The invention relates to a medicine for treating male oligozoospermia and improving semen quality. Various natural edible plant medicines such as Rhizoma Polygonati, Fructus Lycii, Cordyceps militaris (L.) Link., Fructus Rubi, Fructus Mori, Fructus Hippophae, Semen Coicis, Radix Ginseng, and Concha Ostreae (calcined) serve as raw materials, are combined suitably, and jointly have effects of invigorating the spleen and replenishing Qi, and nourishing the kidney and replenishing essence, Lepidium Meyenii contains macaenes and macamides which are used as active substances has effects of promoting sexual function, increasing the number of sperms and improving activity of the sperms, selenium yeast, aminoacid, L-carnitine tartrate, calcium carbonate and fructose can strengthen and protect energy metabolism of the sperms, taurine and vitamin effectively remove reactive oxide species and protect activity of the sperms, and folacin can promote maturity of the sperms and improve functions of the sperms. The medicine is reasonable in composition, and the synergistic effect of various components is utilized, so that the medicine is remarkable and lasting in treatment effect, safe and reliable and convenient to take orally, and can effectively promote spermatogenesis, improve survival rate of the sperms and improve activity of the sperms.