46 results about "Anterior cornea" patented technology

The invention relates to a method for providing control data for an ophthalmic laser (12) of a treatment device (10). A control unit (18) determines (S10) corneal parameters of an anterior surface (24) of a cornea (16) from predetermined examination data; determines (S12) an epithelial map of an epithelial layer (26) of the cornea (16) from the predetermined examination data, wherein the thickness of the epithelial layer (26) is provided in the epithelial map; calculates (S14) a stromal wavefront map as a function of the determined corneal parameters of the anterior surface (24) of the cornea and the determined epithelial map; determines (S16) correction data for correcting a refractive error based on the stromal wavefront map; and provides (S18) the control data comprising the correction data determined on the basis of the stromal wavefront map.

The present invention discloses a one-time implant artificial cornea, belonging to the technical field of in-vivo prosthesis implantation. It solves at least the problems existing in the prior art, such as the need for donor corneas, multiple surgeries, large trauma, and inapplicability to patients with severe corneal blindness. The one-time implant artificial cornea includes a stent and a lens column. The lens column includes a lens column body and a rear disc coaxially arranged at the rear end face of the lens column body. The lens column is detachably connected to the stent coaxially. In the use state, the rear end of the lens column body behind the rear disc protrudes into the eye, the rear disc fits the posterior surface of the cornea, and the stent fits the anterior surface of the cornea. The stent is fixed on the corneal surface by using a suture method. At the same time, the stent and the rear disc clamp the cornea from the front and the back. The present invention also provides a method for using the one-time implant artificial cornea. It has the advantages of one-time implantation, no need for donor corneas, small trauma, and applicability to patients with severe corneal blindness, and has broad application prospects.

The present invention relates to apparatuses, computer programs, and methods for visual ametropia correction. In a first example, a position of a desired focusing point relative to a retina of an individual eye may be determined, based on obtained topographic information of the anterior surface and of the posterior surface of the cornea, and refractive aberration information for the eye. In a second example, correction information relating to the anterior surface of the cornea may be determined, such as to optimize focusing onto a retina of the eye, based on the obtained topographic information of the anterior surface and of the posterior surface of the cornea and based on obtained topographic information of an anterior surface and of a posterior surface of a lens of the individual eye.

In certain embodiments, an ophthalmic system for determining the topography of the anterior surface of the cornea of an eye comprises an illuminator, a camera, and a computer. The illuminator illuminates the anterior surface of the cornea of the eye with a Placido pattern. The Placido pattern comprises a plurality of rings. A ring of the plurality of rings has a distinguishing feature that distinguishes the ring from an adjacent ring. The anterior surface of the cornea reflects the Placido pattern. The camera captures an image of the reflected Placido pattern. The computer: analyzes the image to detect a distortion of the ring that indicates an anomaly of the anterior surface of the cornea; identifies the ring of the plurality of rings according to the distinguishing feature of the ring; and generates the topography of the surface of the cornea that includes the anomaly.

The invention relates to the technical field of image data processing, in particular to a corneal defocusing amount calculation method and system based on a corneal axial curvature difference chart, and the method comprises the steps: obtaining a corneal front surface axial curvature difference chart before and after a user wears an orthokeratology lens; positioning a circular contour region in the axial curvature difference chart, and partitioning the circular contour region based on a preset physical distance interval to obtain sub-regions corresponding to different optical functional regions of the cornea; establishing a mapping relation library of reference colors and defocusing amount values; for each pixel point in the circular contour area, calculating the difference degree between the color of the pixel point and each reference color in the mapping relation library, determining a matched reference color according to a preset tolerance threshold, and obtaining a defocusing amount corresponding to the pixel point; carrying out statistical analysis on the defocusing amount of the pixel points in each sub-region, calculating the relative proportion of different defocusing amounts in the corresponding sub-region, and outputting a statistical result in a structured form; according to the invention, rapid and automatic calculation of the defocusing amount is realized.

A device and method for early detection of eye disease including a corneal topography device including a camera, such as a rotating Scheimpflug camera, configured to measure the elevation of a patient's two anterior corneas sequentially or simultaneously; a computer processor; and non-transitory computer readable media including computer readable instructions, which, when executed by the computer processor, causes the device to measure and store elevation data at a plurality of points on the patient's anterior corneal surfaces; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography.

