166 results about "Muscle atrophy" patented technology

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the anti-aging aspect. The bifidobacterium longum subsp. Infantis Y46 is obtained from excrement of infants. Animal experiments prove that living cell thalli (Y46) and thermally inactivated cell thalli (HKY46) obtained by culturing the bifidobacterium longum subsp. Infantis Y46 by using an MRS liquid culture medium containing L-cysteine hydrochloride (0.05%, v / v) can significantly reduce accumulation of lipofuscin in a host, and prolong the healthy life and life of the host. Therefore, the bifidobacterium longum subsp. Infantis Y46 is a promising probiotic and a promising metagen with an anti-aging function.

The invention belongs to the technical field of microbial function development, and particularly relates to lactobacillus plantarum YD666 and application of the lactobacillus plantarum YD666 in products for slowing down muscle atrophy and osteoporosis, the lactobacillus plantarum YD666 is preserved in the China Center for Type Culture Collection with the preservation number of CCTCC No: M 2025897, a preparation method of a lactobacillus plantarum YD666 bacterial suspension is provided, and the lactobacillus plantarum YD666 bacterial suspension can be used for preparing the lactobacillus plantarum YD666 bacterial suspension with the preservation number of CCTCC No: M 2025897. According to the lactobacillus plantarum YD666 and the application of the lactobacillus plantarum YD666 bacterial suspension in preparation of products for slowing down muscle atrophy and osteoporosis, the weight index of skeletal muscles of suspended tail rats can be increased by slowing down muscle weight loss caused by weightlessness; growth of muscle fibers is promoted, and the proportion of conversion from slow muscles to fast muscles is reduced, so that a weightlessness environment is resisted; the muscle movement contraction strength of the suspended tail rats is maintained, so that the application of relieving muscle atrophy under weightlessness is achieved, and the device is suitable for astronauts, crowds lack of movement and bedridden people who suffer from long-term illness and has wide market potential and application prospects.

There is provided a method for diagnosing a subject with early onset muscle atrophy, said method comprising: obtaining a biosample from the subject; and assaying the biosample for one or more biomarkers, said one more biomarkers are taurine, proline, citrulline, trigonelline, thymidine, ornithine, glutamate, L-pyroglutamic acid, creatinine, adenine, nicotinamide, 2-methylhippuric acid, maltol, L-arginine, hypotaurine, L-glutamine, homogentisic acid, methylhistidine, oxoglutaric acid, xanthine, L-carnitine, succinate, or a combination thereof; and identifying the subject with early onset muscle atrophy on the basis of a deviation in the one or more of said one more biomarkers.

The invention discloses a bionic self-crimping material and application in the nerve field, and relates to the technical field of nano materials. The preparation method comprises the following steps: firstly, carrying out ultraviolet photopolymerization on acrylic acid and acrylic acid-N-hydroxysuccinimide, adding chitosan and glutaraldehyde to form hydrogel, and introducing epigallocatechin gallate into a chitosan-acrylic acid network. The material is rapidly and autonomously curled into a tube shape after being in contact with wet nerves, glutaraldehyde is directionally and orderly diffused by adopting a three-channel micro-fluidic chip, and the fineness is improved, so that the matching degree of nerve broken ends with different thicknesses is increased; the surface active groups of the material and the natural component chitosan cooperate to realize suture-free fixation; the plant phenol antioxidant removes free radicals at nerve injury parts; the degradation period is synchronous with natural healing of nerves, and secondary operation for taking out is not needed. The electroneurographic signals using the material are transmitted more smoothly, the target muscle atrophy degree is reduced, and the limb movement function is recovered to be close to the normal level.

