1 results about "Docusate Sodium" patented technology

This invention provides a high-performance liquid chromatography (HPLC) method for detecting sodium docusate content, relating to the field of pharmaceutical analysis, including sample preparation and detection. Sample preparation involves accurately weighing and grinding acetaminophen / vitamin C effervescent tablets into powder, adding a mixed alcohol-EDTA composite solvent, and ultrasonically dispersing. Then, a bifunctional modified limiting medium, mesoporous silica dispersion, is added, followed by vortexing, centrifugation, and membrane filtration to obtain the test sample. Detection involves performing HPLC on the test sample, using an organic phase and an aqueous phase; wherein the organic phase is acetonitrile, and the aqueous phase is a mixed ionic liquid system. This method is effective for detecting sodium docusate content in compound preparations such as acetaminophen / vitamin C effervescent tablets, and has advantages such as high specificity, simplicity, speed, high sensitivity, accuracy, and reliability.