31 results about "Melanosis" patented technology

The invention discloses skin-whitening and speckle-removing cleansing milk comprising the following components in weight percentage: 3%-10% of octadecanol, 5.0%-15% of glycerol, 1.0%-5.0% of isopropanol, 0.2%-1.2% of triethanolamine, 25%-40% of amino acid surfactants, 2.0%-10.0% of jojoba oil, 0.2%-1.0% of diazolidinyl urea, 0.05%-0.5% of essence, 2%-5% of angelica root extract, 2%-10% of red flower extract, 3%-10% of aloe vera gel and 5%-10% of arbutin. The product in the invention has the advantages of pure color and luster, simple and elegant aroma, fine and smooth texture, use safety and no toxicity, simulation and sensitization, can gradually fade and remove freckles, chloasma, melanosis, acnes and age pigments on skin and has the effects of clearing heat and detoxicating, shrinking pores, moistening the skin and preventing skin aging.

The invention relates to a skin care product containing bird's nest peptides and a preparation method of the skin care product and belongs to the technical field of skin care products. The skin care product is prepared from the following raw materials in parts by weight: 10-25 parts of bird's nest peptides, 5-20 parts of pearl essence, 1-5 parts of tetrahydrocurcumin, 0-15 parts of a green tea extract and 15-35 parts of a grape seed extract. The bird's nest peptide is capable of reducing and preventing melanosis, and has excellent effects of fading spots, whitening and repairing; the tetrahydrocurcumin has an obvious antioxidant effect; the pearl essence is capable of inhibiting melanin synthesis, has an effect of scavenging free radicals and contributes to fading spots, whitening and delaying skin aging; the green tea extract is capable of eliminating ultraviolet-induced free radicals so as to protect normal functions of melanin cells and inhibiting melanogenesis, and pigmentation canbe reduced; the grape seed extract is capable of fading pigments. Moreover, the skin care product has excellent effects of moisturizing and moistening. Due to co-actions of the multiple raw materials, the effects of removing beverage, whitening and repairing the skin can be achieved.

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.

The invention discloses a novel melanosis inhibitor and application thereof in seawater shrimps. Aiming at the problem that a melanosis inhibitor prepared by directly compounding compounds has potential hazards to the human health, the invention provides a novel melanosis inhibitor which is safe and has no potential hazard to the human body, and the novel melanosis inhibitor is prepared from the following components by mixing: tyrosine hydroxylase, traditional Chinese medicine extracts, fruit and vegetable enzyme powder, honey and water. The prepared novel melanosis inhibitor has a longer action time of inhibiting melanosis of seawater shrimps, has better compatibility with the environment, can be absorbed by plants or degraded automatically, is pollution-free and has an outstanding effect of inhibiting melanosis of seawater shrimps.

The present application relates to a peptide having skin whitening activity and uses thereof, and provides: a peptide comprising an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3; a composition for skin whitening, comprising the peptide; a cosmetic composition comprising the composition for skin whitening; and a pharmaceutical composition for preventing or treating melanosis and hyperpigmentation diseases. The pharmaceutical composition comprises the composition for skin whitening.

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.

The present invention provides a skin-whitening product which contains human angiogenin with effective concentration to inhibit the production of melanose of skin, said effective concentration is 0.000001% to 0.1% of total weight. Said product can be used for removing freckle, black spot, aged-mark, melanotic nevus and dermal abnormal change due to melanosis, and / or can be used for eliminating wrinkles, raising skin elasticity and preventing dermal senility.

The invention provides a whitening and spot-removing cream and a preparation process thereof, which relate to the technical field of beauty and health care. The whitening and spot-removing cream of the present invention is made of the following raw materials: the whitening and spot-removing cream is made of the following raw materials in parts by weight: 10 parts of Angelica dahurica, 10 parts of Radix Baishui, 10 parts of Atractylodes macrocephala, 3 parts of Bai Fuling, and 12 parts of Bletilla striata , 6 parts of raw aconite and 9 parts of Asarum. The speckle-removing cream prepared by the present invention is a natural Chinese medicine product, does not contain any toxic substances, has the effects of expelling wind and dredging collaterals, removing blood stasis and eliminating spots, moisturizing skin and removing wrinkles, and is used for melanosis, pigmentation spots, etc. An ideal skin care product for facial chloasma, freckles, dark spots, pigmentation, facial wrinkles, and rough skin; it can not only effectively remove facial spots, but also maintain and whiten the skin.

