94 results about "Corneal surface" patented technology

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The invention provides methods of treating an eye disorder and compositions for use therein, the methods comprising applying a crosslinkable liquid composition onto an anterior corneal surface of said eye using a mold; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a crosslinked composition on the anterior corneal surface of the eye; and correcting the curvature of the crosslinked composition.

The present invention discloses a one-time implant artificial cornea, belonging to the technical field of in-vivo prosthesis implantation. It solves at least the problems existing in the prior art, such as the need for donor corneas, multiple surgeries, large trauma, and inapplicability to patients with severe corneal blindness. The one-time implant artificial cornea includes a stent and a lens column. The lens column includes a lens column body and a rear disc coaxially arranged at the rear end face of the lens column body. The lens column is detachably connected to the stent coaxially. In the use state, the rear end of the lens column body behind the rear disc protrudes into the eye, the rear disc fits the posterior surface of the cornea, and the stent fits the anterior surface of the cornea. The stent is fixed on the corneal surface by using a suture method. At the same time, the stent and the rear disc clamp the cornea from the front and the back. The present invention also provides a method for using the one-time implant artificial cornea. It has the advantages of one-time implantation, no need for donor corneas, small trauma, and applicability to patients with severe corneal blindness, and has broad application prospects.

The invention discloses a contact lens defocusing amount optimization method and system, electronic equipment and a medium, and relates to the technical field of data processing. The method comprises the following steps: acquiring reference eye optical data of a tested eye through a wavefront aberration instrument, wherein the reference eye optical data comprises the eye axis length, the corneal curvature radius and the reference value of the lens equivalent refractive power; establishing a correlation model of the eye axis length and the corneal curvature and a correlation model of the eye axis length and the lens equivalent refractive power, and determining a change threshold value of the eye axis length. Acquiring an eye axis length acquisition value through an ultrasonic measuring instrument, and calculating the variable quantity of the eye axis length acquisition value and a reference value; and when the variable quantity exceeds a threshold value, substituting the variable quantity into the correlation model to calculate the estimated values of the curvature radius of the cornea surface and the equivalent refractive power of the crystalline lens, and constructing an optical state parameter set of the eye. And finally, based on the parameter set, calculating defocusing amount values of the contact lens at a plurality of radial positions through a ray tracing algorithm. By implementing the technical scheme provided by the invention, the defocusing amount accuracy of the contact lens can be improved.

A device and method for early detection of eye disease including a corneal topography device including a camera, such as a rotating Scheimpflug camera, configured to measure the elevation of a patient's two anterior corneas sequentially or simultaneously; a computer processor; and non-transitory computer readable media including computer readable instructions, which, when executed by the computer processor, causes the device to measure and store elevation data at a plurality of points on the patient's anterior corneal surfaces; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography.

A method implemented in an ophthalmic surgical laser system that employs a resonant scanner, scan line rotator, and XY- and Z-scanners, for forming a corneal flap in a patient's eye with improved bubble management during each step of the flap creation process. A pocket cut is formed first below bed level, followed by the bed connected to the pocket cut, then by a side cut extending from the bed to the anterior corneal surface. The pocket cut includes a pocket region located below the bed level and a ramp region connecting the pocket region to the bed. The bed is formed by a hinge cut and a first ring cut at lower laser energies, followed by a bed cut and then a second ring cut, which ensures that any location in the flap bed is cut twice to minimize tissue adhesion. The side cut is formed by multiple side-cut layers at different depths which are joined together. All cuts are formed by scanning a laser scan line generated by the resonant scanner.

The present invention relates to a crosslinkable liquid composition for use in a method of treating an eye disease of a subject eye, comprising (i) polyethylene glycol diacrylate (PEGDA), (ii) gelatin or a gelatin-based crosslinkable biomaterial, and (iii) a photoinitiator and optionally a coinitiator, the method comprising applying the crosslinkable liquid composition to the anterior corneal surface of the eye having the eye disease using a mold, crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a composition crosslinked on the anterior corneal surface of the eye, and correcting the curvature of the crosslinked composition.

