123 results about "Sarcopenia" patented technology

The invention discloses a sarcopenia risk assessment method based on a knowledge graph, and relates to the field of medical large models. Full-dimensional multi-source data of a patient is collected and preprocessed; defining a six-tuple entity relationship model, introducing a dynamic entity life cycle and heterogeneous relationship type system, and realizing multi-modal feature fusion through modal adaptive weight learning, knowledge conflict resolution and entity evolution embedding; based on an enhanced space-time diagram convolutional network, through heterogeneous relation attention space convolution, space-time adaptive time convolution and triple contrast learning tasks, enhanced entity embedding is output, and the enhanced entity embedding comprises a historical state, a current state, an evolution rate and a future trend. Through multi-modal space-time alignment and enhanced knowledge graph construction, deep fusion of multi-source heterogeneous data and space-time dynamic relationship modeling are realized, and comprehensiveness and accuracy of sarcopenia risk assessment are remarkably improved.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention discloses ultrasonic response type hydrogel as well as a preparation method and application thereof. According to the ultrasonic response type hydrogel preparation, an ultrasonic triggering threshold value is reduced to 1W / cm < 2 > by utilizing a synergistic anti-inflammatory mechanism that the Mxene enzyme activity is enhanced by ultrasound, muscle heat tolerance is met, and heat loss is avoided. And under the ultrasonic activation condition, the activity of various enzymes of Mxene is increased. Besides, according to the anti-aging multi-mechanism collaborative design, aiming at inflammation-aging-atrophy vicious circle of sarcopenia, ultrasonic enhanced enzyme activity, anti-inflammation, anti-oxidation and anti-aging treatment of sarcopenia is realized for the first time.

The invention provides application of desulfurization vibrio in screening of drugs or functional food for preventing and treating sarcopenia. According to the application disclosed by the invention, a main intestinal flora desulfurization vibrio capable of promoting amyotrophy is firstly found, and the desulfurization vibrio can be used as a main target for screening sarcopenia and can be used for screening medicines or functional foods for preventing and treating sarcopenia. Sinopenia susceptible people are screened through abundance of desulfurization vibrio in excrement, and early discovery and targeted early intervention can be carried out; aiming at the mechanism that desulfurization vibrio in intestinal tracts promotes occurrence and development of sarcopenia, drugs or functional food for treating sarcopenia can be further screened, and then substances / new therapy for preventing and treating sarcopenia are developed.

The invention relates to medicine, in particular to gerontology and therapy and can be used for treating sarcopenia in elderly patients.Summary of the invention consists in alternating for 1…2 days the intravenous administration of ozonized 0.9% NaCl solution and major autohemotherapy, namely 500 mL of a 0.9% NaCl solution ozonized with an ozone-oxygen mixture, with an ozone concentration of 5…10 µg / mL, are administered, and major autohemotherapy consists in collecting 300…400 mL of venous blood from the patient, which is ozonized, with an ozone concentration of 15 µg / mL and transfused to the patient, the treatment course includes 8…10 consecutive procedures, then it is extended with minor autohemotherapy, which consists in collecting 5…10 mL of venous blood, which is ozonized, with an ozone concentration of 15 µg / mL and administered intramuscularly every 10th day of alternation and includes 3 consecutive procedures, and the ozonized 0.9% NaCl solution is administered for up to 6…8 weeks.

The present disclosure can improve the degree of soy protein proteolysis and the ability to produce valine, isoleucine, and leucine, which are branched-chain amino acids, as well as other amino acids, such as threonine, glycine, tyrosine, and lysine. Accordingly, the present disclosure can prevent sarcopenia and has antioxidant activity. Also, the present disclosure can maintain protein metabolic balance and relieve sarcopenia by muscle synthesis.The self-aggregation, hydrophobicity, and intestinal adhesion of a mixed strain is improved compared to a case where a single strain used for the mixed strain is used. Therefore, when the mixed strain of the present disclosure is ingested, the strain can remain for a long time in the intestine.

This invention discloses a limb muscle rehabilitation device for patients with sarcopenia, including an airbag assembly, a plate assembly connected to the lower part of the airbag assembly, and a support leg assembly connected to the plate assembly. The support leg assembly includes a support leg body and a sleeve located radially outside the support leg body. The upper end of the sleeve is fixedly connected to the plate assembly. The support leg body can move up and down along the inner wall of the sleeve. The lower end of the support leg body extends out of the bottom of the sleeve. A spring is fitted on the outer wall of the support leg body, and an extension is provided on the outer wall of the support leg body. The lower end of the spring abuts against the upper end of the extension. When the support leg body moves upward, it can compress the spring. This invention provides a limb muscle rehabilitation device for patients with sarcopenia, which helps reduce fatigue during exercise and increases rehabilitation exercise time.

