219 results about "Sarcopenia" patented technology

The invention discloses a sarcopenia risk assessment method based on a knowledge graph, and relates to the field of medical large models. Full-dimensional multi-source data of a patient is collected and preprocessed; defining a six-tuple entity relationship model, introducing a dynamic entity life cycle and heterogeneous relationship type system, and realizing multi-modal feature fusion through modal adaptive weight learning, knowledge conflict resolution and entity evolution embedding; based on an enhanced space-time diagram convolutional network, through heterogeneous relation attention space convolution, space-time adaptive time convolution and triple contrast learning tasks, enhanced entity embedding is output, and the enhanced entity embedding comprises a historical state, a current state, an evolution rate and a future trend. Through multi-modal space-time alignment and enhanced knowledge graph construction, deep fusion of multi-source heterogeneous data and space-time dynamic relationship modeling are realized, and comprehensiveness and accuracy of sarcopenia risk assessment are remarkably improved.

The invention belongs to the field of medical health, and provides a preliminary sarcopenia screening method based on paired foot pressure data, which comprises the following steps: firstly, acquiring foot pressure signals of left and right feet of a subject in a walking process to obtain corresponding foot pressure characteristics of the left and right feet; fusing by adopting a multiplicative combination mode to obtain total pressure characteristics of each walking stage in each walking period; then, a GMM model is adopted to create a plantar pressure mode, plantar pressure mode features are obtained, attention mechanism fusion is adopted to obtain single-cycle fusion pressure mode features and multi-cycle fusion pressure mode features, and time sequence features are obtained through learning of an improved GRU module; and finally, sending the corresponding multi-cycle fusion pressure mode features and the time sequence features into a multi-layer perceptron, and outputting the prediction probability of the sarcopenia. The method fully considers the independence of the left and right foot pressure signal features, introduces the joint relation of the two features, more comprehensively learns the gait features, and effectively improves the accuracy of primary screening of sarcopenia.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.

The invention discloses an integrated flexible probe device combining muscle electrical stimulation and ultrasonic imaging treatment, which is characterized in that an ultrasonic imaging and treatment module is connected with external ultrasonic imaging equipment and ultrasonic treatment equipment, and is used for realizing ultrasonic matching with a part to be imaged and treated and emitting ultrasonic waves; the returned ultrasonic waves are received and transmitted to external ultrasonic imaging equipment and ultrasonic treatment equipment; the electrical stimulation module is connected with an external electrical stimulation circuit and used for emitting electrical stimulation pulses. According to the scheme, after the rigid ultrasonic imaging probe, the ultrasonic treatment piezoelectric ceramic piece array and the electrode layer are integrally arranged and connected with the external ultrasonic imaging device, the ultrasonic treatment device and the external electrical stimulation circuit, the defect of a discrete treatment scheme of an existing device is overcome, visual ultrasonic guidance is achieved, damaged atrophic muscles are accurately positioned, and the treatment efficiency is improved. Real-time ultrasonic monitoring and ultrasonic and electrical stimulation dual treatment effects are achieved, so that accurate and targeted treatment of sarcopenia is achieved, and the treatment effect and the treatment efficiency are improved.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention discloses ultrasonic response type hydrogel as well as a preparation method and application thereof. According to the ultrasonic response type hydrogel preparation, an ultrasonic triggering threshold value is reduced to 1W / cm < 2 > by utilizing a synergistic anti-inflammatory mechanism that the Mxene enzyme activity is enhanced by ultrasound, muscle heat tolerance is met, and heat loss is avoided. And under the ultrasonic activation condition, the activity of various enzymes of Mxene is increased. Besides, according to the anti-aging multi-mechanism collaborative design, aiming at inflammation-aging-atrophy vicious circle of sarcopenia, ultrasonic enhanced enzyme activity, anti-inflammation, anti-oxidation and anti-aging treatment of sarcopenia is realized for the first time.