A method implemented in an ophthalmic surgical laser system for forming a corneal flap in a patient's eye with improved bubble management. The flap includes a horizontal bed and a vertical or near vertical side cut around the periphery of the bed except for an uncut hinge area. The side cut has a bubble barrier layer that can prevent bubbles formed by the laser-tissue interaction from escaping into an interface between the corneal and the patient interface lens. In some embodiments, the bubble barrier layer is a thin uncut layer, located in the epithelium of the cornea, that separates the side cut into two portions. In other embodiments, the side cut does not reach the anterior corneal surface, leaving an uncut bubble barrier layer located with the epithelium. In other embodiments, an additional side cut portion is formed through the uncut bubble barrier layer as the last step.

The invention relates to a crosslinkable liquid composition comprising a gelatin or a gelatin-based crosslinkable biomaterial for use in a method of myopia management in a subject, such as for use in a method of one or more of preventing or reducing the progression of myopia or preventing an eye disease associated with myopia progression in a subject. In particular, the method may comprise: applying a crosslinkable liquid composition onto the anterior corneal surface of the eyes of the subject, wherein the method comprises introducing the crosslinkable liquid composition into a mold which is positioned onto the anterior corneal surface of the eyes; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eyes, thereby obtaining a crosslinked composition on the anterior corneal surface of the eyes; and correcting the curvature of the crosslinked composition to create a peripheral myopic defocus.

Methods of treating eyes are described. The method may include administering an agent capable of disrupting corneal cell junctures to a corneal surface of the eye, the corneal surface comprising an intact epithelium and stroma; and administering riboflavin to the corneal surface after or simultaneously with the agent. The riboflavin may diffuse through the eye to penetrate the stroma within 10 minutes of administration of the riboflavin.

A corneal elastic modulus measurement device and method based on magnetic nanoparticle excitation, including a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module, and a data processing module. The soft contact lens is wrapped with a sealing film and attached to the corneal surface, and generates a mechanical response under the controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and its optical path is coaxially adapted with the annular electromagnetic structure to ensure synchronization of imaging and excitation. The data processing module extracts displacement information through multi-stage signal processing, combines the magnetic field force and the correction coefficient to compensate for the influence of corneal geometric parameters, and generates a high-resolution two-dimensional elastic modulus map. The system realizes real-time regional measurement of corneal mechanical properties with micron-level resolution, avoids the inadaptability of traditional technology with millimeter-level deformation, significantly improves the detection accuracy, safety and comfort, and is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

During use, the contact lens (10) forms a hollow space between its concave inner surface and the convex outer surface of the eye, and due to the presence of multiple microprotrusions (13), the contact lens (10) contacts the corneal epithelium only on a portion of its inner surface facing the eye, and the microprotrusions (13) allow the contact lens (10) to be raised a few micrometers relative to the corneal surface.

Disclosed are various systems and methods of using interferometry to measure the tear film for disease prediction and treatment. A point-by-point scan of a corneal surface of an eye is obtained from an interferometry system, including at least an interference signal. Next, a large field-of-view of the corneal surface is obtained from an objective lens with a curved focal plane matched to a curvature of the corneal surface. Subsequently, motion correction is performed on the point-by-point scan. Then, noise is filtered from the interference signal. A tear film lipid layer signal and a precorneal tear film signal are separated from the filtered interference signal. Later, a best fit frequency for the tear film lipid layer signal and the precorneal tear film signal are determined. Then, a thickness of the tear film lipid layer and the precorneal tear film are determined based at least in part on the best fit frequency.

Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.

The invention provides a cornea surface shape construction method and system, and relates to the technical field of cornea surface shape construction.The cornea surface shape construction method includes the steps that original scanning data are obtained by scanning a cornea, and cornea tomography data are obtained according to preset cornea anatomical structure division; removing invalid data points with noise, motion artifacts or signal loss to obtain effective cornea tomography data, and marking the positions of the effective data points based on an equipment space coordinate system to obtain effective cornea tomography data with position information; acquiring initial cornea optical image data, and adjusting image parameters according to the initial cornea optical image data to obtain final image data; and segmenting the final image data to obtain a cornea image, identifying the feature points to obtain three-dimensional coordinates, modeling based on the coordinates, and performing Gaussian smoothing to obtain the cornea surface shape, so that the cornea surface shape can be accurately constructed through a complete process from cornea scanning data processing, optical image optimization to feature point extraction and modeling smoothing, and the cornea surface shape can be accurately constructed. And a reliable morphological basis is provided for related diagnosis and treatment or research of the cornea.