1. The name of the design product: Handbag (Sarcopenia and Cardiovascular Disease Research Group Promotion). 2. The use of the design product: For containing articles and hospital sarcopenia and cardiovascular disease research group promotion. 3. The design points of the design product: The combination of shape and pattern. 4. The picture or photo that best indicates the design points: Front view.

The invention discloses a sarcopenia electromyographic signal acquisition and analysis system, and belongs to the technical field of medical detection. The system comprises an electromyographic signal acquisition module, a signal preprocessing module, a feature extraction module, an analysis and diagnosis module and a result output module which are electrically connected in sequence, the electromyographic signal acquisition module adopts a flexible dry electrode array to realize noninvasive and anti-interference acquisition; the signal preprocessing module outputs high-quality electromyographic signals through self-adaptive trapped wave, band-pass filtering and standardization processing; the feature extraction module extracts time domain, frequency domain and nonlinear multi-dimensional features; the analysis and diagnosis module is used for completing low, medium and high three-level risk assessment of sarcopenia and judgment of muscle fiber atrophy type, innervation disorder type and metabolic disorder type decline types on the basis of a deep learning model; and the result output module stores the data and generates an evaluation result. According to the invention, noninvasive, accurate and efficient screening and diagnosis of sarcopenia are realized, a scientific basis is provided for clinical intervention, and the method is suitable for various medical health scenes.

The invention discloses a collagen peptide composition with a function of increasing muscle strength and application of the collagen peptide composition. The collagen peptide composition comprises fish collagen peptide and beef tendon collagen peptide. A mouse senescence sarcopenia model is constructed, then a collagen peptide composition is used for intragastric intervention, and the improvement effect is evaluated through behavioral testing, body component analysis and HE staining. The potential target and regulatory pathway of the collagen peptide composition are explored by combining network pharmacology and molecular docking. Results show that the four-limb grip strength, treadmill exhaustion time and movement distance of a model mouse can be remarkably improved, quadriceps femoris muscle and gastrocnemius muscle indexes are recovered, and muscle fiber atrophy and collagen deposition are relieved. And it is found that TNF, IL1B, AKT1, mTOR and MAPK1 may be core targets of the TNF, IL1B, AKT1, mTOR and MAPK1. The polypeptide plays a role by regulating and controlling biological processes such as MAPK cascade, protein processing and inflammatory reaction, cell apoptosis, a cAMP pathway and a calcium signal pathway.

The invention provides a muscle mass evaluation method and system, and relates to the technical field of medical imaging, and the method comprises the steps: carrying out the ultrasonic scanning of human limbs, collecting an ultrasonic total scattering signal, and obtaining an ultrasonic image; acquiring a muscle structure image according to the ultrasonic image; performing segmentation processing on the muscle structure image to obtain contour information of a target muscle; and calculating the cross-sectional area and volume of the target muscle based on the contour information. According to the invention, the annular probe performs three-dimensional spiral scanning in the scanning process, and simultaneously obtains spatial information in the horizontal and vertical directions; echo signals are processed by adopting a delay superposition beam forming algorithm, and image segmentation is carried out in combination with a deep learning technology. According to the invention, radiation-free, high-precision, low-cost and portable muscle mass measurement is realized, and the method is especially suitable for evaluation, screening and monitoring of sarcopenia.

The present invention relates to a composition for diagnosing sarcopenia, and the like, and was completed by discovering biomarkers enabling the diagnosis of sarcopenia with high accuracy and sensitivity through qualitative and quantitative analysis of the proteome of a sarcopenia animal model. In particular, the biomarkers according to the present invention were confirmed to have a positive or negative correlation with sarcopenia-related indicators such as muscle mass, grip strength, rotarod score, and inverted strength. Therefore, instead or in addition to conventional methods that have relied on the measurement of muscle mass and muscle function, through molecular diagnosis using the markers of the present invention, it is possible to diagnose sarcopenia, and furthermore, it is also possible to determine the severity of sarcopenia through the association of the markers with muscle function. In particular, biomarkers which show consistent correlations with sarcopenia indicators are also expected to be applicable as targets for the treatment of sarcopenia. Furthermore, since sarcopenia is a disease closely related to aging, the biomarkers according to the present invention are expected to be the basis for securing of anti-aging treatment targets and the development of aging control technologies.

