30 results about "Muscle atrophy" patented technology

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

1. Name of the product in this design: Upper Limb Rehabilitation Therapy Device. 2. Purpose of this design: This design is intended to improve voluntary movement ability and prevent muscle atrophy in affected limbs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present application relates to a kind of traditional Chinese medicine liquid and traditional Chinese medicine paste for regulating muscle strength balance and preparation method thereof, the traditional Chinese medicine liquid for regulating muscle strength balance is prepared from the following raw materials by weight percentage: 8-12 parts of jieseng, 12-18 parts of eucommia ulmoides, 10-15 parts of taxillus, 15-20 parts of radix puerariae, 12-18 parts of radix astragali, 6-10 parts of chuanxiong, 9-12 parts of radix paeoniae alba, 10-15 parts of radix anemarrhena, 5-8 parts of mentha, and 6-8 parts of licorice.The preparation method of the traditional Chinese medicine liquid includes the following steps: a. pretreatment of raw materials; b. double extraction; c. concentration and mixing; d. blending and homogenization; and e. sterilization and packaging.The traditional Chinese medicine liquid and traditional Chinese medicine paste for regulating muscle strength balance are used for the regulation of spastic, atrophic and mixed muscle strength imbalance, and the relief of muscle spasm, muscle atrophy, and incoordination of limb movement, etc., and are suitable for post-stroke rehabilitation, secondary imbalance of cervical and lumbar spondylosis, and recovery of sports injury, etc., and have the advantages of bidirectional regulation and targeted penetration, etc.

Provided herein are compositions and methods for tissue repair. In particular, the compositions and methods described herein find use in repairing, regenerating, and modulating fibrosis and inflammation in a variety of tissues such as, for example, large volume muscle loss, including skeletal and heart muscle, blast wave injury, muscle loss from diabetes and resulting from frailty as a result of aging.

The utility model discloses a kind of postoperative shaping auxiliary devices for neck and back, applied in rehabilitation engineering technical field, including support plate, the top of the support plate is bolted with fixed plate, the top of the front of fixed plate is bolted with adjusting box;The utility model can reduce blood stasis caused by long-term braking by moderate activity design, accelerate inflammation subsides and wound healing, reduce muscle spasm and nerve compression on the basis of maintaining neck physiological curvature, relieve postoperative pain, reduce postoperative muscle fatigue and joint stiffness by dispersing neck pressure, improve patient comfort degree;While maintaining the stability of spine, allow moderate activity, avoid muscle atrophy or joint stiffness caused by long-term complete braking, support device shares back muscle load, relieve postoperative muscle fatigue and spasm caused by compensatory effort, buffer layer reduces the friction of skin and hard brace, reduce the risk of skin damage caused by long-term wearing.

This invention relates to the field of medical device technology and discloses a rehabilitation exercise device for preventing muscle atrophy. The device includes an elastic locking bandage that can be strapped to the periphery of a rod structure, a pressure-controlled damping mechanism, and a movable driven mechanism. Its structure includes a piston plate placed on an outer hollow tube and capable of moving axially along the outer hollow tube; a second helical spring capable of returning the piston plate to its upward position; a loop-shaped grip rod located directly below the outer hollow tube and capable of driving the piston plate; and a spherical airbag installed at the horizontal part of the loop-shaped grip rod and in an inflated state. This rehabilitation exercise device for preventing muscle atrophy utilizes the gripping motion to generate pneumatic damping, thereby exercising the patient's forearm muscles. Furthermore, through elastic stretching and gas flow restriction, it provides damping for the bending of the forearm and upper arm, thus exercising the patient's forearm and upper arm and preventing muscle atrophy.

The present application relates to the technical field of medicine, and provides application of strong loquat juice in preparation of a medicine for improving and / or treating muscle atrophy. The strong loquat juice is applied in preparation of the medicine for improving and / or treating muscle atrophy, in particular age-related muscle atrophy or inflammation factor-induced muscle atrophy, and the strong loquat juice improves and / or treats muscle atrophy by improving motor function, promoting myotube differentiation and hypertrophy, and maintaining muscle fiber structural integrity. The present application discloses the improvement effect of the strong loquat juice on muscle structure and function in cell and animal models: in a TNF-alpha-induced C2C12 myotube atrophy model, the strong loquat juice can significantly increase myotube diameter and improve myosin heavy chain expression; in an aging-related Caenorhabditis elegans model, the strong loquat juice can significantly enhance body bending ability, pharyngeal pump movement rate and muscle fiber structural integrity.

