367 results about "Sarcopenia" patented technology

The invention discloses a milk-derived polypeptide sequence for promoting skeletal muscle cell proliferation and application of the milk-derived polypeptide sequence, and belongs to the field of bioactive peptides. The milk-derived bioactive polypeptide RHPHPHLSF provided by the invention has the effect of promoting muscle cell proliferation, and is expected to be used for preparing medicines for promoting muscle cell proliferation and preventing sarcopenia. The milk-derived bioactive polypeptide RHPHPHLSF is convenient to synthesize, can be industrially produced, and has a good application prospect in the fields of foods, medicines, cosmetics and the like.

The invention relates to a sarcopenia prediction model construction method and system without physique measurement, and belongs to the field of medical informatization. The method comprises the steps of establishing a crowd data set, preprocessing sample data, dividing a training set and a test set, screening modeling features, constructing a plurality of machine learning classifiers, selecting an optimal model, evaluating and predicting performance and the like. The high-performance sarcopenia prediction model can be constructed by only using information such as age, gender, height, weight and the like which can be obtained through questions and answers or self-evaluation as independent variables without physical fitness measurement such as grip strength and physical fitness test. The system comprises a data acquisition module, a data analysis module and a result output module, can realize rapid, low-cost, remote and self-evaluation prediction of sarcopenia risk, is suitable for scenes of various medical institutions, communities, families and the like at all levels, and is beneficial to early screening, intervention and dynamic monitoring of sarcopenia.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention discloses a sarcopenia risk assessment method based on a knowledge graph, and relates to the field of medical large models. Full-dimensional multi-source data of a patient is collected and preprocessed; defining a six-tuple entity relationship model, introducing a dynamic entity life cycle and heterogeneous relationship type system, and realizing multi-modal feature fusion through modal adaptive weight learning, knowledge conflict resolution and entity evolution embedding; based on an enhanced space-time diagram convolutional network, through heterogeneous relation attention space convolution, space-time adaptive time convolution and triple contrast learning tasks, enhanced entity embedding is output, and the enhanced entity embedding comprises a historical state, a current state, an evolution rate and a future trend. Through multi-modal space-time alignment and enhanced knowledge graph construction, deep fusion of multi-source heterogeneous data and space-time dynamic relationship modeling are realized, and comprehensiveness and accuracy of sarcopenia risk assessment are remarkably improved.

The invention relates to the technical field of microorganisms, in particular to lactococcus lactis subsp. Lactis JYLL-51 for improving sarcopenia obesity as well as a microbial agent and application of the lactococcus lactis subsp. Lactis JYLL-51. The Lactococcus lactis subsp. Lactis JYLL-51 is preserved in China General Microbiological Culture Collection Center (CGMCC) on March 13, 2024, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.30016. The Lactococcus lactis subsp. Lactis JYLL-51 has the advantages that the Lactococcus lactis subsp. Lactis JYLL-51 can be used for preparing the Lactococcus lactis subsp. Lactis JYLL-51; the invention provides a lactococcus lactis subsp. Lactis JYLL-51, and experiments show that the lactococcus lactis subsp. Lactis JYLL-51 microbial inoculum prepared from the strain can not only improve the weight and strength of skeletal muscle, but also reduce fat accumulation induced by high fat, and can significantly improve sarcopenia obesity.

The invention discloses a milk-derived polypeptide VSL for promoting skeletal muscle cell proliferation and application thereof, and belongs to the field of bioactive peptides. The milk-derived bioactive polypeptide VSL provided by the invention has the effect of promoting muscle cell proliferation, and is expected to be used for preparing medicines for promoting muscle cell proliferation and preventing sarcopenia. The milk-derived bioactive polypeptide VSL is convenient to synthesize, can be industrially produced, and has a good application prospect in the fields of foods, medicines, cosmetics and the like.