The invention discloses a fracture risk prediction method and system, and relates to the technical field of health management. According to the prediction method, serious sarcopenia is selected to diagnose and assess the sarcopenia state, the ratio of monocytes to lymphocytes reflects the immune inflammation level, the prediction model is constructed in combination with the femoral neck bone mineral density T value, and the fracture risk influence factors are comprehensively covered; and the risk identification capability on special high-risk groups with sarcopenia, immune dysfunction and the like is effectively improved. And secondly, only three target independent variables are selected, and the three target independent variables are indexes which can be directly obtained or simply calculated in clinical routine examination, so that the data collection difficulty is greatly reduced. Meanwhile, the prediction model is visualized through a column diagram, complex calculation is not needed, a clinician can quickly inquire the fracture risk score through the actual value of the target subject, and the method is suitable for being efficiently applied to conventional outpatient service, hospitalization and other scenes.

The application belongs to the technical field of biotechnology, and particularly relates to application of albumin polypeptide gel beads in a product for treating or preventing sarcopenia. Egg white protein is used as raw material to extract protein, and albumin dipeptide-based peptidase-IV inhibitory peptide is prepared through a biological enzymolysis method. Bioinformatics analysis is used to screen out the inhibitory peptide TPYMFP, and the IC50 value of the inhibitory peptide TPYMFP for dipeptide-based peptidase-IV reaches 3.12 ± 0.49 mmol / L. Further, the optimal preparation conditions of sodium alginate SA and carboxymethyl chitosan CMCS-based gel beads CMCS / SA / TPYMFP are explored. When the SA concentration is 1.5% (w / v), the CMCS concentration is 0.5% (w / v), and the CaCl2 concentration is 1% (w / v), the polypeptide encapsulation rate is increased to 98.26% ± 0.25%. It is verified that the albumin polypeptide gel beads have good pH response characteristics, and efficient protection and intestinal target delivery of the sarcopenia inhibitory peptide are realized. The albumin polypeptide gel beads are applied to preparation of a product for treating or preventing sarcopenia, or in preparation of a related product for increasing muscle mass and strength.

The present invention provides a body composition estimation program and information processing device that estimate body composition based on measurable values ​​without invasiveness. [Solution] Terminal 1 includes a lean body mass estimation means for estimating lean body mass based on the user's age, gender, height, and weight; a muscle mass estimation means for estimating muscle mass based on the user's age, gender, height, and weight; a sarcopenia determination means for determining the likelihood of sarcopenia based on at least one of lean body mass and muscle mass; a survival rate evaluation means 104 for evaluating the survival rate based on at least one of lean body mass and muscle mass; and a standard index calculation means 105 for calculating a standard index for insurance enrollment based on at least one of lean body mass and muscle mass.

The present invention provides novel 2,4-dinitrophenol (DNP) derivatives and prodrugs thereof as modulators of mitochondrial function. The present invention also provides pharmaceutical compositions comprising the compounds of the present invention and methods for using the same to treat various diseases and conditions associated with or related to mitochondrial dysfunction (e.g., obesity, diabetes, insulin resistance, liver disease, heart or kidney failure, neurodegenerative diseases, and aging-related diseases, including but not limited to sarcopenia, osteoporosis, etc.).

This invention discloses a machine learning model integrating oral microbiome and clinical features and its application in predicting sarcopenia at high altitudes. The method targets high-altitude populations residing at altitudes >3500 meters, collecting oral microbiome 16S rRNA sequencing data, clinical features, and lifestyle data. Core predictive factors are selected through adaptive preprocessing and elastic network regularized regression, and a classification model is constructed using logistic regression. To address the sample imbalance problem in high-altitude areas, this scheme introduces a synthetic balanced sampling strategy based on target distribution doubling; simultaneously, Platt Scaling is used for two-layer probability calibration, combined with a dynamic threshold optimization mechanism based on F1-Score to improve discrimination accuracy. This invention is the first to integrate oral microbiome shaped by the high-altitude environment (such as…)… Selenomonas , Veillonella (etc.) are incorporated into the predictive model. Experiments show that the model achieves an AUC of 0.868 on the independent test set and has advantages such as being completely non-invasive, low-cost, and highly interpretable. This invention provides an efficient early screening program for sarcopenia in resource-scarce high-altitude areas.