The utility model discloses an orthopedic nursing traction support, which relates to the technical field of medical instruments, and comprises a bracket, an adjusting pad is arranged on one side of the bracket in a sliding and penetrating manner, the other side of the bracket is fixedly connected with a stand column, the bottom of the bracket is fixedly connected with an assembly block, and the lower end of the assembly block is provided with a first hydraulic oil cylinder. By means of the assembling block and the connecting shaft, the angle of the extension rods on the two sides is adjusted, the fixing device is suitable for patients of different body types, after the feet of the patients are fixed to the fixing base, the stability of the position of the fracture broken end can be maintained, shortening and displacement of the fracture broken end are overcome, fracture reduction is more accurate, and during follow-up rehabilitation training, the rehabilitation training efficiency is improved. The position of the sliding seat on the extension rod can be adjusted, the knee joint is driven to be bent in cooperation with rotation of the extension rod, and the provided traction force assists in functional exercise of limbs, promotes blood circulation, prevents amyotrophy and joint stiffness and accelerates recovery of limb functions.

The invention provides application of desulfurization vibrio in screening of drugs or functional food for preventing and treating sarcopenia. According to the application disclosed by the invention, a main intestinal flora desulfurization vibrio capable of promoting amyotrophy is firstly found, and the desulfurization vibrio can be used as a main target for screening sarcopenia and can be used for screening medicines or functional foods for preventing and treating sarcopenia. Sinopenia susceptible people are screened through abundance of desulfurization vibrio in excrement, and early discovery and targeted early intervention can be carried out; aiming at the mechanism that desulfurization vibrio in intestinal tracts promotes occurrence and development of sarcopenia, drugs or functional food for treating sarcopenia can be further screened, and then substances / new therapy for preventing and treating sarcopenia are developed.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

This disclosure provides ActRII-binding proteins such as anti-ActRIIA and anti-ActRIIB antibodies, and compositions and methods for making the ActRII-binding proteins. In certain embodiments, the ActRII-binding proteins inhibit, or antagonize ActRII activity. In addition, the disclosure provides compositions and methods for diagnosing and treating diseases and conditions associated with muscle wasting; a fibrotic condition; an inflammatory, cardiovascular, pulmonary, musculoskeletal, neurologic, ocular, skeletal, autoimmune, or metabolic disease or condition; wound healing; and cancer, and other ActRII-mediated diseases and conditions.

The invention discloses a sarcopenia electromyographic signal acquisition and analysis system, and belongs to the technical field of medical detection. The system comprises an electromyographic signal acquisition module, a signal preprocessing module, a feature extraction module, an analysis and diagnosis module and a result output module which are electrically connected in sequence, the electromyographic signal acquisition module adopts a flexible dry electrode array to realize noninvasive and anti-interference acquisition; the signal preprocessing module outputs high-quality electromyographic signals through self-adaptive trapped wave, band-pass filtering and standardization processing; the feature extraction module extracts time domain, frequency domain and nonlinear multi-dimensional features; the analysis and diagnosis module is used for completing low, medium and high three-level risk assessment of sarcopenia and judgment of muscle fiber atrophy type, innervation disorder type and metabolic disorder type decline types on the basis of a deep learning model; and the result output module stores the data and generates an evaluation result. According to the invention, noninvasive, accurate and efficient screening and diagnosis of sarcopenia are realized, a scientific basis is provided for clinical intervention, and the method is suitable for various medical health scenes.

Provided are methods of treating spinal muscular atrophy (SMA) using a combination of a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and an agent that increases motor neuron survival (SMN) protein expression. Furthermore, provided herein is a composition, a pharmaceutical formulation, or a kit comprising a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and an agent that increases the expression of a motor neuron survival (SMN) protein.

The utility model discloses a nursing device for preventing muscle atrophy of a bedridden patient. The nursing device comprises a supporting assembly and a nursing assembly movably connected to the supporting assembly. When the nursing bed is used, the supporting assembly is connected with a bed body, meanwhile, the to-be-nursed part of a patient is located on the nursing assembly, and the position and angle of the to-be-nursed part of the patient are adjusted by moving and / or rotating the nursing assembly relative to the supporting assembly. When the nursing bed is used, the position and the angle of the nursing assembly are adjusted by moving and / or rotating the nursing assembly relative to the supporting assembly, the use comfort of a patient in the nursing process is improved, and the recovery progress of the bedridden patient is promoted.