The invention relates to a traditional Chinese medicine composition and traditional Chinese medicine pill for treating melanosis coli as well as preparation methods and applications thereof, and belongs to the technical field of Chinese herbal medicine preparations for treating melanosis coli. Peach kernel and angelica sinensis are used as monarch drugs, rhizoma sparganii, curcuma zedoary, cistanche, radix glehniae, raw astragalus membranaceus and bighead atractylodes rhizome are used as ministerial drugs, fried semen raphani, girardiana heterophylla decne and radix paeoniae alba are used as adjuvant drugs, and fig is used as a conductant drug, so that no side effect is caused. The traditional Chinese medicine pill has the characteristics of simple pill preparation process, low price and remarkable curative effect. The whole formula has the effects of promoting blood circulation to remove blood stasis, promoting the circulation of qi, relaxing the bowels, nourishing yin and nourishing the intestines, and the clinical symptoms such as constipation, stomachache, abdominal distension and anorexia of patients are remarkably improved. The effective rate of treating the melanosis coli reaches 95% or above. The problem that a patient suffering from the melanosis coli often takes a laxative and other strong irritant medicines during treatment at present is solved, the trust effect on the laxative is avoided, the canceration probability of the melanosis coli is reduced, and the pain of the patient is relieved to a great extent.

The invention relates to a traditional Chinese medicine for treating melanosis, which can effectively solve the problems in melanosis treatment. The traditional Chinese medicine is prepared from the following components: 10-15g of Radix Rehmanniae Preparata, 5-8g of Dioscorea opposita thumb, 5-8g of dogwood, 4-6g of cortex moutan, 4-6g of Poria cocos, 4-6g of rhizoma alismatis, 4-6g of rhizoma cyperi, 1-2g of cinnamon, 5-8g of red ginseng and 10-15g of pseudo-ginseng; and a preparation method of the traditional Chinese medicine for treating melanosis comprises the following steps of: respectively crushing the Radix Rehmanniae Preparata, the Dioscorea opposita thumb, the dogwood, the rhizoma cyperi and the pseudo-ginseng into ultramicro fine powder; passing through the ultramicro fine powder with a 300-mesh sieve and evenly mixing into fine powder; then adding water the weight of which is 6-8 times the weight sum of the cortex moutan, the Poria cocos, the rhizoma alismatis, the cinnamon and the red ginseng and decocting two times for 1.5 hours each time; merging decoctions and concentrating into an extract the relative density of which is 1.20-1.30; mixing the fine power with the extract to synthesize a medicine block; and pelletizing the medicine block and coating. The invention has the advantages of rich raw materials, simple preparation process, easiness in production, low cost, convenience in administration and good curative effect and is the innovation of the medicines for treating the melanosis.

A traditional Chinese medicine for treating melanosis is composed of the following raw materials in parts by weight: peach seed, safflower, ligusticum wallichii, Chinese angelica, red peony root, red sage root, radix rehmanniae preparata, Chinese yam, cortex moutan, semen cuscutae, semen astragali complanati, radix bupleuri, poria cocos, bighead atractylodes rhizome, and curcuma tuber. The application method comprises the following steps: adding 700 mL of water into a first decoction comprising the raw materials mentioned above, decocting until 200 mL of water is left; adding 500 mL of water into a second decoction, decocting until 200 mL of water is left; and orally taking the decoction twice a day on an empty stomach, one in the morning, and the other in the evening.

The invention discloses scrubbing particles with exfoliating and complexion brightening functions. The scrubbing particles comprise the following compositions of, by weight, 1-10 parts of tabebuia impetiginosa barks, 1-10 parts of cedrus atlantica barks and 2-8 parts of hamamelis virginiana barks. The compositions of the scrubbing particles have the functions of exfoliating, melanosis removing, spot lightening, skin self-repair promoting, thereby finally improving rough skin and brightening complexion.

