Integrated flexible probe device combining muscle electrical stimulation and ultrasonic imaging treatment

Abstract

The invention discloses an integrated flexible probe device combining muscle electrical stimulation and ultrasonic imaging treatment, which is characterized in that an ultrasonic imaging and treatment module is connected with external ultrasonic imaging equipment and ultrasonic treatment equipment, and is used for realizing ultrasonic matching with a part to be imaged and treated and emitting ultrasonic waves; the returned ultrasonic waves are received and transmitted to external ultrasonic imaging equipment and ultrasonic treatment equipment; the electrical stimulation module is connected with an external electrical stimulation circuit and used for emitting electrical stimulation pulses. According to the scheme, after the rigid ultrasonic imaging probe, the ultrasonic treatment piezoelectric ceramic piece array and the electrode layer are integrally arranged and connected with the external ultrasonic imaging device, the ultrasonic treatment device and the external electrical stimulation circuit, the defect of a discrete treatment scheme of an existing device is overcome, visual ultrasonic guidance is achieved, damaged atrophic muscles are accurately positioned, and the treatment efficiency is improved. Real-time ultrasonic monitoring and ultrasonic and electrical stimulation dual treatment effects are achieved, so that accurate and targeted treatment of sarcopenia is achieved, and the treatment effect and the treatment efficiency are improved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of ultrasonic and electric pulse probe, and particularly relates to a flexible probe device integrating compound muscle electric stimulation and ultrasonic imaging treatment. BACKGROUND

[0002] Sarcopenia is a comprehensive degenerative sign characterized by reduction of skeletal muscle fiber volume and quantity, muscle strength, increase of connective tissue and fat, etc. The prevalence rate thereof increases rapidly with age, and the prevalence rate among disabled and hospitalized patients is also very high. Therefore, sarcopenia is a major health problem faced by the elderly and hospitalized patients in China at present and in the future. Exploring the best diagnosis and treatment means of sarcopenia, and realizing early detection, accurate diagnosis and active treatment are the keys to improve and enhance the quality of life and survival rate of patients.

[0003] Neuromuscular electric stimulation and phased focused pulse ultrasonic both have the effects of promoting muscle tissue regeneration, improving muscle atrophy and enhancing muscle function, and are important treatment means for rehabilitation treatment of sarcopenia. The combination of the two can enhance the treatment effect and shorten the treatment time and rehabilitation course. Meanwhile, combined with high-frequency continuous wave ultrasonic diagnosis technology, visual ultrasonic guidance can accurately locate the damaged atrophic muscle and monitor the treatment effect in real time, so as to realize accurate and targeted treatment of sarcopenia and improve the treatment effect and efficiency. Therefore, the neuromuscular electric stimulation combined with phased focused pulse ultrasonic under visual ultrasonic guidance becomes a high-efficiency, accurate and safe treatment method for sarcopenia.

[0004] Therefore, it is necessary to develop an ultrasonic imaging and treatment integrated flexible probe for compound muscle electric stimulation treatment, so as to realize the integration of ultrasonic accurate guidance and electric / ultrasonic three-mode compound physiotherapy and the interface of human body action. SUMMARY

[0005] In view of the above problems, the purpose of the present application is to provide a flexible probe device integrating compound muscle electric stimulation and ultrasonic imaging treatment, which realizes good acoustic matching design through integrated structure design and combination of flexible matching layer and rigid matching layer, realizes the integrated requirements of ultrasonic imaging, ultrasonic treatment and electric stimulation treatment, meets the acoustic matching between the probe and the human body and good electric stimulation output, and makes the probe and the skin well adhere.

[0006] The specific technical scheme for realizing the purpose of the present application is as follows:

[0007] A flexible probe device integrating compound muscle electric stimulation and ultrasonic imaging treatment, comprising an ultrasonic imaging and treatment module and an electric stimulation module.