This disclosure provides a secretion centric therapy to overcome muscle wasting. Provided are mesenchymal stem cell secretion-based therapies to overcome muscle wasting due to: old age; as a consequence of immobilization (e.g., mobility restricted or paralytics administered); due to use of ventilators (e.g., in an ICU or long-term immobilization); in microgravity during long space flights; or, resulting from drug side effects (e.g., the use of weight loss drugs, chemotherapies, etc.). Uris disclosure further provides methods and compositions for modulating, including regulating or altering, the structure and function of diaphragm muscle cells and / or diaphragm muscle fibers in particular, and skeletal muscle in general. In certain embodiments extracellular vesicles are applied to patients affected by muscle wasting.

The present application relates to the microRNA drug technical field, specifically to the application of hsa-let-7f-5p in the preparation of a drug for treating muscle steatosis, and discloses that hsa-let-7f-5p can inhibit muscle fat infiltration by inhibiting fibroblast / adipogenic progenitor cell adipogenic differentiation, and hsa-let-7f-5p can be used as a microRNA drug in the treatment of diseases such as muscle fat infiltration and muscle steatosis, and diseases related to fat infiltration, for example, muscle atrophy, muscle injury, obesity, diabetes, etc. The relevant nucleic acid fragments are wrapped in liposomes, so that the drug stability and drug efficiency can be improved. The technical scheme can solve the technical problem that there is no drug capable of effectively inhibiting muscle steatosis and treating muscle injury in the prior art, and has an ideal application and promotion prospect in the fields of sports medicine and rehabilitation treatment.

The present invention provides a therapeutic drug for frailty or muscular dystrophy, and particularly for sarcopenia, and a medicinal drug for improving motor function. The present invention provides a motor function improver that contains a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof and additionally contains an ATP precursor substance or is used in combination with an ATP precursor substance. The ATP precursor substance is preferably inosine, inosinic acid, or hypoxanthine. This motor function improver is preferably used as a medicinal drug and is used as a therapy or preventive for frailty and sarcopenia and as a therapy or preventive for muscle wasting and muscle loss.

The application provides application of ABT199 in preparation of a drug for treating muscle atrophy. Compared with the prior art, the application provides a new use of ABT199 in treating muscle atrophy. Experimental research proves that ABT199 administration can significantly restore the exercise capacity of a cachexia-induced muscle atrophy mouse, improve the muscle cross-sectional area of the mouse, restore the reduced glutathione content of the mouse, and improve the superoxide dismutase activity, so as to improve the muscle atrophy phenotype of the mouse and muscle atrophy-related biochemical indexes. ABT199 can significantly restore cell muscle atrophy-related gene and protein expression, and improve the cachexia-induced muscle atrophy phenotype by reducing related inflammatory mediators; ABT199 can significantly improve the mitochondrial membrane potential, increase the expression of mitochondrial neogenesis-related genes, and reduce the production of active oxygen.

The invention discloses an adjustable nursing bed which comprises a base and a mounting frame, a first stabilizing plate is arranged above the mounting frame, a drooping block is fixedly connected to the side face of the first stabilizing plate, the drooping block is rotationally connected with a third stabilizing plate, shaft columns are symmetrically arranged above the third stabilizing plate, the shaft columns are rotationally connected with a shell, and thin rods are fixedly mounted in the shell. According to the invention, the health problems of amyotrophy, soreness of waist and back pain, bedsore and the like caused by long-term lying in bed are solved, on one hand, a patient can drive the lower limbs to move by treading the pedal, and meanwhile, a back massage structure and a second cam are linked to rotate, so that the pressure on the muscles of the lower back can be relieved, and the blood circulation of the limbs can be promoted; on the other hand, the treading action can trigger the fan blades to rotate, air is blown to the buttocks through the breathable plate to cool the buttocks, dynamic pressure reduction and breathability are achieved in combination with the air circulation design, and the occurrence risk of bedsores at the parts such as the sacrococcygeal region and the heels is effectively reduced.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

Disclosed are methods of treating muscular atrophy diseases, such as spinal muscular dystrophy or muscular dystrophy, using matrix-bound vesicles (MBV). Compositions for the treatment of muscular atrophic diseases are also disclosed.

