacrylate (PEGDA), (ii) gelatin or a gelatin-based crosslinkable biomaterial, and (iii) a photoinitiator and optionally a coinitiator, the method comprising applying the crosslinkable liquid composition to the anterior corneal surface of the eye having the eye disease using a mold, crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a composition crosslinked on the anterior corneal surface of the eye, and correcting the curvature of the crosslinked composition.

During use, the contact lens (10) forms a hollow space between its concave inner surface and the convex outer surface of the eye, and due to the presence of multiple microprotrusions (13), the contact lens (10) contacts the corneal epithelium only on a portion of its inner surface facing the eye, and the microprotrusions (13) allow the contact lens (10) to be raised a few micrometers relative to the corneal surface.

The invention provides a cornea surface shape construction method and system, and relates to the technical field of cornea surface shape construction.The cornea surface shape construction method includes the steps that original scanning data are obtained by scanning a cornea, and cornea tomography data are obtained according to preset cornea anatomical structure division; removing invalid data points with noise, motion artifacts or signal loss to obtain effective cornea tomography data, and marking the positions of the effective data points based on an equipment space coordinate system to obtain effective cornea tomography data with position information; acquiring initial cornea optical image data, and adjusting image parameters according to the initial cornea optical image data to obtain final image data; and segmenting the final image data to obtain a cornea image, identifying the feature points to obtain three-dimensional coordinates, modeling based on the coordinates, and performing Gaussian smoothing to obtain the cornea surface shape, so that the cornea surface shape can be accurately constructed through a complete process from cornea scanning data processing, optical image optimization to feature point extraction and modeling smoothing, and the cornea surface shape can be accurately constructed. And a reliable morphological basis is provided for related diagnosis and treatment or research of the cornea.

The invention provides an infrared eye movement tracking device and eye movement tracking equipment, and relates to the technical field of eye movement tracking. The device comprises a single infrared light emitting diode, a collimating element, a metasurface device, an image sensor and a control processing unit. The metasurface device is arranged on the light emitting path of the collimating element and located between the infrared light emitting diode and the human eye observation area; the metasurface device is a device designed based on a two-dimensional metasurface grating structure and is configured to diffract and modulate an incident light beam into a plurality of illumination light beams separated in space so as to form a plurality of light spots distributed in a concentric ring shape on the cornea surface of a target eyeball; the image sensor is used for collecting a cornea reflection image containing a plurality of light spots; and the control processing unit is in communication connection with the image sensor and is used for outputting sight line direction data based on the relative position relationship between a plurality of light spots in the cornea reflection image and the pupil center, so that the eye movement tracking performance with higher precision and higher reliability is realized while hardware is simplified.

The invention relates to the technical field of eye movement tracking, in particular to an eye movement tracking method and device based on an optical waveguide near-infrared luminous point, and the method comprises the steps: controlling a near-infrared light machine to generate illumination light in a near-infrared band, and guiding the illumination light to an in-coupling region of a near-infrared light waveguide lens; the illumination light is coupled into the near-infrared light waveguide lens through an in-coupling diffractive optical element arranged in the in-coupling area, so that the illumination light is transmitted in the near-infrared light waveguide lens along a predetermined propagation path and reaches the out-coupling area; in the out-coupling area, an out-coupling diffractive optical element is used for emitting the illumination light from the near-infrared light waveguide lens to form a plurality of near-infrared light-emitting points distributed on the near-infrared light waveguide lens, and the emitting direction of the near-infrared light-emitting points is made to point to the pupil area of the user, so that corresponding cornea reflection light spots are formed on the cornea surface of the user; an infrared eye movement camera is used for collecting an eye image containing a pupil area and a cornea reflection light spot; and performing feature extraction on the eye image to obtain an image coordinate of the pupil center and an image coordinate of the cornea reflection facula, establishing an eyeball geometric model based on a cornea reflection method, and performing calculation to obtain the sight line direction of the user. According to the invention, the problems that the frame is too wide, the view shielding is too large and the wearing comfort is insufficient when the eye movement glasses adopt a cornea reflex method can be solved.