The invention relates to the technical field of medical instruments, and discloses a wearable intraocular pressure monitoring device which comprises a lens body, the corneal pressure of a patient is monitored by adopting an air injection method, and an air outlet pipe with branches is arranged at the output end of a micro fan; the air outlets of the air outlet pipes are aligned with the top ends of the left side and the right side of a single eye of a patient wearing the lens body so that pressure can be more evenly distributed on the surface of the cornea, and therefore measurement errors possibly caused by too large single-point pressure are reduced, and meanwhile the intraocular pressure monitoring sensor located on the inner side of the lens body is matched so that the cornea pressure of the patient can be monitored; the monitored data are transmitted to a signal processing unit in a hollow shell in the middle above the front end of the mirror body, then controlled by a main controller located in the hollow shell, and sent to a terminal through wireless transmission units on the left side and the right side of the front end face of the mirror body, so that a patient and a doctor can remotely check and analyze the data conveniently; and the monitoring convenience is improved.

The application belongs to the technical field of ophthalmic medical instruments, and provides a corneal topography measurement method, an instrument, an electronic device and a program product, the corneal topography measurement method obtains the corneal diameter and the corneal vertex of the eye cornea of a detected object; determines the distance between the corneal vertex and the vertex of a Placido disc, determines the eccentricity of the Placido disc; determines the shape of the Placido disc according to the eccentricity of the Placido disc, and determines the ring number of the Placido disc according to the corneal diameter; collects the corneal topography imaging after the concentric ring on the Placido disc is reflected on the corneal surface of the detected object; based on the shape and the ring number of the Placido disc, analyzes a plurality of concentric rings contained in the corneal topography imaging, and obtains the corneal topography data of the detected object. The accuracy of measuring the corneal topography is improved, so that the micro-landscape features of the corneal surface can be more accurately obtained.

The present invention discloses a liquid sac-shaped corneal contact lens and a preparation method thereof. The liquid sac-shaped corneal contact lens is composed of a transparent film and a transparent oxygen-permeable liquid, and the oxygen-permeable liquid is wrapped inside the film; the film includes an inner elastomer layer and an outer hydrophilic polymer hydrogel layer. The liquid sac-shaped corneal contact lens of the present invention has the characteristic of being able to change its shape, can remain in a narrow pipeline in the form of a liquid drop, can be directly dropped into the eye from the pipeline, spread out on the corneal surface, is convenient to carry and has a simple wearing method.

The invention discloses a nano-robot based on tear driving, a preparation method of the nano-robot and application of the nano-robot in eye drops. The preparation method comprises the following steps: step 1, loading ophthalmic disease treatment drugs such as amphotericin B, voriconazole and natamycin into nano-particles such as polylactic acid-glycolic acid copolymer, chitosan and sodium alginate; 2, coupling urease on the surfaces of the nano-particles to obtain a nano-robot with autonomous movement ability; step 3, performing morphology characterization on the obtained nanometer robot driven by the tear liquid; and step 4, dispersing the prepared tear-driven nano-robot in a buffer solution to prepare the eye drops. The tear-driven nano-robot can utilize urea in tears as fuel to generate cluster motion on the cornea surface, so that the retention time is remarkably prolonged, the drug retention amount is increased, and the treatment effect is improved. The nano-robot eye drops based on tear driving have biocompatibility and treatment safety, and have wide application prospects in the field of ophthalmic local administration.

The invention provides an infrared eye movement tracking device and eye movement tracking equipment, and relates to the technical field of eye movement tracking. The device comprises a single infrared light emitting diode, a collimating element, a metasurface device, an image sensor and a control processing unit. The metasurface device is arranged on the light emitting path of the collimating element and located between the infrared light emitting diode and the human eye observation area; the metasurface device is a device designed based on a two-dimensional metasurface grating structure and is configured to diffract and modulate an incident light beam into a plurality of illumination light beams separated in space so as to form a plurality of light spots distributed in a concentric ring shape on the cornea surface of a target eyeball; the image sensor is used for collecting a cornea reflection image containing a plurality of light spots; and the control processing unit is in communication connection with the image sensor and is used for outputting sight line direction data based on the relative position relationship between a plurality of light spots in the cornea reflection image and the pupil center, so that the eye movement tracking performance with higher precision and higher reliability is realized while hardware is simplified.