1. Name of the product in this design: Upper Limb Rehabilitation Therapy Device. 2. Purpose of this design: This design is intended to improve voluntary movement ability and prevent muscle atrophy in affected limbs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention pertains to a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for use in preventing and / or treating a metabolic disorder and / or muscle atrophy. It also pertains to a method of preventing and / or treating a metabolic disorder and / or muscle atrophy in a subject. It furthermore pertains to use of a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for increasing the level of insulin and / or glucagon in the blood of a subject and the present invention also pertains to a non-therapeutic use or method of a) beta-lactoglobulin or b) a nutritional composition comprising BLG. It also pertains to beta-lactoglobulin (BLG) for use in preventing and / or treating diabetes or prediabetes in a subject. It furthermore pertains to a nutritional composition for use in preventing and / or treating diabetes or prediabetes in a subject.

The present application relates to a kind of traditional Chinese medicine liquid and traditional Chinese medicine paste for regulating muscle strength balance and preparation method thereof, the traditional Chinese medicine liquid for regulating muscle strength balance is prepared from the following raw materials by weight percentage: 8-12 parts of jieseng, 12-18 parts of eucommia ulmoides, 10-15 parts of taxillus, 15-20 parts of radix puerariae, 12-18 parts of radix astragali, 6-10 parts of chuanxiong, 9-12 parts of radix paeoniae alba, 10-15 parts of radix anemarrhena, 5-8 parts of mentha, and 6-8 parts of licorice.The preparation method of the traditional Chinese medicine liquid includes the following steps: a. pretreatment of raw materials; b. double extraction; c. concentration and mixing; d. blending and homogenization; and e. sterilization and packaging.The traditional Chinese medicine liquid and traditional Chinese medicine paste for regulating muscle strength balance are used for the regulation of spastic, atrophic and mixed muscle strength imbalance, and the relief of muscle spasm, muscle atrophy, and incoordination of limb movement, etc., and are suitable for post-stroke rehabilitation, secondary imbalance of cervical and lumbar spondylosis, and recovery of sports injury, etc., and have the advantages of bidirectional regulation and targeted penetration, etc.

The invention discloses a nursing bed for preventing bedsores and cleaning excreta in time, a massage structure is arranged on a nursing bed body, and a urination opening is formed in the edge of the massage structure. The invention relates to the technical field of nursing beds, and has the beneficial effects that a negative pressure suction device and a matched drying function enable urine of a patient to be removed in time, so that the skin wetting time is shortened, the occurrence rate of urinary tract infection and perineum dermatitis is reduced, the cost of adult diapers is reduced, and the defects caused by the adult diapers are overcome. Automatic massage and electrical stimulation solve the problem of passively preventing bedsores, the electrical stimulation is particularly suitable for completely paralyzed patients, muscle atrophy can be effectively delayed, the effect of promoting blood circulation is achieved, and the frequency of turning over is reduced.

The invention relates to the technical field of nerve injury repair, in particular to a spinal cord injury repair system based on ordered collagen scaffold carried cell transplantation combined with electroacupuncture stimulation application. The invention provides a spinal cord injury repairing system, which comprises a biological material support transplanting module, a cell inoculating module and a spinal cord injury repairing module, and the electro-acupuncture stimulation module is used for applying electro-acupuncture stimulation to acupuncture points after the biological material stent inoculated with the cells is transplanted to the spinal cord injury part. According to the system, electroacupuncture stimulation and biomaterial stent transplantation cells are combined for application, the microenvironment can be remarkably improved, survival, differentiation and function integration of the transplantation cells can be promoted, meanwhile, muscle atrophy and joint degeneration are relieved, an innovative treatment system is provided for spinal cord injury, and the system has high clinical feasibility and is worthy of popularization and application. Good application prospects are realized in the field of spinal cord injury repair.