The invention discloses a whitening mint emulsifiable paste, according to the mass percentage content comprises the following components: 2.5-3% of a mint component, 1.5-2% of camphor, 4-6% of arbutin, 1.3-1.5% of dimethyl sulfoxide, 5-7% of propylene glycol, 0.8-1.2% of triethanolamine, 0.8-1.2% of vitamin C, 5-7% of monoglyceride stearate, 8-10% of octadecanol, 0.8-1.2% of beeswax, 7-9% of liquid wax, 0.3-0.5% of Nipagin esters and the balance of deionized water. The emulsifiable paste selects the plant extract arbutin as a raw material, has high safety, effectiveness and performance to price ratio, and can relieve skin epidermal pigmentation, freckles, chloasma and Riehl's Melanosis. The whitening mint emulsifiable paste can effectively inhibit in vivo tyrosinase activity of melanin, effectively reduce the formation of melanin, and desalinate formed melanin color spots.

The present invention provides a skin-whitening product which contains human angiogenin with effective concentration to inhibit the production of melanose of skin, said effective concentration is 0.000001% to 0.1% of total weight. Said product can be used for removing freckle, black spot, aged-mark, melanotic nevus and dermal abnormal change due to melanosis, and / or can be used for eliminating wrinkles, raising skin elasticity and preventing dermal senility.

The invention discloses skin whitening and acne removing emulsion. The skin whitening and acne removing emulsion comprises the following components in parts by mass: 20-40 parts of Radix Ginseng, 12-68 parts of Radix Angelicae Dahuricae, 25-43 parts of Semen Sojae Preparatum, 15-50 parts of Semen Pruni, 11-50 parts of carbamide, 25-54 parts of Spica Prunellae, 25-50 parts of dimethyl sulfoxide, 20-90 parts of propylene glycol, 18-55 parts of triethanolamine, 25-63 parts of Fructus Crataegi slice, 22-46 parts of glyceryl monostearate, 15-50 parts of chrysanthemum, 20-60 parts of argireline, 10-50 parts of liquid wax and 80-160 parts of deionized water. Therefore, skin epidermal hyperpigmentation can be relieved, the effect of removing freckles, chloasma and Riehl's melanosis is good, formation of melanin can be reduced effectively, and the effect of removing spots of formed melanin is achieved.

The application discloses a traditional Chinese medicine whitening and acne-removing cream, which comprises 10-40 parts of glycyrrhizin, 12-68 parts of glucose, 15-43 parts of light tempeh, 10-50 parts of arbutin, and 21 parts of urea in parts by mass. ‑50 parts, 15‑54 parts of Prunella, 25‑50 parts of dimethyl sulfoxide, 30‑90 parts of propylene glycol, 28‑55 parts of triethanolamine, 20‑63 parts of lactic acid, 22‑46 parts of glyceryl monostearate, 10-50 parts of burdock fruit, 20-60 parts of achirelin, 10-50 parts of liquid wax, and 80-160 parts of deionized water. Thus, it can reduce skin epidermal pigmentation, have a good effect on removing freckles, chloasma and Riehl's melanosis, effectively reduce the formation of melanin, and dilute the formed melanin.

The invention also provides a novel long noncoding RNA gene, and the sequence of the novel long noncoding RNA gene is shown as SEQ ID NO.1. The invention also provides an application of the novel longnoncoding RNA gene to preparation of a reagent for detecting or diagnosing early melanosis, and also provides tissue expression characteristics, melanogenesis promoting effect and action mechanism ofthe new gene, thereby providing a theoretical basis for development of clinical medicines for treating melanosis in the next step. The novel long noncoding RNA provided by the invention can be used for early clinical detection of various melanosis diseases so as to facilitate early intervention of diseases, is not limited to melanoma, can also be used for early clinical detection and prevention of various melanosis diseases with tissue melanin hyperplasia, and is wider in application range.

