6 results about "Docusate Sodium" patented technology

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The preparation method comprises the following steps: dissolving docusate sodium in n-heptane to obtain a docusate sodium solution, adding water, uniformly mixing to obtain a micro-emulsion, adding polydimethylsiloxane into the micro-emulsion, uniformly mixing, adding tetraethyl orthosilicate, uniformly mixing, adding dibutyltin dilaurate, uniformly mixing, standing and cross-linking to obtain the microporous polydimethylsiloxane-doped composite membrane. And uniformly coating the surface of a PVDF substrate membrane with the coating liquid, crosslinking at normal temperature, and drying to obtain the PVDF film. According to the invention, docusate sodium with low boiling point is used as a surfactant, n-heptane is used as a continuous phase and water is used as a dispersion phase to construct a W / O type emulsion, the W / O type emulsion is used as a diluent, PDMS is added into the W / O type emulsion to obtain a film coating liquid, the preparation process is mild in condition and simple in step, the uniformity of a polymerization process is ensured, and the prepared pervaporation film is high in separation factor and good in stability. The membrane flux is up to 600-1200 g / m < 2 >. H, and the separation performance of the pervaporation membrane is enhanced.

This invention provides a high-performance liquid chromatography (HPLC) method for detecting sodium docusate content, relating to the field of pharmaceutical analysis, including sample preparation and detection. Sample preparation involves accurately weighing and grinding acetaminophen / vitamin C effervescent tablets into powder, adding a mixed alcohol-EDTA composite solvent, and ultrasonically dispersing. Then, a bifunctional modified limiting medium, mesoporous silica dispersion, is added, followed by vortexing, centrifugation, and membrane filtration to obtain the test sample. Detection involves performing HPLC on the test sample, using an organic phase and an aqueous phase; wherein the organic phase is acetonitrile, and the aqueous phase is a mixed ionic liquid system. This method is effective for detecting sodium docusate content in compound preparations such as acetaminophen / vitamin C effervescent tablets, and has advantages such as high specificity, simplicity, speed, high sensitivity, accuracy, and reliability.

The invention relates to a preparation method of dibenzoyl peroxide gel, which comprises the following steps: 1) preparing a gel phase: sequentially adding purified water, glycerol and carbomer 980 into the gel phase, and stirring for later use; (2) preparing an active phase, namely sequentially adding purified water, propylene glycol, poloxamer 182, edetate disodium and docusate sodium into a beaker, stirring until the mixture is clear, slowly adding polydimethylsiloxane, derivatives thereof and colloidal silicon dioxide, continuously stirring until the mixture is uniformly dispersed, adding 5% dibenzoyl peroxide, and stirring until the raw materials are uniformly dispersed; 3) active phase homogenization: starting high-pressure emulsification and stirring; 4) mixing the gel phase and the active phase: pouring the gel phase into the active phase and stirring; (5) fixing the volume: supplementing purified water to 100%; and 6) pH adjustment: adding a NaOH solution to adjust the pH to 4.8-5.8. According to the preparation method of the dibenzoyl peroxide gel, the preparation process and the types of auxiliary materials are adjusted, and the light stability of the dibenzoyl peroxide gel and the fineness of particles are improved.

The invention discloses a herbal targeting agent which comprises limonene and docusate sodium. The herbal targeting agent disclosed by the invention is safe and environment-friendly, free of drug residues or few in residues, good in effect stability, wide in application range, good in quick-acting property, long in validity period, free of harmful drug residues, especially friendly to ecological environment, and harmless to animals, frogs, toads and bees.

The utility model provides a ferrous fumarate docusate sodium capsule preparation mixing device, and belongs to the technical field of capsule medicament production. The device is ingenious in structure, good in material mixing effect, good in splash-proof effect and convenient in material loading and taking. A mixing barrel of the device is erected in a base, a driving motor is arranged on the base, a driving gear is arranged at the driving end of the driving motor, the driving gear is meshed with a gear ring arranged outside the mixing barrel, a stirring disc is hoisted on the base and inserted into the mixing barrel, materials are added into the mixing barrel, and the stirring disc stands and rotates in the mixing barrel to form relative movement. And stirring and mixing the materials. The mixing barrel of the device is detachably erected and is convenient to mount, dismount, replace and clean, the discharging hopper is arranged on the stirring disc, material adding and progress observation are convenient, material splashing can be avoided, the contact area between the spiral stirring pieces and materials is increased, the stirring efficiency is high, and the stirring effect is good.