The invention relates to a sarcopenia rehabilitation system based on an artificial intelligence large model. Clustering operation is performed according to the initial index information of the patient, and the rehabilitation scheme is generated by taking the patient cluster as a unit, so that the generation efficiency of the initial rehabilitation scheme is improved; in the execution process of the rehabilitation scheme, clustering operation is still carried out in the patient clustering cluster by taking the patient clustering cluster as a unit according to index recovery conditions corresponding to all the patients in the patient clustering cluster; the representative index recovery deviation information corresponding to all the patient clustering sub-clusters in the patient clustering cluster is obtained, whether the rehabilitation schemes corresponding to all the patients in the patient clustering sub-clusters need to be adjusted in a unified mode or not is judged, and the adjustment efficiency of the follow-up rehabilitation schemes is improved. And a new patient cluster is generated by adopting a layer-by-layer progressive sorting mode, so that the uniformity of all patient information is ensured when rehabilitation schemes of all patients in a cluster sub-cluster are uniformly adjusted each time, and the feasibility of rehabilitation scheme adjustment by taking the cluster as a unit is ensured.

The present invention relates to a composition for enhancing or protecting muscles, comprising a fermented salmon roe product. According to the present invention, if salmon roe is fermented, the amino acid composition of proteins changes, and the effects of promoting muscle synthesis, inhibiting muscle degradation and damage, and protecting muscles are greatly improved. Therefore, the fermented salmon roe product of the present invention can be applied to food to exhibit effects of enhancing and protecting muscles, and can also be used as a pharmaceutical composition for preventing or treating sarcopenia or amyotrophic diseases through the effects.

The invention discloses an intelligent walking aid training method and device for sarcopenia rehabilitation. The intelligent walking aid training method comprises the steps that grip strength data of a rehabilitation person is collected in real time through a grip strength sensor; collecting pressure data applied to the armrest by the rehabilitation person through a pressure sensor; acquiring real-time image data of a rehabilitation person through a camera module; based on the collected multi-modal data, adaptive damping control, human body posture recognition and fall risk prediction are executed; training parameters are adjusted according to the analysis result, and real-time feedback is provided through a display screen. According to the method, data results recognized by a sensor and an algorithm can be fully utilized, the fall probability of the rehabilitation person can be predicted through an improved Transform structure according to the data, and if the fall probability is larger than a threshold value, the outside world can be reminded to intervene in time.

The invention discloses an early prediction model construction method for senile sarcopenia and metabolic high-risk phenotypes. The method comprises the steps that 3D scanning data, body composition data and health phenotype data of senile patients are acquired, and data preprocessing is carried out; respectively extracting feature vectors of the three types of data after data preprocessing, and performing alignment and weighted fusion to obtain fusion vectors; inputting the fusion vector into a subtype classification model for training to obtain a preliminary prediction model; in the training process of the subtype classification model, an unsupervised learning method and a supervised learning method are adopted at the same time, and a staged freezing strategy and a five-fold cross validation method are adopted; the preliminary prediction model is verified and finely adjusted by using a verification data set prepared in advance, so that a final early prediction model of senile sarcopenia and metabolic high-risk phenotypes is obtained, and accurate diagnosis of sarcopenia and intelligent identification of metabolic high-risk subtypes can be realized through the constructed prediction model.

The invention discloses an icaritin derivative, a composition and application, the structural formula of the icaritin derivative is as follows: in the structural formula, R1 is independently selected from hydrogen, hydroxyl and C1-C3 alkoxy; r2 is independently selected from hydrogen, an isopentenyl group, an isoamyl group and a Mannich base; r3 is independently selected from hydrogen, hydroxyl or OR3 ', R3 'is selected from rhamnosyl, rhamnose-(2-> 1)-glucosyl, rhamnose-(3-> 1)-glucosyl, propynyl and triazole groups substituted by alcoholic hydroxyl, benzyl and glycosyl; r4 is independently selected from a hydroxyl group or OR4 ', and R4' is selected from a propynyl group, a glucosyl group, and an alcoholic hydroxyl group, a benzyl group and a glycosyl substituted triazole group; r5 is independently selected from hydrogen, isopentenyl and Mannich base; mannich base is selected from N (CH3) 2 and N (CH2CH3) 2, R6 is independently selected from hydroxyl and OR6 ', and R6' is selected from hydrogen, rhamnosyl, rhamnose-(2-> 1)-xylosyl and rhamnose-(2-> 1)-rhamnosyl.The icaritin derivative provides a new direction for treatment of sarcopenia.