The present invention discloses a contact lens for preventing and controlling myopia using diffraction defocus, comprising: an optical body and a peripheral contact area; the optical body comprising a base curve posterior surface that contacts the cornea and a contact lens front surface having a diffraction area forming a bifocal pattern; the optical body is provided with a primary focus and a myopia defocus focus; a human eye model is established in Zemax, wherein the curvature of the optical zone of the base curve posterior surface of the contact lens is the same as the curvature of the corneal anterior surface of the human eye model, thereby designing the basic surface shape of the contact lens front surface and the diffraction area of the contact lens front surface. The contact lens designed in the present invention has a long-lasting shaping effect, and the defocus signal is stable when the human eye switches between near and far vision.

A method implemented in an ophthalmic surgical laser system that employs a resonant scanner, scan line rotator, and XY- and Z-scanners, for forming a corneal flap in a patient's eye with improved bubble management during each step of the flap creation process. A pocket cut is formed first below bed level, followed by the bed connected to the pocket cut, then by a side cut extending from the bed to the anterior corneal surface. The pocket cut includes a pocket region located below the bed level and a ramp region connecting the pocket region to the bed. The bed is formed by a hinge cut and a first ring cut at lower laser energies, followed by a bed cut and then a second ring cut, which ensures that any location in the flap bed is cut twice to minimize tissue adhesion. The side cut is formed by multiple side-cut layers at different depths which are joined together. All cuts are formed by scanning a laser scan line generated by the resonant scanner.

The present invention provides a goniolens and gonioscopy tool that can be freely moved on the cornea, thereby allowing for easy adjustment of the viewing angle and direction. [Solution] The goniolens 1 comprises a convex aspherical portion 2 that partially contacts the cornea 11, and a convex spherical portion 3 provided on the opposite side of the aspherical portion 2 for observing the iridocorneal angle 12 through the aspherical portion 2. The iridocorneal angle observation device 6 comprises the goniolens 1 and a holder 5 that holds the goniolens 1.

The application relates to a corneal drug delivery scleral lens, which comprises a lens body, the lens body comprises a treatment area, a reverse area and a landing area from the center to the outside, the treatment area is located in the center, the reverse area is arranged around the treatment area and is used for connecting the treatment area and the landing area, the landing area is arranged around the reverse area and is used for supporting a scleral surface, so that a liquid accumulation layer is formed between a corneal front surface and the lens body; a flow guide pipe is arranged in the lens body in the radial direction, forming a liquid injection end and a drug delivery hole. The scleral lens of the application can supplement liquid medicine through the flow guide pipe without taking off the lens, dynamic fluid replacement is realized, and the cornea is prevented from being damaged by repeated taking off and wearing. When the lens is designed, the height of the reverse area is taken as a core variable parameterization design, the thickness of the liquid accumulation area and the drug concentration are accurately controlled. The overflow hole is normally sealed, and the risk of infection is reduced. The liquid medicine is diffused from the edge to the center, the whole surface of the cornea is uniformly soaked, and the bioavailability is improved.

The invention discloses an in-vivo cornea biomechanical characteristic measuring device and application, and belongs to the technical field of ophthalmology biomechanical measurement, the in-vivo cornea biomechanical characteristic measuring device comprises a negative pressure adsorption module and an imaging module; wherein a single-side opening groove is formed in the negative pressure adsorption module; the open side of the open slot is adsorbed on the limbus of the cornea; the open slot and the front surface of the cornea form a closed cavity; the closed cavity is used for receiving external negative pressure, so that the cornea is stressed to expand; the external negative pressure is monotonically changed and is changed once every preset time, so that the cornea stress is changed and the morphology is changed; by means of the designed negative pressure adsorption module, stable pressurization of external negative pressure on the closed cavity instead of instantaneous pressure can be achieved, so that the cornea is stably stressed to generate morphology changes, the stable morphology is kept instead of the transient morphology, and the influence of cornea inertia and viscoelasticity is effectively avoided; and accurate measurement of the static biomechanical characteristics of the cornea can be realized in a non-invasive manner.

The present invention discloses a scleral lens, comprising a lens body, wherein the lens body is continuously formed with an optical zone, a transition zone and a positioning zone from the center to the outside, and the connection between the cornea and the sclera is divided into a corneal part, a transition zone and a scleral part in sequence along the direction from the cornea to the sclera. The positioning zone is attached to the sclera for positioning the scleral lens, and the transition zone spans the upper part of the cornea and the sclera, so that the optical zone is arranged at the front end of the cornea and provides vision correction for the eye. The transition zone is arranged as any one of a one-segment arc structure, a two-segment arc structure or a three-segment arc structure according to different shapes of the corneal part, the transition part and the scleral part, and can be differentiated and designed according to different shapes of the corneal part, the transition part and the scleral part to improve wearing comfort.