To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

Example embodiments relate to a computer-implemented method for generating an opto-mechanical model of a camera-type eye from ocular biometry parameters that define the anatomy of the camera-type eye; wherein the ocular biometry parameters comprise at least a pupil size (224) and an iris thickness (223). The computer- implemented method comprises obtaining a predetermined iris shape (220) and a predetermined ciliary body shape (230); anchoring (201) one or more data points (221) of an outer edge of the iris shape (220) to one or more reference points of the posterior corneal surface; transforming (202) the iris shape (220) as to respect the pupil size (224) and the iris thickness (223); anchoring (203) a first portion of the outer edge (250) of the ciliary body shape to a portion of an outer edge (225) of the iris shape; transforming (204) the ciliary body shape (230) such that a second portion of an outer edge (231) of the ciliary body shape coincides with a portion of the inner scleral surface (212); and generating (205) one or more polygons (261, 262) indicative for respective zonular fibres, wherein the respective one or more polygons are defined by at least two data points located on the crystalline lens surface (240) and at least two data points located on an inner edge (232) of the ciliary body shape.

Various embodiments are presented for a method of wide-field self-referenced interference for OCT imaging, that allows for a focus on the cornea over a large diameter while reducing the number of artifacts in the signal. To accomplish this, the method includes operating a super luminescent diode to emit a light, using that light to illuminate an interferometer, collimating the light, and coupling the collimated light to an optical scanner and lens to produce a probing beam. The method also includes directing the beam through the lens onto the anterior corneal surface of the cornea and creating an incident angle between the probing beam and the anterior corneal surface. Finally, the method includes using the lens to ensure the beam is perpendicular to the corneal surface with the incident angle at less than two degrees, focusing from the center to the periphery of the corneal surface, aligning the beam with the reflective corneal surface to generate a self-referencing signal, and using the self-referencing signal to generate self-referenced interference. The self-referenced interference is detected with a spectrometer to generate a high-resolution image of the cornea over a large diameter while reducing the number of reflection artifacts experienced in typical OCT system. Additionally, a hybrid dual-path and self-referenced imaging method is disclosed in which an optical shutter in the reference arm enables sequential acquisition of conventional OCT and localized self-reference apex imaging, followed by fusion into a composite artifact-free OCT image.

The present invention relates to a diagnostic method and a diagnostic apparatus for differentiating a dry eye type. The method comprises: (a) a step of examining a tear film break-up time point and position, photographing a cornea of an eye of a subject to be examined and examining at least one tear film break-up time point in time series as time elapses, at which a break-up appearance is determined from an image of the photographed cornea reflection; (b) a step of examining a corneal surface temperature, measuring the corneal surface temperature of the subject to be examined using a thermal imaging camera, and examining a change in the surface temperature of the cornea over time in time series, which is performed simultaneously with photographing a tear film of the eye; (c) a step of mapping the at least one tear film break-up time point and the change in the surface temperature of the cornea based on time and comparing a position of the at least one tear film break-up time point with a position of the surface temperature of the cornea; and (d) a step of diagnosing a type of dry eye, in a mapping result of step (c), based on any one position of the at least one tear film break-up time point and a position of a change time point of the surface temperature of the cornea corresponding thereto, a type of dry eye is diagnosed.

This invention provides an animal eye imaging method, apparatus, and electronic device based on SS-OCT. The method involves scanning the eye of a target animal using SS-OCT to acquire three-dimensional volumetric data of a designated region of the eye. The designated region includes at least the area from the anterior corneal surface to the retina. An imaging result of the animal eye is generated based on the three-dimensional volumetric data, and the imaging result includes at least one imaging data morphology. This method uses three-dimensional volumetric data as a unified geometric reference to generate at least one imaging data morphology of the animal eye, thereby achieving accurate imaging of the animal eye.

The invention discloses an ophthalmological diagnostic instrument, and relates to the technical field of medical equipment.The ophthalmological diagnostic instrument comprises a topographic map structure, a crack projection structure, an off-axis imaging structure, a dichroic optical element and a rotating mechanism, opaque circular rings and semitransparent circular rings which are alternately distributed are arranged on the Praxiso disc, the red light source is configured to perform backlight illumination on the semitransparent circular rings, and the first camera is a color sensitive image sensor, is aligned along the visual axis of the eye and is used for capturing a Praxiso pattern reflected by the surface of the cornea and a color image of the anterior segment of the eye; the fissure projection structure comprises a visual axis along the topographic map structure and projects a blue fissure light beam to the anterior segment, the off-axis imaging structure comprises a second camera, the second camera is obliquely arranged relative to the visual axis and is used for capturing an anterior segment cross section image irradiated by the blue fissure light beam, and the dichroic optical element is arranged along the visual axis.

A device and method for early detection of eye disease including a corneal topography device configured to measure the elevation of a patient's anterior and posterior corneas sequentially or simultaneously; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography. A quantitative corneal symmetry index that measures the three-dimensional (3D) volume difference between the corneal surfaces of fellow eyes for differentiating between normal and abnormal corneas, including early detection and prognosis of ectatic disorders such as keratoconus and Fuchs dystrophy.