[0008] The ultrasonic imaging and treatment module is connected with the external ultrasonic imaging device and ultrasonic treatment device, used for realizing ultrasonic matching with the part to be imaged and treated, emitting ultrasonic waves, receiving returned ultrasonic waves and transmitting to the external ultrasonic imaging device and ultrasonic treatment device.

[0009] The electric stimulation module is connected with the external electric stimulation circuit, used for emitting electric stimulation pulses.

[0010] Further, the electric stimulation module comprises an electrode layer.

[0011] The electrode layer is a "hui" type electrode with two pieces of positive and negative electrodes separated in the middle, and leads are drawn out and connected with the external electric stimulation circuit to receive electric pulses generated by the external electric stimulation circuit and output.

[0012] Further, the ultrasonic imaging and treatment module comprises a flexible matching layer, a piezoelectric composite layer and a double-layer flexible circuit layer.

[0013] The flexible matching layer, the piezoelectric composite layer and the double-layer flexible circuit layer are connected in sequence.

[0014] The double-layer flexible circuit layer is used for connecting the piezoelectric composite layer with the external ultrasonic imaging device and ultrasonic treatment device.

[0015] The flexible matching layer and the piezoelectric composite layer cooperate to realize acoustic impedance matching between the probe device and the part to be acted on.

[0016] Further, the piezoelectric composite layer comprises an ultrasonic imaging probe and ultrasonic treatment piezoelectric ceramic pieces.

[0017] The ultrasonic imaging probe and the ultrasonic treatment piezoelectric ceramic pieces are arranged on the piezoelectric composite layer substrate.

[0018] A plurality of the ultrasonic treatment piezoelectric ceramic pieces are arranged in an array form, and the ultrasonic imaging probe is arranged at the center of the array.

[0019] A double-layer rigid acoustic matching layer is spin-coated on the ultrasonic treatment piezoelectric ceramic pieces.

[0020] The double-layer rigid acoustic matching layer spin-coated on the ultrasonic treatment piezoelectric ceramic pieces and the flexible matching layer together realize acoustic impedance matching with the part to be acted on.

[0021] Further, the acoustic impedance of the double-layer rigid acoustic matching layer and the flexible matching layer is set as: ; ; ;

[0022] ; is the acoustic impedance of the piezoelectric ceramic piece, the acoustic impedance of the first layer of rigid acoustic matching layer spin-coated under the ultrasonic treatment piezoelectric ceramic sheet, the acoustic impedance of the first layer of rigid acoustic matching layer spin-coated under the ultrasonic treatment piezoelectric ceramic sheet, the acoustic impedance of the second layer of rigid acoustic matching layer spin-coated under the ultrasonic treatment piezoelectric ceramic sheet, the acoustic impedance of the flexible matching layer.

[0023] Further, the double-layer flexible circuit layer comprises a positive flexible island-bridge circuit layer and a negative flexible island-bridge circuit layer;

[0024] The negative flexible island-bridge circuit layer is used to connect the ultrasonic treatment piezoelectric ceramic sheet with the negative pole of the external ultrasonic treatment device.

[0025] The positive flexible island-bridge circuit layer comprises an ultrasonic treatment positive pole circuit, an ultrasonic imaging positive pole circuit and an ultrasonic imaging negative pole circuit, the ultrasonic treatment positive pole circuit connects the ultrasonic treatment piezoelectric ceramic sheet with the positive pole of the external ultrasonic treatment device, and the ultrasonic imaging positive pole circuit and the ultrasonic imaging negative pole circuit connect the probe device with the positive and negative poles of the external ultrasonic imaging device.

[0026] Further, the electrodes of the electrode layer are cast by taking graphene as a filler and PDMS as a base material.