The present invention relates to novel lactic acid bacteria, Bifidobacterium bifidum P61 KCCM13367P, Lactobacillus paracasei P62 KCCM13368P, or a mixture thereof. The novel lactic acid bacteria and the mixture thereof of the present invention change the composition of intestinal microorganisms to inhibit the expression of sarcopenia markers (MuRF-1, MAFbx / Atrogin-1, etc.), increase muscle strength and muscle mass, and promote muscle formation, thereby alleviating sarcopenia. In addition, the present invention improves cognitive dysfunction by inhibiting behavior similar to cognitive dysfunction and regulating the expression of factors (BDNF, IL-10, etc.) associated with said dysfunction. In addition, the present invention has the effect of treating inflammation by reducing the expression of inflammatory markers (TNF-α, IL-6, IL-1ß, and MPO) and increasing the expression of an anti-inflammatory marker (IL-10).

The invention discloses a senile sarcopenia risk prediction and grouping multi-motion intervention system and method, and the system comprises a data layer which is used for data collection, storage and task standardization; the service layer is used for processing and analyzing the data acquired by the data layer, performing sarcopenia risk assessment on the elderly patients, and appointing an exercise training scheme according to a risk assessment result and a data analysis result; the application layer comprises personal information management, patient information management, medical care information management and system maintenance management; and the user side is used for personal information management and exercise demand assessment, and preliminarily assessing the exercise demand according to own feelings. Data are collected through a physical condition scale and a tumble risk prediction tool, the model construction module is used for analysis, the sarcopenia risk of the elderly patient can be accurately evaluated, high-risk people can be recognized in the early stage of the disease, a basis is provided for follow-up intervention, an exercise scheme is adjusted according to a data analysis result, the management efficiency is improved, and the management cost is reduced. And high-quality services can be provided for more old people.

The invention discloses a traditional Chinese medicine composition for treating sarcopenia, the traditional Chinese medicine composition is prepared from six medicines of sugared ginseng, cistanche, rhizoma polygonati, poria cocos, gastrodia elata and bighead atractylodes rhizome through compatibility, the traditional Chinese medicine composition takes spleen strengthening, qi supplementing, kidney tonifying and essence replenishing as the treatment rule, syndrome differentiation treatment is carried out aiming at the spleen and kidney deficiency pathogenesis of sarcopenia, multi-target intervention on sarcopenia is achieved, and the traditional Chinese medicine composition has the advantages that the curative effect is good; the traditional Chinese medicine composition not only can quickly improve muscle strength and endurance functions, but also can continuously promote muscle mass reconstruction, and has dual effects of atrophy resistance and fibrosis resistance, and animal experiment results show that the traditional Chinese medicine composition has a remarkable curative effect on liver and kidney deficiency type sarcopenia.

The invention discloses a heptapeptide with a muscle building function as well as preparation and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the heptapeptide SR7 is Ser-Ser-Gly-Lys-Phe-Leu-Arg, and the amino acid sequence of the heptapeptide SR7 is as shown in the specification. The heptapeptide can be obtained through artificial synthesis or directional enzymolysis of wheat protein. Functional verification shows that the heptapeptide SR7 and the wheat peptide obtained through directional enzymolysis have the muscle building function which is mainly reflected in enhancing the exercise ability, including increasing the total exercise distance, the moving speed and the activeness frequency; and increase muscle strength and muscle mass. And the food-borne bioactive peptide is high in biological safety. Therefore, the compound can be applied to preparation of medicines for improving sarcopenia or health-care foods for increasing muscle. The invention provides a novel active substance with a muscle building function, and the novel active substance has a good market prospect and application potential.

The invention belongs to the technical field of biological food, and particularly relates to compound hydrolyzed whey protein powder capable of preventing sarcopenia and a preparation method. The invention discloses compound hydrolyzed whey protein powder capable of preventing sarcopenia. The compound hydrolyzed whey protein powder consists of hydrolyzed whey protein A, hydrolyzed whey protein B, hydrolyzed whey protein C, hydrolyzed whey protein D, hydrolyzed whey protein E, hydrolyzed whey protein F, hydrolyzed whey protein G and hydrolyzed whey protein H. The compound hydrolyzed whey protein powder prepared by the technical scheme has the effect of preventing sarcopenia of old people, and a new idea of compounding hydrolyzed whey protein powder of different brands and different hydrolysis degrees and actual application effect verification are provided.