The invention provides a whitening and spot-fading compound preparation with fresh fructus phyllanthi pulp as a main raw material and a preparation method thereof. Main active ingredients of the whitening and spot-fading compound preparation comprise fresh fructus phyllanthi pulp and prinsepia utilis royle oil. The compound preparation provided by the invention takes fresh fructus phyllanthi fresh fruit pulp as a main raw material, and can effectively inhibit the activity of tyrosinase so as to inhibit the formation of melanin, so that the compound preparation can improve the dull skin, brighten the skin color, improve the skin quality and nourish the skin. The whitening and spot-fading compound preparation can be applied to pigmented diseases, such as chloasma, melanosis, hyperpigmentation after inflammation, seborrheic keratosis, spina formosa, freckles, sunburn and the like. The whitening and spot-fading compound preparation can also be applied to daily whitening and skin care, blackening of skin after solarization and the like. The whitening and spot-fading compound preparation provided by the invention is natural and healthy in components, mild and safe in texture, simple in preparation method, easy to operate and suitable for large-scale production.

The present application discloses a moisturizing and whitening emulsion, which comprises 10-60 parts of hawthorn slices, 12-28 parts of velvet antler, 15-63 parts of cassia seed, 20-60 parts of arbutin, 11-50 parts of motherwort, Subtilis 15-45 parts, Dimethyl sulfite 22-30 parts, Yu Liren 20-70 parts, Triethanolamine 18-45 parts, Lactic acid 10-43 parts, Glyceryl monostearate 20-60 parts, Decyl alcohol 10-50 parts 30-60 parts of lotus leaf, 30-50 parts of liquid wax, 110-200 parts of deionized water. Thus, it can reduce skin epidermal pigmentation, have a good effect on removing freckles, chloasma and Riehl's melanosis, effectively reduce the formation of melanin, and dilute the formed melanin.

The invention discloses a composite preservative for inhibiting blackening of Penaeus vannamei, which consists of the following components in mass percentage: 0.01-0.03% glucose oxidase, 0.3-0.5% dithiothreitol, and 0.03-0.05% lactic acid Streptococcus, 0.5-1% sodium caseinate, 0.05-0.1% metallothionein, 3-5% rosmarinic acid, 8-10% propolis aqueous extract, and the balance is water. The compound antistaling agent of the invention has scientific and reasonable formula, low cost, good safety, good freshness preservation, antibacterial antisepsis and anti-blackening effects, and can effectively prolong the freshness period of Penaeus vannamei. The invention also discloses a preparation method of a composite antistaling agent for inhibiting the blackening of Penaeus vannamei. Firstly, glucose oxidase, dithiothreitol, nisin, sodium caseinate, metallothionein, rosemary Mix the acid and water evenly, then add the propolis water extract and mix evenly. The preparation method of the invention has simple process steps, strong operability, low equipment requirements and low investment, and is suitable for large-scale industrial production.

The invention relates to a traditional Chinese medicine for treating melanosis, which can effectively solve the problems in melanosis treatment. The traditional Chinese medicine is prepared from the following components: 10-15g of Radix Rehmanniae Preparata, 5-8g of Dioscorea opposita thumb, 5-8g of dogwood, 4-6g of cortex moutan, 4-6g of Poria cocos, 4-6g of rhizoma alismatis, 4-6g of rhizoma cyperi, 1-2g of cinnamon, 5-8g of red ginseng and 10-15g of pseudo-ginseng; and a preparation method of the traditional Chinese medicine for treating melanosis comprises the following steps of: respectively crushing the Radix Rehmanniae Preparata, the Dioscorea opposita thumb, the dogwood, the rhizoma cyperi and the pseudo-ginseng into ultramicro fine powder; passing through the ultramicro fine powder with a 300-mesh sieve and evenly mixing into fine powder; then adding water the weight of which is 6-8 times the weight sum of the cortex moutan, the Poria cocos, the rhizoma alismatis, the cinnamon and the red ginseng and decocting two times for 1.5 hours each time; merging decoctions and concentrating into an extract the relative density of which is 1.20-1.30; mixing the fine power with the extract to synthesize a medicine block; and pelletizing the medicine block and coating. The invention has the advantages of rich raw materials, simple preparation process, easiness in production, low cost, convenience in administration and good curative effect and is the innovation of the medicines for treating the melanosis.