The application provides a sarcopenia ultrasound MRC automatic grading method based on deep learning multi-source feature fusion. The method comprises the following steps: constructing a multi-dimensional data set, wherein the multi-dimensional data set comprises an ultrasound image, an anatomical label, a morphological parameter and an MRC grading label; processing data in the multi-dimensional data set to obtain multi-dimensional input data; constructing an MRC grading model, wherein the MRC grading model comprises a data processing module, a feature extraction module and a feature fusion and classification module; training the MRC grading model based on the multi-dimensional input data; and processing to-be-processed data by using the trained MRC grading model to obtain a sarcopenia ultrasound MRC automatic grading result. The technical scheme provided by the application can realize objective, stable and repeatable automatic grading of the muscle strength level of sarcopenia.

The invention relates to application of traditional Chinese medicine herba epimedii, especially an aqueous extract of herba epimedii and epimedin A in prevention and / or improvement of sarcopenia. Compared with a blank control group and a negative control group, the body lengths of the herba epimedii aqueous extract with the concentration of 1 mg / mL, the total flavonoids with the concentration of 0.026 mg / mL, the epimedium A with the concentration of 50 [mu] M, the epimedium B with the concentration of 200 [mu] M, the epimedium C with the concentration of 100 [mu] M, the icariin with the concentration of 200 [mu] M and the icaritin with the concentration of 100 [mu] M are increased by 21.40%, 23.09%, 26.69%, 24.91%, 29.22%, 33.15% and 28.35% respectively. The icariin administration concentration is improved, and the growth promoting effect concentration dependence is obviously enhanced. The body length of the caenorhabditis elegans is increased by 24.19% and even exceeds that of a positive control group. Epimedin A of 50 mu M can effectively increase the body length of caenorhabditis elegans, and other Epimedin A needs higher concentration; 50 [mu] M has the best effect of protecting and relieving the muscular structure. The invention provides a thought for developing medicines for improving dyskinesia and muscle volume reduction, prolonging life, improving muscle fiber atrophy, treating muscle strength decline, tonifying liver and kidney and strengthening muscles and bones, and the medicine is high in safety.

The invention belongs to the technical field of medical products and health care products, and particularly relates to a product for preventing and treating sarcopenia or skeletal muscle atrophy and application of the product. According to the application, it is found for the first time that morusin can effectively increase the cross sectional area of muscle fibers and improve muscle quality and muscle strength, shows a clear and prominent treatment effect in the aspect of reversing the muscle atrophy process, and has important application value in preparation and development of products for resisting sarcopenia and skeletal muscle atrophy.

The invention belongs to the technical field of biological medicine and health food, and provides a composition for preventing and improving sarcopenia and immunity decline caused by cancers and related treatment as well as a preparation method and application of the composition. The composition comprises the following components: nucleotide, beta-hydroxy beta-methyl butyrate, arginine, histidine, glutathione, fish oil, algal oil and vitamin E. The composition has a remarkable effect on improving sarcopenia and immunity decline caused by cancers and related treatment under the compounding of the components.

The present invention provides a compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt, prodrug, stereoisomer, stereoisomer mixture, tautomer, deuterated compound, hydrate or solvate thereof, and a use thereof. The compound has a good agonistic effect on APJ receptors, and can be used for treating and / or preventing diseases such as obesity, hypertension, pulmonary hypertension, and sarcopenia.

The invention provides a compound as shown in a formula (I) or pharmaceutically acceptable salt, prodrug, stereoisomer, tautomer, deuterated compound, hydrate or solvate thereof, and a preparation method and application of the compound or the pharmaceutically acceptable salt, prodrug, stereoisomer, tautomer, deuterated compound, hydrate or solvate thereof. The compound has a good agonistic effect on an APJ receptor, and can be used for treating and / or preventing obesity, hypertension, pulmonary arterial hypertension, sarcopenia and other diseases.

The invention discloses flaxseed and wheat oligopeptide mixed powder with an effect of improving sarcopenia, and belongs to the field of biological medicines. The invention relates to a composition with an effect of improving sarcopenia. The composition comprises active ingredients including wheat oligopeptide and flaxseed meal, wherein the flaxseed powder contains secoisolariciresinol diglucoside, and a mixture of small molecules with the molecular weight smaller than 1000 Da in the wheat oligopeptide accounts for 90% or above. The invention discloses a differentiated molecular path on which the two components play roles, the wheat oligopeptide has outstanding effects in the aspects of remarkably activating a PI3K / Akt pathway and promoting FOXO3a phosphorylation inactivation, the mechanism complementarity of'upstream regulation 'and'downstream blocking' lays a solid theoretical foundation for realizing a more comprehensive anti-atrophy effect through combined use, and the wheat oligopeptide has a good application prospect. And a composite scheme with a fuzzy mechanism in the prior art is exceeded. In addition, the formula disclosed by the invention can also improve the in-vivo environment which is not beneficial to muscle maintenance from the source by relieving chronic inflammation and oxidative stress.