An ophthalmic laser system and related method for performing corneal lenticule incision and extraction for treating hyperopia and mixed astigmatism of the eye are described. Various techniques are used to optimize the procedure for concave lenticule incisions. One technique employs a fast-scan-slow-sweep scanning scheme to form the lenticule incisions, where the sweep angle increment is set to ensure at least double-pass cut for the entire lenticule. Another technique allows for desired distribution of refractive powers between the top and bottom lenticule incisions. Other techniques configure the lenticule such that its edge thickness is a constant; or such that the highest point of the top lenticule incision, located near the lenticule periphery, is at a predefined depth below the anterior corneal surface; or to maximize lenticule thickness for refractive treatment while ensuring that minimum anterior depth and minimum residual bed thickness in the peripheral region of the lenticule are maintained.

The utility model provides a personalized corneal contact lens microneedle device for treating corneal dilation diseases, which comprises a fixing device and a drug delivery device, the drug delivery device comprises a drug delivery main body and a drug delivery microneedle arranged on the drug delivery main body; the fixing device surrounds the periphery of the drug delivery main body and is concentric with the drug delivery main body and embedded with the drug delivery main body; wherein the fixing device fixes the whole corneal contact lens microneedle device on the surface of a cornea through the fixing microneedle, a biomechanical effect is generated around the cornea to control the corneal curvature progress, and meanwhile, the medicine delivery microneedle is fixed in the center of the cornea; the drug delivery microneedle is used for penetrating through the cornea epithelium to reach the cornea stroma layer, so that the drug on the drug delivery main body permeates into the cornea stroma layer, and finally, the thickness and hardness of the cornea stroma layer are increased in combination with ultraviolet irradiation, and the disease progress is controlled. The treatment mode of the device is safe and efficient, and nano-drugs are not needed.

The invention relates to the technical field of medical supplies for ophthalmology, and particularly discloses a cornea surface protective agent based on a compound polysaccharide synergistic effect and a preparation method of the cornea surface protective agent. The protective agent comprises chitosan quaternary ammonium salt, trehalose and recombinant human collagen as core active components, and a specific buffer system is supplemented. Through the specific proportioning combination of the core components, the protective agent can quickly form a stable and light-transmitting protective film on the cornea surface, and provides the comprehensive effects of long-acting moisturizing, epithelial repair promotion and inflammation resistance. Experiments show that the moisturizing time of the protective agent can reach more than 90 minutes, the light transmittance exceeds 98%, and corneal epithelium injury repair can be remarkably accelerated. The invention further provides a preparation method of the protective agent, and the preparation method is simple in process and suitable for industrial production.

The present disclosure is directed to contact lenses for the correcting a refractive error, particularly astigmatism, and other corneal irregularities. An exemplary lens comprises an inner portion, a peripheral portion, and a juncture therebetween. The inner portion provides optical correction for an eye. The peripheral portion conforms to a corneal surface of the eye. The juncture is a structurally flexible portion of the ophthalmic lens such that deformation of the peripheral portion in response to conforming to an astigmatism or higher order aberration of the corneal surface does not substantially deform the inner portion. When the lens is placed on the eye, the inner portion vaults over the corneal surface to form a lenticular volume. The optical correction is provided by a combination of the inner portion and the lenticular volume.

A system and method for use in eye surgery. The system includes at least one light source, a detection unit, and a detection circuit. The at least one light source is configured and operable to emit one or more illumination beams directed at a region of a corneal surface of a patient's eye. The detection unit includes an arrangement of light detectors positioned for collecting a reflected beam reflected from the region of the corneal surface of the patient's eye. The detection circuit is configured for collecting and analyzing a detection signal from the detection unit, and for detecting variations of the reflected beam pattern over time indicative of surface curvature changes of the corneal surface region. In response to detecting surface curvature change exceeding a predefined threshold, the detection circuit generate a response signal triggering operation of an anti-vacuum surge (AVS) mechanism.

An ophthalmic laser surgical system for treating an eye includes a laser device, one or more cameras, and a computer. The eye has anatomical features, including the cornea with the anterior corneal surface. The laser device directs a laser beam towards the eye. A camera generates images of the anatomical features, including the anterior corneal surface. The computer facilitates docking a patient interface onto the eye by accessing eye information describing the eye. The eye information comprises an eye model describing the anatomical features. The computer determines from the eye model the predicted corneal surface position when the eye is aligned to dock the patient interface onto the eye. The computer detects from the images the actual corneal surface position prior to docking the patient interface onto the eye, and compares the predicted corneal surface position with the actual corneal surface position to detect misalignment.