[0027] The preparation process of the electrode layer electrode is as follows:

[0028] (1) Add anhydrous ethanol in a test tube and perform ultrasonic cleaning, and clean after cleaning;

[0029] (2) Prepare a glass tube liquid, take graphene to the glass tube to reach the required mass, and add a diluent in a proportion of 1:10, and place the prepared glass tube liquid in an ultrasonic instrument for ultrasonic mixing;

[0030] (4) Prepare a test tube liquid, and the graphene glass tube liquid needs to correspond to two bottles of test tube liquid, which are referred to as ab tubes below, wherein a tube is a mixture of PDMS and cyclohexane in a proportion of 1:1, and b tube is a mixture of a curing agent and cyclohexane in a proportion of 1:1, and the amount of each is 10% of PDMS, and after the test tube liquid is prepared, it is placed on a jog mixer for jog mixing;

[0031] (4) After the ab test tube liquid is mixed and the glass tube liquid is ultrasonically mixed, first add the a tube liquid to the glass tube for magnetic stirring, and then add the b tube liquid to the glass tube for continuous magnetic stirring;

[0032] (5) Drop the liquid in the glass tube into a mold and stand still to complete the electrode preparation.

[0033] Further, the flexible matching layer is prepared by spin coating with alumina as filler and PDMS as base material, the acoustic impedance of the flexible matching layer is 2-3 MRayl, and the thickness of the flexible matching layer (2) is , is an ultrasonic wavelength.

[0034] Further, the preparation process of the flexible matching layer is as follows:

[0035] (1) add anhydrous ethanol in a test tube and perform ultrasonic cleaning;

[0036] (2) determine the mass of each component of PDMS, cyclohexane and curing agent according to the proportion;

[0037] (3) take alumina into the test tube to reach the required mass;

[0038] (4) take a small amount of PDMS into the test tube for multiple times to reach the required mass;

[0039] (5) take a small amount of cyclohexane and curing agent into the test tube for multiple times in sequence to reach the required mass;

[0040] (6) point the test tube and mix for 8 minutes;

[0041] (7) drop the liquid in the test tube into a mold, place and heat to solidify, and stand still to complete the preparation of the flexible matching layer (2).

[0042] Compared with the prior art, the present application has the following advantages:

[0043] (1) The rigid ultrasonic imaging probe, ultrasonic treatment piezoelectric ceramic sheet array and electrode layer are integrated in the present application, and after being connected with external ultrasonic imaging equipment, ultrasonic treatment equipment and external electric stimulation circuit, the defects of the existing separate treatment scheme are overcome, visual ultrasonic guidance is realized, damaged atrophic muscles are accurately positioned, real-time ultrasonic monitoring and ultrasonic and electric stimulation double treatment effect are realized, so that precise and targeted treatment of sarcopenia is realized, and treatment effect and treatment efficiency are improved.

[0044] (2) In the present application, most of the materials are composed of flexible material polydimethylsiloxane (PDMS), and the acoustic impedance matching with the affected part is realized by the designed double-layer rigid acoustic matching layer and flexible matching layer together, the dynamic adaptation, long-time fitting and efficient acoustic coupling to the curved surface of the affected part are realized, the traditional liquid couplant required by the existing ultrasonic equipment is replaced, and problems such as frequent replacement caused by long-term use and wound infection caused by the use of traditional liquid couplant are avoided.

[0045] The present application will be further described in conjunction with the specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0046] Figure 1 Structure diagram of the flexible probe device of the integrated composite muscle electrical stimulation and ultrasound imaging treatment of the present application.

[0047] Figure 2 Schematic diagram of the electrode layer of the present application.

[0048] Figure 3 Schematic diagram of the piezoelectric composite layer of the present application.

[0049] Figure 4 Schematic diagram of the piezoelectric ceramic and the double-layer rigid ultrasound matching layer in the piezoelectric composite layer of the present application.

[0050] Figure 5 Schematic diagram of the positive flexible island-bridge circuit layer of the present application.

[0051] Figure 6 Schematic diagram of the through-hole connection between the positive flexible island-bridge circuit layer and the piezoelectric composite layer in the embodiment of the present application.

[0052] Figure 7 Schematic diagram of the negative flexible island-bridge circuit layer of the present application.

[0053] Figure 8 Schematic diagram of the through-hole connection between the negative flexible island-bridge circuit layer and the piezoelectric composite layer in the embodiment of the present application.