This invention belongs to the field of biomedical technology, specifically involving the application of the MRPL41 gene / protein in the preparation of drugs for treating age-related sarcopenia. This invention is the first to demonstrate that MRPL41 is a key rate-limiting factor in the assembly of mitochondrial ribosomes in aging muscle satellite cells, establishing it as a core target for the treatment of age-related sarcopenia. Overexpression of MRPL41 can promote the assembly of mitochondrial 55S holoenzymes, improve the translation efficiency of mitochondrial-encoded proteins, repair mitochondrial dysfunction at its source, thereby promoting muscle repair, improving muscle atrophy, and achieving the treatment of age-related sarcopenia. This invention provides a precise microscopic target for the treatment of age-related sarcopenia, overcoming the limitations of existing clinical therapies (such as hormone replacement and simple nutritional supplementation) due to significant side effects and "anabolism resistance," providing a new direction for the development of innovative drugs specifically for the treatment of age-related sarcopenia, and has excellent application prospects.

The present invention is a muscular atrophy inhibitor comprising at least one pyrimidine nucleotide or a precursor thereof as an active ingredient. Also, the present invention is a method for inhibiting muscular atrophy by administrating at least one pyrimidine nucleotide or a precursor thereof.

The application discloses an application of a tRF-GlyGCC expression regulator in preparation of a muscle atrophy diagnosis product, and relates to the technical field of biological detection.The application specifically discloses the application of the tRF-GlyGCC expression regulator in preparation of the muscle atrophy diagnosis product, wherein the sequence of the tRF-GlyGCC is shown as SEQ ID NO.1.The tRF-GlyGCC expression regulator is a tRF-GlyGCC expression promoter or a tRF-GlyGCC expression inhibitor; the sequence of the tRF-GlyGCC expression promoter is shown as SEQ ID NO.2, and the sequence of the tRF-GlyGCC expression inhibitor is shown as SEQ ID NO.3.The application applies the tRF-GlyGCC expression regulator to the diagnosis of the muscle atrophy, so as to solve the problem that the existing muscle atrophy diagnosis lacks related diagnosis markers and targets.

Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle dystrophy (DM1).

The application discloses a function exercise device for distal radius fracture and relates to the technical field of orthopedic rehabilitation medical instruments, which comprises arc-shaped symmetrical circular arc plates, two of which are rotationally connected through a hinge in the middle, a function exercise assembly fixedly installed at one end of the two circular arc plates away from the wrist, and two fixed boxes included in the function exercise assembly. The function exercise device for distal radius fracture can realize rehabilitation training through the meshing transmission structure of the worm gear and the helical gear, can drive the finger joints to make soft and uniform flexion and extension movement through the linkage of the bilateral air bags, can realize the synchronous and integrated exercise of the wrist joint and the finger joints, can effectively accelerate local blood circulation, can reduce soft tissue swelling, can prevent muscle atrophy and joint stiffness, can reduce the risk of osteoporosis, can significantly shorten the fracture healing period, and can efficiently promote the comprehensive recovery of the motion function of the affected limb.

The utility model discloses a kind of lower limbs rehabilitation equipment for patient of inconvenient action, belong to rehabilitation sickbed technical field, specifically including electric sickbed and vibration host, one end of the electric sickbed is provided with vibration host by connecting frame, the vibration host includes installation shell, vibration shell and vibration mechanism, installation shell is fixedly connected with mounting bracket, vibration shell is movably sleeved in the other end of installation shell, vibration shell is rotatably connected by connecting mechanism between vibration shell and installation shell, vibration shell is fixedly connected with vibration bracket, and vibration mechanism is arranged on mounting bracket;The utility model is provided with electric sickbed and vibration host, can guide inconvenient action patient to rely on dead weight pressure effect on vibration host, combined with the alternate vibration of vibration host, dynamic traction is formed to lower limb muscle, solve the existing equipment for inconvenient action patient, sub serious patient, rehabilitation early patient's rehabilitation and the problem that pertinence is weak, cannot effectively prevent muscle atrophy, cannot effectively prevent muscle atrophy.