The present invention relates to the field of cosmetics, in particular to a composition comprising amide derivatives and its application in cosmetics, said composition comprising: a. at least one amide derivative (A) represented by formula (1) b. at least one resorcinol derivative (B) represented by formula (2); and c. at least one cosmetically acceptable component (C). The amide derivative contained in the composition described in the present application has a positive enhancement effect on the transdermal delivery of the composition, which is beneficial for the active substance of the composition to penetrate through each layer of skin to reach the site of action, and to prevent skin melanosis, skin aging, etc. The prevention and / or inhibition of visible discontinuous appearance changes of the skin caused by or other diseases, the treatment, regulation or prevention of skin oxidative stress or degenerative process, the inhibition of melanin production and precipitation, the reduction of skin color deepening, the increase of skin, the skin Stay translucent and fair.

The invention provides a traditional Chinese medicine composition for treating colorectal melanosis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of Bai Ziren, 30-70 parts of raw Atractylodes macrocephala, 30-50 parts of raw white peony, 10-30 parts of Cortex Mori, 20 parts of Cistanche ~30 parts, 20~40 parts of white poria cocos, 10~20 parts of white silkworm, 10~20 parts of bletilla striata, 20~30 parts of hedyotis diffusa, 10~15 parts of angelica dahurica, 10~15 parts of white poria, 6~ 15 parts, 15-30 parts of angelica, 10-20 parts of citrus aurantium, 5-10 parts of roasted licorice. Experimental results show that the traditional Chinese medicine composition of the invention not only has good safety, but also has an excellent therapeutic effect on colorectal melanosis, and the total effective rate is as high as 100%. The traditional Chinese medicine composition of the invention can be used to prepare medicines for treating and / or preventing intestinal diseases (especially large intestine melanosis), and has good application prospect.

The invention provides a traditional Chinese medicine composition for treating large intestine melanosis and a preparation method thereof. The traditional Chinese medicine composition is prepared fromthe following raw material medicines in parts by weight: 10-30 parts of platycladi seeds, 30-70 parts of raw atractylodes macrocephala koidz, 30-50 parts of raw radix paeoniae alba, 10-30 parts of cortex mori radicis, 20-30 parts of cistanche deserticola, 20-40 parts of white poria cocos, 10-20 parts of silkworm larva, 10-20 parts of bletilla striata, 20-30 parts of oldenlandia diffusa, 10-15 parts of radix angelicae dahuricae, 10-15 parts of radix ampelopsis, 6-15 parts of flos carthami, 15-30 parts of radix angelicae sinensis, 10-20 parts of fructus aurantii immaturus and 5-10 parts of radix glycyrrhizae preparata. Experimental results show that the traditional Chinese medicine composition is good in safety and has an excellent treatment effect on large intestine melanosis, and the total effective rate is up to 100%. The traditional Chinese medicine composition provided by the invention can be used for preparing medicines for treating and / or preventing intestinal diseases (especially large intestine melanosis), and has a good application prospect.

The preparation process of the silver bar powder for the traditional Chinese medicine composition comprises the steps of material selection, cleaning, fine selection, blanching, drying, crushing, sieving, packaging and the like, and the prepared silver bar powder for the traditional Chinese medicine composition can be applied to a traditional Chinese medicine prescription for constipation, large intestine melanosis or irritable bowel syndrome. According to the process, fresh Sargentodoxa cuneata is taken as a raw material, effective pharmacological components in the fresh Sargentodoxa cuneata are reserved and played to the maximum extent through improvement of the preparation and processing process, and the Sargentodoxa cuneata which is convenient to store, transport and use, remarkable in medicinal effect, capable of being independently or compatibly used in a traditional Chinese medicine composition and capable of being used for a long time is prepared. The silver bar powder has a good treatment effect on constipation, large intestine melanosis or irritable bowel syndrome, so that the application of the silver bar powder in medical clinic is expanded.