The present invention relates to an apparatus, a computer program and a method for correcting refractive errors of vision. In a first example, a position (480) of a desired focus point (440) relative to the retina of an eye can be determined based on topographic information obtained about the anterior corneal surface (401) and the posterior corneal surface (402) and refractive aberration information of an individual eye. In a second example, correction information (416, 496) related to the anterior corneal surface (401) can be determined based on the topographic information obtained about the anterior corneal surface (401) and the posterior corneal surface (402) and based on topographic information obtained about the anterior lens surface (431) and the posterior lens surface (432) of the individual eye to optimize focusing on the retina of the eye.

The invention discloses a corneal elastic modulus measuring device and method based on magnetic nanoparticle excitation. The corneal elastic modulus measuring device comprises a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module and a data processing module. The soft contact lens is attached to the cornea surface by wrapping magnetic nanoparticles with the sealing film, and generates mechanical response under a controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and an optical path of the OCT module is coaxially matched with the annular electromagnetic structure to guarantee synchronization of imaging and excitation. And the data processing module extracts displacement information through multi-stage signal processing, compensates the influence of cornea geometric parameters in combination with a magnetic field acting force and a correction coefficient, and generates a high-resolution two-dimensional elastic modulus map. According to the system, real-time regionalization measurement of corneal mechanical characteristics is achieved with micron-level resolution, discomfort of millimeter-level deformation in the prior art is avoided, detection precision, safety and comfort are remarkably improved, and the system is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

The invention relates to a device, a computer program and a method for correcting ametropia of vision. In a first example, a position (480) of a desired focus point (440) relative to a retina of an individual eye may be determined based on obtained topographic information of an anterior corneal surface (401) and a posterior corneal surface (402) and refractive aberration information of the eye. In a second example, correction information (416, 496) related to the anterior corneal surface (401) may be determined based on the obtained topographic information of the anterior corneal surface (401) and posterior corneal surface (402) and based on the obtained topographic information of the anterior lens surface (431) and posterior lens surface (432) of the individual's eye to optimize focus onto the retina of the eye.

The invention discloses an eye movement tracking method based on an MEMS micromirror and a glasses device. The eye movement tracking method based on the MEMS micromirror comprises the following steps: S1, setting an initial eyeball position, and adjusting an initial angle of the micromirror to enable a reflected laser vector to be incident to the center of an eyeball cornea; s2, controlling a micro-mirror resonance scanning laser beam to continuously deflect on the surface of the cornea; s3, the laser spot generates a periodic scanning track on the surface of the cornea of the eyeball, a photoelectric detector receives a signal and generates a characteristic pulse peak at the central position of the cornea, and the time difference of the pulse peak values in a single scanning period is analyzed to obtain the rotation condition of the eyeball; the glasses device comprises a glasses frame, a photoelectric detector, an MEMS micromirror and a laser component thereof, and is used for realizing the above eye movement tracking steps. According to the accurate eye position judgment method based on the geometrical relationship, the computing power requirement is low, positioning is more accurate, the performance of an eye movement tracking system is improved, the MEMS micromirror has the advantages of being small in size, high in response speed, low in power consumption and the like, and the problems that an existing eye movement tracking technology is low in accuracy and low in portability are effectively solved.

The invention relates to the technical field of eye movement tracking, in particular to an eye movement tracking method and device based on an optical waveguide near-infrared luminous point, and the method comprises the steps: controlling a near-infrared light machine to generate illumination light in a near-infrared band, and guiding the illumination light to an in-coupling region of a near-infrared light waveguide lens; the illumination light is coupled into the near-infrared light waveguide lens through an in-coupling diffractive optical element arranged in the in-coupling area, so that the illumination light is transmitted in the near-infrared light waveguide lens along a predetermined propagation path and reaches the out-coupling area; in the out-coupling area, an out-coupling diffractive optical element is used for emitting the illumination light from the near-infrared light waveguide lens to form a plurality of near-infrared light-emitting points distributed on the near-infrared light waveguide lens, and the emitting direction of the near-infrared light-emitting points is made to point to the pupil area of the user, so that corresponding cornea reflection light spots are formed on the cornea surface of the user; an infrared eye movement camera is used for collecting an eye image containing a pupil area and a cornea reflection light spot; and performing feature extraction on the eye image to obtain an image coordinate of the pupil center and an image coordinate of the cornea reflection facula, establishing an eyeball geometric model based on a cornea reflection method, and performing calculation to obtain the sight line direction of the user. According to the invention, the problems that the frame is too wide, the view shielding is too large and the wearing comfort is insufficient when the eye movement glasses adopt a cornea reflex method can be solved.