This invention provides a method for constructing and applying an animal model of sarcopenia, belonging to the field of animal model construction technology. This invention uses... adora2b Targeting genes, by knocking out the aforementioned adora2b Genetic constructing of a sarcopenia animal model. This invention uses CRISPANT technology to construct a knockout gene. adora2b Zebrafish model of genes adora2b Mutant zebrafish exhibit muscle atrophy and dysfunction, showing reduced muscle fluorescence area and average intensity, increased cellular senescence, and significantly decreased expression of muscle function-related genes, indicating that the mutant zebrafish have experienced muscle degeneration and dysfunction. The present invention provides… adora2b Mutant zebrafish serve as an animal model of sarcopenia. adora2b Research on the relationship between gene mutations and the pathogenesis of sarcopenia, as well as the screening of drugs for the prevention and treatment of sarcopenia, have laid a theoretical foundation.

The application discloses a nursing device for preventing muscle atrophy in neurosurgery, and relates to the technical field of medical equipment. A switching training assembly is installed on a nursing bed plate, shaft pipes are symmetrically welded on the bottom end of a switching port, side retaining edges are hinged on the two sides of a rotating supporting plate, a headboard is welded on one end of the rotating supporting plate, a sliding plate is slidably installed in a sliding groove, a control rope is threaded through the headboard and wound on the outside of a winding shaft, and an expansion function assembly is installed on the nursing bed plate and the side retaining edges. The patient can hold the top end of the sliding plate, and the patient can perform a squatting and leg bending operation by moving the sliding plate downward. The patient can be supported by the sliding plate, and the patient can perform a rehabilitation training operation for preventing muscle atrophy without the help of medical staff, thereby reducing the burden of the medical staff. The subsequent recovery evaluation is facilitated by a tension sensor, the treatment effect is improved, the device is suitable for patients in different recovery stages, the patient does not need to walk or be assisted to move, and the burden of the patient is reduced.

The application provides an application of 3-(methylsulfonyl) propionitrile in preparation of a medicine for treating peripheral nerve adhesion diseases, relates to the field of biomedical technology, and is verified through a sciatic nerve adhesion mouse model that 3-(methylsulfonyl) propionitrile can effectively reduce the adhesion degree of nerves and peripheral tissues, and can significantly improve muscle atrophy symptoms; compared with the traumatic and high recurrence rate of surgical treatment, the drug is a non-invasive or minimally invasive treatment, has good patient tolerance, can effectively reduce treatment risks and rehabilitation costs, and has wider clinical applicability. Secondly, the drug plays a treatment effect through a double action mechanism: on the one hand, adhesion formation is inhibited, and nerve compression is released; on the other hand, nerve myelin sheath regeneration can be promoted, myelin sheath structure integrity is improved, nerve conduction velocity is improved, and the synergistic effect of 'adhesion release + nerve repair' is realized. Animal experiments prove that the drug can significantly improve the motion balance ability and gait function of model mice.

The present application relates to the field of microbial technology, and particularly relates to the application of AKK bacteria and products thereof in anti-aging and / or anti-oxidation. The preservation number of the AKK bacteria is CGMCC No. 20954, and the strain is preferably used in a pasteurized form. Through three kinds of zebrafish model experiments, it is proved that the strain can effectively improve cell aging, specifically, the telomere length is improved, the expression amount of anti-aging gene spns1 is enhanced, and the symptoms of muscle atrophy and cognitive impairment caused by aging are obviously improved. In particular, the minimum effective amount of the strain in the water body for feeding zebrafish is 250 μg / mL, and the minimum effective amount in the human body is 30 billion AFU per person per day. The present application provides a clear strain source and dosage basis for developing a multi-dimensional and systematic anti-aging functional composition.

Among other things, the present disclosure provides oligonucleotide compositions and methods thereof. In some embodiments, oligonucleotides comprise various chemical modifications of sugars, nucleobases, and / or internucleotidic linkages and patterns thereof and are useful for exon skipping. In some embodiments, the present disclosure provides technologies useful for skipping exon 45 of dystrophin (DMD) transcripts. In some embodiments, the present disclosure provides technologies useful for modulating DMD transcript splicing. In some embodiments, the present disclosure provides methods for preventing or treating conditions, disorders or diseases including Duchenne muscular dystrophy.