The embodiment of the invention provides an optical lens. The optical lens comprises a first lens group, a diaphragm and a second lens group which are sequentially arranged along the same optical axis. The first lens group comprises a first lens and a second lens which are arranged along the optical axis, and the second lens is positioned on one side close to the diaphragm; the second lens group comprises a third lens, a fourth lens, a fifth lens and a sixth lens which are arranged along the optical axis, the third lens is located on the side close to the diaphragm, and the sixth lens is located on the side away from the diaphragm; the first lens comprises a first surface far away from the diaphragm and a second surface close to the diaphragm, the curvature radius of the first surface is the same as that of the front surface of the cornea of the human eye, and the curvature radius of the second surface is the same as that of the rear surface of the cornea of the human eye.

Disclosed are various systems and methods of using interferometry to measure the tear film for disease prediction and treatment. A point-by-point scan of a corneal surface of an eye is obtained from an interferometry system, including at least an interference signal. Next, a large field-of-view of the corneal surface is obtained from an objective lens with a curved focal plane matched to a curvature of the corneal surface. Subsequently, motion correction is performed on the point-by-point scan. Then, noise is filtered from the interference signal. A tear film lipid layer signal and a precorneal tear film signal are separated from the filtered interference signal. Later, a best fit frequency for the tear film lipid layer signal and the precorneal tear film signal are determined. Then, a thickness of the tear film lipid layer and the precorneal tear film are determined based at least in part on the best fit frequency.

A corneal cross-linking operation effect prediction method comprises the following steps: acquiring corneal biomechanics dynamic detection video data, and making a data set; extracting the cornea contour of each frame in the video, and after arrangement and integration according to a time axis, calculating the height difference of each pixel point by taking the height of the central cornea of the first frame as a reference to obtain a three-dimensional data matrix; building a corneal crosslinking operation prediction model based on a deep neural network, and predicting a postoperative three-dimensional data matrix of the corneal crosslinking operation by using a three-dimensional data matrix training network; and restoring the predicted data matrix into the front and rear surface contours of the cornea arranged according to time, and calculating biomechanical parameters to obtain predicted cross-linking postoperative biomechanical characteristics. According to the method, the dynamic response characteristics in dynamic detection video data of corneal biomechanics are fully excavated, shallow details and deep semantics are considered, end-to-end deployment of a medical image system is supported, pre-evaluation of a preoperative operation effect is realized, prediction accuracy is improved, and a foundation is laid for regulation and control of personalized operation parameters.

The present invention relates to an apparatus, a computer program and a method for correcting refractive errors of vision. In a first example, a position (480) of a desired focus point (440) relative to the retina of an eye can be determined based on topographic information obtained about the anterior corneal surface (401) and the posterior corneal surface (402) and refractive aberration information of an individual eye. In a second example, correction information (416, 496) related to the anterior corneal surface (401) can be determined based on the topographic information obtained about the anterior corneal surface (401) and the posterior corneal surface (402) and based on topographic information obtained about the anterior lens surface (431) and the posterior lens surface (432) of the individual eye to optimize focusing on the retina of the eye.

The invention relates to a device, a computer program and a method for correcting ametropia of vision. In a first example, a position (480) of a desired focus point (440) relative to a retina of an individual eye may be determined based on obtained topographic information of an anterior corneal surface (401) and a posterior corneal surface (402) and refractive aberration information of the eye. In a second example, correction information (416, 496) related to the anterior corneal surface (401) may be determined based on the obtained topographic information of the anterior corneal surface (401) and posterior corneal surface (402) and based on the obtained topographic information of the anterior lens surface (431) and posterior lens surface (432) of the individual's eye to optimize focus onto the retina of the eye.

One aspect of the invention provides a method of treating a cornea. The method includes controlling a light source to apply light energy pulses to a single corneal layer selected from the group consisting of: an anterior corneal layer and a posterior corneal layer. The light energy pulses are below an optical breakdown threshold for the cornea and ionize water molecules within the treated corneal layer to generate reactive oxygen species that cross-link collagen within the single corneal layer. Another aspect of the invention provides a method of treating a cornea. The method includes controlling a light source to apply light energy pulses to at least a corneal stroma layer of a cornea. The light energy pulses are below an optical breakdown threshold for the cornea and ionize water molecules within the treated corneal stromal layer to generate reactive oxygen species that cross-link collagen within the cornea.