The invention discloses a sarcopenia patient self-health intervention management system, which comprises a system overall architecture module, a personalized scheme generation module, a monitoring and feedback module, an evaluation and adjustment module and a data storage and analysis module, and is characterized in that the output end of the system overall architecture module is electrically connected with the input end of the personalized scheme generation module; the invention relates to the technical field of medical health management. According to the self-health intervention management system for the patients with sarcopenia, factors of different age groups, genders, physical conditions, personal preferences and the like are comprehensively considered, exercise and nutrition intervention are organically combined, personalized exercise and nutrition plans are generated, and the self-health intervention management system for the patients with sarcopenia is provided for the patients with sarcopenia. The limitation of single movement or nutrition intervention and lack of personalized schemes in the prior art is overcome, the prognosis condition of the patient with sarcopenia can be more effectively improved, and the patient is comprehensively assisted to improve the muscle quality, enhance the muscle strength, improve the body function and the like.

The invention belongs to the field of medical health, and provides a preliminary sarcopenia screening method based on paired foot pressure data, which comprises the following steps: firstly, acquiring foot pressure signals of left and right feet of a subject in a walking process to obtain corresponding foot pressure characteristics of the left and right feet; fusing by adopting a multiplicative combination mode to obtain total pressure characteristics of each walking stage in each walking period; then, a GMM model is adopted to create a plantar pressure mode, plantar pressure mode features are obtained, attention mechanism fusion is adopted to obtain single-cycle fusion pressure mode features and multi-cycle fusion pressure mode features, and time sequence features are obtained through learning of an improved GRU module; and finally, sending the corresponding multi-cycle fusion pressure mode features and the time sequence features into a multi-layer perceptron, and outputting the prediction probability of the sarcopenia. The method fully considers the independence of the left and right foot pressure signal features, introduces the joint relation of the two features, more comprehensively learns the gait features, and effectively improves the accuracy of primary screening of sarcopenia.

The present invention relates to a composition comprising Lactobacillus gasseri for preventing and treating sarcopenia and, particularly, to: a composition comprising Lactobacillus gasseri BNR17 for preventing, treating or alleviating sarcopenia, a decrease in muscle mass and muscle function, and a decrease in muscular strength and muscular endurance, which are induced by causes such as stress, obesity, aging, drugs, tumors, and the like.

The invention discloses application of a bifidobacterium animalis subspecies F1-3-2 in preparation of a medicine for preventing or treating sarcopenia, belongs to the technical field of microorganism application, and provides application of the bifidobacterium animalis subspecies F1-3-2 in preparation of the medicine for preventing or treating sarcopenia. The invention relates to an application of bifidobacterium animalis subspecies F1-3-2 in preparation of a medicine for correcting intestinal flora imbalance caused by sarcopenia. The invention finds that the bifidobacterium animalis subspecies F1-3-2 can effectively improve the skeletal muscle quality of mice with sarcopenia, improve the condition of tension reduction, improve the level of serum markers in sarcopenia, regulate the homeostasis of intestinal flora so as to relieve muscular atrophy, prepare freeze-dried bacterial powder and enrich products for improving sarcopenia.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.

The invention discloses a peripheral blood and CT-based liver transplantation recipient sarcopenia classification method and device, and the method comprises the steps: carrying out the single-factor COX regression preliminary screening of collected peripheral blood biochemical indexes of liver transplantation recipients, and obtaining potential prediction factors related to sarcopenia; performing LASSO regression screening on the potential predictive factors to obtain core predictive factors related to sarcopenia; multiplying each core predictive factor by a regression coefficient calculated in LASSO regression, performing accumulation calculation to obtain an LASSO + COX model score, and dividing liver transplantation recipients into different risk groups according to the size of the LASSO + COX model score; and carrying out definite diagnosis on sarcopenia according to a risk group division result in combination with a CT image examination result. According to the method, a new strategy of peripheral blood prediction preliminary screening and high-risk CT confirmation is realized, the radiation risk, cost and detection threshold are reduced, and the sarcopenia management efficiency is improved.

