59 results about "Anterior cornea" patented technology

Optical coherence tomography (OCT) is used to map the surface elevation and thickness of the cornea. The OCT maps are used to plan laser procedures for the treatment of an irregular, opacified or weakened cornea, and in the treatment of refractive errors. In the excimer laser phototherapeutic keratectomy (PTK) procedure, the OCT data is used to plan a map of ablation depth needed to restore a smooth optical surface. In the excimer laser photorefractive keratectomy procedure, OCT mapping of epithelial thickness is used to achieve clean laser epithelial removal. In femtosecond laser anterior keratoplasty procedure, OCT data is used to plan the depth of femtosecond laser dissection to remove an anterior layer of the cornea, leaving a smooth recipient bed of uniform thickness to receive a disk of donated corneal tissue. The linkage of an OCT system to a precise laser surgical system enables the performance of new procedures that are safer, less invasive and produce faster visual recovery than conventional surgical procedures.

Described herein are designs and design methods for intracorneal inlays with intrinsic dioper power (i.e., index of refraction different from the surrounding cornea tissue). The designs and design methods achieve a desired refractive change by a combination of the intrinsic diopter power of the inlay and the physical shape of the inlay, which alters the shape of the anterior cornea surface.

The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and a computer readable medium encoding the method thereof.

Ophthalmic conditions such as presbyopia, myopia, and astigmatism can be corrected by the use of a molding contact lens in combination with a pharmaceutical composition suitable for delivery to the eye. The molding contact lenses are preferably commercially available and are not specifically designed for orthokeratology. The agents in the pharmaceutical compositions such as hyaluronase allow the cornea of the eye to be molded in order to correct the refractive error of the eye. The contact lenses and the pharmaceutical composition induce a change in the radius of curvature of the anterior surface of the cornea, thereby correcting the refractive error of the eye. One advantage of the inventive technique is that the patient with his or her own individual visual needs guides the treatment until the patient near and far visual needs are met. The present invention also provides for kits, which contain molding contact lenses, pharmaceutical composition suitable for delivery to the eye, and instructions, useful in the inventive system.

The invention provides a design method for a cornea contact lens based on a wave front technology. The method is a technology for obtaining a surface type structure of the cornea contact lens according to an objective measurement data of eye vision light; according to actually measured corneal topography data, optimum spherical or circular fitting is processed for the cornea front surface by MATLAB software programming to design the surface type structure of an optical region on the back surface of the cornea contact lens. The spreading of the wave front that is transmitted to the cornea front surface from the exit pupil plane through a tear lens and a cornea contact lens medium is calculated according to the actually measured wave front aberration data of human eyes based on a diffractive angular spectrum theory so as to obtain the equivalent wave front aberration of the front surface of the cornea contact lens and then fit to figure out the optimum curved surface type of the optical region on the front surface of the cornea contact lens for correcting the wave front aberration of eye; and the optimum sphericity, column degree and parallactic angle of an astigmatism axis of the cornea contact lens are figured out for the cornea contact lens by calculating and fitting the designed surface type structures for optical region on the front and back surfaces of the cornea contact lens.

A method of selecting a toric lens by taking into consideration the magnitude and orientation of the posterior cornea and / or the location of the incision axis is described. The magnitude and orientation of the posterior cornea can be calculated as a function of the measured pre-operative orientation of the steep meridian of the anterior cornea.

The invention discloses a cornea measuring method and a cornea measuring system. The cornea measuring method comprises the following steps: carrying out measurement by adopting an optical coherence tomography method, thus obtaining the optical path L0 from the front surface to the rear surface of the cornea; moving a focusing lens, wherein when the focal point of detection light is located on thefront and rear surfaces of the cornea, the signal intensity is the maximal value, and acquiring the distance L1 between the two corresponding positions where the focusing lens is located when the focal point of detection light is located on the front and rear surfaces of the cornea; acquiring the refractive index of the cornea and the thickness of the cornea by utilizing the ray tracing technology. With the method and the system, the non-contact in-vivo accurate measurement for the refractive index of the cornea and the thickness of the cornea is realized and can serve as the reference for therefractive surgery of the human eyes, a reliable basis is provided for calculating the eye parameters, and thus the ideal refraction effect is achieved for the human eyes after the surgery.