The present application relates to the technical field of medical devices, and discloses a three-dimensional dynamic adjustable fixing brace for the conservative treatment of developmental dislocation of the hip joint of infants, comprising ball shafts rotatably connected to both sides of the double-joint ball socket, a rack arranged on one side of the surface of the ball shaft, and a tension adjusting block sliding rail, a shaft seat and an inner sleeve arranged inside the double-joint ball socket. The present application has a reasonable structure, and through the cooperation of the double-joint ball socket and the ball shaft, the three-dimensional dynamic adjustable fixing brace can realize the flexible adjustment of the multiple degrees of freedom between the back clamping mechanism and the leg supporting structure, can adapt to the leg differences of infants and preschool children of different ages, and can significantly improve the versatility and clinical application range of the device. The unique elastic locking mechanism allows to retain a micro multi-directional movement space within a safe range while ensuring the stability of the hip joint reduction, conforms to the physiological activity needs of infants, and relieves the discomfort and muscle atrophy risk of traditional braces.

This muscular atrophy inhibitor contains a pyrimidine nucleotide or a precursor thereof as an active ingredient. This method is for inhibiting muscular atrophy through administration of a pyrimidine nucleotide or a precursor thereof.

This application relates to a training device for patients with muscular atrophy, belonging to the technical field of muscular atrophy training devices. To address the problem that existing training devices can only train the upper and lower limbs separately, this application provides a training device for patients with muscular atrophy, including a frame, a lower limb training mechanism, an upper limb training mechanism, a counterweight device, and an automatic disconnection device. The lower limb training mechanism is located at the lower end of the frame and is used for leg lifting training; the upper limb training mechanism is located at the upper end of the frame and is used for arm pull-down training. Both share the same adjustable counterweight device as a resistance source. The automatic disconnection device enables multiple modes of independent and coordinated training of the upper and lower limbs. In these multiple modes, an automatic rewinding device and a buffer device are provided to avoid interference from the ropes during training and to provide cushioning protection under stress. Therefore, this provides a compact, easy-to-operate, comprehensive, safe, and effective rehabilitation training device for patients with muscular atrophy.

A wheelchair leg exercise device relates to wheelchair equipment field, including crosspiece, movable part and pedal, one end of movable part is installed with long axle part, the other end is connected with crosspiece, the lower end of long axle part is fixedly connected with fixed head, the pedal is fixedly installed on fixed head, the lower end of crosspiece is hinged with impedance slide cylinder, impedance slide column is hinged on movable part, impedance slide column is slidably connected in impedance slide cylinder, the utility model discloses an innovative leg exercise device to realize active training of calf muscle, simulates walking action mode to strengthen patient action ability, utilizes the friction resistance design of damping head and impedance slide cylinder, provides adjustable impedance training, significantly improves muscle exercise effect, and the structure is simple and reliable, and high -efficient rehabilitation training can be realized without complex power system, provides the comprehensive solution for the patient who sits for a long time to prevent muscle atrophy, promotes the comprehensive solution of blood circulation.

Use of a ketone body and a ketone body ester for preserving glycogen and / or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-β-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.

This invention discloses a multifunctional integrated space physiological countermeasures and movement assistance suit and its control method. The spacesuit includes: a negative pressure fluid regulation system that applies controllable negative pressure to regulate fluid distribution; a biomimetic muscle system that applies controllable torque to simulate muscle exertion; an axial loading system that applies longitudinal compressive stress to simulate bone compression; and a control system that coordinates the operation of each system. In a preferred embodiment, the negative pressure system has multiple sealed zones with the negative pressure value increasing from the head side to the foot side and synchronizing with the cardiac cycle. The biomimetic muscle system can switch between assisted, resistive, and free modes. The axial loading system includes independent subsystems for the cervical spine and trunk-lower limbs. This invention is the first to integrate zoned stepped negative pressure, synchronized cardiac cycle regulation, biomimetic muscle coordination, and graded axial loading into a single wearable system, enabling all-weather simulation of Earth's gravity effects and addressing issues such as head-to-head fluid shift, muscle atrophy, bone loss, and disuse changes in the spine under microgravity.

