Use of phosphoprotein phosphatase related factors for diagnosis and treatment of fertility defects

By detecting the phosphorylation levels of phosphoprotein phosphatase 6 regulatory subunit 3, eukaryotic translation initiation factor 3 subunit C and eukaryotic translation initiation factor 4 gamma 1, the problem of unclear male reproductive function in mammals in the existing technology is solved, and accurate diagnosis and prediction of male fertility defects are achieved.

CN120591389APending Publication Date: 2025-09-05SHANDONG UNIV
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Patent Information

Application Number
CN202510239615.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-28
Publication Date
2025-09-05

AI Technical Summary

Technical Problem

The existing technology lacks research on the exact function of phosphorylation in mammalian male reproduction, which makes it difficult to effectively detect and predict male fertility defects.

Method used

Provides methods for diagnosing and predicting male fertility defects, including gene and protein testing, by detecting the phosphorylation levels of protein phosphatase 6 regulatory subunit 3 (PPP6R3), eukaryotic translation initiation factor 3 subunit C (EIF3C), and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1).

Benefits of technology

It achieves accurate diagnosis and prediction of male fertility defects, provides corresponding diagnostic methods and kits, and can detect whether S39 of EIF3C and S1217 of EIF4G1 are abnormal, and judge fertility defects.

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Abstract

The present invention provides methods for diagnosing or predicting a fertility defect, such as infertility, in a mammalian or human male subject by detecting PPP6R3 or a combination of PPP6R3, EIF3C and EIF4G1. The invention also provides kits and instruments for diagnosing or predicting fertility defects, such as infertility disorders, in mammalian male individuals by detecting said proteins. According to the application, it is found and proved that PPP6R3 is crucial to spermatogenesis for the first time, S39 of EIF3C and S1217 of EIF4G1 are targets for PP6 to regulate spermatogonial differentiation, a new insight is provided for the relation between phosphorylation participated by phosphoprotein phosphatase and spermatogonial differentiation, and deep research on the relation is beneficial to development of a male infertility treatment method.
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