[0054] Figure 9 Schematic diagram of the connection between the probe device and the action site in the embodiment of the present application.

[0055] Figure 10 Schematic diagram of the connection between the probe device and the external electrical stimulation circuit and the ultrasound equipment in the embodiment of the present application. DETAILED DESCRIPTION

[0056] EMBODIMENT

[0057] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. The described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0058] As shown in the present application and claims, unless the context clearly indicates otherwise, the words “one”, “a”, “an”, and / or “the” do not refer to the singular, but also include the plural, unless the context clearly indicates otherwise. Generally speaking, the terms “comprise” and “include” only indicate the inclusion of the steps and elements explicitly identified, and these steps and elements do not constitute an exclusive list, and the method or device can also include other steps or elements.

[0059] Unless otherwise specifically stated, the relative arrangement of the parts and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present application. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to actual proportional relationships. The techniques, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods and equipment should be considered as part of the authorization specification. In all examples shown and discussed here, any specific values ​​should be interpreted as being merely exemplary and not as limitations. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.

[0060] Combine Figure 1 , an integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy, including an ultrasound imaging and therapy module and an electrical stimulation module;

[0061] The ultrasonic imaging and treatment module is connected to an external ultrasonic imaging device and an ultrasonic treatment device to achieve ultrasonic matching with the part to be imaged and treated, emit ultrasonic waves, receive returned ultrasonic waves, and transmit them to the external ultrasonic imaging device and ultrasonic treatment device. The ultrasonic imaging and treatment module and the electrical stimulation module are bonded sequentially from top to bottom, and the entire structure is encapsulated by PDMS.

[0062] The electrical stimulation module is connected to an external electrical stimulation circuit and is used to emit electrical stimulation pulses;

[0063] In this embodiment, the ultrasound imaging and treatment module is connected to the external ultrasound imaging device and ultrasound treatment device via wires, and the electrical stimulation module is also connected to the external electrical stimulation circuit via wires.

[0064] Combine Figure 2 , the electrical stimulation module includes an electrode layer 1;

[0065] The electrode layer 1 is composed of two positive and negative U-shaped electrodes separated in the middle, and copper wires are led out to connect to the external electrical stimulation circuit respectively, to receive and output the electrical pulses generated by the external electrical stimulation circuit.

[0066] The ultrasonic imaging and treatment module includes a flexible matching layer 2, a piezoelectric composite layer 3 and a double-layer flexible circuit layer;

[0067] The flexible matching layer 2, the piezoelectric composite layer 3 and the double-layer flexible circuit layer are bonded in sequence from bottom to top;

[0068] The double-layer flexible circuit layer is used to connect the piezoelectric composite layer 3 with external ultrasonic imaging equipment and ultrasonic treatment equipment.

[0069] The flexible matching layer 2 and the piezoelectric composite layer 3 cooperate to realize acoustic impedance matching of the probe device and the part to be acted on.

[0070] Specifically, in combination with Figure 3 , the piezoelectric composite layer 3 includes an ultrasonic imaging probe 3.1 and an ultrasonic treatment piezoelectric ceramic sheet 3.2.

[0071] The ultrasonic imaging probe 3.1 and the ultrasonic treatment piezoelectric ceramic sheet 3.2 are arranged on the piezoelectric composite layer 3 substrate, i.e., PDMS.

[0072] A plurality of the ultrasonic treatment piezoelectric ceramic sheets 3.2 are arranged in an array form, and the ultrasonic imaging probe 3.1 is arranged at the center of the array. In the embodiment, the ultrasonic treatment piezoelectric ceramic sheets 3.2 are 64 in total and are arranged in an 8X8 array form, and the ultrasonic imaging probe 3.1 is arranged at the center position of the array.

[0073] In combination with Figure 4 , a double-layer rigid acoustic matching layer is spin-coated on the ultrasonic treatment piezoelectric ceramic sheet 3.2, and the hollow slot between the layers is filled with perfusion PDMS.

