Purposes of flavane derivatives

A use and pharmaceutical technology, applied in the field of pharmaceutical use of flavan derivatives, can solve the problems of unexplained anti-hypoxic active ingredients, anti-hypoxic activities of flavonoids and flavan compounds have not been reported, etc.

Inactive Publication Date: 2013-04-10
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the hypoxic protective effect of total flavonoids of South Suanzizao fruit has also been documented (Li Zengxi et al.; Protective effect of total flavonoids of Guangzao jujube on animal hypoxia tolerance and acute myocardial ischemia: Chinese Herbal Medicine, 1984, Volume 15, No. 6, pp. 25-27), but did not elucidate the anti-hypoxic active ingredients
The anti-hypoxic activity and application of the flavonoids and flavanoids isolated and prepared from Ziziphus jujuba in the present invention have not been reported so far

Method used

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  • Purposes of flavane derivatives
  • Purposes of flavane derivatives
  • Purposes of flavane derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1. The separation and preparation of compound I

[0033] 3.2kg of dry bark of Choerospondias axillaries (Roxb.) Burtt. et Hill. (collected in August 1999 from Mengla, Yunnan) was pulverized and extracted with commercially available medical ethanol at room temperature, each time with 95% (V / V ) in 25 liters of aqueous ethanol soaked for 7 days, extracted 4 times altogether, combined extracts, concentrated and dried under reduced pressure to obtain 750 g of ethanol extract. 750 g of the ethanol extract was suspended in 3 liters of water, extracted successively with chloroform, ethyl acetate, and n-butanol, each solvent was used for 3 liters each, extracted 4 times respectively, the same extracts were combined, concentrated and dried under reduced pressure, and obtained 60 g of the chloroform extract, 310 g of the ethyl acetate extract, 300 g of the n-butanol extract, and 80 g of the aqueous layer residue.

[0034] Take 100g of ethyl acetate extract, dissolve i...

Embodiment 2

[0037] Embodiment 2. The separation and preparation of compound II and III

[0038] Dissolve 300 g of the n-butanol extract of Jujube jujube obtained in Example 1 with an appropriate amount of methanol, add an appropriate amount of macroporous resin AB-8 for adsorption, dry, and put on the macroporous resin AB-8 column (column bed 8.5 cm × 48cm in water), Gradient elution with water-ethanol (100:0 → 0:100) in different volume ratios, the combined eluents were collected according to the TLC test results, concentrated and dried under reduced pressure, and two water-washed fractions B- 1 (20 g), B-2 (38 g) and several subsequent eluting aqueous ethanol fractions B-3 (total 230 g, water-ethanol 90:10→0:100 elution fraction).

[0039] Component B-2 (38g) was dissolved in an appropriate amount of methanol, added an appropriate amount of polyamide for adsorption, dried, and applied to a polyamide column (column bed in water 7.5cm×18.5cm), and eluted with a gradient of water-acetone i...

Embodiment 3

[0043] Embodiment 3. The separation and preparation of compound IV and V

[0044] The medicinal dregs extracted by volume percentage 95% ethanol in Example 1 are further extracted with 60% volume percentage ethanol water at room temperature, soaked for 7 days with 25 liters of aqueous ethanol each time, and are extracted 3 times altogether, and the combined extracts are reduced. Concentrate and dry under pressure to obtain 90 g of aqueous ethanol extract.

[0045] Take 80g of the hydrous ethanol extraction extract, dissolve it with an appropriate amount of methanol, add 150g of polyamide to absorb, dry, put on a polyamide column (fill 250g of polyamide in water, column bed 8.5cm×22cm), and elute with water-ethanol-acetone system , according to the thin layer detection results, the combined eluate was collected, concentrated and dried under reduced pressure to obtain five components: WE-1 (10g, water eluted part), WE-2 (17g, water eluted part), WE-3 (2g, water-ethanol volume rat...

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Abstract

The invention relates to purposes of flavane derivatives, and specifically relates to the purposes of flavane derivatives represented by a formula VI in the preparations of anti-anoxia medicines and anti-anoxia health products. The invention also relates to the purposes of the compounds in preparing the medicines used for preventing and / or treating various hypoxic diseases, or in ameliorating andrelieving various malaise symptoms related to anoxia under hypoxia environments. The formula VI is shown below.

Description

[0001] This application is based on the divisional application of the Chinese patent application with the application number 200810211765.4, the application date is September 24, 2008, and the invention title is "Preparation method and application of flavone and flavan derivatives". Technical field: [0002] The invention relates to a preparation method of flavonoids and flavan derivatives contained in the medicinal plant Jujube jujuba, and the use of these compounds for preparing functional foods such as anti-hypoxia drugs and anti-hypoxia health products. Background technique: [0003] Oxygen is indispensable in human life activities, and oxygen molecules play an important role in the energy metabolism of tissues and cells in the body. A variety of factors can lead to insufficient oxygen supply to human tissues and cells, such as certain diseases or being in a special hypoxic environment (such as plateau), etc., and hypoxia can in turn cause cell and tissue damage and even ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P39/00A23L1/30
Inventor 崔承彬李长伟蔡兵韩冰李明明范明
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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