The invention discloses an integrated flexible probe device combining muscle electrical stimulation and ultrasonic imaging treatment, which is characterized in that an ultrasonic imaging and treatment module is connected with external ultrasonic imaging equipment and ultrasonic treatment equipment, and is used for realizing ultrasonic matching with a part to be imaged and treated and emitting ultrasonic waves; the returned ultrasonic waves are received and transmitted to external ultrasonic imaging equipment and ultrasonic treatment equipment; the electrical stimulation module is connected with an external electrical stimulation circuit and used for emitting electrical stimulation pulses. According to the scheme, after the rigid ultrasonic imaging probe, the ultrasonic treatment piezoelectric ceramic piece array and the electrode layer are integrally arranged and connected with the external ultrasonic imaging device, the ultrasonic treatment device and the external electrical stimulation circuit, the defect of a discrete treatment scheme of an existing device is overcome, visual ultrasonic guidance is achieved, damaged atrophic muscles are accurately positioned, and the treatment efficiency is improved. Real-time ultrasonic monitoring and ultrasonic and electrical stimulation dual treatment effects are achieved, so that accurate and targeted treatment of sarcopenia is achieved, and the treatment effect and the treatment efficiency are improved.

The invention belongs to the technical field of diagnostic model construction, and particularly relates to a diagnostic model for sarcopenia of cardiovascular disease patients and a construction method. Comprising the steps that health related data of a tester are collected, the health related data serve as candidate variables, key factors related to SP are obtained through screening with a multi-dimensional feature selection method, and the key factors comprise continuous variables and classification variables; performing standardization or normalization on the continuous variables to obtain processed continuous variables, and performing One-Hot on the classification variables to obtain processed classification variables; constructing an extreme gradient enhancement model according to the processed continuous variable and the processed classification variable; and performing parameter tuning on the extreme gradient enhancement model by adopting a grid search method in combination with a five-time cross validation method to obtain a diagnosis model. The selected sample has representativeness, and the constructed model is high in diagnosis accuracy.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention provides a multi-modal sarcopenia diagnosis system, method and device and a medium, a technical framework of the multi-modal sarcopenia diagnosis system, method and device integrates multi-modal data integration, a complex neural network technology, a personalized meta-learning algorithm and an interpretable artificial intelligence technology, and aims to create an accurate sarcopenia diagnosis tool with high adaptability. The method not only makes a breakthrough on the basis of a traditional bioelectrical impedance technology, but also shows a huge potential of realizing efficient and personalized diagnosis and monitoring in diversified medical environments through application of multi-modal data fusion and an intelligent model.

The invention discloses ultrasonic response type hydrogel as well as a preparation method and application thereof. According to the ultrasonic response type hydrogel preparation, an ultrasonic triggering threshold value is reduced to 1W / cm < 2 > by utilizing a synergistic anti-inflammatory mechanism that the Mxene enzyme activity is enhanced by ultrasound, muscle heat tolerance is met, and heat loss is avoided. And under the ultrasonic activation condition, the activity of various enzymes of Mxene is increased. Besides, according to the anti-aging multi-mechanism collaborative design, aiming at inflammation-aging-atrophy vicious circle of sarcopenia, ultrasonic enhanced enzyme activity, anti-inflammation, anti-oxidation and anti-aging treatment of sarcopenia is realized for the first time.

The invention discloses a metabolite for treating sarcopenia and application of the metabolite in a health-care product additive, and belongs to the technical field of biomedicine, and the application comprises application of indole-3-formaldehyde in preparation of a medicine for treating sarcopenia. The invention further discloses a health care product additive and a medicine for treating sarcopenia, wherein the medicine comprises indole-3-formaldehyde. According to the present invention, the indole-3-formaldehyde can be adopted as the health product additive or the effective component in the drug, can be used for treating sarcopenia, and can recover the skeletal muscle cell mitochondrial homeostasis so as to improve the muscle cell mitochondrial function index.

