4 results about "Spermatogenesis" patented technology

The application discloses a seminal plasma metabolic biomarker combination for male infertility spermatogenesis obstacle typing diagnosis, and relates to the field of biological science and technology.The application records the metabolic fingerprints of 475 seminal plasma samples by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry, and constructs a seminal plasma metabolic fingerprint database related to spermatogenesis obstacle (SPGF). Then, through machine learning and statistical analysis, six metabolic biomarkers for SPGF typing diagnosis are screened and identified in the seminal plasma, and the six metabolic biomarkers can realize accurate typing of SPGF (AUC=0.814). The application has the advantages of simple sample pretreatment, fast analysis speed and low cost by means of recording the metabolic fingerprints of seminal plasma by means of nanoparticle-enhanced laser desorption / ionization mass spectrometry. Through the synthesized iron oxide nanoparticles as a matrix, small molecule metabolites in the seminal plasma can be efficiently captured and ionized, and complex pretreatment steps such as deproteinization and chromatographic separation are not needed, so that super-fast analysis, super-high sensitivity, extremely low sample consumption and excellent repeatability detection are realized.

The invention provides a pyrrolidone tricyclic compound and a preparation method thereof, and application of the pyrrolidone tricyclic compound in preparation of drugs for treating neurodegenerative diseases, especially antidepressant drugs. The structural formula of the pyrrolidone tricyclic compound is as shown in general formulas A and 13. Experimental studies on in-vitro PC12 cell injury protection activity, in-vivo mouse anti-depression activity, hERG potassium channel inhibition and mouse head shaking show that the compound disclosed by the invention can be used for preparing neurodegenerative diseases, especially quickly-acting anti-depression drugs, and has the remarkable advantage of improving the spermatogenesis function.

The invention relates to the technical field of animal breeding, in particular to a boar semen improved feed additive based on a herba epimedii compound as well as a preparation method and application of the boar semen improved feed additive. The improved feed additive is prepared from the following active ingredients in parts by weight: 15 to 35 parts of herba epimedii extract, 10 to 25 parts of radix salviae miltiorrhizae extract, 8 to 20 parts of radix rehmanniae extract, 5 to 15 parts of caulis sinomenii extract, 0.1 to 0.8 part of vitamin E and 0.05 to 0.2 part of organic zinc. According to the invention, multiple active ingredients such as the herba epimedii extract, the organic zinc, the radix salviae miltiorrhizae, the radix rehmanniae and the caulis sinomenii are systematically matched with a preferred carrier, so that multi-path synergy in the aspects of spermatogenesis promotion, oxidation resistance, inflammation resistance, endocrine regulation, preparation delivery and the like is realized, and the semen quality of boars is remarkably improved.

The invention provides a spermatogenic function multi-dimensional evaluation method and system, and the method comprises the steps: obtaining abnormal parameters from spermatogenic problem positioning, determining the deviation degree through comparison with a preset normal range, and obtaining a male evaluation score; if the type is female, extracting an ovarian reserve mark from the preliminary classification result, processing reserve parameters by adopting a support vector machine model, judging a reserve level, and obtaining reserve problem positioning; obtaining a level index from reserve problem positioning, determining a reserve deviation by calculating a difference with a preset reference, and obtaining a female evaluation score; integrating the deviation data from the male assessment score or the female assessment score, generating a comprehensive feedback report by adopting a fusion algorithm, and determining an overall fertility level; and grade information is extracted from the comprehensive feedback report, a clinical result is generated through a rapid output module, and a final evaluation conclusion is obtained.