[0074] The double-layer rigid acoustic matching layer spin-coated on the ultrasonic treatment piezoelectric ceramic sheet 3.2 and the flexible matching layer (2) together realize acoustic impedance matching with the part to be acted on.

[0075] According to the KLM model, the acoustic impedance of the double-layer rigid acoustic matching layer and the flexible matching layer is set as:

[0076]

[0077]

[0078]

[0079] wherein, is the acoustic impedance of the piezoelectric ceramic sheet, is the acoustic impedance of the part to be acted on, is the acoustic impedance of the first layer of rigid acoustic matching layer spin-coated below the ultrasonic treatment piezoelectric ceramic sheet, is the acoustic impedance of the second layer of rigid acoustic matching layer spin-coated below the ultrasonic treatment piezoelectric ceramic sheet, is the acoustic impedance of the flexible matching layer.

[0080] In the embodiment, the value is , the value is , The value is Due to experimental manufacturing errors, The acoustic impedance can be in the range of 10 MRayl-11 MRayl, The acoustic impedance can be in the range of 4 MRayl-5 MRayl, The acoustic impedance can be in the range of 2 MRayl-3 MRayl.

[0081] In addition, the piezoelectric composite layer 3 in this embodiment adopts 1-3 type PZT / epoxy resin piezoelectric composite material as the ultrasonic transducer unit material, and the two layers of rigid matching layers are composite materials of epoxy resin and aluminum oxide.

[0082] In combination Figures 5 to 8 , the double-layer flexible circuit layer includes a positive flexible island-bridge circuit layer 4 and a negative flexible island-bridge circuit layer 5; the double-layer flexible circuit layer includes the positive flexible island-bridge circuit layer 4 and the negative flexible island-bridge circuit layer 5 which are connected with the piezoelectric composite layer 3 through the through holes arranged, and the double-layer flexible circuit layer includes the positive flexible island-bridge circuit layer 4 and the negative flexible island-bridge circuit layer 5 which are also connected with the ultrasonic imaging probe 3.1 respectively;

[0083] The negative flexible island-bridge circuit layer 5 is used to connect the ultrasonic treatment piezoelectric ceramic sheet 3.2 with the negative pole of the external ultrasonic treatment device.

[0084] The positive flexible island-bridge circuit layer 4 includes an ultrasonic treatment positive circuit 4.1, an ultrasonic imaging positive circuit 4.3 and an ultrasonic imaging negative circuit 4.4, the ultrasonic treatment positive circuit 4.1 connects the ultrasonic treatment piezoelectric ceramic sheet 3.2 with the positive pole of the external ultrasonic treatment device, and the ultrasonic imaging positive circuit 4.3 and the ultrasonic imaging negative circuit 4.4 connect the probe device with the positive and negative poles of the external ultrasonic imaging device.

[0085] The composite flexible probe of the scheme integrates ultrasonic imaging and treatment of the composite muscle electric stimulation treatment, so that the ultrasonic imaging probe, the ultrasonic treatment piezoelectric ceramic sheet array and the electric stimulation electrode are combined together and independently driven, and are cooperated with each other during use, so as to not only realize the good piezoelectric performance of the wide-band ultrasonic imaging and ultrasonic treatment, but also realize the good electric conduction output of the electric stimulation treatment.

[0086] In addition, except that the ultrasonic imaging probe and the ultrasonic treatment piezoelectric ceramic sheet array are rigid, all other parts adopt flexible polydimethylsiloxane (PDMS) or composite material with PDMS as the base (without changing the flexibility of PDMS), so that the probe has good flexibility and can be adaptively attached to the leg with different bending curvatures, can be better attached to the skin by the pressure applied by the outer side band in actual operation, and can effectively and accurately complete the treatment of the sarcopenia patient.