This invention discloses the application of a traditional Chinese medicine composition in the preparation of a drug for treating sarcopenia, wherein the traditional Chinese medicine composition consists of Astragalus membranaceus and Anemarrhena asphodeloides. The study found that the combination of Astragalus membranaceus and Anemarrhena asphodeloides can significantly improve the differentiation function of C2C12 myoblasts induced by high glucose and inhibit lipid deposition, and improve skeletal muscle mass, muscle strength, and motor function in a streptozotocin-induced C57BL / 6 diabetic sarcopenia mouse model. In vitro and in vivo experiments have confirmed that this drug has significant effects in improving muscle atrophy, enhancing motor function, and restoring muscle strength; it can effectively increase the cross-sectional area of ​​muscle fibers, promote myotube fusion, and accelerate damage repair, showing a clear potential to inhibit diabetic muscle atrophy. This provides an effective traditional Chinese medicine compound intervention strategy for the clinical treatment of diabetic sarcopenia and has good prospects for development and application.

The application discloses application of SKP-SC-EVs in preparation of DPN treatment drugs and belongs to the technical field of biological medicine.The SKP-SC-EVs in the application can be internalized by SCs, and can directly repair and protect damaged SCs in multiple dimensions, laying a good cell foundation for nerve regeneration, in contrast to other source EVs.In addition, through treatment of DPN model rats with the SKP-SC-EVs, it is proved that the SKP-SC-EVs can effectively improve the nerve sensory and motor functions of the DPN rats, promote the regeneration of the nerve structure and myelin sheath of the rats, enhance the nerve internal microcirculation blood flow, delay the atrophy and degenerative changes of the target muscle, and realize systematic repair of the three functional units of "nerve-vascular-muscle".The DPN treatment scheme provided by the application effectively overcomes the defects in the prior treatment schemes, i.e., single repair effect dimension and difficulty in realizing fundamental reconstruction of nerve functions and keeping long-term stability.

This utility model relates to the technical field of foot immobilization devices, specifically, to a foot immobilization device for preventing pressure sores. It includes a U-shaped plate, with a strap fixedly connected to the top of the U-shaped plate. A rotating shaft is rotatably connected inside the U-shaped plate, and a rotating plate is fixedly connected to the outer left surface of the rotating shaft. Fixing ropes are fixedly connected to the outer left and right sides of the rotating plate, and a fixing plate is fixedly connected to the inner surface of the U-shaped plate. This utility model first rotates the handle, causing the rotating shaft to rotate. Then, the rotating shaft rotates, causing the rotating plate to rotate. Following this, a spring rebounds, causing the mounting plate to move up and down. This up-and-down movement of the mounting plate causes the rolling shaft to move up and down, closely adhering to the bottom of the leg. As the rotating plate rotates, the bottom of the leg rubs against the rolling shaft, causing the rolling shaft to rotate. The friction between the rolling shaft and the bottom of the leg accelerates blood flow to the bottom of the leg, reducing the formation of pressure sores. It also helps patients rotate their ankles, preventing muscle atrophy and ankle stiffness caused by prolonged immobility of the legs and feet, thus facilitating subsequent rehabilitation and walking.

The present invention relates to a pharmaceutical composition for preventing or treating muscle diseases, comprising an extract of Brassica juncea as an active ingredient. Inhibitory activity against myotube cell atrophy, a muscle anabolic factor expression promoting activity, and an effect of recovering from dexamethasone-induced enhancement of muscle cell catabolism and inhibition of anabolism of the Brassica juncea extract have been analyzed, and the effects of the Brassica juncea extract on recovery of reduced muscle tissue size, weight and muscle fiber size, biostability, a serum LDH level recovery effect, and an effect of reducing CK and creatinine levels in animal models have been analyzed, and thus it has been identified that the Brassica juncea extract can be used for preventing or treating sarcopenia or muscle atrophy.

Provided is a pharmaceutical composition for preventing and treating muscle loss, comprising an oregonin compound derived from a plant of the genus Alnus as an active ingredient.

Short expansion mutations in PABPN1 cause adult-onset, autosomal dominant oculopharyngeal muscular dystrophy (OPMD). The molecular hallmark of OPMD is the presence of insoluble nuclear aggregates of the expanded (exp)PABPN1. The aggregation of PABPN1 results in reduced levels of functional PABPN1. In OPMD, PABPN1 levels are under a critical threshold which leads to muscle weakness. Interestingly, reduced levels of PABPN1 are also found in ageing muscles, where these reduced levels lead to muscle atrophy and has also been found to be associated with other adult-onset pathologies affecting tissues other than skeletal muscles, such as cancers, including bladder cancer, and heart diseases.