Described herein are treatment regimens, therapies, pharmaceutical formulations and methods of using quercetin to prevent, treat, and / or protect from muscle wasting including 1) sarcopenia associated with aging; and 2) cachexia associated with chronic diseases and their treatments including but not limited to cancer, cardiovascular disease, chronic obstructive pulmonary disease (COPD), HIV, and kidney disease.

The invention belongs to the technical field of rehabilitation instruments, and particularly relates to an adjustable senile sarcopenia rehabilitation training protector which comprises two rehabilitation plates, the lower ends of the two rehabilitation plates are connected with supporting strength adjusting assemblies through angle adjusting assemblies, and the side walls of the two rehabilitation plates and the side walls of the two supporting strength adjusting assemblies are connected with binding covers. The knee joint supporting strength can be automatically adjusted according to the muscle recovery degree of a patient, the progressive whole process of sarcopenia rehabilitation training can be precisely adapted, high-strength supporting is provided for the patient with weak muscle strength and insufficient joint stability in the initial rehabilitation stage, the risk that the knee joint is damaged due to excessive impact in the training process is effectively reduced, and the training efficiency is improved. In the middle rehabilitation stage, the supporting strength is automatically and moderately reduced along with the increase of the muscle strength of the patient, the situation that the joint movement range and the muscle force application space are limited due to excessive protection is avoided, the training effectiveness is guaranteed, and the rehabilitation training efficiency and safety of the senile sarcopenia patient are remarkably improved.

The application discloses a sarcopenia detection method and device based on a chain prompt and a multi-modal large model, and belongs to the technical field of video processing. The method comprises the following steps: collecting a patient action video, and dividing each frame into a plurality of small blocks to be mapped into a feature vector sequence; information fusion is performed between the same frame and different time points, and a global visual feature vector with spatial and temporal context is output; a continuous feature sequence is cut into a plurality of semantic coherent action stages; corresponding segmented prompt text is retrieved from a pre-defined mapping table based on the test type; a natural language description containing quantitative indicators and action features is generated at one time; a sarcopenia diagnosis and its detailed reasons are output; a probability value is taken as the confidence of the diagnosis; and a complete diagnosis report containing quantitative and qualitative analysis is output by one key. The application can greatly improve the universality and robustness across scenes and devices, and significantly improve the explainability of model decision.

The utility model discloses a detection device for predicting fall risk assessment of senile sarcopenia patients, which comprises a track action plate, the top of the track action plate is fixedly connected with two support plates, and a connecting plate is fixedly connected between the two support plates. Compared with a traditional device, by arranging the supporting plate, the track groove, the sliding plate, the connecting belt and the protection plate, corresponding protection measures can be conveniently provided according to the action of a patient; by arranging a semicircular plate, a first empty groove, a rack, a gear, a rotating shaft, an adjusting plate, a square groove, a square block, a threaded rod, a worm and a bracket, the angle and height of the bracket can be conveniently changed and adjusted according to armpit heights of different elderly patients, so that protection is provided when the elderly patients are detected, and the phenomenon of falling down is avoided; therefore, the safety is improved.

Provided is a sarcopenia diagnosis method executed by a sarcopenia diagnosis device operated by at least one processor, the sarcopenia diagnosis method comprising the steps of: monitoring gait propulsion variability on the basis of gait data collected during walking; and diagnosing early signs of sarcopenia when the gait propulsion variability is not smaller than a threshold value.

The utility model discloses a household osteoporosis-sarcopenia combined monitoring and rehabilitation assisting device in the technical field of rehabilitation treatment, which comprises a leg sleeve, a portable ultrasonic bone mineral density instrument and a bioelectrical impedance analyzer, a plurality of grooves are arranged on the periphery of the leg sleeve, a plurality of electromagnets are fixedly connected in the leg sleeve along the periphery, and the electromagnets are connected with the bioelectrical impedance analyzer. A controller is fixedly connected in the leg sleeve, the controller is electrically connected with a data plug, and the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer are both in signal connection with a data socket. Through the arrangement of the leg sleeve, the electromagnet, the data plug and the data plugboard, the weight of the required balancing weight is determined according to data monitored by the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer, and then the balancing weight is attracted through the electromagnet, so that the weight of the balancing weight is adjusted. Through data, patients with osteoporosis and patients with sarcopenia can conveniently carry out aerobic training such as load-bearing jogging according to physical conditions, and therefore the recovery training effect is better achieved.