The invention discloses a pharmaceutical composition for relieving malaise after chemoradiotherapy and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal materials: codonopsis pilosula, astragalus membranaceus, Chinese yam, liquorice, Chinese-dates, acanthopanax, sea-buckthorn, human placenta, thellung pimpinella herb, arillus longan, lily, radix ophiopogonis, mulberry, light wheat, schisandra chinensis, lotus seed, poria with hostood, valerian, vine of multiflower knotweed, gynostemma pentaphylla, lucid ganoderma, vicia sativa and cortex albiziae. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition is used for benefiting vital energy and nourishing the heart as primary functions, and tonifying the stomach and spleen and sterilizing and detoxifying as auxiliary functions by using the theory of the traditional Chinese medicine in China, the immune system of the organism can be improved, the myocardial function is protected, the gastrointestinal reaction is reduced, the renal toxicity is reduced, the liver is protected, the pathogenic factor resisting abilities, of disinfecting, sterilizing and the like, of the body are improved, and the pharmaceutical composition has the effects of being good in effect, quick to take effect, high in safety and free of toxic and side effects in the aspect of relieving malaise after chemoradiotherapy.