A system and method for use in eye surgery. The system includes at least one light source, a detection unit, and a detection circuit. The at least one light source is configured and operable to emit one or more illumination beams directed at a region of a corneal surface of a patient's eye. The detection unit includes an arrangement of light detectors positioned for collecting a reflected beam reflected from the region of the corneal surface of the patient's eye. The detection circuit is configured for collecting and analyzing a detection signal from the detection unit, and for detecting variations of the reflected beam pattern over time indicative of surface curvature changes of the corneal surface region. In response to detecting surface curvature change exceeding a predefined threshold, the detection circuit generate a response signal triggering operation of an anti-vacuum surge (AVS) mechanism.

Method for providing control data for a laser (18) of a treatment device (10) for the correction of a cornea (26) of a human or animal eye, the method comprising the following steps carried out by a control device (20): - determining (S10) a corneal geometry of the eye from predetermined examination data, wherein the corneal geometry comprises at least an anterior corneal curvature; - determining (S12) a correction to be achieved, wherein an anterior and a posterior boundary surface (14, 16) of a lenticule (12) of the cornea (26) are determined by the correction to be achieved; - determining (S14) a deformed cornea (26) that is expected due to the removal of the lenticule (12) from the cornea (26) by means of a corneal deformation model that is determined based on the Euler-Bernoulli beam theory, wherein in the corneal deformation model the cornea (26) with the determined corneal geometry is described by a solid body, wherein the solid body is formed from respective central corneal surfaces (34, 36) between an anterior corneal surface (30) and a posterior corneal surface (32), and to determine the deformed cornea, a closure of a region between the anterior (16) and the posterior boundary surface (14) of the lenticule (12) is modeled in the solid body, thereby changing the curvatures of the central corneal surfaces (34, 36) and the anterior corneal curvature; - determining (S16) a deformation correction value by means of the deformed cornea (26) of the corneal deformation model, which indicates which correction is achieved according to the deformed cornea; - Adjusting (S18) the correction to be achieved depending on the determined deformation correction value, - Providing (S20) the control data for controlling the laser (18) which have the adjusted correction to be achieved.

A dendrimer-hyaluronic acid hydrogel including a methacrylate-functionalized hyaluronic acid ("HA") and a methacrylate-functionalized hydroxyl dendrimer [poly(amidoamine) can be easily applied over or into a corneal wound or a partially removed cornea to form new corneal tissue. The HA crosslinked hydrogel slowly degrades and facilitates regeneration of the cornea over a 6–10-month period, resulting in a tissue structure with structural and functional elements of the original cornea. The HA promotes corneal tissue regeneration, while the dendrimer component allows the ideal modulus within the hydrogel network, preserving corneal surface integrity.

To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

According to the system and method for detecting corneal pathogens, in the system and method, the adsorption capacity is enhanced through ionic liquid modified MXene, silk fibroin in silk fibroin composite hydrogel has good biocompatibility, pathogens on the surface of the cornea can be accurately extracted after compounding, the bacterial adsorption efficiency reaches 92.3 + / -2.7%, and the bacterial adsorption efficiency reaches 92.3 + / -2.7%. The adsorption efficiency of fungi reaches 85.4 + / -3.8%, the adsorption efficiency of viruses reaches 88.6 + / -3.5%, high adsorption efficiency is achieved, and non-invasive sampling is achieved. The combined use of the micro-fluidic chip and the LAMP technology can accurately identify the nucleic acid sequence of a target pathogen, the detected pathogen can be judged only according to the detected fluorescence signal or color change, the pathogen detection can be rapidly completed within 1 h, the detection sensitivity reaches 101-102 CFU / mL, high-sensitivity, rapid and non-invasive detection is realized, and the detection cost is reduced. The kit is suitable for early diagnosis of keratitis.