[0087] In addition, in the embodiment, the electrode of the electrode layer 1 is casted by 25% graphene as filler and PDMS as base material, and the resistance value of the electrode is 0.2kΩ-1kΩ, and the thickness of the electrode is 0.1cm-0.2cm;

[0088] The preparation process of the electrode of the electrode layer 1 is as follows:

[0089] (1) Add anhydrous ethanol in a test tube, and clean with a dust-free cloth after ultrasonic cleaning for 15 minutes;

[0090] (2) Calculate the mass of each component according to the proportion. Put on gloves, open the electronic balance, and then zero the weight after placing the disposable glass tube on the electronic balance. Then, prepare the glass tube liquid, take graphene to the glass tube to reach the required mass, and add diluent according to the proportion of 1:10 (in actual experiments, usually add diluent according to the proportion of 1:15 or higher, and the standard is that the diluent is higher than the graphene). After preparing the glass tube liquid, put it into the ultrasonic instrument for ultrasonic mixing for 1h, and change the water every 10 minutes or so;

[0091] (4) Prepare the test tube liquid. The graphene glass tube liquid needs to correspond to two bottles of test tube liquid (take 2g PDMS as an example). The following is referred to as ab tube, in which a tube is a mixture of PDMS and cyclohexane in a proportion of 1:1, and b tube is a mixture of curing agent and cyclohexane in a proportion of 1:1. The amount of each is 10% of PDMS. After preparing the test tube liquid, put it into the point-to-point mixing machine for point-to-point mixing, and take 8-10 minutes as the reference;

[0092] (4) After the ab tube test tube liquid is mixed and the glass tube liquid is ultrasonically mixed, first add the a tube liquid to the glass tube for magnetic stirring for 1h, and then add the b tube liquid to the glass tube for magnetic stirring for 0.5h. The stirring speed is 1500rpm at room temperature (the time can be extended);

[0093] (5) Drop the liquid in the glass tube into the mold and stand for 1-2 days to complete the electrode preparation.

[0094] The flexible matching layer 2 is prepared by spin coating 25% alumina as filler and PDMS as base material. The acoustic impedance of the flexible matching layer 2 is 2MRayl-3MRayl, and the thickness of the flexible matching layer 2 is , the wavelength of the ultrasonic wave.

[0095] The preparation process of the flexible matching layer 2 is as follows:

[0096] (1) Add anhydrous ethanol in a test tube, and clean with a dust-free cloth after ultrasonic cleaning for 15 minutes;

[0097] (2) Determine the mass of each component of PDMS, cyclohexane and curing agent according to the proportion (PDMS:cyclohexane:curing agent is 1:1:0.2).

[0098] (3) Take the alumina to the test tube to reach the required quality;

[0099] (4) A small number of multiple suction PDMS to the test tube to reach the required quality;

[0100] (5) In turn, a small number of multiple suction cyclohexane, curing agent to the test tube to reach the required quality;

[0101] (6) The test tube is point to mix evenly for 8 minutes;

[0102] (7) The liquid in the test tube is dropped into the mold, and the heating platform is placed to solidify at 100 degrees Celsius, and the preparation is completed after standing for 1-2 days.

[0103] The double-layer flexible circuit layer is first prepared by respectively making a PDMS film with a through hole corresponding to the positive and negative poles of the ultrasonic therapy piezoelectric ceramic sheet and the positive and negative poles of the ultrasonic imaging probe, then spraying a target circuit pattern and filling the through hole on the PDMS film by electrofluid jet printing technology, sintering, keeping at 85°C for 30 minutes, keeping at 160°C for 10 minutes, keeping at 280°C for 10 minutes, and keeping at 350°C for 10 minutes, and then pouring a layer of PDMS film with a through hole corresponding to the negative pole of the ultrasonic therapy piezoelectric ceramic sheet, continuing to spray the second layer of circuit and fill the through hole, and heating and curing after spraying is completed.