The invention provides application of desulfurization vibrio in screening of drugs or functional food for preventing and treating sarcopenia. According to the application disclosed by the invention, a main intestinal flora desulfurization vibrio capable of promoting amyotrophy is firstly found, and the desulfurization vibrio can be used as a main target for screening sarcopenia and can be used for screening medicines or functional foods for preventing and treating sarcopenia. Sinopenia susceptible people are screened through abundance of desulfurization vibrio in excrement, and early discovery and targeted early intervention can be carried out; aiming at the mechanism that desulfurization vibrio in intestinal tracts promotes occurrence and development of sarcopenia, drugs or functional food for treating sarcopenia can be further screened, and then substances / new therapy for preventing and treating sarcopenia are developed.

The invention relates to medicine, in particular to gerontology and therapy and can be used for treating sarcopenia in elderly patients.Summary of the invention consists in alternating for 1…2 days the intravenous administration of ozonized 0.9% NaCl solution and major autohemotherapy, namely 500 mL of a 0.9% NaCl solution ozonized with an ozone-oxygen mixture, with an ozone concentration of 5…10 µg / mL, are administered, and major autohemotherapy consists in collecting 300…400 mL of venous blood from the patient, which is ozonized, with an ozone concentration of 15 µg / mL and transfused to the patient, the treatment course includes 8…10 consecutive procedures, then it is extended with minor autohemotherapy, which consists in collecting 5…10 mL of venous blood, which is ozonized, with an ozone concentration of 15 µg / mL and administered intramuscularly every 10th day of alternation and includes 3 consecutive procedures, and the ozonized 0.9% NaCl solution is administered for up to 6…8 weeks.

The application discloses a milk-derived polypeptide VSL for promoting proliferation of skeletal muscle cells and application thereof, and belongs to the field of bioactive peptides. The milk-derived bioactive polypeptide VSL has the effect of promoting proliferation of muscle cells, and is expected to be used for preparing drugs for promoting proliferation of muscle cells and preventing sarcopenia. The milk-derived bioactive polypeptide VSL is convenient to synthesize, can be produced industrially, and has a good application prospect in the fields of food, medicine and cosmetics.

The present disclosure can improve the degree of soy protein proteolysis and the ability to produce valine, isoleucine, and leucine, which are branched-chain amino acids, as well as other amino acids, such as threonine, glycine, tyrosine, and lysine. Accordingly, the present disclosure can prevent sarcopenia and has antioxidant activity. Also, the present disclosure can maintain protein metabolic balance and relieve sarcopenia by muscle synthesis.The self-aggregation, hydrophobicity, and intestinal adhesion of a mixed strain is improved compared to a case where a single strain used for the mixed strain is used. Therefore, when the mixed strain of the present disclosure is ingested, the strain can remain for a long time in the intestine.

This invention discloses a limb muscle rehabilitation device for patients with sarcopenia, including an airbag assembly, a plate assembly connected to the lower part of the airbag assembly, and a support leg assembly connected to the plate assembly. The support leg assembly includes a support leg body and a sleeve located radially outside the support leg body. The upper end of the sleeve is fixedly connected to the plate assembly. The support leg body can move up and down along the inner wall of the sleeve. The lower end of the support leg body extends out of the bottom of the sleeve. A spring is fitted on the outer wall of the support leg body, and an extension is provided on the outer wall of the support leg body. The lower end of the spring abuts against the upper end of the extension. When the support leg body moves upward, it can compress the spring. This invention provides a limb muscle rehabilitation device for patients with sarcopenia, which helps reduce fatigue during exercise and increases rehabilitation exercise time.