The invention discloses a method for preparing a decellularized lamellar cornea matrix sheet. The method comprises the steps of disinfecting a fresh animal eyeball; treating with filter paper dipped with alcohol after disinfecting, and then erasing an epithelial cell layer; incising the corneal limbus under an operation microscope, stretching into an iris restorer to separate the anterior cornea, and then shearing the anterior cornea with corneal scissors; drilling the lamellar cornea with a corneal annulus; soaking the fresh lamellar cornea into serum, and then rinsing or performing ice-bath electrophoresis treatment; performing gradient dehydration after the treatment to obtain a non-dried lamellar tissue engineering corneal frame, sterilizing with ethylene oxide, and preserving for later use; drying the non-dried cornea matrix sheet in a 24-pore plate to obtain dried decellularized lamellar cornea; and sterilizing the dried sample with cobalt 60, and performing rehydration treatment to obtain a rehydrated lamellar cornea matrix sheet. The obtained cornea matrix sheet is high in transparency, low in structural destroy, good in biocompatibility, close to fresh cornea in performance and thorough in decellularization.

Ophthalmic conditions such as presbyopia, myopia, and astigmatism can be corrected by the use of a molding contact lens in combination with a pharmaceutical composition suitable for delivery to the eye. The molding contact lenses are preferably commercially available and are not specifically designed for orthokeratology. The agents in the pharmaceutical compositions such as hyaluronase allow the cornea of the eye to be molded in order to correct the refractive error of the eye. The contact lenses and the pharmaceutical composition induce a change in the radius of curvature of the anterior surface of the cornea, thereby correcting the refractive error of the eye. One advantage of the inventive technique is that the patient with his or her own individual visual needs guides the treatment until the patient near and far visual needs are met. The present invention also provides for kits, which contain molding contact lenses, pharmaceutical composition suitable for delivery to the eye, and instructions, useful in the inventive system.

The invention discloses a sclera mirror. The mirror comprises a mirror body, wherein an optical area, a transition area and a positioning area are continuously formed on the lens body from the centerto the outside, the joint of a cornea and the sclera is sequentially divided into a cornea part, a transition part and a sclera part in the direction from the cornea to the sclera, the positioning area is attached to the sclera and used for positioning the sclera mirror, the transition area stretches across upper parts of the cornea and the sclera, an optical area is arranged at a front end of thecornea and provides vision correction for eyes, the transition area is arranged to be of any one of a one-section arc structure or a two-section arc structure or a three-section arc structure according to different shapes of the cornea part, the transition part and the sclera part, distinguishing design can be conducted according to different shapes of the cornea part, the transition part and thesclera part, and the wearing comfort is improved.

A pre-formed intrastromal corneal insert for use in treating Keratoconus and similar dystrophies and methods of using the same. An intrastromal insert of the present invention comprises a biocompatible polymer and may be used to adjust corneal curvature, thereby correcting vision abnormalities caused by disease or other surgical procedures. The insert may be comprised of a circular or semi-circular ring shape or a portion of a ring, or “arc”, encircling the anterior cornea within the frontal circumference of the cornea. The insert may be used in multiples to form complete arcs or to form constructs of varying thicknesses. The insert of the present invention possesses a cross section that results in a low scattering level of light.

The invention relates to a corneal shaping lens. The corneal shaping lens comprises an inner surface facing the human cornea during wearing and an outer surface opposite to the inner surface, whereinthe inner surface comprises a base curve area located in the center, the base curve area is used for pressing the front surface of the cornea and shaping the front surface of the cornea to be consistent with the base curve area and comprises two or more areas, and the at least two of the areas have different curvature radii.

The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and a computer readable medium encoding the method thereof.