The invention relates to a sarcopenia rehabilitation system based on an artificial intelligence large model. Clustering operation is performed according to the initial index information of the patient, and the rehabilitation scheme is generated by taking the patient cluster as a unit, so that the generation efficiency of the initial rehabilitation scheme is improved; in the execution process of the rehabilitation scheme, clustering operation is still carried out in the patient clustering cluster by taking the patient clustering cluster as a unit according to index recovery conditions corresponding to all the patients in the patient clustering cluster; the representative index recovery deviation information corresponding to all the patient clustering sub-clusters in the patient clustering cluster is obtained, whether the rehabilitation schemes corresponding to all the patients in the patient clustering sub-clusters need to be adjusted in a unified mode or not is judged, and the adjustment efficiency of the follow-up rehabilitation schemes is improved. And a new patient cluster is generated by adopting a layer-by-layer progressive sorting mode, so that the uniformity of all patient information is ensured when rehabilitation schemes of all patients in a cluster sub-cluster are uniformly adjusted each time, and the feasibility of rehabilitation scheme adjustment by taking the cluster as a unit is ensured.

The invention relates to the technical field of human body measurement, and discloses a body index evaluation device, method and system. The basic concept is that the body fat rate of a user is calculated according to the waistline and gender of the user; combining the body fat rate with the height and the weight to calculate one or more of fat mass, subcutaneous fat weight, visceral fat weight, visceral fat grade, segmental fat weight, skeletal muscle weight, segmental muscle weight, sarcopenia evaluation, moisture weight, mineral weight, protein weight and cell moisture of the user; the calculation method of the body fat rate is as follows: the male body fat rate is equal to 36.4-((110-waistline) * 0.6), and the female body fat rate is equal to 48-((110-waistline) * 0.6); and the value range of the waistline is 60 to 110 cm. According to the method, accurate data are obtained through calculation, the user can make preliminary body screening in multiple aspects with extremely low cost, and the method can be used for the category of obesity and sarcopenia so as to reduce the cost of screening related diseases by the government.

The present invention relates to a composition for enhancing or protecting muscles, comprising a fermented salmon roe product. According to the present invention, if salmon roe is fermented, the amino acid composition of proteins changes, and the effects of promoting muscle synthesis, inhibiting muscle degradation and damage, and protecting muscles are greatly improved. Therefore, the fermented salmon roe product of the present invention can be applied to food to exhibit effects of enhancing and protecting muscles, and can also be used as a pharmaceutical composition for preventing or treating sarcopenia or amyotrophic diseases through the effects.

The invention discloses an intelligent walking aid training method and device for sarcopenia rehabilitation. The intelligent walking aid training method comprises the steps that grip strength data of a rehabilitation person is collected in real time through a grip strength sensor; collecting pressure data applied to the armrest by the rehabilitation person through a pressure sensor; acquiring real-time image data of a rehabilitation person through a camera module; based on the collected multi-modal data, adaptive damping control, human body posture recognition and fall risk prediction are executed; training parameters are adjusted according to the analysis result, and real-time feedback is provided through a display screen. According to the method, data results recognized by a sensor and an algorithm can be fully utilized, the fall probability of the rehabilitation person can be predicted through an improved Transform structure according to the data, and if the fall probability is larger than a threshold value, the outside world can be reminded to intervene in time.

Provided are compositions comprising, and methods of administering, gene therapy vectors, particularly recombinant AAV vectors encoding AUF1 proteins for expression in muscle cells for restoring or increasing muscle mass, muscle function or performance, and / or reducing or reversing muscle atrophy. The compositions and methods may be used for the treatment of subject suffering from sarcopenia, muscle degenerative disease or traumatic injury.

The present invention relates to activin receptor IIA type variants and methods of use thereof. The present invention features a polypeptide comprising an extracellular ActRIIa variant. In some embodiments, the polypeptides of the present invention comprise an extracellular ActRIIa variant fused to an Fc domain monomer or part. The invention also features the treatment of diseases and conditions involving muscle weakness and atrophy using said polypeptides, such as Duchenne muscular dystrophy, facial shoulder brachial muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; the present invention relates to pharmaceutical compositions and methods for treating a metabolic disease, such as obesity, type 1 diabetes mellitus or type 2 diabetes mellitus.