4 results about "Prostatic epithelium" patented technology

The invention belongs to the technical field of biological medicines, and provides an imide aryl piperazine derivative as well as a preparation method and application thereof. The imide aryl piperazine derivative with the structure as shown in the formula (I) provided by the invention shows that the imide aryl piperazine derivative has relatively strong cytotoxicity to PC-3, LNCaP and DU145 cancer cells and human normal prostate epithelial cells in experiments of toxicity to the PC-3, LNCaP and DU145 cancer cells, but shows weak activity and high selectivity to the human normal prostate epithelial cells; the compound can be further used as an anti-prostatic cancer treatment candidate drug with an excellent effect.

The invention relates to an application of light waves in preparation of a medical instrument for treating chronic prostate inflammation, and the medical instrument generates light waves with energy of 3-50J / cm < 2 > and wavelength of 630nm + / -10nm. According to the prostate epithelial cell apoptosis inhibitor disclosed by the invention, the prostate epithelial cell activity is remarkably improved, H2O2-induced prostate epithelial cell apoptosis is inhibited, macrophages can be regulated to be converted towards the inflammation inhibition direction, prostate cell inflammation can be effectively improved, and normal functions of prostate can be recovered.

The present invention relates to a composition for the prevention or treatment of benign prostatic hyperplasia comprising a benzophenone derivative as an active ingredient. A composition for the prevention or treatment of benign prostatic hyperplasia comprising N-cyclopropyl-4'-(4-(2,3-dihydroxypropoxy)benzoyl)-6-methyl-[1,1'-biphenyl]-3-carboxamide, a benzophenone derivative according to the present invention, as an active ingredient exhibits excellent effects in reducing the size of the prostate, reducing the weight of the prostate, and reducing the thickness of the prostatic epithelial tissue. Therefore, the benzophenone derivative according to the present invention can be usefully utilized as a pharmaceutical composition or a health functional food composition for the prevention or treatment of benign prostatic hyperplasia.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and preparation and application thereof. The composition provided by the present application comprises Ramulus cinnamomi, Poria cocos, Cortex moutan, Semen persicae, Radix paeoniae alba, Radix rubiae, Cornus officinalis, and Rhizoma sparganii. The composition can obviously reduce the prostate index and prostate epithelial thickness of a benign prostatic hyperplasia model rat, and relieve interstitial edema. The experimental results show that the composition can obviously reduce the content of dihydrotestosterone, estradiol, testosterone, gonadotropin-releasing hormone, and rat luteinizing hormone in the prostate serum of a model mouse, and increase the content of follicle-stimulating hormone. The above results show that the traditional Chinese medicine composition can inhibit sex hormone disorder, and has the effect of treating prostatic hyperplasia.