To provide a novel technology for preventing muscle atrophy by directly promoting muscle synthesis or inhibiting muscle breakdown without physical activity.SOLUTION: Provided is a muscle atrophy prevention agent containing, as an active ingredient, lactic acid bacteria with muscle synthesis-promoting effects and / or muscle breakdown-inhibiting effects, a processed product of the lactic acid bacteria, or an extract thereof, the lactic acid bacteria with muscle synthesis-promoting effects being Lactobacillus gasseri or the like, the lactic acid bacteria with muscle breakdown-inhibiting effects being Lactobacillus reuteri or the like.SELECTED DRAWING: Figure 1

The present invention pertains to a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for use in preventing and / or treating a metabolic disorder and / or muscle atrophy. It also pertains to a method of preventing and / or treating a metabolic disorder and / or muscle atrophy in a subject. It furthermore pertains to use of a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for increasing the level of insulin and / or glucagon in the blood of a subject and the present invention also pertains to a non-therapeutic use or method of a) beta-lactoglobulin orb) a nutritional composition comprising BLG. It also pertains to beta-lactoglobulin (BLG) for use in preventing and / or treating diabetes or prediabetes in a subject. It furthermore pertains to a nutritional composition for use in preventing and / or treating diabetes or prediabetes in a subject.

Provided herein are compositions and methods for tissue repair. In particular, the compositions and methods described herein find use in repairing, regenerating, and modulating fibrosis and inflammation in a variety of tissues such as, for example, large volume muscle loss, including skeletal and heart muscle, blast wave injury, muscle loss from diabetes and resulting from frailty as a result of aging.

The invention discloses flaxseed and wheat oligopeptide mixed powder with an effect of improving sarcopenia, and belongs to the field of biological medicines. The invention relates to a composition with an effect of improving sarcopenia. The composition comprises active ingredients including wheat oligopeptide and flaxseed meal, wherein the flaxseed powder contains secoisolariciresinol diglucoside, and a mixture of small molecules with the molecular weight smaller than 1000 Da in the wheat oligopeptide accounts for 90% or above. The invention discloses a differentiated molecular path on which the two components play roles, the wheat oligopeptide has outstanding effects in the aspects of remarkably activating a PI3K / Akt pathway and promoting FOXO3a phosphorylation inactivation, the mechanism complementarity of'upstream regulation 'and'downstream blocking' lays a solid theoretical foundation for realizing a more comprehensive anti-atrophy effect through combined use, and the wheat oligopeptide has a good application prospect. And a composite scheme with a fuzzy mechanism in the prior art is exceeded. In addition, the formula disclosed by the invention can also improve the in-vivo environment which is not beneficial to muscle maintenance from the source by relieving chronic inflammation and oxidative stress.

The utility model discloses a kind of postoperative shaping auxiliary devices for neck and back, applied in rehabilitation engineering technical field, including support plate, the top of the support plate is bolted with fixed plate, the top of the front of fixed plate is bolted with adjusting box;The utility model can reduce blood stasis caused by long-term braking by moderate activity design, accelerate inflammation subsides and wound healing, reduce muscle spasm and nerve compression on the basis of maintaining neck physiological curvature, relieve postoperative pain, reduce postoperative muscle fatigue and joint stiffness by dispersing neck pressure, improve patient comfort degree;While maintaining the stability of spine, allow moderate activity, avoid muscle atrophy or joint stiffness caused by long-term complete braking, support device shares back muscle load, relieve postoperative muscle fatigue and spasm caused by compensatory effort, buffer layer reduces the friction of skin and hard brace, reduce the risk of skin damage caused by long-term wearing.

Methods of treating muscle atrophy (e.g., reduced muscle mass or muscle loss) using GSK-3β inhibitors are provided.