The invention discloses a composition for treating seborrheic alopecie and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 0.1 to 5 parts of cortex moutan extracts, 0.1 to 5 parts of cacumen platyclade extracts, 0.1 to 5 parts of rosemary extracts, 0.1 to 5 parts of tea plant extracts, 0.1 to 5 parts of radix angelicae sinensis extracts, 0.1 to 5 parts of radix astragali seu hedysari extracts, 0.1 to 5 parts of herba ecliptae extracts, 0.01 to 2 parts of salvia extracts, 0.01 to 2 parts of saw palmetto extracts, 0.01 to 2 parts of lupulus extracts, 0.01 to 2 parts of morinda citrifolia extracts, 0.01 to 0.05 part of biotin, 0.1 to 2 parts of phaseomannite, 0.1 to 1 part of hydrolyzed wheat protein, 0.1 to 1 part of oat glucan, 0.1 to 5 parts of zinc gluconate, 0.1 to 5 parts of herba menthae, 0.01 to 1 part of biphenyl acetate and 0.001 to 10 parts of fullerene and corresponding derivatives. The composition has the effect of preventing or treating seborrheic alopecie and androgen-dependent alopecia hereditarian.