A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and / or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea. The method includes removing corneal epithelium, isolating and transplanting a segment of soft tissue to the de-epithelialized cornea, creating a receiving area in the soft tissue, positioning a keratoprosthesis relative to the receiving area anterior to the cornea, and securing the keratoprosthesis.

The invention relates to a keratectasia measurement method based on optical CT. The keratectasia measurement method comprises the following steps: 1, acquiring a full-cornea three-dimensional cross section image through optical CT at a long scanning depth; step 2, adopting the shortest path and a dynamic programming optimization algorithm to automatically extract the height information of front and rear surfaces of the full cornea and rebuilding a three-dimensional full-cornea height information graph based on image feature information; step 3, building two indexes representing cornea surface irregularity, namley surface extension rate (as shown in the specification) and cornea surface curvature square (as shown in the specification) based on the height information of the front and rear surfaces of the full cornea. According to the invention, the full-cornea three-dimensional cross section image is acquired through optical CT at the long scanning depth, and the two indexes representing cornea surface irregularity, namely the surface extension rate (as shown in the specification) and the cornea surface curvature square (as shown in the specification) are built.

The invention discloses an anterior segment sectional image feature extraction method based on machine vision, and the method comprises the following steps: collecting an anterior segment sectional image under low-illumination illumination; enhancing the contrast of the anterior segment sectional image by adopting a Retinex algorithm; performing Gaussian filtering to remove noise generated after the step S2; finding a potential corneal region through binarization and blob shape analysis; roughly positioning the edges of the front and rear surfaces of the cornea in the potential cornea region by using a gradient maximum method; determining sub-pixel precision boundaries of the front surface and the rear surface of the cornea through a Gaussian fitting positioning method; according to the solved sub-pixel precision boundaries of the front and rear surfaces of the cornea, finding initial points of the iris and the crystalline lens, and obtaining accurate boundary values of the front and rear surfaces of the cornea, the front surface of the crystalline lens and the front surface of the iris through tracking. The invention has the following advantages and effects that high-precision processing can be performed on the image in a low-illumination imaging mode, and the matching degree and the comfort degree of a patient can be greatly improved.

The invention provides a method for detecting intraocular astigmatism and astigmatism axis, which comprises the following steps: 1, obtaining ocular diopter by using retinoscopy optometry or computeroptometry, converting the ocular diopter from a glasses plane to a cornea plane, and obtaining ocular total astigmatism according to the diopter of the cornea plane; 2, indirectly obtaining corneal anterior surface astigmatism by using a corneal curvature meter; and 3, detecting intraocular astigmatism by utilizing a vector relationship among total ocular astigmatism, intraocular astigmatism and corneal anterior surface astigmatism. According to the method, the intraocular astigmatism degree and the astigmatism axis can be accurately obtained no matter how the relation between intraocular total astigmatism and corneal anterior surface astigmatism is by adopting existing simple equipment and simple and convenient optometry means such as retinoscopy optometry or a computer optometry instrument and a corneal curvature meter. The method is simple, convenient to operate and high in accuracy.

The invention relates to a lens curvature and diopter acquisition method and system based on an IOLMaster image. The system is used for executing the following method: acquiring a cornea front surface curvature radius and a lens thickness valuea lens, corresponding lens morphology picture; acquiring cornea anterior surface pixels, crystalline lens anterior surface pixels, crystalline lens rear surface pixels; and outputting the curvature radius value of the front surface of the crystalline lens and the curvature radius value of the rear surface of the crystalline lens, the ratio of the curvature radius of the front surface of the cornea to the curvature radius of the front surface of the crystalline lens is equal to the ratio of the pixel of the front surface of the cornea to the pixel of the front surface of the crystalline lens, and the ratio of the curvature radius of the front surface of the cornea to the curvature radius of the rear surface of the crystalline lens is equal to the ratio of the pixel of the front surface of the cornea to the pixel of the rear surface of the crystalline lens; and outputting the lens front and rear surface refractive power and the lens total refractive power; according to the method, crystalline lens parameters can be visually obtained based on an IOLMaster image, and the high efficiency of corresponding research is greatly improved.