The utility model belongs to the field of appliances for helping patients or the disabled to walk, particularly relates to an adjustable protector for rehabilitation training of senile sarcopenia, and aims to solve the problem that an existing rehabilitation training mode is often lack of pertinence and is difficult to meet individual requirements of different patients. In order to solve the problem that in the prior art, in order to solve the problem that in the rehabilitation training process, the elderly patients are prone to being injured due to non-standard actions or too large amplitude, the following scheme is provided that the rehabilitation training device comprises two first fixing plates and two second fixing plates, and the two second fixing plates are located between the two first fixing plates. Through the design of a fixing assembly and an auxiliary assembly, flexible adjustment can be conducted according to the specific situation of a patient, it is ensured that the device can be tightly attached to the knee portion of the patient, personalized rehabilitation training support is provided, through the design of a sliding plate and a second spring, a user is allowed to easily adjust the position of a second rectangular plate according to needs, and the rehabilitation training efficiency is improved. Therefore, the limitation on the rotation angle of the outer protection plate is changed.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of treating a subject having, or at risk of developing, muscular dystrophy, sarcopenia, heart disease, or cachexia are also provided. The methods may include administering a pharmaceutical composition including the micro-dystrophin gene and a delivery vehicle to a subject. Further, the methods may include administering the pharmaceutical composition a subject having Duchenne muscular dystrophy or Becker muscular dystrophy.

1. The name of the design product: Handbag (Sarcopenia and Cardiovascular Disease Research Group Promotion). 2. The use of the design product: For containing articles and hospital sarcopenia and cardiovascular disease research group promotion. 3. The design points of the design product: The combination of shape and pattern. 4. The picture or photo that best indicates the design points: Front view.

The invention discloses a sarcopenia electromyographic signal acquisition and analysis system, and belongs to the technical field of medical detection. The system comprises an electromyographic signal acquisition module, a signal preprocessing module, a feature extraction module, an analysis and diagnosis module and a result output module which are electrically connected in sequence, the electromyographic signal acquisition module adopts a flexible dry electrode array to realize noninvasive and anti-interference acquisition; the signal preprocessing module outputs high-quality electromyographic signals through self-adaptive trapped wave, band-pass filtering and standardization processing; the feature extraction module extracts time domain, frequency domain and nonlinear multi-dimensional features; the analysis and diagnosis module is used for completing low, medium and high three-level risk assessment of sarcopenia and judgment of muscle fiber atrophy type, innervation disorder type and metabolic disorder type decline types on the basis of a deep learning model; and the result output module stores the data and generates an evaluation result. According to the invention, noninvasive, accurate and efficient screening and diagnosis of sarcopenia are realized, a scientific basis is provided for clinical intervention, and the method is suitable for various medical health scenes.

The invention discloses a collagen peptide composition with a function of increasing muscle strength and application of the collagen peptide composition. The collagen peptide composition comprises fish collagen peptide and beef tendon collagen peptide. A mouse senescence sarcopenia model is constructed, then a collagen peptide composition is used for intragastric intervention, and the improvement effect is evaluated through behavioral testing, body component analysis and HE staining. The potential target and regulatory pathway of the collagen peptide composition are explored by combining network pharmacology and molecular docking. Results show that the four-limb grip strength, treadmill exhaustion time and movement distance of a model mouse can be remarkably improved, quadriceps femoris muscle and gastrocnemius muscle indexes are recovered, and muscle fiber atrophy and collagen deposition are relieved. And it is found that TNF, IL1B, AKT1, mTOR and MAPK1 may be core targets of the TNF, IL1B, AKT1, mTOR and MAPK1. The polypeptide plays a role by regulating and controlling biological processes such as MAPK cascade, protein processing and inflammatory reaction, cell apoptosis, a cAMP pathway and a calcium signal pathway.

The invention provides a muscle mass evaluation method and system, and relates to the technical field of medical imaging, and the method comprises the steps: carrying out the ultrasonic scanning of human limbs, collecting an ultrasonic total scattering signal, and obtaining an ultrasonic image; acquiring a muscle structure image according to the ultrasonic image; performing segmentation processing on the muscle structure image to obtain contour information of a target muscle; and calculating the cross-sectional area and volume of the target muscle based on the contour information. According to the invention, the annular probe performs three-dimensional spiral scanning in the scanning process, and simultaneously obtains spatial information in the horizontal and vertical directions; echo signals are processed by adopting a delay superposition beam forming algorithm, and image segmentation is carried out in combination with a deep learning technology. According to the invention, radiation-free, high-precision, low-cost and portable muscle mass measurement is realized, and the method is especially suitable for evaluation, screening and monitoring of sarcopenia.

The present invention relates to methods and materials for treating GNE-related disorders such as GNE myopathy, GNE-dependent ALS, thrombocytopenia, sarcopenia and aging using a dual gene recombinant adeno-associated virus comprising the GNE gene and the follistatin gene. This therapy is unique in that it can rebuild lost muscle strength at the same time that it prevents subsequent muscle disease from occurring.