Contact lenses for the treatment of a refractive error, particularly astigmatism, are provided. An exemplary lens comprises a soft continuous lens body configured to cover a corneal surface, the lens body having a posterior surface to be suspended over the corneal surface forming a free volume thereover, and at least one discrete discontinuity. The free volume may be configured to fill with tear fluid, forming a tear lens over the corneal surface for correcting the ocular refractive error. The discrete discontinuity may allow a portion of the lens body to conform to a meridian of the eye without substantially distorting an optical region of the lens body. The discrete discontinuity may allow tear fluid to flow into and out of the free volume to form the tear lens. Optical correction is provided by a combination of the optical region of the lens body and the tear lens.

Methods, kits, and material compositions for use in correcting eye conditions are disclosed. This involves a selected three-dimensional patterning of the user's corneal surface. The pattern is selected to provide an optical effect according to a given visual impairment of the user. A dispersant in liquid (aqueous solution) form containing nanoparticles is applied onto the selected three-dimensional pattern, thereby dispersing the nanoparticles in the incision areas of the pattern. The nanoparticles include biocompatible protein-based nanoparticles. The dispersant may also be used as eye drops, thereby allowing the nanoparticles to occupy etching areas on the cornea, thereby functionalizing and maintaining the visual correction effect of the pattern on the eye condition. The disclosure further provides methods and kits for ablating corneal tissue in a selected pattern by using visible-spectrum light.

The invention discloses a manufacturing method of a refractive operation surface type optical equivalent device and an optimal surface type obtaining method, and belongs to the field of visual imaging and corneal refraction correction. The manufacturing method comprises the following steps: obtaining preoperative corneal surface type parameters of a patient before a refractive operation and a plurality of preset postoperative corneal surface type parameters corresponding to the refractive operation; for each postoperative corneal surface type parameter, an incident plane is constructed based on each postoperative corneal surface type parameter, an emergent plane is constructed based on a preoperative corneal surface type parameter, a series of corneal contact lenses composed of the incident planes and the emergent planes are constructed, and optical equivalent devices corresponding to each postoperative corneal surface type parameter are constructed based on the corneal contact lenses. By means of the method, the patient can directly experience and evaluate the visual effects of different corneal surface types after the operation before the operation, then the optimal corneal surface type parameters after the operation are screened out, the patient can experience the corneal surface type most suitable for the patient before the operation, and the consistency of the corneal refraction operation prediction result and the subjective feeling of the patient is improved.

The invention discloses a common-sphere-center decoupling excitation device and cornea biomechanical parameter measuring equipment which are used for local measurement of cornea mechanical parameters. The device comprises a base, a micro-motion adjusting mechanism installed on the base, a decoupling adjusting mechanism connected to the micro-motion adjusting mechanism, an air injection excitation unit installed on the decoupling adjusting mechanism and a non-contact positioning unit fixed to the base. After a virtual sphere center of the device is aligned with a fitting sphere center of a cornea through a non-contact positioning unit, an arc-shaped guide assembly moving around the sphere center in a decoupling adjusting mechanism and a mounting seat capable of moving in the radial direction are combined with rotation around a shaft; the air injection position, the air injection angle and the air injection distance of the air injection excitation unit relative to the cornea can be independently adjusted without interference, so that standardized local excitation of any target point on the surface of the cornea is realized, and a key hardware foundation is provided for obtaining a high-resolution cornea biomechanical parameter distribution diagram.

The invention belongs to the technical field of medical instruments, and discloses a portable traditional Chinese medicine eye nebulization therapy device which comprises a frame and a liquid storage bottle, the frame is connected with a bandage and a nebulization drug delivery assembly, the nebulization drug delivery assembly comprises a base body, the base body is connected with a circular cover plate, a center cylinder and a nebulization pump, the circular cover plate is provided with an arc-shaped groove, the center cylinder is connected with a linkage frame, and the linkage frame is connected with the liquid storage bottle. The linkage frame is connected with four linkage shafts and an adjusting handle, the four linkage shafts are all connected with expansion bodies, the four expansion bodies are close to and / or far away from one another by rotating the adjusting handle, the atomizing pump is communicated with a spray head through a liquid guide pipe, and the spray head is arranged among the four expansion bodies. By controlling the angle of the adjusting handle relative to the base body and controlling the traction state of the expansion body to eyelids around the eyes, the opening and / or closing state of the eyes is further controlled, medicine administration is conducted when the eyes are in the stable opening state, the covering effect of medicine droplets, the conjunctival sac and the cornea surface is good, and the atomization treatment effect is good.