The invention discloses a diopter calculation method for a toric intraocular lens. The method comprises the following steps of: calculating the change of the tangential curvature of the front surfaceof a cornea through SIA provided by a doctor after a corneal incision is made, and obtaining the tangential curvatures of a flat axis and a steep axis of the front surface of the cornea; calculating curvature radiuses of flat axis and the steep axis of the front surface of the cornea according to the tangential curvature of the flat axis and the steep axis of the front surface of the cornea, and calculating curvature radiuses of the flat axis and the steep axis of the rear surface of the cornea according to the tangential curvatures of the flat axis and the steep axis of the rear surface of the cornea; further calculating the focal length of the incident light and the output light on the anterior surface of the flat and steep axes, the focal length of the incident light and the output light on the posterior surface and the focal length of the incident light on the intraocular lens according to the radius of curvature, corneal thickness, anterior chamber depth, ocular axis length, intraocular lens parameters and reserved diopter of the anterior and posterior surfaces of the flat and steep axes, and then calculating the diopter of the required IOL flat axis and steep axis.

Provided are systems and methods for correcting a corneal surface irregularity surface in a subject. The system generally comprises a infrared laser, for example, and infrared laser and a laser control unit, a corneal contacting unit, a gel solidifying unit and an electronic device tangibly storing algorithms to operate the units. In the methods, a polymerizable or thermo-reversible gel or polymerized resin is applied to the anterior corneal surface and solidified as a layer over the cornea. A first correcting cut is lasered into the stroma of an applanated cornea, the gel layer is then removed and a second correcting cut is lasered in the stroma of the applanated cornea. The lenticel formed intrastromaly by the first and second correcting cuts is removed such that the cornea has a corrected corneal curvature.

A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and / or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea. The method includes removing corneal epithelium, isolating and transplanting a segment of soft tissue to the de-epithelialized cornea, creating a receiving area in the soft tissue, positioning a keratoprosthesis relative to the receiving area anterior to the cornea, and securing the keratoprosthesis.

The invention provides a corneal thickness measuring method based on subdivision of pulses, which belongs to an ultrasonic thickness measuring method. Measurement precision of the corneal thickness measuring method can achieve the micrometer level. Subdivision of pulse is realized by the aid of phase shift of a transmitted pulse, an ultrasonic signal which is reflected back is received, the frontwall and the rear wall of a cornea are judged, a single measurement result is calculated, a next transmitted pulse shifts by a subdivided phase of a pi phase, an ultrasonic signal which is reflected back is received, a current measurement result is obtained, and after total transmitted pulses shift by the pi phase, a last measurement result is obtained. Accurate distances from two sides of the cornea to an ultrasonic sensor are calculated according to the phases corresponding to the maximum values of all the subdivision results, and the final cornea thickness value is obtained by means of subtracting the two accurate distances. If subdivided steps are N, measurement precision is 1 / N of semi-wavelength. The corneal thickness measuring method has the advantages that the ultrasonic thicknessmeasuring method is realized by the aid of subdivision of pulses, the measurement precision can achieve the micrometer level. Resolution ratio of the method is high, center frequency of a probe does not need to be too high, and the corneal thickness measuring method is easy to be popularized.

Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

In certain embodiments, an ophthalmic system for determining the topography of the anterior surface of the cornea of an eye comprises an illuminator, a camera, and a computer. The illuminator illuminates the anterior surface of the cornea of the eye with a Placido pattern. The Placido pattern comprises a plurality of rings. A ring of the plurality of rings has a distinguishing feature that distinguishes the ring from an adjacent ring. The anterior surface of the cornea reflects the Placido pattern. The camera captures an image of the reflected Placido pattern. The computer: analyzes the image to detect a distortion of the ring that indicates an anomaly of the anterior surface of the cornea; identifies the ring of the plurality of rings according to the distinguishing feature of the ring; and generates the topography of the surface of the cornea that includes the anomaly.

A method of selecting a toric lens by taking into consideration the magnitude and orientation of the posterior cornea and / or the location of the incision axis is described. The magnitude and orientation of the posterior cornea can be calculated as a function of the measured pre-operative orientation of the steep meridian of the anterior cornea.