[0104] The preparation process of the integrated flexible probe device for composite muscle electrical stimulation and ultrasonic imaging treatment is as follows: the positive and negative pole leads connected to the external electrical stimulation driving are placed in the mold, the electrode layer 1 is poured and cured, and then the flexible matching layer 2 is poured, the ultrasonic imaging probe 3.1 and the ultrasonic therapy piezoelectric ceramic sheet 3.2 array with double-layer rigid acoustic matching layer on the bottom are placed after the flexible matching layer 2 is poured, the interlayer hollow slot is filled with PDMS, and the positive and negative poles of the ultrasonic imaging probe 3.1 and the ultrasonic therapy piezoelectric ceramic sheet 3.2 array with double-layer rigid acoustic matching layer on the bottom are exposed;

[0105] The mold corresponding to the through hole is placed at the positive and negative poles, PDMS is poured, and after curing is completed, the circuit pattern sprayed on the PDMS film by electrofluid jet printing technology is sintered, the lead wire is welded with the circuit pattern after sintering is completed, a layer of PDMS is poured by fixing and placing the through hole mold, the second layer of circuit is continuously sprayed, and the copper lead wire of the ultrasonic imaging and treatment module and the electrode layer is welded with the circuit pattern after heating and curing.

[0106] Test the on-off of the circuit, confirm that it is good, and then package with PDMS, and lead out the copper lead wire of the ultrasonic imaging and treatment module and the electrode layer.

[0107] As Figure 9and Figure 10 As shown in the figure, the probe device with complete electrical connection is bound on the thigh of a person, so that the functions of ultrasonic imaging monitoring, ultrasonic treatment and electrical stimulation treatment can be realized.

[0108] The above-mentioned embodiments only express several implementation manners of the application, and the description is relatively specific and detailed, but it should not be understood as a limitation on the patent scope of the application. It should be pointed out that, for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the application, and these all belong to the protection scope of the application. Therefore, the protection scope of the patent of the application should be subject to the appended claims.

Claims

1. An integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy, characterized in that: Includes ultrasound imaging and treatment module and electrical stimulation module; The ultrasonic imaging and treatment module is connected to an external ultrasonic imaging device and an ultrasonic treatment device, and is used to achieve ultrasonic matching with the part to be imaged and treated, emit ultrasonic waves, receive returned ultrasonic waves and transmit them to the external ultrasonic imaging device and ultrasonic treatment device; The electrical stimulation module is connected to an external electrical stimulation circuit and is used to emit electrical stimulation pulses.

2. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 1, characterized in that: The electrical stimulation module comprises an electrode layer (1); The electrode layer (1) is composed of two positive and negative U-shaped electrodes separated in the middle, and leads are respectively connected to an external electrical stimulation circuit to receive and output electrical pulses generated by the external electrical stimulation circuit.

3. The integrated flexible probe device for composite muscle electrical stimulation and ultrasound imaging therapy according to claim 1, wherein the ultrasound imaging and therapy module comprises a flexible matching layer (2), a piezoelectric composite layer (3) and a double-layer flexible circuit layer; The flexible matching layer (2), the piezoelectric composite layer (3) and the double-layer flexible circuit layer are connected in sequence; in, The double-layer flexible circuit layer is used to connect the piezoelectric composite layer (3) with external ultrasonic imaging equipment and ultrasonic treatment equipment; The flexible matching layer (2) and the piezoelectric composite layer (3) cooperate to achieve acoustic impedance matching between the probe device and the part to be acted on.

4. The integrated flexible probe device for composite muscle electrical stimulation and ultrasound imaging therapy according to claim 3, wherein the piezoelectric composite layer (3) comprises an ultrasound imaging probe (3.1) and an ultrasound therapy piezoelectric ceramic sheet (3.2); The ultrasonic imaging probe (3.1) and the ultrasonic therapeutic piezoelectric ceramic sheet (3.2) are arranged on a piezoelectric composite layer (3) substrate; A plurality of the ultrasonic therapeutic piezoelectric ceramic sheets (3.2) are arranged in an array, and the ultrasonic imaging probe (3.1) is arranged at the center of the array; A double-layer rigid acoustic matching layer is spin-coated on the ultrasonic treatment piezoelectric ceramic sheet (3.2); The double-layer rigid acoustic matching layer and the flexible matching layer (2) spin-coated on the ultrasonic treatment piezoelectric ceramic sheet (3.2) together achieve acoustic impedance matching with the site to be acted on.

5. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 4, wherein the acoustic impedance of the double-layer rigid acoustic matching layer and the flexible matching layer is set to: ； ； ； in, is the acoustic impedance of the piezoelectric ceramic, is the acoustic impedance of the target site, The acoustic impedance of the first rigid acoustic matching layer spin-coated under the ultrasonic treatment piezoelectric ceramic sheet is The acoustic impedance of the second rigid acoustic matching layer spin-coated under the ultrasonic treatment piezoelectric ceramic sheet is is the acoustic impedance of the flexible matching layer.

6. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 4, wherein the double-layer flexible circuit layer comprises a positive flexible island-bridge circuit layer (4) and a negative flexible island-bridge circuit layer (5); in, The negative electrode flexible island-bridge circuit layer (5) is used to connect the ultrasonic therapeutic piezoelectric ceramic sheet (3.2) to the negative electrode of an external ultrasonic therapeutic device; The positive electrode flexible island-bridge circuit layer (4) includes an ultrasonic treatment positive electrode circuit (4.1), an ultrasonic imaging positive electrode circuit (4.3) and an ultrasonic imaging negative electrode circuit (4.4). The ultrasonic treatment positive electrode circuit (4.1) connects the ultrasonic treatment piezoelectric ceramic sheet (3.2) to the positive electrode of an external ultrasonic treatment device, and the ultrasonic imaging positive electrode circuit (4.3) and the ultrasonic imaging negative electrode circuit (4.4) connect the probe device to the positive and negative electrodes of the external ultrasonic imaging device.

7. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 2, characterized in that: The electrodes of the electrode layer (1) are cast with graphene as filler and PDMS as base material. The preparation process of the electrode layer (1) is as follows: (1) Add anhydrous ethanol to the test tube and perform ultrasonic cleaning. Clean after cleaning. (2) Prepare the glass tube liquid, take graphene to the glass tube to reach the required mass, add diluent at a ratio of 1:10, and put the prepared glass tube liquid into the ultrasonic instrument for ultrasonic mixing; (4) Prepare the test tube liquid. The graphene glass tube liquid needs to correspond to two bottles of test tube liquid, hereinafter referred to as ab tubes. Tube a is a mixture of PDMS and cyclohexane in a ratio of 1:1, and tube b is a mixture of curing agent and cyclohexane in a ratio of 1:

1. The dosage of both is 10% PDMS. After the test tube liquid is prepared, put it on a jog mixer for jog mixing; (4) After the liquids in tubes a and b are mixed and the liquid in the glass tube is ultrasonically mixed, first add the liquid in tube a to the glass tube for magnetic stirring, then add the liquid in tube b to the glass tube and continue magnetic stirring; (5) Drop the liquid in the glass tube into the mold and let it stand to complete the electrode preparation.

8. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 3, characterized in that: The flexible matching layer (2) is formed by spin coating with alumina as filler and PDMS as base material. The acoustic impedance of the flexible matching layer (2) is 2MRayl-3MRayl, and the thickness of the flexible matching layer (2) is , Ultrasonic length.

9. The integrated flexible probe device for combined muscle electrical stimulation and ultrasound imaging therapy according to claim 3, characterized in that: The preparation process of the flexible matching layer (2) is as follows: (1) Add anhydrous ethanol into the test tube and perform ultrasonic cleaning; (2) Determine the mass of each component of PDMS, cyclohexane, and curing agent according to the proportion; (3) Add alumina until the test tube reaches the required mass; (4) Pipette PDMS in small amounts and multiple times until the test tube reaches the required mass; (5) Pipette cyclohexane and curing agent in small amounts and multiple times until the test tube reaches the required mass; (6) Mix the test tube by shaking for 8 minutes; (7) Drop the liquid in the test tube into the mold, heat and solidify it, and let it stand to complete the preparation of the flexible matching layer (2).

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