The present disclosure provides a kind of transmission interference and full-field optical coherence tomography combined imaging system and method, it is related to medical imaging technical field.The system includes: illumination emission light path, for generating linearly polarized light, and linearly polarized light is incident to the eye of the person to be examined, wherein the part of linearly polarized light is generated back reflection or backscattering at the corneal anterior and posterior surface and corneal internal microstructure of the eye of the person to be examined, forms corneal back reflection light, another part occurs multiple scattering via posterior ocular tissue and returns to the eye front direction, forms secondary illumination light from the eye back to the eye front irradiation, secondary illumination light passes through cornea again, generates transmission interference light;Corneal transmission interference imaging light path is used for collecting the interference information of transmission interference light, obtains large field of view corneal transmission interference image;Full-field optical coherence tomography imaging light path is used for carrying out corneal axial tomography based on corneal back reflection light, obtains corneal tomogram.

The invention provides a corneal curvature determination method and device for intraocular lens degree calculation of an eye after an LASIK operation and electronic equipment, and relates to the technical field of medical data processing, and the corneal curvature determination method comprises the following steps: obtaining a corneal topographic map; extracting data points of the axial curvature of the front surface of the cornea based on the corneal topographic map, and screening out all curvature data points in a first diameter circular area from the data points of the axial curvature of the front surface of the cornea; calculating a curvature average value of two intersection points of the flat axis and the edge of the target area as a flat axis diopter, and calculating a curvature average value of two intersection points of the steep axis and the edge of the target area as a steep axis diopter; based on the steep axis diopter and the flat axis diopter, the intraocular lens degree of the LASIK postoperative eye is calculated. According to the method, the axial curvature data of the front surface of the cornea is smoothed, a K value calculation method is improved based on delimitation of a target area and an effective optical area, and system errors of IOL calculation are reduced.

Various embodiments are presented for a method of wide-field self-referenced interference for OCT imaging, that allows for a focus on the cornea over a large diameter while reducing the number of artifacts in the signal. To accomplish this, the method includes operating a super luminescent diode to emit a light, using that light to illuminate an interferometer, collimating the light, and coupling the collimated light to an optical scanner and lens to produce a probing beam. The method also includes directing the beam through the lens onto the anterior corneal surface of the cornea and creating an incident angle between the probing beam and the anterior corneal surface. Finally, the method includes using the lens to ensure the beam is perpendicular to the corneal surface with the incident angle at less than two degrees, focusing from the center to the periphery of the corneal surface, aligning the beam with the reflective corneal surface to generate a self-referencing signal, and using the self-referencing signal to generate self-referenced interference. The self-referenced interference is detected with a spectrometer to generate a high-resolution image of the cornea over a large diameter while reducing the number of reflection artifacts experienced in typical OCT system. Additionally, a hybrid dual-path and self-referenced imaging method is disclosed in which an optical shutter in the reference arm enables sequential acquisition of conventional OCT and localized self-reference apex imaging, followed by fusion into a composite artifact-free OCT image.

The invention provides an analysis method, system and equipment based on refractive postoperative intraocular lens degree, and is applied to the technical field of data processing. The method comprises the following steps: performing model construction processing on human eye related data of a target user before and after a refractive operation, a cornea front surface three-dimensional coordinate set of the target user, a target pupil size and postoperative monofocal lens position information to generate an initial human eye model after the refractive operation; the anterior chamber depth of the target user before the refractive surgery is completed is processed, and postoperative single-focus crystalline lens position information is generated; processing the surface radius, curvature radius, thickness and optical characteristic information of the single-focus intraocular lens to generate visual effect information after the target user replaces the single-focus intraocular lens; the eye physiological parameters and the eye using habit parameters of the target user are processed, and eye risk adjustment factors of the target user are generated; and processing the visual effect information and the eye risk adjustment factor to generate a target degree of the single-focus crystal.

This invention provides an animal eye imaging method, apparatus, and electronic device based on SS-OCT. The method involves scanning the eye of a target animal using SS-OCT to acquire three-dimensional volumetric data of a designated region of the eye. The designated region includes at least the area from the anterior corneal surface to the retina. An imaging result of the animal eye is generated based on the three-dimensional volumetric data, and the imaging result includes at least one imaging data morphology. This method uses three-dimensional volumetric data as a unified geometric reference to generate at least one imaging data morphology of the animal eye, thereby achieving accurate imaging of the animal eye.

The present invention provides a method for treating an eye disorder and a composition used in the method. The method includes applying a crosslinkable liquid composition to the front surface of the cornea of the eye using a mold, crosslinking the crosslinkable liquid composition on the front surface of the cornea of the eye, obtaining a composition crosslinked on the front surface of the cornea of the eye by crosslinking, and correcting the curvature of the crosslinked composition.