The invention provides a corneal thickness measuring method based on subdivision of pulses, which belongs to an ultrasonic thickness measuring method. Measurement precision of the corneal thickness measuring method can achieve the micrometer level. Subdivision of pulse is realized by the aid of phase shift of a transmitted pulse, an ultrasonic signal which is reflected back is received, the frontwall and the rear wall of a cornea are judged, a single measurement result is calculated, a next transmitted pulse shifts by a subdivided phase of a pi phase, an ultrasonic signal which is reflected back is received, a current measurement result is obtained, and after total transmitted pulses shift by the pi phase, a last measurement result is obtained. Accurate distances from two sides of the cornea to an ultrasonic sensor are calculated according to the phases corresponding to the maximum values of all the subdivision results, and the final cornea thickness value is obtained by means of subtracting the two accurate distances. If subdivided steps are N, measurement precision is 1 / N of semi-wavelength. The corneal thickness measuring method has the advantages that the ultrasonic thicknessmeasuring method is realized by the aid of subdivision of pulses, the measurement precision can achieve the micrometer level. Resolution ratio of the method is high, center frequency of a probe does not need to be too high, and the corneal thickness measuring method is easy to be popularized.

The invention provides tofacitinib nanocrystal eye drops for treating immunity-related eye diseases and a preparation method thereof, and the tofacitinib nanocrystal eye drops are prepared by the following steps: dispersing micronized tofacitinib in a surfactant solution at a high speed, then mixing with a stabilizer, uniformly dispersing, and then carrying out high-pressure homogenization circulation, so as to obtain the tofacitinib nanocrystal eye drops. The tofacitinib nanocrystal eye drops meeting the particle size requirement are obtained. Wherein the surfactant is P188-lecithin, and the stabilizer is any one or a mixture of more of HPMC (Hydroxy Propyl Methyl Cellulose), polyvinyl alcohol and HPMC-docusate sodium. Through cooperation of the surfactant and the stabilizer, the particle size and the potential of the eye drops are influenced, the stability and the adhesiveness are improved, the residence time of the medicine in eyes is prolonged, and the medicine carrying rate is high. The loss speed of the medicine in front of the cornea is reduced, so that the medicine can be slowly released, the eye drop frequency of a patient is reduced, the compliance of the patient is improved, and a good clinical application prospect is achieved.

The present disclosure describes an orthokeratology lens for myopia control, the orthokeratology lens having an inner surface configured to alter the distribution of epithelial cells on the anterior surface of the cornea, and an outer surface opposite the inner surface, the inner surface from the center outward A basal arc area, an inversion area, and a fitting area are continuously formed. The basal arc area is configured to be an aspherical shape in which epithelial cells on the front surface of the cornea migrate from the central portion of the cornea to the mid-peripheral portion of the cornea. The basal arc area has a central area and a surrounding area. A peripheral area of ​​the central area, the radius of curvature of the central area is smaller than the radius of curvature of the peripheral area, the inversion area is configured to have a shape to receive the corneal anterior surface epithelial cells migrating from the central portion of the cornea to the mid-peripheral portion of the cornea, and the fitting area has The site that contacts and locates the cornea. According to the present disclosure, it is possible to provide an orthokeratology lens for myopia control with an aspherical surface design to facilitate the formation of an effective myopic defocus amount.

Provided are systems and methods for correcting a corneal surface irregularity surface in a subject. The system generally comprises a infrared laser, for example, and infrared laser and a laser control unit, a corneal contacting unit, a gel solidifying unit and an electronic device tangibly storing algorithms to operate the units. In the methods, a polymerizable or thermo-reversible gel or polymerized resin is applied to the anterior corneal surface and solidified as a layer over the cornea. A first correcting cut is lasered into the stroma of an applanated cornea, the gel layer is then removed and a second correcting cut is lasered in the stroma of the applanated cornea. The lenticule formed intrastromaly by the first and second correcting cuts is removed such that the cornea has a corrected corneal curvature.