The invention discloses a storage device for cornea transportation, and belongs to the technical field of medical instruments, a circulating pump is started to enable a filter box to extract storage liquid in a liquid extraction header pipe, a second valve pipe extracts the storage liquid from the bottom in a storage bottle through a plurality of liquid extraction long pipes, and the storage liquid flows into the filter box together; a filter membrane additionally arranged in the filter box can filter tiny impurities to prevent the impurities from blocking a pipeline, the filtered preserving fluid enters a liquid guide header pipe through a circulating pump, and the liquid guide header pipe guides the preserving fluid into a liquid guide short pipe through a plurality of first valve pipes, so that the preserving fluid in a storage bottle can slowly flow from top to bottom; due to the fact that slow convection is formed in liquid guiding and extracting work of the short liquid guiding pipe and the long liquid extracting pipe, nutrient substances evenly cover the surface of the cornea, the fluidity of the stored liquid in the storage bottle is improved, the nutrient substances are prevented from being distributed in a gradient mode, even distribution of cornea nutrition is guaranteed, and therefore activity is improved.

The application discloses a common ball core decoupling excitation device and a corneal biomechanical parameter measuring device, which are used for local measurement of corneal mechanical parameters. The device comprises a base, a micro-motion adjusting mechanism mounted on the base, a decoupling adjusting mechanism connected to the micro-motion adjusting mechanism, a jet excitation unit mounted on the decoupling adjusting mechanism and a non-contact positioning unit fixed to the base. After the virtual ball core of the device is aligned with the fitting ball core of the cornea by the non-contact positioning unit, the jet position, the jet angle and the jet distance of the jet excitation unit relative to the cornea can be independently and non-interferingly adjusted by using the arc-shaped guide assembly moving around the ball core, the radially movable mounting seat and the rotation around the shaft in the decoupling adjusting mechanism, so that the standardized local excitation of any target point on the corneal surface is realized, and a key hardware foundation for obtaining a high-resolution corneal biomechanical parameter distribution diagram is provided.

This application relates to a method and apparatus for determining corneal axial curvature. The method includes: acquiring the anterior corneal surface layering line and / or posterior corneal surface layering line for each of multiple corneal images of a target cornea; determining the axial position of the target cornea based on the anterior and / or posterior corneal surface layering lines of each corneal image; and determining the axial curvature of the target cornea based on the axial position of the target cornea. This method, by introducing the axial position of the cornea, and thus determining the axial curvature of the cornea based on the axial position, achieves the effect of accurately calculating the corneal axial curvature even when the scanning center is not on the axial direction due to systematic errors.

An ophthalmic laser system and related method for performing corneal lenticule incision and extraction for treating hyperopia and mixed astigmatism of the eye are described. Various techniques are used to optimize the procedure for concave lenticule incisions. One technique employs a fast-scan-slow-sweep scanning scheme to form the lenticule incisions, where the sweep angle increment is set to ensure at least double-pass cut for the entire lenticule. Another technique allows for desired distribution of refractive powers between the top and bottom lenticule incisions. Other techniques configure the lenticule such that its edge thickness is a constant; or such that the highest point of the top lenticule incision, located near the lenticule periphery, is at a predefined depth below the anterior corneal surface; or to maximize lenticule thickness for refractive treatment while ensuring that minimum anterior depth and minimum residual bed thickness in the peripheral region of the lenticule are maintained.

The invention relates to the technical field of ophthalmic biological materials, in particular to composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from an extracellular vesicle solution, a rhein solution, a calcium chloride solution and a sodium hyaluronate solution, in the hydrogel, the concentration of the rhein is 0.7 mM to 24.6 mM, the concentration of the calcium chloride is 0.10 mM to 0.5 mM, the final concentration of the sodium hyaluronate is 1.0 percent to 1.5 percent by mass, and the concentration of the extracellular vesicles is 1.9 * 10 < 6 > particles / mL to 1.9 * 10 < 11 > particles / mL; the extracellular vesicles are pseudo-ginseng derived extracellular vesicles prepared from pseudo-ginseng. According to the slow release effect of the composite hydrogel on the pseudo-ginseng derived extracellular vesicles, the pseudo-ginseng derived extracellular vesicles are delivered to the cornea, and the pseudo-ginseng derived extracellular vesicles are uniformly embedded and slowly released in gel channels, so that the retention time of the pseudo-ginseng derived extracellular vesicles on the cornea surface is prolonged.