The present invention relates to a composition for diagnosing sarcopenia, and the like, and was completed by discovering biomarkers enabling the diagnosis of sarcopenia with high accuracy and sensitivity through qualitative and quantitative analysis of the proteome of a sarcopenia animal model. In particular, the biomarkers according to the present invention were confirmed to have a positive or negative correlation with sarcopenia-related indicators such as muscle mass, grip strength, rotarod score, and inverted strength. Therefore, instead or in addition to conventional methods that have relied on the measurement of muscle mass and muscle function, through molecular diagnosis using the markers of the present invention, it is possible to diagnose sarcopenia, and furthermore, it is also possible to determine the severity of sarcopenia through the association of the markers with muscle function. In particular, biomarkers which show consistent correlations with sarcopenia indicators are also expected to be applicable as targets for the treatment of sarcopenia. Furthermore, since sarcopenia is a disease closely related to aging, the biomarkers according to the present invention are expected to be the basis for securing of anti-aging treatment targets and the development of aging control technologies.

The invention discloses a fracture risk prediction method and system, and relates to the technical field of health management. According to the prediction method, serious sarcopenia is selected to diagnose and assess the sarcopenia state, the ratio of monocytes to lymphocytes reflects the immune inflammation level, the prediction model is constructed in combination with the femoral neck bone mineral density T value, and the fracture risk influence factors are comprehensively covered; and the risk identification capability on special high-risk groups with sarcopenia, immune dysfunction and the like is effectively improved. And secondly, only three target independent variables are selected, and the three target independent variables are indexes which can be directly obtained or simply calculated in clinical routine examination, so that the data collection difficulty is greatly reduced. Meanwhile, the prediction model is visualized through a column diagram, complex calculation is not needed, a clinician can quickly inquire the fracture risk score through the actual value of the target subject, and the method is suitable for being efficiently applied to conventional outpatient service, hospitalization and other scenes.

The invention develops a sarcopenia prediction system for an adult group. The sarcopenia prediction method comprises the following steps: determining a crowd range and a standard included in the prediction system; determining a sarcopenia diagnosis standard and collecting outcomes in the target population; selecting a tree-based machine learning model according to the data features; screening the features by using a Boruta algorithm to construct a first set of screening model with high recall rate; screening features by using a pre-SHAP analysis method to construct a second set of auxiliary models for balancing the recall rate and the accuracy rate; optimal models of the system are determined by comparing model performance parameters, and finally prediction is achieved by combining the models. Features used by the system only depend on basic demographic features and physical activity questionnaires without clinical indexes, meanwhile, high performance is achieved in a model parallel connection mode, and the system is suitable for early screening detection of sarcopenia.

The application belongs to the technical field of biotechnology, and particularly relates to application of albumin polypeptide gel beads in a product for treating or preventing sarcopenia. Egg white protein is used as raw material to extract protein, and albumin dipeptide-based peptidase-IV inhibitory peptide is prepared through a biological enzymolysis method. Bioinformatics analysis is used to screen out the inhibitory peptide TPYMFP, and the IC50 value of the inhibitory peptide TPYMFP for dipeptide-based peptidase-IV reaches 3.12 ± 0.49 mmol / L. Further, the optimal preparation conditions of sodium alginate SA and carboxymethyl chitosan CMCS-based gel beads CMCS / SA / TPYMFP are explored. When the SA concentration is 1.5% (w / v), the CMCS concentration is 0.5% (w / v), and the CaCl2 concentration is 1% (w / v), the polypeptide encapsulation rate is increased to 98.26% ± 0.25%. It is verified that the albumin polypeptide gel beads have good pH response characteristics, and efficient protection and intestinal target delivery of the sarcopenia inhibitory peptide are realized. The albumin polypeptide gel beads are applied to preparation of a product for treating or preventing sarcopenia, or in preparation of a related product for increasing muscle mass and strength.

The present invention relates a pharmaceutical composition for alleviation, treatment, and prevention of sarcopenia, including, as an active ingredient, a microorganism transformed with a cell surface display vector operably linked with a gene encoding myostatin and activin A proteins.