The invention relates to the field of surgical instruments, in particular to a cornea puncture knife which comprises a knife body, the right side of the knife body is connected with a supporting arm, the left side of the supporting arm is fixedly connected with a limiting plate, the limiting plate is parallel to the knife body, a gap is formed between the knife body and the supporting arm, a fillet is arranged on the left side of the limiting plate, and the fillet is arranged on the right side of the limiting plate. The top of the supporting arm is connected with an inserting rod. In the operation process, it is convenient to observe that the tip end of the scalpel body advances between cornea layers, a gap is reserved between the scalpel body and the supporting arm, a cornea anterior lamella is located in the gap, the thickness of the anterior lamella is always kept consistent along with advancing of the scalpel tip in the cornea layers, the cornea anterior lamella cannot be damaged when the scalpel is punctured into eyes by arranging the filleted corner, and the operation efficiency is improved. By effectively controlling the consistency of the interlayer depth of the knife body in the cornea interlayer puncture process, the sealing performance of an operative incision is improved, then the infection rate after an operation is reduced, and the safety of the operation is improved.

The invention belongs to the technical field of ophthalmic optics, and relates to a lens design method capable of correcting high-order aberration of human eyes and a lens. Adjusting parameters of the basic eye model to obtain a target basic eye model; optimizing the surface type of the front surface of the crystalline lens and the surface type of the front surface of the cornea in the target basic eye model to obtain a fitting eye model; a paraxial surface is placed on the front surface of the fitting eye model, the vitreous body depth of the fitting eye model is adjusted, a target fitting eye model is obtained, and the paraxial surface is removed; rotating angles of eyeballs in the target fitting eye model are changed, and target eye models at different rotating angles are obtained; and optimizing the parameters of the to-be-optimized lens to obtain the lens capable of correcting the high-order aberration of the human eyes by taking the condition that the high-order aberration values of the light passing through the to-be-optimized lens when the light is imaged on the target eye model at different rotation angles are smaller than or equal to a second preset threshold value as a target. The lens capable of correcting human eye high-order aberration provided by the scheme can effectively correct high-order aberration generated by far-axis light and light outside the optical axis view field range.

A method of generating three dimensional shapes for a cornea and lens of an eye, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of said eye based on said multiple sections of light. For each one of the obtained multiple sectional images, the following processes are performed:a) automatically identifying arcs, in two-dimensional space, corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the one of the obtained multiple sectional images; and) determining an intersection of lines ray traced back from the identified arcs in two-dimensional space with a known position of a section of space containing the section of light that generated the one of the obtained multiple sectional images, wherein the determined intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the anterior and posterior cornea surfaces and the anterior and posterior lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.

The application provides an intraocular lens power analysis method, system and device based on refractive surgery, and applies to the technical field of data processing. The application performs model construction processing on the human eye related data of a target user before and after refractive surgery, the three-dimensional coordinate set of the corneal anterior surface of the target user, the target pupil size and the postoperative monofocal lens position information, generates an initial post-refractive surgery human eye model; processes the anterior chamber depth of the target user before completing the refractive surgery, generates the postoperative monofocal lens position information; processes the surface radius, curvature radius, thickness and optical property information of the monofocal intraocular lens, generates the visual effect information of the target user after replacing the monofocal intraocular lens; processes the eye physiological parameters and eye use habit parameters of the target user, generates the eye risk adjustment factor of the target user; processes the visual effect information and the eye risk adjustment factor, and generates the target power of the monofocal lens.

This application discloses a personalized wavefront compensation method, system, computer device, and storage medium based on the wearing geometry optical path. The method includes: acquiring prescription parameters, geometric parameters, and individualized ocular physiological parameters including corneal anterior surface morphology data of the wearer's eyeball; constructing a vector tracing model containing the dynamic trajectory of the corneal apex and the posterior surface of the lens, with the eyeball rotation center as the origin; inputting the geometric parameters into the model for ray tracing to calculate the distortion phase distribution; generating a personalized wavefront compensation term based on the distortion phase distribution; fusing the compensation term with the basic phase field corresponding to the prescription parameters to obtain a fused phase field; performing a conformal mapping transformation on the fused phase field to obtain a planarized customized phase distribution; and generating height field data for driving micro / nano manufacturing processes based on the planarized customized phase distribution. This application solves the technical problem of planar lenses being difficult to match in three-dimensional wearing states, achieving wavefront compensation that accurately matches actual wearing conditions.

Methods and systems for planning and forming incisions in a cornea, lens capsule, and / or crystalline lens nucleus are disclosed. A method includes measuring spatial dispositions, relative to a laser surgery system, of at least portions of the corneal anterior and posterior surfaces. A spatial disposition of an incision of the cornea is generated based at least in part on the measured corneal anterior and posterior spatial dispositions and at least one corneal incision parameter. A composite image is displayed that includes an image representative of the measured corneal anterior and posterior surfaces and an image representing the corneal incision.