The invention discloses a traditional Chinese medicine used for treating blackish facial patches, melanosis and chloasma, and a preparation method. The traditional Chinese medicine comprises radix saposhnikoviae, rhizoma notopterygii, herba schizonepetae, lotus stamen, white summer silkworms, pigeon feces, Cissus repens Lamk. flos, rhizoma typhonii, radix ampelopsis, amylum, tercel feces with white heads, Syringa oblata Lindl. var. alba Rehder, Beesia calthifolia herba, rhizoma nardostachyos, rhizoma bletillae, radix angelicae dahurioae, atractylodis macrocephalae rhizome, white poria, radix angelicae pubescentis and lablab album semen. The preparation method of the traditional Chinese medicine comprises the following steps of: S1: selecting raw materials; S2: preprocessing the raw materials; S3: placing the raw materials; S4: grinding medicine materials; and S5: packaging the medicine materials. By use of the preparation method disclosed by the invention, a traditional Chinese medicine decocting procedure is avoided so as to be favorable for patients to recover, under a situation that no auxiliary materials or additives are added, the raw materials are grinded into fine powders, the traditional Chinese medicine has the efficacy of relieving exterior syndromes, dispelling cold, dispelling wind, eliminating dampness and killing pain, performs an anti-inflammation and pain alleviation function, improves antibacterial activity, is capable of promoting blood circulation to remove blood stasis and dispersing the liver and rectify qi, solves the problems of skin bottom layer melanin pigmentation and lesion through an external application smearing way, and fundamentally solves the problems of chloasma, freckles, blackish facial patches, melanosis and acnes.

The invention discloses an acne-removing vesicle composition as well as a preparation method and application thereof, and belongs to the field of cosmetics. According to the invention, seven active ingredients of papain, nicotinamide, zinc gluconate, capryloyl glycine, caprylyl glycol, linoleic acid and acetylchitosamine are combined, the acne problem is solved from four dimensions of epidermis excessive keratinization regulation, oil control, sterilization and inflammation resistance, a good treatment effect is achieved on acne vulgaris from the first level to the second level, and acne markscaused by acne inflammation and melanosis can be eliminated; besides, the seven active ingredients are embedded in the vesicles, so that the stability of the seven active ingredients can be improved,and the prepared acne-removing vesicle composition is stable, good in compatibility, good in effect, simple in preparation method and low in cost.

The invention discloses traditional Chinese medicine composition for treating melanosis and belongs to the field of traditional Chinese medicine composition. The traditional Chinese medicine composition comprises 3-15 parts of bryozoatum, 1-10 parts of chamomile, 1-8 parts of cicada slough, 6-30 parts of Polygonum paleaceum Wall, 6-18 parts of giant knotweed rhizome, 0.2-5 parts of fructus tribuli, 0.05-1 part of common threewingnut roots, 1-8 parts of spreading hedyotis herb, 0.5-7 parts of siberian cocklour fruits, 6-20 parts of dandelion, 8-25 parts of Chinese wolfberry root-bark, 6-20 parts of cape jasmine fruits, 0.5-5 parts of common curculigo rhizome, 3-15 parts of glossy privet fruits, 3-15 parts of medicinal indianmulberry roots, 1-7 parts of roselle, 3-15 parts of lotus leaves, 1-10 parts of flowers of Chinese Ixora and 3-20 parts of roots of Cornus macrophylla Wall. The traditional Chinese medicine composition is prepared according to the principle of sovereign, minister, assistant and courier and performs the function of fundamentally treating melanosis through the synergic effect of components, and the cure rate is 100%.

Disclosed are anti-melanosic releasing agents, anti-melanosic systems, and methods of preventing or reducing melanosis in crustaceans, particularly shrimp. Melanosis in shrimp is prevented or reduced by exposing shrimp to the anti-melanosic system containing the anti-melanosic releasing agent, e.g., green tea.