Docusate sodium soft capsule

A technology of docusate sodium and soft capsules is applied in the directions of capsule delivery, ester active ingredients, medical preparations of non-active ingredients, etc. It can solve the problems of colon melanosis, weak effect, drug dependence, etc. Beautiful, fast-acting, compliant results

Active Publication Date: 2013-05-01
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically used bulky laxatives such as polyethylene glycol 4000 and lubricating laxatives such as liquid paraffin have poor taste and weak effects, and can cause absorption disorders of vitamins A, D, K, calcium and phosphorus; and long-term use Stimulant laxatives, such as Chinese medicine rhubarb or similar ingredients, can cause patients to become dependent on the drug, and damage the nerves of the intestinal wall, leading to melanosis of the colon, which in turn may cause colon cancer, so it is not suitable for long-term use

Method used

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  • Docusate sodium soft capsule
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Examples

Experimental program
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Effect test

Embodiment 1

[0033] The docusate sodium soft capsule of the present invention comprises a soft capsule rubber and a docusate sodium solution wrapped in the soft capsule rubber, and the docusate sodium solution is composed of the following components by weight percentage:

[0034] Docusate Sodium 10%

[0035] Polyethylene glycol 200 90%

[0036] Described soft capsule rubber comprises red rubber and white rubber; Described red rubber is made up of following components by weight percentage:

[0037]

[0038] Described white rubber is made up of following components by weight percentage:

[0039]

[0040] Preparation of docusate sodium soft capsules of the present invention comprises the following steps:

[0041] 1. Preparation of red gelatin solution:

[0042] Dissolve the plasticizer in water, add it into the glue tank and heat it to 40°C, add gelatin, stir and dissolve at 60°C. Add the coloring agent Ⅰ into the water, stir evenly to obtain a pigment solution, add the pigment solu...

Embodiment 2

[0050] The docusate sodium soft capsule of the present invention comprises a soft capsule rubber and a docusate sodium solution wrapped in the soft capsule rubber, and the docusate sodium solution is composed of the following components by weight percentage:

[0051] Docusate Sodium 20%

[0052] Polyethylene glycol 400 70%

[0053] Propylene Glycol 10%;

[0054] Described soft capsule rubber comprises red rubber and white rubber; Described red rubber is made up of following components by weight percentage:

[0055]

[0056] Described white rubber is made up of following components by weight percentage:

[0057]

[0058]

[0059] Preparation of docusate sodium soft capsules of the present invention comprises the following steps:

[0060] 1. Preparation of red gelatin solution:

[0061] Dissolve the plasticizer in water, add it into the glue tank and heat it to 50°C, add gelatin, stir and dissolve at 70°C. Add the coloring agent Ⅰ into the water, stir evenly to obt...

Embodiment 3

[0069] The docusate sodium soft capsule of the present invention comprises a soft capsule rubber and a docusate sodium solution wrapped in the soft capsule rubber, and the docusate sodium solution is composed of the following components by weight percentage:

[0070] Docusate Sodium 30%

[0071]Polyethylene glycol 600 65%

[0072] Glycerin 5%;

[0073] Described soft capsule rubber comprises red rubber and white rubber; Described red rubber is made up of following components by weight percentage:

[0074]

[0075] Described white rubber is made up of following components by weight percentage:

[0076]

[0077] Preparation of docusate sodium soft capsules of the present invention comprises the following steps:

[0078] 1. Preparation of red gelatin solution:

[0079] Dissolve the plasticizer in water, add it to the glue tank and heat it to 60°C, add gelatin, stir to dissolve at 75°C. Add the coloring agent Ⅰ into the water, stir evenly to obtain a pigment solution, a...

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Abstract

The invention discloses a docusate sodium soft capsule which comprises a soft capsule rubber skin and docusate sodium solution packaged in the soft capsule shell. The docusate sodium soft capsule is characterized in that the docusate sodium solution consists of the following components in percentage by weight: 10% to 50% of docusate sodium, 35% to 90% of polyethylene glycol and 0% to 15% of polyhydric alcohol; the soft capsule shell comprises a red shell and a white shell; the red rubber skin consists of the following components in percentage by weight: 45% to 80% of gelatin, 10% to 40% of plasticizer, 0.01% to 0.4% of colorant I and 5% to 15% of water; and the white shell consists of the following components in percentage by weight: 45% to 80% of gelatin, 10% to 40% of plasticizer, 0.1% to 4.0% of additive and 5% to 15% of water. The invention aims to overcome the defects in the prior art and provide the docusate sodium soft capsule which comprises simple components and has strong adaptability and high response speed.

Description

technical field [0001] The invention relates to a docusate sodium soft capsule. Background technique [0002] Chronic functional constipation is one of the more common gastrointestinal diseases in clinical practice, which is caused by the abnormal function of the colon, rectum and anus, resulting in decreased stool frequency or intractable dry stool. Local and general discomfort Chronic constipation can cause local and systemic symptoms, such as bitter mouth, sticky mouth, epigastric fullness, hypochondriac pain, belching, and some patients may also experience loss of appetite, listlessness, dizziness, fatigue, general malaise, and headache , insomnia, etc. Constipation can cause local harm to the body and directly cause anorectal diseases. If it is not treated in time, it will seriously endanger the quality of life of patients. Therefore, maintaining stool moisture and increasing stool volume is a better way to treat constipation in the elderly. Clinically used bulky laxa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/22A61K47/42A61K47/34A61P1/10
Inventor 毛万祥贾卫东张丁酉
Owner 安士制药(中山)有限公司
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