Use of tocotrienol composition for the prevention of cancer

A technology of tocotrienol and composition, which is applied in the field of cancer biochemistry and molecular biology, molecular biology and biochemistry, and can solve problems such as side effects of patients

Inactive Publication Date: 2011-06-08
DAVOS LIFE SCI PTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Most known cancer treatments have serious side effects for patients

Method used

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  • Use of tocotrienol composition for the prevention of cancer
  • Use of tocotrienol composition for the prevention of cancer
  • Use of tocotrienol composition for the prevention of cancer

Examples

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other Embodiment approach

[0109] Other implementations fall within the following claims and non-limiting examples. In addition, where features or aspects of the invention are described in terms of Markush groups, those skilled in the art will recognize that the invention is also thereby described in terms of any individual member or subgroup of members of said Markush group.

Embodiment

[0111] 1. In the following experiments, the antiproliferative effects of different tocopherols and tocotrienol isomers were compared using melanoma cell lines. All 8 vitamin E isomers were found to inhibit the proliferation of malignant skin cancer cells. Potency varies between the various isomers, with γ-T3 being the most potent. A detailed study of the effect of γ-T3 revealed that γ-T3 treatment of two melanoma cell lines resulted in the induction of apoptosis, which was associated with the downregulation of pro-survival factors such as Id-1 or EGFR. Meanwhile, activation of JNK and inactivation of NK-κB were also observed after treatment. Inhibition of JNK activity by a specific inhibitor (SP600125) partially blocked sensitivity to γ-T3 treatment, suggesting that γ-T3-induced apoptosis is mediated through the JNK signaling pathway. In addition, γ-T3 treatment also restored the expression of E-cadherin, γ-catenin and suppressed the expression of mesenchymal markers in mela...

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Abstract

The present invention is directed to a method of preventing cancer or preventing the recurrence of cancer after undergoing a cancer treatment by administering a composition comprising at least one of Gamma-tocotrienol or Gamma-tocotrienol, wherein the cancer is selected from the group consisting of melanoma, prostate cancer, prostate intraepithelial neoplasia, colon cancer, liver cancer, bladder cancer, breast cancer and lung cancer. The present invention is further directed to a composition comprising at least one of Gamma-tocotrienol or Delta-tocotrienol and Docetaxel and / or Dacarbazine, and to a method of inhibiting or arresting or reversing of cancer by administering a composition comprising at least one of Gamma-tocotrienol or Gamma-tocotrienol together with Docetaxel and / or Dacarbazine. The present invention is also directed to methods of manufacturing those compositions.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 107,842, filed October 23, 2008, which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] The invention relates to the fields of molecular biology and biochemistry, especially to the fields of cancer biochemistry and molecular biology. Background technique [0004] Cancer, or more precisely a malignant neoplasm, is a group of cells that exhibits uncontrolled growth (division beyond normal limits), invasion (invasion and destruction of adjacent tissues) and sometimes metastases (spread through lymphatic or blood to other locations in the body). [0005] The progression of a given cancer, or the lack thereof, is highly variable and depends on the type of neoplasm and the response to treatment. Treatment options include surgery, chemotherapy, radiation therapy, hormone manipulation, and immunotherapy. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/4164A61K31/337A61P35/00
CPCA61K31/4164A61K31/655A61K31/353A61K31/337A61P35/00A61P43/00A61K2300/00
Inventor 凌明达叶惠妮王云川叶一霖
Owner DAVOS LIFE SCI PTE
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